What is dutasteride? Dutasteride is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Dutasteride helps improve urinary flow and may also reduce your need for prostate surgery later on. dutasteride is for use in men only. Dutasteride may also be used for purposes not listed in this medication guide. Warnings Dutasteride should never be taken by a woman or a child. Dutasteride can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride capsules should not be handled by a woman who is pregnant or may become pregnant. Before taking this medicine You should not use dutasteride if you are allergic to dutasteride or finasteride. Dutasteride should never be taken by a woman or a child. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle dutasteride capsules. Tell your doctor if you have ever had: liver disease. Using dutasteride may increase your risk of developing prostate cancer. Your doctor will test your prostate specific antigen (PSA) to check for cancer while you are using this medicine. Dutasteride is not for use by women, and this medicine can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away. How should I take dutasteride? Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using dutasteride. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take the medicine at the same time each day, with or without food. Swallow the capsule whole and do not crush, chew, break, or open it. It may take up to 6 months or longer before you receive the full benefit of taking dutasteride. Your doctor will determine how long to treat you with this medicine. Keep using the medication as directed. You will need frequent medical tests. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking dutasteride? Do not donate blood while taking dutasteride and for at least 6 months after your treatment ends. Dutasteride can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains dutasteride. Dutasteride side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Common side effects may include: decreased libido (sex drive); decreased amount of semen released during sex; impotence (trouble getting or keeping an erection); or breast tenderness or enlargement. The sexual side effects of dutasteride may continue after you stop taking dutasteride. Talk to your doctor if you have concerns about these side effects. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Dutasteride dosing information Usual Adult Dose for Benign Prostatic Hyperplasia: 0.5 mg orally once a day Use: Treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to reduce the risk of acute urinary retention (AUR) and BPH-related surgery.   What other drugs will affect dutasteride? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Other drugs may affect dutasteride, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is Dyrenium? Dyrenium is a potassium-sparing diuretic (water pill) that is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney condition called nephrotic syndrome. Dyrenium is also used to treat edema caused by using steroid medicine or having too much aldosterone in your body. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in your body. Dyrenium may also be used for purposes not listed in this medication guide. Warnings You should not use Dyrenium if you have severe kidney or liver disease, urination problems, or high levels of potassium in your blood. You should not take Dyrenium if you also take potassium supplements, or other diuretics such as amiloride or spironolactone. Call your doctor right away if you have signs of hyperkalemia (high potassium), such as nausea, irregular heartbeats, weakness, or loss of movement. High potassium may be more likely in older adults, or in people with kidney disease, diabetes, or severe illness. Before taking this medicine You should not use Dyrenium if you are allergic to it, or if you have: severe kidney disease, or if you are unable to urinate; severe liver disease; high potassium levels (hyperkalemia); or if you take potassium supplements, or another potassium-sparing diuretic such as amiloride, eplerenone, or spironolactone. Tell your doctor if you have ever had: diabetes; heart disease; kidney disease; liver disease; gout; or kidney stones. Using Dyrenium may increase your risk of developing hyperkalemia (high levels of potassium in your blood). High potassium may be more likely in older adults, or in people with kidney disease, diabetes, or severe illness. Tell your doctor if you are pregnant or if you become pregnant. Dyrenium may harm an unborn baby. However, the benefit of treating edema during pregnancy may outweigh the risk to the baby. You should not breastfeed while using Dyrenium. Dyrenium is not approved for use by anyone younger than 18 years old. How should I take Dyrenium? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take Dyrenium after eating a meal to avoid stomach upset. Taking a diuretic can make you urinate more often, which could disrupt your sleep. If you take Dyrenium only once per day, take it in the morning to reduce the chance of night-time urination. You may need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Dyrenium. If you need surgery, tell the surgeon ahead of time that you are using Dyrenium. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased nausea, vomiting, unusual heart rate, muscle weakness, or loss of movement. What should I avoid while taking Dyrenium? Avoid driving or hazardous activity until you know how Dyrenium will affect you. Your reactions could be impaired. Drinking alcohol with this medicine can cause side effects. Dyrenium could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Dyrenium side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Dyrenium and call your doctor at once if you have: pale skin, easy bruising or bleeding; slow, fast, or uneven heartbeat; jaundice (yellowing of the skin or eyes); little or no urinating; signs of a kidney stone--sudden pain in your back or side, vomiting, fever, chills, painful urination, and urine that looks, red, pink, brown, or cloudy; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: nausea, diarrhea; dizziness, headache; dry mouth; or feeling weak or tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Dyrenium? Tell your doctor about all your other medicines, especially: any other diuretic; lithium; insulin or oral diabetes medicine; heart or blood pressure medicine; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect Dyrenium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is efavirenz, emtricitabine, and tenofovir (Atripla)? Atripla is a combination antiviral medication that prevents human immunodeficiency virus (HIV) from reproducing in your body. Atripla is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Atripla is not a cure for HIV or AIDS. Atripla is for use in adults and children who are at least 12 years old and weigh at least 88 pounds (40 kilograms). Atripla may also be used for purposes not listed in this medication guide. Warnings Do not take Atripla together with adefovir, atazanavir, voriconazole, or medications that contain emtricitabine, lamivudine, or tenofovir. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together. Atripla can cause severe or fatal liver problems. Call your doctor at once if you have symptoms such as stomach pain or swelling, loss of appetite, dark urine, or yellowing of your skin or eyes. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired. If you've ever had hepatitis B, it may become active or get worse after you stop using Atripla. You may need frequent liver function tests for several months. Before taking this medicine You should not take efavirenz, emtricitabine, and tenofovir if you are allergic to efavirenz (Sustiva), emtricitabine (Emtriva), or tenofovir (Viread). Do not take Atripla together with adefovir, atazanavir, voriconazole, or any medications that contain emtricitabine, lamivudine, or tenofovir (such as Combivir, Complera, Descovy, Epivir, Epzicom, Genvoya, Odefsey, Stribild, Trizivir, Truvada, Vemlidy). Tell your doctor if you have ever had: liver or kidney disease; long QT syndrome; mental illness, use of antipsychotic medication, or injection drug use; epilepsy or other seizure disorder; low bone mineral density; or hepatitis B or C infection. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk. Atripla can cause birth defects. Do not use if you are pregnant, and do not get pregnant for at least 12 weeks after you stop taking Atripla. Atripla can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using Atripla, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. How should I take Atripla? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take this medicine on an empty stomach with a full glass of water. You will need frequent medical tests. This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Atripla. Store Atripla in the original container at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use. If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using Atripla. You may need frequent liver function tests while using this medicine and for several months after your last dose. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include uncontrolled muscle movements. What should I avoid while taking Atripla? Avoid driving or hazardous activity until you know how efavirenz, emtricitabine, and tenofovir will affect you. Your reactions could be impaired. Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Atripla side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired. Call your doctor at once if you have: unusual thoughts or behavior, anger, severe depression, thoughts of hurting yourself or others, hallucinations; a seizure (convulsions); kidney problems--increased thirst and urination, muscle pain or weakness; or liver problems--swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Atripla affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have: signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects may include: dizziness, drowsiness, tired feeling; nausea, diarrhea; headache, depressed mood, trouble concentrating; sleep problems (insomnia), strange dreams; rash; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Efavirenz / emtricitabine / tenofovir side effects (more detail) Efavirenz, emtricitabine, and tenofovir dosing information Usual Adult Dose for HIV Infection: 1 tablet orally once a day Use: As a complete regimen or in combination with other antiretroviral agents for the treatment of HIV-1 infection Usual Adult Dose for Nonoccupational Exposure: US CDC Recommendations: 1 tablet orally once a day Duration of therapy: 28 days Comments: -Only with expert consultation, an alternative regimen for HIV nonoccupational postexposure prophylaxis (nPEP) -Efavirenz is contraindicated as nPEP in pregnant women; it should be avoided in nPEP regimens during the first trimester and should not be used for women of childbearing potential who might become pregnant during antiretroviral prophylaxis. -Prophylaxis should be started as soon as possible, within 72 hours of exposure. -Current guidelines should be consulted for additional information. Usual Adult Dose for Occupational Exposure: US Public Health Service working group recommendations: 1 tablet orally once a day Duration of therapy: 28 days, if tolerated Comments: -Only with expert consultation, an alternative regimen for use as HIV postexposure prophylaxis -Prophylaxis should be started as soon as possible, preferably within hours after exposure. -The optimal duration of prophylaxis is unknown and may differ based on institution protocol. -Current guidelines should be consulted for additional information. Usual Pediatric Dose for HIV Infection: At least 40 kg: 1 tablet orally once a day Use: As a complete regimen or in combination with other antiretroviral agents for the treatment of HIV-1 infection   What other drugs will affect efavirenz, emtricitabine, and tenofovir? