What is eletriptan? Eletriptan is used to treat migraine headaches with or without aura in adults. Eletriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Eletriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use eletriptan only if your condition has been confirmed by a doctor as migraine headaches. Eletriptan may also be used for purposes not listed in this medication guide. Warnings You should not use eletriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not take eletriptan within 24 hours before or after using another migraine headache medicine. Do not use eletriptan within 72 hours before or after taking: clarithromycin, troleandomycin, itraconazole, ketoconazole, nefazodone, ritonavir, or nelfinavir. Before taking this medicine You should not use eletriptan if you are allergic to it, or if you have: heart problems, or a stroke (including "mini-stroke"); circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome; uncontrolled high blood pressure; or a headache that seems different from your usual migraine headaches. Do not take eletriptan within 24 hours before or after using another migraine headache medicine, including: medicines like eletriptan--almotriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, and others; or ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine. Do not use eletriptan within 72 hours before or after taking: clarithromycin, troleandomycin, itraconazole, ketoconazole, nefazodone, ritonavir, or nelfinavir. Tell your doctor if you have ever had: liver or renal disease; heart problems or stroke; or risk factors for coronary artery disease (such as high blood pressure, high cholesterol, diabetes, menopause, smoking, a family history of coronary artery disease, being overweight, or being older than 40 and a man). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with eletriptan and cause a serious condition called serotonin syndrome. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether eletriptan will harm an unborn baby. However, having migraine headaches during pregnancy may cause complications such as high blood pressure or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating migraines may outweigh any risks to the baby. It may not be safe to breastfeed while using eletriptan. Ask your doctor about any risk. Eletriptan is not approved for use by anyone younger than 18 years old. How should I take eletriptan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take eletriptan as soon as you notice migraine symptoms. After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. Do not take more than 80 mg of eletriptan in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets. Call your doctor if your headache does not go away at all after taking the first eletriptan tablet. If you use eletriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Store at room temperature away from moisture and heat. What happens if I miss a dose? Since eletriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using eletriptan. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking eletriptan? Avoid driving or hazardous activity until you know how eletriptan will affect you. Your reactions could be impaired. Eletriptan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: fast, slow, or uneven heart rate; sudden severe stomach pain (especially after meals), constipation or diarrhea, weight loss; fever, diarrhea that is bloody; numbness, tingling, cold feeling or burning pain in your feet or toes; tightness or heavy feeling in your legs, pale or blue-colored appearance in your fingers or toes; severe headache, blurred vision, pounding in your neck or ears; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Stop using eletriptan and call your doctor at once if you have: heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Common side effects may include: dizziness, drowsiness; nausea; or weakness, feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Eletriptan dosing information Usual Adult Dose for Migraine: Use only after a clear diagnosis of migraine has been established Initial dose: 20 mg or 40 mg orally, once -Provided there has been some response to first dose, a second dose may be administered at least 2 hours later if migraine returns or symptoms recur. Maximum dose: 80 mg in a 24-hour period Comments: -Doses should be individualized as responses vary; in clinical trials, benefit was observed with 20 mg, 40 mg, and 80 mg doses; however an increased incidence of side effects was observed at the 80 mg dose. -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 3 or more migraine attacks in a 30-day period has not been established. Use: For the acute treatment of migraine with or without aura.   What other drugs will affect eletriptan? Tell your doctor about all your other medicines, especially an antidepressant. Other drugs may affect eletriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is rizatriptan? Rizatriptan is a headache medicine that narrows the blood vessels around the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Rizatriptan is used to treat migraine headaches. Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Rizatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use rizatriptan only if your condition has been confirmed by a doctor as migraine headaches. Rizatriptan may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you have uncontrolled high blood pressure, heart problems, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not take rizatriptan within 24 hours before or after using another migraine headache medicine. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Before taking this medicine You should not use rizatriptan if you are allergic to it, or if you have: heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; uncontrolled high blood pressure; severe liver disease; or a headache that seems different from your usual migraine headaches. Do not use rizatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: liver or kidney disease; heart problems, chest pain; shortness of breath; or risk factors for coronary artery disease (such as high blood pressure, high cholesterol, diabetes, menopause, smoking, a family history of coronary artery disease, being overweight, or being older than 40 and a man). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rizatriptan and cause a serious condition called serotonin syndrome. Rizatriptan disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). Tell your doctor if you are pregnant or breastfeeding. Rizatriptan is not approved for use by anyone younger than 6 years old. How should I use rizatriptan? Take rizatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Take the regular tablet whole with a full glass of water. Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves. After taking a tablet (for adults): If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. If your symptoms have not improved, contact your doctor before taking any more tablets. After taking a tablet (for children ages 6 to 17): If your headache does not completely go away, or goes away and comes back, contact your doctor before taking any more tablets. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Call your doctor if your symptoms do not improve, or if you have more than 4 headaches in one month (30 days). Rizatriptan can raise blood pressure to dangerous levels. Your blood pressure may need to be checked often while you are using rizatriptan. If you use rizatriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Store at room temperature away from moisture and heat. What happens if I miss a dose? Since rizatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using rizatriptan? Do not take rizatriptan within 24 hours before or after using another migraine headache medicine, including: almotriptan, eletriptan, frovatriptan, naratriptan, sumatriptan, zolmitriptan; or ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine. Avoid driving or hazardous activity until you know how rizatriptan will affect you. Your reactions could be impaired. Rizatriptan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using rizatriptan and call your doctor at once if you have: sudden and severe stomach pain and bloody diarrhea; cold feeling or numbness in your feet and hands; severe headache, blurred vision, pounding in your neck or ears; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: dizziness, drowsiness, feeling tired; or pain or a feeling of pressure in your throat or chest. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rizatriptan dosing information Usual Adult Dose for Migraine: Use only after a clear diagnosis of migraine has been established Initial dose: 5 mg or 10 mg orally, once -Provided there has been a response to first dose, a second dose may be administered at least 2 hours later if migraine returns Maximum dose: 30 mg in a 24-hour period Comments: -The 10 mg dose may provide greater effect, however there may be a greater risk of adverse reactions. -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the effectiveness of a second dose or subsequent doses has not been established in placebo-controlled trials. Use: For the acute treatment of migraine with or without aura. Usual Pediatric Dose for Migraine: Use only after a clear diagnosis of migraine has been established 6 years or older and weight less than 40 kg: -Initial dose: 5 mg orally once 6 years or older and weight 40 kg or greater: -Initial dose: 10 mg orally once Maximum: 1 dose in any 24-hour period Comments: -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the safety and effectiveness of more than 1 dose within 24 hours has not been established. Use: For the acute treatment of migraine with or without aura in patients 6 years or older.   What other drugs will affect rizatriptan? Tell your doctor about all your other medicines, especially: propranolol; an antidepressant; or medicine to treat a mood disorder. This list is not complete. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Tell your doctor about all your other medicines, especially any type of antidepressant. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sumatriptan injection? Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Sumatriptan is used to treat migraines and cluster headaches in adults. Sumatriptan will only treat a headache. sumatriptan will not prevent headaches or reduce the number of attacks. Sumatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches. Sumatriptan may also be used for purposes not listed in this medication guide. Warnings You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not use sumatriptan within 24 hours before or after using another migraine headache medicine. Before taking this medicine You should not use sumatriptan if you are allergic to it, if you have a headache that seems different from your usual migraine headaches, or if you have ever had: heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome; uncontrolled high blood pressure; or severe liver disease. Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: liver or kidney disease; epilepsy or other seizure disorder; high blood pressure, a heart rhythm disorder; or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or being older than 40 and a man). It is not known whether sumatriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using sumatriptan. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Sumatriptan injection is not approved for use by anyone younger than 18 years old. How should I use sumatriptan injection? Use sumatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Sumatriptan is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself. This medicine comes in a vial (bottle), a needle-free injector device, or a prefilled cartridge for an auto-injector syringe. Each type is for one use only. Read and carefully follow any Instructions for Use provided with your medicine. Do not use sumatriptan if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions. Prepare your injection only when you are ready to give it. Do not use a vial if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine. After an injection: If your headache does not completely go away, call your doctor before using a second injection. If your headache goes away and then comes back, use a second injection if it has been at least 1 hour since your first injection. Do not use more than 2 injections in 24 hours. Call your doctor if your symptoms do not improve. Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed. Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.   What happens if I miss a dose? Since sumatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using sumatriptan. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions). What should I avoid while using sumatriptan injection? Do not use sumatriptan within 24 hours before or after using another migraine headache medicine, including: sumatriptan tablets or nasal spray, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan; or ergot medicine such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine. Avoid driving or hazardous activity until you know how sumatriptan will affect you. Your reactions could be impaired. Sumatriptan injection side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sumatriptan and call your doctor at once if you have: sudden and severe stomach pain