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Atripla can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Tell your doctor about all your current medicines. Many drugs can affect Atripla, especially: St. John's wort; an antibiotic or antifungal medicine; an antidepressant; any other HIV medicines; cholesterol medication; heart or blood pressure medication; medicine to prevent organ transplant rejection; medicine to treat hepatitis; seizure medicine; or tuberculosis medication. This list is not complete. Many drugs can affect Atripla, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is eletriptan? Eletriptan is used to treat migraine headaches with or without aura in adults. Eletriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Eletriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use eletriptan only if your condition has been confirmed by a doctor as migraine headaches. Eletriptan may also be used for purposes not listed in this medication guide. Warnings You should not use eletriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not take eletriptan within 24 hours before or after using another migraine headache medicine. Do not use eletriptan within 72 hours before or after taking: clarithromycin, troleandomycin, itraconazole, ketoconazole, nefazodone, ritonavir, or nelfinavir. Before taking this medicine You should not use eletriptan if you are allergic to it, or if you have: heart problems, or a stroke (including "mini-stroke"); circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome; uncontrolled high blood pressure; or a headache that seems different from your usual migraine headaches. Do not take eletriptan within 24 hours before or after using another migraine headache medicine, including: medicines like eletriptan--almotriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, and others; or ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine. Do not use eletriptan within 72 hours before or after taking: clarithromycin, troleandomycin, itraconazole, ketoconazole, nefazodone, ritonavir, or nelfinavir. Tell your doctor if you have ever had: liver or renal disease; heart problems or stroke; or risk factors for coronary artery disease (such as high blood pressure, high cholesterol, diabetes, menopause, smoking, a family history of coronary artery disease, being overweight, or being older than 40 and a man). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with eletriptan and cause a serious condition called serotonin syndrome. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether eletriptan will harm an unborn baby. However, having migraine headaches during pregnancy may cause complications such as high blood pressure or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating migraines may outweigh any risks to the baby. It may not be safe to breastfeed while using eletriptan. Ask your doctor about any risk. Eletriptan is not approved for use by anyone younger than 18 years old. How should I take eletriptan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take eletriptan as soon as you notice migraine symptoms. After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. Do not take more than 80 mg of eletriptan in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets. Call your doctor if your headache does not go away at all after taking the first eletriptan tablet. If you use eletriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Store at room temperature away from moisture and heat. What happens if I miss a dose? Since eletriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using eletriptan. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking eletriptan? Avoid driving or hazardous activity until you know how eletriptan will affect you. Your reactions could be impaired. Eletriptan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: fast, slow, or uneven heart rate; sudden severe stomach pain (especially after meals), constipation or diarrhea, weight loss; fever, diarrhea that is bloody; numbness, tingling, cold feeling or burning pain in your feet or toes; tightness or heavy feeling in your legs, pale or blue-colored appearance in your fingers or toes; severe headache, blurred vision, pounding in your neck or ears; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Stop using eletriptan and call your doctor at once if you have: heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Common side effects may include: dizziness, drowsiness; nausea; or weakness, feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Eletriptan dosing information Usual Adult Dose for Migraine: Use only after a clear diagnosis of migraine has been established Initial dose: 20 mg or 40 mg orally, once -Provided there has been some response to first dose, a second dose may be administered at least 2 hours later if migraine returns or symptoms recur. Maximum dose: 80 mg in a 24-hour period Comments: -Doses should be individualized as responses vary; in clinical trials, benefit was observed with 20 mg, 40 mg, and 80 mg doses; however an increased incidence of side effects was observed at the 80 mg dose. -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 3 or more migraine attacks in a 30-day period has not been established. Use: For the acute treatment of migraine with or without aura.   What other drugs will affect eletriptan? Tell your doctor about all your other medicines, especially an antidepressant. Other drugs may affect eletriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is emtricitabine and tenofovir? Emtricitabine and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body. Emtricitabine and tenofovir is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). emtricitabine and tenofovir is not a cure for HIV or AIDS, but it can be used to treat HIV in adults and children who are at least 12 years old and weigh at least 17 kilograms (37 pounds). Emtricitabine and tenofovir is also used in children who weigh between 55 and 77 pounds (25 to 35 kilograms) and who take certain other HIV medications. Truvada PrEP is used together with safer-sex practices to reduce the risk of becoming infected with HIV. You must be HIV-negative and an adult to use Truvada PrEP for this purpose. Emtricitabine and tenofovir may also be used for purposes not listed in this medication guide. Warnings Do not take this combination medicine if you also take other medicines that contain emtricitabine, tenofovir, lamivudine, or adefovir. Truvada PrEP is used to reduce the risk of becoming infected with HIV in adults who are HIV-negative. This medicine alone will not protect you from infection with HIV. You must also use safer sex practices and get tested for HIV at least every 3 months. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired. If you've ever had hepatitis B, it may become active or get worse after you stop using emtricitabine and tenofovir. You may need frequent liver function tests for several months. Before taking this medicine You should not take emtricitabine and tenofovir if you are allergic to emtricitabine or tenofovir. Do not take if you also use other medicines that contain emtricitabine, tenofovir, lamivudine, or adefovir (such as Atripla, Combivir, Complera, Descovy, Dutrebis, Emtriva, Epivir, Epzicom, Genvoya, Hepsera, Odefsey, Stribild, Triumeq, Trizivir, or Viread). If you take Truvada PrEP to reduce your risk of HIV infection: You must have a negative HIV test immediately before you start taking the medicine. Do not take Truvada PrEP to reduce infection risk if you are HIV-positive, if have been exposed to HIV within the past month, or if you had any symptoms (such as fever, sore throat, night sweats, swollen glands, diarrhea, body aches). Tell your doctor if you have ever had: liver disease (you may be tested for hepatitis B before you can use this medicine); osteopenia (low bone mineral density); or kidney disease. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk. Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby. Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. A child receiving this medicine must weigh at least 37 pounds. How should I take emtricitabine and tenofovir? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may take this medicine with or without food. Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor. You will need frequent medical tests to check your kidney and liver function, or your bone mineral density. Truvada PrEP alone will not protect you from infection with HIV. You must also use safer sex practices and get tested for HIV at least every 3 months. Store in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use. If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using emtricitabine and tenofovir. You may need frequent liver function tests while using this medicine and for several months after your last dose.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skipping doses may increase the risk of your virus becoming resistant to antiviral medicine. Try not to miss any doses. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking emtricitabine and tenofovir? Using emtricitabine and tenofovir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Emtricitabine and tenofovir side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired. Call your doctor at once if you have: symptoms of new HIV infection--fever, night sweats, tiredness, muscle or joint pain, sore throat, vomiting, diarrhea, rash, swollen glands in your neck or groin; sudden or unusual bone pain; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or liver problems--nausea, swelling around your midsection, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Emtricitabine and tenofovir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have: signs of a new infection--fever, sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects may include: headache, dizziness, feeling depressed or tired; trouble sleeping, strange dreams; nausea, stomach pain; weight loss; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect emtricitabine and tenofovir? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Emtricitabine and tenofovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Other drugs may affect emtricitabine and tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is enalapril? Enalapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Enalapril is used to treat high blood pressure (hypertension) in adults and children who are at least 1 month old. Enalapril is also used to treat congestive heart failure (CHF). CHF is a disorder of the ventricles (the lower chambers of the heart) which decreases the heart’s ability to pump blood to the body. Warnings Do not use enalapril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not use enalapril if you have ever had angioedema. Do not take enalapril within 36 hours before or after taking any medicine that contains sacubatril (such as Entresto). If you have diabetes, do not use enalapril together with any medication that contains aliskiren (such as Tekturna or Tekamlo). Enalapril can affect your heart or your electrolyte levels. Call your doctor if you have chest pain, pounding heartbeats or fluttering in your chest, a slow heart rate or weak pulse, a tingly feeling, muscle weakness, or muscle tightness or contraction. Before taking this medicine You should not use enalapril if you are allergic to it, or if you have: you have a history of angioedema; you recently took a heart medicine called sacubatril; or if you are allergic to any other ACE inhibitor, such as benazepril, captopril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril. Do not take enalapril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto). If you have diabetes, do not use enalapril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo). You may also need to avoid taking enalapril with aliskiren if you have kidney disease. To make sure enalapril is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis); liver disease; a history of blood clot or stroke (including TIA or "mini-stroke"); an electrolyte imbalance (such as high levels of potassium in your blood); or heart disease. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Enalapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Enalapril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine. How should I take enalapril? Take enalapril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take enalapril with or without food. Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking enalapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. If you need surgery, tell the surgeon ahead of time that you are using enalapril. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Store the liquid medicine in the refrigerator, do not freeze. Throw away any liquid medicine not used within 60 days.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol can further lower your blood pressure and may increase certain side effects of enalapril. Do not use salt substitutes or potassium supplements while taking enalapril, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Enalapril side effects Get emergency medical help if you have signs of an allergic reaction to enalapril: hives; severe stomach pain; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; slow heartbeats; pounding heartbeats or fluttering in your chest; little or no urination; jaundice (yellowing of the skin or eyes); numbness, tingling, or burning pain in your hands or feet; fever, chills, cold or flu symptoms; easy bruising, unusual bleeding; or high potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common enalapril side effects may include: dizziness, feeling tired; cough; or feeling light-headed. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect enalapril? Tell your doctor about all medicines you use, and those you start or stop using during your treatment with enalapril, especially: lithium; a diuretic or "water pill"; gold injections to treat arthritis; or NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may interact with enalapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is hydrochlorothiazide and enalapril? Hydrochlorothiazide is a thiazide diuretic (water pill) and enalapril is an ACE inhibitor (ACE stands for angiotensin converting enzyme). Hydrochlorothiazide and enalapril is a combination medicine used to treat hypertension (high blood pressure). Hydrochlorothiazide and enalapril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and enalapril and tell your doctor right away. You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or enalapril, or if: you are unable to urinate; you have ever had angioedema; you recently took a heart medicine called sacubitril; you are allergic to sulfa drugs; or you are allergic to any ACE inhibitor (benazepril, captopril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril). Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and enalapril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: asthma or allergies; kidney disease (or if you are on dialysis); cirrhosis or other liver disease; glaucoma; congestive heart failure; gout; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); lupus; if you are allergic to penicillin; or if you are on a low salt diet. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Enalapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while you are using this medicine. How should I take hydrochlorothiazide and enalapril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and enalapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and enalapril. Keep using hydrochlorothiazide and enalapril as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased thirst, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and enalapril? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol may increase certain side effects of hydrochlorothiazide and enalapril. Hydrochlorothiazide and enalapril side effects Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; jaundice (yellowing of the skin or eyes); blurred vision, tunnel vision, eye pain, or seeing halos around lights; fever, chills, flu-like symptoms, sore throat, mouth sores; signs of an electrolyte imbalance--leg cramps, constipation, muscle pain or weakness, irregular heartbeats, feeling jittery, increased thirst or urination, numbness or tingling, loss of movement; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Common side effects may include: dizziness; cough; headache; or nausea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and enalapril dosing information Usual Adult Dose for Hypertension: Enalapril 5 to 10 mg-Hydrochlorothiazide 12.5 to 25 mg orally once a day Maximum dose: Enalapril 20 mg-Hydrochlorothiazide 50 mg per day Comments: Hydrochlorothiazide may be increased after 2 to 3 weeks. Use: Treatment of hypertension only after failure to achieve the desired effect with monotherapy or the titrated components.   What other drugs will affect hydrochlorothiazide and enalapril? Tell your doctor about all your current medicines. Many drugs can affect hydrochlorothiazide and enalapril, especially: other blood pressure medications, including another diuretic or "water pill"; digoxin; lithium; cancer medicine; gold injections to treat arthritis; insulin or oral diabetes medicine; a muscle relaxer; medicine to prevent organ transplant rejection--cyclosporine, everolimus, sirolimus, tacrolimus; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete and many other drugs may affect hydrochlorothiazide and enalapril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is entecavir? Entecavir is an antiviral medicine that is used to treat chronic hepatitis B virus (HBV) in adults and children who are at least 2 years old and weigh at least 22 pounds (10 kilograms). Entecavir is not a cure for hepatitis. It is not known whether entecavir will prevent cirrhosis or liver cancer. Entecavir may also be used for purposes not listed in this medication guide. Warnings You should not take entecavir if you have HIV (human immunodeficiency virus) that is not being treated. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired. Hepatitis B may become active or get worse after you stop using entecavir. You may need frequent liver function tests for several months. Before taking this medicine You should not take entecavir if you are allergic to it, or if you also have HIV (human immunodeficiency virus) that is not being treated. You may need to be tested for HIV before you start taking entecavir. Taking medicine to treat chronic hepatitis B can cause HIV infection to become resistant to certain HIV and AIDS medications. Tell your doctor if you have ever had: HIV or AIDS (or if you have been exposed to HIV); kidney disease; liver problems other than HBV; a liver transplant; or if you also take lamivudine (Epivir, Epzicom, Trizivir) or telbivudine (Tyzeka). Tell your doctor about all medicines you have used to treat hepatitis B in the past. Entecavir may not be the right medication if you have used certain other medicines for HBV. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you are overweight, if you've taken antiviral medication for a long time, or if you are a woman. Ask your doctor about your risk. Tell your doctor if you are pregnant or breastfeeding. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of entecavir on the baby. How should I take entecavir? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take entecavir on an empty stomach, at least 2 hours before or 2 hours after eating. Measure liquid medicine carefully, using the dosing syringe with your medicine (not a kitchen spoon). Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Entecavir doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight. Use entecavir regularly to get the most benefit and to keep your condition from getting worse. Call your doctor if your hepatitis symptoms do not improve, or if they get worse. Do not change your dose or dosing schedule without your doctor's advice. Every person with HBV should remain under the care of a doctor. Store entecavir at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Keep the bottle of oral liquid in its original carton. Throw away any unused entecavir oral liquid after the expiration date on the label has passed. Hepatitis B may become active or get worse in the months after you stop using entecavir. You may need frequent liver function tests while using entecavir and for several months after your last dose.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking entecavir? Using entecavir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HBV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Entecavir side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Some people using entecavir develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as: unusual muscle pain; feeling cold; trouble breathing; feeling dizzy, light-headed, tired, or very weak; stomach pain, vomiting; or fast or irregular heartbeats. Entecavir may also cause severe liver symptoms. Call your doctor at once if you have: swelling around your midsection, nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common side effects may include: nausea; dizziness, tired feeling; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect entecavir? Other drugs may affect entecavir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is eplerenone? Eplerenone is used to lower the risk of death from heart failure after a heart attack. Eplerenone is also used to treat high blood pressure (hypertension). Eplerenone may also be used for purposes not listed in this medication guide. Warnings You may not be able to take eplerenone if you have severe kidney disease, high potassium levels in your blood, or type 2 diabetes with increased levels of albumin (a protein) in your urine. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together. Before taking this medicine You may not be able to take this medicine if you are allergic to eplerenone, or if you have: high potassium levels in your blood (hyperkalemia); severe kidney disease; or type 2 diabetes with increased levels of albumin (a protein) in your urine. Some medicines can cause unwanted or dangerous effects when used with eplerenone. Your doctor may change your treatment plan if you also use: nefazodone; a potassium supplement; an antibiotic--clarithromycin, telithromycin; antifungal medicine--itraconazole, ketoconazole; a diuretic or "water pill"--amiloride, spironolactone, triamterene; or antiviral medicine to treat HIV/AIDS--indinavir, nelfinavir, ritonavir, saquinavir. Tell your doctor if you have ever had: kidney disease; diabetes; liver disease; high cholesterol or triglycerides; or if you take other heart or blood pressure medications. Tell your doctor if you are pregnant or breastfeeding. It is not known whether eplerenone will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). Heart failure can get worse during pregnancy and may cause complications such as premature birth. The benefit of treating hypertension or heart failure may outweigh any risks to the baby. This medicine may affect fertility (ability to have children) in men. How should I take eplerenone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Eplerenone may be taken with or without food. You may need blood tests, and your blood pressure will need to be checked often. If you have high blood pressure, keep using eplerenone even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking eplerenone? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. This drug side effects Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; diarrhea, vomiting; little or no urination; fast or irregular heartbeats; trouble breathing; swelling in your feet or lower legs; or high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: high potassium; headache; or dizziness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Eplerenone dosing information Usual Adult Dose for Congestive Heart Failure: Initial dose: 25 mg orally once a day; titrate to the target dose preferably within 4 weeks as tolerated. Target dose: 50 mg orally once a day Use: To improve survival of stable patients with symptomatic heart failure with reduced ejection fraction (40% or less) after an acute myocardial infarction. Usual Adult Dose for Hypertension: Initial dose: 50 mg orally once a day Maintenance dose: 50 mg orally once or twice a day Maximum dose: 100 mg/day Comments: -Full therapeutic effect is apparent within 4 weeks. -Patients with inadequate blood pressure response to the initial dose may be increased to 50 mg twice a day.   What other drugs will affect eplerenone? Tell your doctor about all your current medicines. Many drugs can affect eplerenone, especially: lithium; heart or blood pressure medicine--amiodarone, benazepril, diltiazem, dronedarone, enalapril, lidocaine, lisinopril, olmesartan, valsartan, verapamil, and others; or; NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete and many other drugs may affect eplerenone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is escitalopram? Escitalopram is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). It affects chemicals in the brain that may be unbalanced in people with depression or anxiety. Escitalopram is used to treat major depressive disorder in adults and adolescents at least 12 years old. Escitalopram is also used to treat anxiety in adults. Warnings You should not use escitalopram you also take pimozide or citalopram (Celexa). Do not use escitalopram within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Do not stop using escitalopram without first asking your doctor. Before taking this medicine You should not use this medicine if you are allergic to escitalopram or citalopram (Celexa), or if: you also take pimozide. Do not use escitalopram within 14 days before or 14 days after you have used an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with escitalopram and cause a serious condition called serotonin syndrome. To make sure escitalopram is safe for you, tell your doctor if you have ever had: liver or kidney disease; seizures; low levels of sodium in your blood; heart disease, high blood pressure; a stroke; bleeding problems; sexual problems; bipolar disorder (manic depression); or drug addiction or suicidal thoughts. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Escitalopram is not approved for use by anyone younger than 12 years old. Ask your doctor about taking this medicine if you are pregnant. Taking an SSRI antidepressant during late pregnancy may cause serious medical complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of escitalopram on the baby. If you are breastfeeding, tell your doctor if you notice drowsiness, agitation, feeding problems, or poor weight gain in the nursing baby. How should I take escitalopram? Take escitalopram exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Take escitalopram at the same time each day, with or without food. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated. Your doctor will need to check your progress on a regular basis. A child taking escitalopram should be checked for height and weight gain. Do not stop using escitalopram suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store escitalopram at room temperature away from moisture and heat. Dosing information Usual Adult Dose for Generalized Anxiety Disorder: Initial dose: 10 mg orally once a day; increase if necessary after at least 1 week of treatment to 20 mg once a day Maintenance dose: 10 to 20 mg orally once a day Maximum dose: 20 mg orally once a day Comment: Treatment should be periodically reassessed to determine the need for ongoing treatment; efficacy beyond 8 weeks has not been systematically studied. Use: Acute treatment of generalized anxiety disorder Usual Adult Dose for Depression: Initial dose: 10 mg orally once a day; increase if necessary after at least 1 week of treatment to 20 mg once a day Maintenance dose: 10 to 20 mg orally once a day Maximum dose: 20 mg orally once a day Comments: -Acute episodes may require several months or longer of sustained pharmacological therapy beyond response to the acute episode. -Patients should be periodically reassessed to determine the need for maintenance treatment. Use: Acute and maintenance treatment of major depressive disorder Usual Geriatric Dose for Depression: Recommended dose: 10 mg orally once a day Use: Acute and maintenance treatment of major depressive disorder Usual Pediatric Dose for Depression: 12 years and older: -Initial dose: 10 mg orally once a day; increase if necessary after at least 3 weeks of treatment to 20 mg once a day -Maintenance dose: 10 to 20 mg orally once a day -Maximum dose: 20 mg orally once a day Comments: -Acute episodes may require several months or longer of sustained pharmacological therapy beyond response to the acute episode. -Patients should be periodically reassessed to determine the need for maintenance treatment. Use: Acute and maintenance treatment of major depressive disorder   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with escitalopram may cause you to bruise or bleed easily. Avoid alcohol. Avoid driving or hazardous activity until you know how escitalopram will affect you. Your reactions could be impaired. Escitalopram side effects Get emergency medical help if you have signs of an allergic reaction to escitalopram: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; racing thoughts, unusual risk-taking behavior, feelings of extreme happiness or sadness; pain or burning when you urinate; (in a child taking escitalopram) slow growth or weight gain; low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Common escitalopram side effects may include: painful urination; dizziness, drowsiness, tiredness, weakness; feeling anxious or agitated; increased muscle movements, feeling shaky; sleep problems (insomnia); sweating, dry mouth, increased thirst, loss of appetite; nausea, constipation; yawning; nosebleed, heavy menstrual periods; or decreased sex drive, impotence, or difficulty having an orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect escitalopram? Using escitalopram with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your current medicines, especially a blood thinner such as warfarin, Coumadin, or Jantoven. Many drugs may interact with escitalopram, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is esomeprazole? Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Esomeprazole may also be given to prevent gastric ulcer caused by infection with Helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Esomeprazole is not for immediate relief of heartburn symptoms. Esomeprazole may also be used for purposes not listed in this medication guide. Warnings Esomeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it. Esomeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. You may be more likely to have a broken bone while taking esomeprazole long term or more than once per day. Before taking this medicine Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. You should not use this medicine if: you had breathing problems, kidney problems, or a severe allergic reaction after taking esomeprazole in the past; or you are allergic to esomeprazole or to similar medicines such as lansoprazole, omeprazole, pantoprazole, rabeprazole, Dexilant, Nexium, Prevacid, Protonix, and others. Tell your doctor if you have ever had: severe liver disease; lupus; osteoporosis or low bone mineral density (osteopenia); or low levels of magnesium in your blood. You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy. Ask a doctor before using this medicine if you are pregnant or breastfeeding. How should I take esomeprazole? Use exactly as directed on the label, or as prescribed by your doctor. Take each dose with a full glass (8 ounces) of water. Esomeprazole should be taken at least one hour before a meal. Swallow the pill whole and do not crush, chew, break, or open it. If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use. The esomeprazole capsule can be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Esomeprazole is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time. Use esomeprazole for the full prescribed length of time, even if your symptoms quickly improve. Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using esomeprazole. Some conditions are treated with a combination of esomeprazole and antibiotics. Use all medications as directed. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking esomeprazole? esomeprazole can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine. Esomeprazole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; seizure (convulsions); kidney problems-- fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Taking esomeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk. If you use esomeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Common side effects may include: headache; diarrhea; nausea, stomach pain, gas, constipation; or dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect esomeprazole? Tell your doctor about all your current medicines. Many drugs can affect esomeprazole, especially: cilostazol; clopidogrel; diazepam; digoxin; erlotinib; iron-containing medicines (ferrous fumarate, ferrous gluconate, ferrous sulfate, and others); methotrexate; mycophenolate mofetil; rifampin; St. John's wort; tacrolimus; warfarin (Coumadin, Jantoven); antifungal medication--ketoconazole, voriconazole; or HIV/AIDS medication--atazanavir, nelfinavir, saquinavir. This list is not complete and many other drugs may affect esomeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is estradiol? Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream, or as an injection. Estradiol is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Estradiol is also used to treat low estrogen levels in women with ovarian failure. It is also indicated to treat certain types of breast cancer and prostate cancer. Estradiol may also be used for purposes not listed in this medication guide. Warnings You should not use estradiol if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina. Do not use estradiol if you are pregnant. Estradiol may increase your risk of developing uterine cancer. Report any unusual vaginal bleeding right away. Using this medicine can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia. Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using this medicine. Before taking this medicine You should not use this medicine if you are allergic to estradiol, or if you have: unusual vaginal bleeding that has not been checked by a doctor; liver disease; a history of heart attack, stroke, or blood clot; an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina. Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke. Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease; liver problems, or prior jaundice caused by pregnancy or taking hormones; kidney disease; cancer; gallbladder disease; asthma; epilepsy or other seizure disorder; migraines; lupus; endometriosis or uterine fibroid tumors; hereditary angioedema; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); a thyroid disorder; or high levels of calcium in your blood. Using estradiol may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk. Estradiol lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding. How should I take estradiol? Take estradiol exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Estradiol may increase your risk of developing uterine cancer. To help lower this risk, your doctor may also want you to take a progestin. Report any unusual vaginal bleeding to your doctor immediately. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using estradiol. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using this medicine. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. If you are taking injectable estrogen, dispose of any needles and syringes in an appropriate sharps container per your state laws. Do not throw away used needles into the garbage. If you are using estradiol spray, avoid fire, flame, or smoking until the spray has dried. Do not apply lotion or sunscreen over the area for at least one hour.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can result in nausea, vomiting and vaginal bleeding. What to avoid Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine. Grapefruit and grapefruit juice may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products. Estradiol side effects Get emergency medical help if you have signs of an allergic reaction to estradiol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; swelling or tenderness in your stomach; jaundice (yellowing of the skin or eyes); memory problems, confusion, unusual behavior; unusual vaginal bleeding, pelvic pain; a lump in your breast; or nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy. Common estradiol side effects may include: nausea, vomiting, diarrhea, stomach cramps; mood changes, sleep problems (insomnia); cold symptoms such as stuffy nose, sinus pain, sore throat; weight gain; headache, back pain, dizziness; breast pain; darkening of the skin or skin rash; thinning scalp hair; or vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect estradiol? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with estradiol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is estradiol? Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream, or as an injection. Estradiol is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Estradiol is also used to treat low estrogen levels in women with ovarian failure. It is also indicated to treat certain types of breast cancer and prostate cancer. Estradiol may also be used for purposes not listed in this medication guide. Warnings You should not use estradiol if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina. Do not use estradiol if you are pregnant. Estradiol may increase your risk of developing uterine cancer. Report any unusual vaginal bleeding right away. Using this medicine can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia. Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using this medicine. Before taking this medicine You should not use this medicine if you are allergic to estradiol, or if you have: unusual vaginal bleeding that has not been checked by a doctor; liver disease; a history of heart attack, stroke, or blood clot; an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina. Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke. Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease; liver problems, or prior jaundice caused by pregnancy or taking hormones; kidney disease; cancer; gallbladder disease; asthma; epilepsy or other seizure disorder; migraines; lupus; endometriosis or uterine fibroid tumors; hereditary angioedema; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); a thyroid disorder; or high levels of calcium in your blood. Using estradiol may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk. Estradiol lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding. How should I take estradiol? Take estradiol exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Estradiol may increase your risk of developing uterine cancer. To help lower this risk, your doctor may also want you to take a progestin. Report any unusual vaginal bleeding to your doctor immediately. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using estradiol. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using this medicine. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. If you are taking injectable estrogen, dispose of any needles and syringes in an appropriate sharps container per your state laws. Do not throw away used needles into the garbage. If you are using estradiol spray, avoid fire, flame, or smoking until the spray has dried. Do not apply lotion or sunscreen over the area for at least one hour.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can result in nausea, vomiting and vaginal bleeding. What to avoid Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine. Grapefruit and grapefruit juice may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products. Estradiol side effects Get emergency medical help if you have signs of an allergic reaction to estradiol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; swelling or tenderness in your stomach; jaundice (yellowing of the skin or eyes); memory problems, confusion, unusual behavior; unusual vaginal bleeding, pelvic pain; a lump in your breast; or nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy. Common estradiol side effects may include: nausea, vomiting, diarrhea, stomach cramps; mood changes, sleep problems (insomnia); cold symptoms such as stuffy nose, sinus pain, sore throat; weight gain; headache, back pain, dizziness; breast pain; darkening of the skin or skin rash; thinning scalp hair; or vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect estradiol? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with estradiol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is eszopiclone? Eszopiclone is a sedative that is used to treat insomnia. eszopiclone causes relaxation to help you fall asleep and stay asleep. Eszopiclone may also be used for purposes not listed in this medication guide. Warnings Some people using this medicine have engaged in activity while not fully awake and later had no memory of it. If this happens to you, stop taking eszopiclone and call your doctor right away. Serious injury or death could occur if you walk or drive while you are not fully awake. Before taking this medicine You should not use eszopiclone if you are allergic to it, or if you have ever taken sleep medicine and engaged in activity you later don't remember. Eszopiclone is not approved for use by anyone younger than 18 years old. Tell your doctor if you have ever had: liver disease; a breathing disorder; depression, mental illness, or suicidal thoughts; or drug or alcohol addiction. Tell your doctor if you are pregnant or breast-feeding. The sedative effects of eszopiclone may be stronger in older adults. Accidental falls are common in elderly patients who take sedatives. Use caution to avoid falling or accidental injury while you are taking eszopiclone. How should I take eszopiclone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Eszopiclone may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away eszopiclone is against the law. Eszopiclone will make you fall asleep. Never take this medicine during your normal waking hours, unless you have at least 7 to 8 hours to dedicate to sleeping. Call your doctor if your symptoms do not improve after 7 to 10 days of treatment, or if they get worse. Do not stop using eszopiclone suddenly after taking it over several days in a row, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription. Insomnia symptoms may also return after you stop taking eszopiclone, and may be even worse than before. Tell your doctor if you still have worsened insomnia after the first few nights without taking eszopiclone. What happens if I miss a dose? Since eszopiclone is taken only at bedtime, you will not be on a frequent dosing schedule. Never take this medicine if you do not have at least 7 to 8 hours to sleep before being active again. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of eszopiclone can be fatal, especially when it is taken together with other medications that can cause drowsiness. What should I avoid while taking eszopiclone? Avoid taking eszopiclone during travel, such as to sleep on an airplane. You may be awakened before the effects of the medication have worn off. Amnesia (forgetfulness) is more common if you do not get at least 8 hours of sleep after taking eszopiclone. Avoid drinking alcohol. Dangerous side effects or death could occur. Avoid taking eszopiclone within 1 hour after eating a high-fat or heavy meal. This will make it harder for your body to absorb the medication. Eszopiclone can cause side effects that may impair your thinking or reactions. You may still feel sleepy the morning after taking eszopiclone. Until you know how this medicine will affect you during waking hours, be careful if you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert. Eszopiclone side effects Eszopiclone may cause a severe allergic reaction. Stop taking eszopiclone and get emergency medical help if you have signs of an allergic reaction: hives; nausea, vomiting; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people using this medicine have engaged in activity while not fully awake and later had no memory of it. This may include walking, driving, or making phone calls. If this happens to you, stop taking eszopiclone and call your doctor right away. Serious injury or death could occur if you walk or drive while you are not fully awake. Call your doctor at once if you have: anxiety, depression, aggression, agitation; memory problems, unusual thoughts or behavior; thoughts of hurting yourself; or confusion, hallucinations (hearing or seeing things). Common side effects may include: day-time drowsiness, dizziness, "hangover" feeling; headache, anxiety; dry mouth; unusual or unpleasant taste in your mouth; rash; or cold or flu symptoms such as fever, body aches, sore throat, cough, runny or stuffy nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Eszopiclone dosing information Usual Adult Dose for Insomnia: Initial dose: 1 mg orally once a day immediately before bedtime Maintenance dose: 1 to 3 mg orally once a day immediately before bedtime Maximum dose: 3 mg/day Comments: -The lowest effective dose should be used. -Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly. -Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment. Use: Treatment of insomnia Usual Geriatric Dose for Insomnia: Initial dose: 1 mg orally once a day immediately before bedtime Maintenance dose: 1 to 2 mg orally once a day immediately before bedtime Maximum dose: 2 mg/day Comments: -The lowest effective dose should be used. -Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly. -Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment. Use: Treatment of insomnia   What other drugs will affect eszopiclone? Using eszopiclone with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, other sleep medicine, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect eszopiclone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is etodolac? Etodolac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Etodolac is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis. Etodolac may also be used for purposes not listed in this medication guide. Warnings Etodolac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding caused by etodolac. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medicine can make your skin more sensitive to sunlight and sunburn may result. Before taking this medicine Etodolac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults. You should not use etodolac if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke; a heart attack, stroke, or blood clot; stomach ulcers or bleeding; asthma; fluid retention; liver or kidney disease; or if you take aspirin to prevent heart attack or stroke. If you are pregnant, you should not take etodolac unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy. Etodolac is not approved for use by anyone younger than 18 years old. How should I take etodolac? Take etodolac exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition. Swallow the extended-release tablet whole and do not crush, chew, or break it. It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. If you use etodolac long-term, you may need frequent medical tests. Etodolac can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Dosing information Usual Adult Dose for Osteoarthritis: Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis Usual Adult Dose for Rheumatoid Arthritis: Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis Usual Adult Dose for Pain: Immediate Release: 200 mg to 400 mg orally every 6 to 8 hours -Maximum dose: 1000 mg/day Use: For the management of acute pain Usual Pediatric Dose for Juvenile Rheumatoid Arthritis: Extended Release: 6 to 16 years: 20 to 30 kg: 400 mg orally once a day 31 to 45 kg: 600 mg orally once a day 40 to 60 kg: 480 mg orally once a day Greater than 60 kg: 1000 mg orally once a day 17 to 18 years: 400 mg to 1000 mg orally once a day Use: For the relief of signs and symptoms of juvenile rheumatoid arthritis Detailed Etodolac dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, vomiting, stomach pain, or stomach bleeding. What to avoid Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). Avoid taking aspirin unless your doctor tells you to. Avoid drinking alcohol. It may increase your risk of stomach bleeding. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb etodolac. Etodolac side effects Get emergency medical help if you have signs of an allergic reaction to etodolac: (hives, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, swelling in your legs, feeling short of breath. Stop using etodolac and call your doctor at once if you have: changes in your vision; any skin rash, no matter how mild; shortness of breath (even with mild exertion); swelling or rapid weight gain; signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); kidney problems - little or no urination, swelling in your feet or ankles, feeling tired; or low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed, cold hands and feet. Common etodolac side effects include: nausea, vomiting, stomach pain, indigestion; diarrhea, constipation, gas; dizziness, headache, tired feeling; rash; or ringing in your ears. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Etodolac side effects (more detail) What other drugs will affect etodolac? Ask your doctor before using etodolac if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily. Tell your doctor about all your other medicines, especially: cyclosporine; lithium; methotrexate; a blood thinner (warfarin, Coumadin, Jantoven); heart or blood pressure medication, including a diuretic or "water pill"; or steroid medicine (such as prednisone). This list is not complete. Other drugs may interact with etodolac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is etodolac? Etodolac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Etodolac is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis. Etodolac may also be used for purposes not listed in this medication guide. Warnings Etodolac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding caused by etodolac. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medicine can make your skin more sensitive to sunlight and sunburn may result. Before taking this medicine Etodolac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Etodolac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using etodolac, especially in older adults. You should not use etodolac if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke; a heart attack, stroke, or blood clot; stomach ulcers or bleeding; asthma; fluid retention; liver or kidney disease; or if you take aspirin to prevent heart attack or stroke. If you are pregnant, you should not take etodolac unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy. Etodolac is not approved for use by anyone younger than 18 years old. How should I take etodolac? Take etodolac exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition. Swallow the extended-release tablet whole and do not crush, chew, or break it. It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. If you use etodolac long-term, you may need frequent medical tests. Etodolac can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Dosing information Usual Adult Dose for Osteoarthritis: Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis Usual Adult Dose for Rheumatoid Arthritis: Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis Usual Adult Dose for Pain: Immediate Release: 200 mg to 400 mg orally every 6 to 8 hours -Maximum dose: 1000 mg/day Use: For the management of acute pain Usual Pediatric Dose for Juvenile Rheumatoid Arthritis: Extended Release: 6 to 16 years: 20 to 30 kg: 400 mg orally once a day 31 to 45 kg: 600 mg orally once a day 40 to 60 kg: 480 mg orally once a day Greater than 60 kg: 1000 mg orally once a day 17 to 18 years: 400 mg to 1000 mg orally once a day Use: For the relief of signs and symptoms of juvenile rheumatoid arthritis   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, vomiting, stomach pain, or stomach bleeding. What to avoid Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). Avoid taking aspirin unless your doctor tells you to. Avoid drinking alcohol. It may increase your risk of stomach bleeding. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb etodolac. Etodolac side effects Get emergency medical help if you have signs of an allergic reaction to etodolac: (hives, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, swelling in your legs, feeling short of breath. Stop using etodolac and call your doctor at once if you have: changes in your vision; any skin rash, no matter how mild; shortness of breath (even with mild exertion); swelling or rapid weight gain; signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); kidney problems - little or no urination, swelling in your feet or ankles, feeling tired; or low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed, cold hands and feet. Common etodolac side effects include: nausea, vomiting, stomach pain, indigestion; diarrhea, constipation, gas; dizziness, headache, tired feeling; rash; or ringing in your ears. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect etodolac? Ask your doctor before using etodolac if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily. Tell your doctor about all your other medicines, especially: cyclosporine; lithium; methotrexate; a blood thinner (warfarin, Coumadin, Jantoven); heart or blood pressure medication, including a diuretic or "water pill"; or steroid medicine (such as prednisone). This list is not complete. Other drugs may interact with etodolac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is exemestane? Exemestane is used to treat breast cancer in postmenopausal women. Exemestane is sometimes given after you have taken tamoxifen for 2 or 3 years, or if tamoxifen did not work or has stopped working. Exemestane may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use exemestane if you are allergic to it, or if: you are pregnant or able to become pregnant; or you have not yet completed menopause, and are still having menstrual periods. Some drugs should not be used together with exemestane. Your doctor may change your treatment plan if you also use medicines that contain estrogen, such as: birth control pills, patches, injections, or implants; or hormone replacement therapy. Tell your doctor if you have ever had: liver or kidney disease; or if you are still having menstrual periods. Exemestane can decrease bone mineral density, which may increase your risk of developing osteoporosis. Talk to your doctor about your individual risk of bone loss. exemestane is for use only in women who can no longer get pregnant. Exemestane can harm an unborn baby. Do not take this medicine if you are pregnant or may become pregnant. You may need to have a negative pregnancy test before starting this treatment. If you are not past menopause, use effective birth control to prevent pregnancy while you are taking exemestane and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant. This medicine may affect fertility (your ability to have children). However, if you are not past menopause you should still use birth control to prevent pregnancy because exemestane can harm an unborn baby. You should not breastfeed while using this medicine and for 1 month after your last dose. How should I take exemestane? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Exemestane is usually taken once per day, after a meal. Try to take the medicine at the same time each day. You will need frequent medical tests. Your doctor may have you take extra vitamin D while you are taking exemestane. Take only the amount of vitamin D that your doctor has prescribed. Use exemestane regularly to get the most benefit. You may need to keep taking take this medication for up to 5 years. Store in the original container at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking exemestane? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Exemestane side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain or pressure; new or unusual bone pain; swelling in your hands or feet; feeling short of breath, even with mild exertion; or signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg. Common side effects may include: hot flashes; headache, feeling tired; joint pain; nausea; increased appetite; sleep problems (insomnia); or increased sweating. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Exemestane dosing information Usual Adult Dose for Breast Cancer: 25 mg orally once a day Comment: -This drug is not indicated for the treatment of breast cancer in premenopausal women. Uses: -Adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to exemestane for completion of a total of five consecutive years of adjuvant hormonal therapy. -Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.   What other drugs will affect exemestane? When you start or stop taking exemestane, your doctor may need to adjust the doses of any other medicines you take on a regular basis. Many drugs can affect exemestane, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is ezetimibe? Ezetimibe is a prescription medicine used to lower levels of total cholesterol and LDL (bad) cholesterol in the blood. Ezetimibe tablets are used to treat high cholesterol. Ezetimibe work to reduce the amount of cholesterol your body absorbs. It does not help you lose weight and ezetimibe has not been shown to prevent heart disease or heart attacks. Ezetimibe is used in patients who cannot control their cholesterol levels by diet and exercise alone. It can be used by itself or with other medicines to treat high cholesterol. You should stay on a cholesterol-lowering diet while taking this medicine. Warnings Ezetimibe is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Some cholesterol medications should not be taken at the same time. If you take ezetimibe with another cholesterol medicine, follow your doctor's dosing instructions very carefully. You should not use ezetimibe if you have moderate to severe liver disease. You should not use this medicine with a "statin" cholesterol medicine if you have active liver disease, or if you are pregnant or breast-feeding a baby. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Before taking this medicine You should not use ezetimibe if you are allergic to it, or if you have: moderate to severe liver disease. Ezetimibe is not approved for use by anyone younger than 10 years old. You should not use ezetimibe with a "statin" cholesterol medicine (Zocor, Lipitor, Crestor, and others) if: you have active liver disease; you are pregnant; or you are breastfeeding a baby. Statin cholesterol medications can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). To make sure this medicine is safe for you, tell your doctor if you have: liver disease; kidney disease; or unexplained muscle pain or weakness. Tell your doctor if you are pregnant or breastfeeding. Use effective birth control to prevent pregnancy while you are using ezetimibe with a statin medicine. Tell your doctor if you plan to become pregnant. Do not breastfeed if you take ezetimibe with a statin medicine. How should I take ezetimibe? Take ezetimibe exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Ezetimibe is usually taken once daily at the same time each day. You may take this medicine with or without food. Ezetimibe may be taken at the same time with fenofibrate, or with a statin medication such as atorvastatin, lovastatin, simvastatin, pravastatin, or fluvastatin. Your treatment may also include diet, exercise, weight control, and blood tests. You may need frequent medical tests, even if you have no symptoms. Your cholesterol levels may not improve for up to 2 weeks. Store at room temperature away from moisture and heat. Dosing information Usual Adult Dose for Hyperlipidemia: 10 mg orally once a day. Usual Adult Dose for Homozygous Familial Hypercholesterolemia: 10 mg orally once a day Usual Adult Dose for Sitosterolemia: 10 mg orally once a day. Usual Pediatric Dose for Hyperlipidemia: 10 years or older: 10 mg orally once a day. Usual Pediatric Dose for Homozygous Familial Hypercholesterolemia: 10 years or older: 10 mg orally once a day. Usual Pediatric Dose for Sitosterolemia: 10 years or older: 10 mg orally once a day.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking ezetimibe? Avoid eating foods high in fat or cholesterol, or this medicine will not be as effective. Ezetimibe side effects Get emergency medical help if you have signs of an allergic reaction to ezetimibe: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Ezetimibe can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine. Side effects may be more likely in older adults. Common ezetimibe side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or muscle pain while taking ezetimibe with a statin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect ezetimibe? If you also take other cholesterol medication: Take ezetimibe 2 hours before or 4 hours after taking cholestyramine, colestipol, or colesevelam. Tell your doctor about all your other medicines, especially: cyclosporine; fenofibric acid; gemfibrozil; or a blood thinner - warfarin, Coumadin, Jantoven. This list is not complete. Other drugs may interact with ezetimibe, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is famciclovir? Famciclovir is an antiviral medicine that is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles. Famciclovir is sometimes used in people with human immunodeficiency virus (HIV) who develop herpes outbreaks around the mouth, genitals, or anal area. Famciclovir may not be effective in treating your first episode of genital herpes, but may help prevent future episodes. Famciclovir also may not be effective in Black or African-American people with genital herpes, and may not be effective in any person with shingles (herpes zoster) affecting the eyes. There is no cure for herpes and famciclovir will not prevent you from developing symptoms in the future. Famciclovir may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use famciclovir if you are allergic to famciclovir or penciclovir cream (Denavir). Tell your doctor if you have ever had: liver disease; kidney disease; a weak immune system; galactose intolerance; severe lactase deficiency; or glucose-galactose malabsorption. Tell your doctor if you are pregnant or plan to become pregnant. Herpes can be passed to your baby during childbirth if you have a genital lesion when your baby is born. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy. Take your medicine as directed to best control your infection. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of famciclovir on the baby. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Famciclovir is not approved for use by anyone younger than 18 years old. How should I take famciclovir? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Taking more famciclovir than prescribed will not make this medicine more effective For cold sores or genital herpes, you should start taking famciclovir as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters). You may take famciclovir with or without food. Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions. To prevent recurrent genital herpes, you may need to take famciclovir for up to 1 year. Follow your doctor's instructions. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses may increase the risk of your virus becoming resistant to medication. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking famciclovir? Taking famciclovir will not prevent you from passing genital herpes to other people. Herpes infections are contagious and you can infect other people even while you are taking famciclovir. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid sexual intercourse or use a latex condom to help keep you from spreading the virus to others. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent the spread of infection. Famciclovir side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: confusion; or kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath. Common side effects may include: headache; or nausea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Famciclovir dosing information Usual Adult Dose for Herpes Simplex -- Mucocutaneous/Immunocompetent Host: Genital herpes: Initial episode: 250 mg orally 3 times a day for 7 to 10 days has been recommended by the US Centers for Disease Control and Prevention (CDC) Recurrent episodes: 1000 mg orally twice a day for 1 day; alternatively, 125 mg orally twice a day for 5 days has been recommended by the CDC Famciclovir should be started at the first sign or symptom of a recurrent episode (such as tingling, burning, itching, pain, or lesion). The efficacy has not been established if started more than 6 hours after onset of symptoms or lesions. Usual Adult Dose for Herpes Simplex -- Mucocutaneous/Immunocompromised Host: Recurrent episodes of orolabial or genital herpes in HIV-infected patients: 500 mg orally twice a day for 7 days (5 to 10 days recommended by the CDC) Famciclovir should be started at the first sign or symptom of a recurrent episode (such as tingling, burning, itching, pain, or lesion). The efficacy has not been established if started more than 48 hours after onset of symptoms or lesions. Usual Adult Dose for Herpes Simplex -- Suppression: Chronic suppression of recurrent genital herpes: Immunocompetent patients: 250 mg orally twice a day HIV-infected patients: 500 mg orally twice a day has been recommended by the CDC Therapy should be continued as clinically appropriate, although the safety and efficacy of famciclovir therapy beyond 1 year have not been established. Usual Adult Dose for Herpes Zoster: 500 mg orally every 8 hours for 7 days Famciclovir is most effective if started within 48 hours of onset of rash. The efficacy has not been established if started more than 72 hours after onset of rash. Usual Adult Dose for Herpes Simplex Labialis: Recurrent herpes labialis: 1500 mg orally as a single dose Famciclovir is most effective if started at the earliest sign or symptom of a cold sore (such as tingling, burning, itching, pain, or lesion).   What other drugs will affect famciclovir?   Other drugs may affect famciclovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is famotidine? Famotidine is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces. Famotidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Famotidine also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn. The Zantac 360 brand of this medicine does not contain ranitidine, a medicine that was withdrawn from market in the United States. Warnings Before taking famotidine, tell your doctor if you have kidney or liver disease, a history of Long QT syndrome, stomach cancer or other problems, or asthma, COPD, or other breathing problems. Famotidine may be only part of a complete program of treatment that also includes changes in diet or lifestyle habits. Follow your doctor's instructions very closely. Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the jaw, arm or shoulder, nausea, sweating, anxiety, light-headedness and a general ill feeling. Before taking this medicine You should not use this medicine if you are allergic to famotidine or similar medicines such as ranitidine (Zantac), cimetidine (Tagamet), or nizatidine (Axid). To make sure this medicine is safe for you, tell your doctor or pharmacist if you have ever had: kidney disease; liver disease; cancer stomach; or long QT syndrome (in you or a family member). Ask a doctor before using famotidine if you are pregnant or breastfeeding. How should I take famotidine? Use famotidine exactly as directed on the label, or as prescribed by your doctor. Famotidine oral is taken by mouth. Famotidine injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. You may take famotidine oral with or without food. Shake the bottle of Pepcid suspension (liquid) vigorously for 5 to 10 seconds prior to each use. Measure the liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Most ulcers heal within 4 weeks of treatment, but it may take up to 8 weeks of using this medicine before your ulcer heals. Keep using the medication as directed. Call your doctor if the condition you are treating with this medicine does not improve, or if it gets worse while using this medicine. Famotidine may be only part of a complete program of treatment that also includes changes in diet or lifestyle habits. Follow all instructions of your doctor or dietitian. Store at room temperature away from moisture, heat, and light. Do not allow the liquid medicine to freeze. Throw away any unused liquid that is older than 30 days.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid drinking alcohol. It can increase the risk of damage to your stomach. Avoid taking other stomach acid reducers unless your doctor has told you to. However, you may take an antacid (such as Maalox, Mylanta, Gaviscon, Milk of Magnesia, Rolaids, or Tums) with famotidine. Famotidine side effects Get emergency medical help if you have any signs of an allergic reaction to famotidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: confusion, hallucinations, agitation, lack of energy; a seizure; fast or pounding heartbeats, sudden dizziness (like you might pass out); or unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Some side effects may be more likely in older adults and in people who have severe kidney disease. Common famotidine side effects may include: headache; dizziness; or constipation or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will interact with famotidine? Famotidine oral can make it harder for your body to absorb other medicines you take by mouth. Tell your doctor if you are taking: cefditoren; dasatinib; delavirdine; fosamprenavir; or tizanidine (if you are taking famotidine liquid). This list is not complete. Other drugs may interact with famotidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is febuxostat? Febuxostat reduces the production of uric acid in your body. A build-up of uric acid can cause gout symptoms. Febuxostat is used to keep uric acid levels from getting to high in people with gout. Febuxostat is for use only in people who cannot take another medicine called allopurinol, or when allopurinol has stopped working. Febuxostat may also be used for purposes not listed in this medication guide. Warnings Taking febuxostat may increase your risk of serious or fatal heart problems. Seek medical attention if you have chest pain, trouble breathing, fast heartbeats, sudden severe headache, numbness or weakness on one side of your body, or problems with vision or speech. You should not use febuxostat if you also use azathioprine or mercaptopurine. Before taking this medicine You should not use febuxostat if you are allergic to it, or if you also use: azathioprine; or mercaptopurine. Taking febuxostat may increase your risk of serious or fatal heart problems. Talk with your doctor about the risks and benefits of febuxostat. Tell your doctor if you have ever had: heart problems; a heart attack or stroke; liver or kidney disease; cancer; Lesch-Nyhan syndrome; or an organ transplant (kidney, liver, lung, heart). Tell your doctor if you are pregnant or breastfeeding. How should I take febuxostat? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take febuxostat with or without food. Febuxostat may be taken with an antacid if needed. You may have an increase in gout symptoms (flares) when you first start taking febuxostat. Your doctor may prescribe other medications for you to use during the first 6 months of treatment with febuxostat. You should not stop using febuxostat suddenly. Stopping suddenly may make your condition worse. For best results, keep using your medications as directed. Call your doctor if your symptoms do not improve after 6 months, or if they get worse. You will need frequent blood tests to check your liver function. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking febuxostat? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Febuxostat side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if you have: a light-headed feeling, like you might pass out; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, fast heartbeats, shortness of breath; liver problems--stomach pain (upper right side), unusual tiredness, dark urine, jaundice (yellowing of the skin or eyes); or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: gout flares, joint pain; nausea; mild rash; or liver problems. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Febuxostat dosing information Usual Adult Dose for Gout: Initial dose: 40 mg orally once a day -If serum uric acid level is greater than 6 mg/dL after 2 weeks, increase the dose to 80 mg orally once a day Maintenance dose: 40 to 80 mg orally once a day Maximum dose: 80 mg/day Comments: -Use of this drug should occur after an acute gout flare subsides. -Gout flares may occur due to increased urate mobilization from tissue deposits, especially during initiation; gout flare prophylaxis with a NSAID or colchicine is recommended and may be beneficial for up to 6 months. -Uric acid levels may be checked as soon as 2 weeks after beginning this drug. Use: For the chronic management of hyperuricemia in patients with gout who have an inadequate experience to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable.   What other drugs will affect febuxostat? Tell your doctor about all your other medicines, especially: theophylline. This list is not complete. Other drugs may affect febuxostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is felodipine? Felodipine is a calcium channel blocker that is used to treat hypertension (high blood pressure) in adults. Lowering blood pressure can help lower your risk of a stroke or heart attack. Felodipine may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use felodipine if you are allergic to it. Tell your doctor if you have ever had: liver disease; or congestive heart failure. Felodipine may harm an unborn baby or cause problems with labor and delivery. Tell your doctor if you are pregnant or plan to become pregnant. You should not breast-feed while using felodipine. Felodipine is not approved for use by anyone younger than 18 years old. How should I take felodipine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take felodipine with or without food, but take it the same way each time. Swallow the tablet whole and do not crush, chew, or break it. Your blood pressure will need to be checked often. You may also need to take other medications, exercise, limit salt intake, stop smoking, and manage other conditions such as diabetes or heart disease. Follow your doctor's instructions very closely. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea. Keep using felodipine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include slow heartbeats, warmth or tingling, and feeling like you might pass out. What should I avoid while taking felodipine? Drinking alcohol can lower your blood pressure further and may increase certain side effects of felodipine. Grapefruit may interact with felodipine and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Felodipine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; chest pain; feeling short of breath; or swelling or rapid weight gain. Felodipine can cause mild gum swelling. Pay special attention to your dental hygiene while taking felodipine. Brush and floss your teeth regularly. Common side effects may include: swelling in your arms, hands, legs, or feet; headache; or flushing (sudden warmth, redness, or tingly feeling). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Felodipine dosing information Usual Adult Dose for Hypertension: Initial dose: 5 mg orally once a day Maintenance dose: 2.5 to 10 mg orally once a day Comments: If needed, dose adjustments should generally occur at intervals of at least 2 weeks. Usual Geriatric Dose for Hypertension: Initial dose: 2.5 to 5 mg orally once a day Maintenance dose: 2.5 to 10 mg orally once a day Comments: If needed, dose adjustments should generally occur at intervals of at least 2 weeks. Usual Pediatric Dose for Hypertension: (Not approved by FDA) NIH and NHLBI recommendations: 1 year or older: Initial dose: 2.5 mg orally once a day Maintenance dose: 2.5 to 10 mg orally once a day Maximum dose: 10 mg/day   What other drugs will affect felodipine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can affect felodipine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is fenofibrate? Fenofibrate belongs to a group of drugs known as "fibrates." It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate is used along with a proper diet to help to treat high cholesterol and high triglyceride levels. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help fenofibrate work better include exercising, losing weight if overweight, and stopping smoking. Warnings You should not take fenofibrate if you have liver disease, gallbladder disease, severe kidney disease, or if you are breast-feeding a baby. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine. Before taking this medicine You should not take fenofibrate if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); liver disease; or gallbladder disease. Do not breast-feed while using this medicine, and for at least 5 days after your last dose. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; or gallbladder problems. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid). It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Fenofibrate is not approved for use by anyone younger than 18 years old. How should I take fenofibrate? Take fenofibrate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Some brands of fenofibrate should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label. Swallow the tablet or capsule whole and do not crush, chew, dissolve, or open it. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Fenofibrate is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IIa (Elevated LDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IV (Elevated VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Geriatric Dose of Fenofibrate for Hyperlipoproteinemia: Tricor: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours. Lofibra and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Antara: 43 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Triglide: 50 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Lipofen: 50 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Fenoglide: 40 mg to 120 mg orally once a day with food   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Fenofibrate side effects Get emergency medical help if you have signs of an allergic reaction to fenofibrate (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: sharp stomach pain spreading to your back or shoulder blade; loss of appetite, stomach pain just after eating a meal; jaundice (yellowing of the skin or eyes); fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or swelling, warmth, or redness in an arm or leg. Common fenofibrate side effects may include: runny nose, sneezing; or abnormal laboratory tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect fenofibrate? Some medicines can make fenofibrate much less effective when taken at the same time. If you take any of the following medicines, take your dose 1 hour before or 4 to 6 hours after you take the other medicine. cholestyramine; colesevelam; or colestipol. Tell your doctor about all your other medicines, especially: other cholesterol lowering medicines; colchicine; a blood thinner such as warfarin, Coumadin, Jantoven; or drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection. This list is not complete. Other drugs may affect fenofibrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is fenofibrate? Fenofibrate belongs to a group of drugs known as "fibrates." It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate is used along with a proper diet to help to treat high cholesterol and high triglyceride levels. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help fenofibrate work better include exercising, losing weight if overweight, and stopping smoking. Warnings You should not take fenofibrate if you have liver disease, gallbladder disease, severe kidney disease, or if you are breast-feeding a baby. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine. Before taking this medicine You should not take fenofibrate if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); liver disease; or gallbladder disease. Do not breast-feed while using this medicine, and for at least 5 days after your last dose. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; or gallbladder problems. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid). It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Fenofibrate is not approved for use by anyone younger than 18 years old. How should I take fenofibrate? Take fenofibrate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Some brands of fenofibrate should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label. Swallow the tablet or capsule whole and do not crush, chew, dissolve, or open it. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Fenofibrate is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IIa (Elevated LDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IV (Elevated VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Geriatric Dose of Fenofibrate for Hyperlipoproteinemia: Tricor: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours. Lofibra and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Antara: 43 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Triglide: 50 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Lipofen: 50 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Fenoglide: 40 mg to 120 mg orally once a day with food   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Fenofibrate side effects Get emergency medical help if you have signs of an allergic reaction to fenofibrate (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: sharp stomach pain spreading to your back or shoulder blade; loss of appetite, stomach pain just after eating a meal; jaundice (yellowing of the skin or eyes); fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or swelling, warmth, or redness in an arm or leg. Common fenofibrate side effects may include: runny nose, sneezing; or abnormal laboratory tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.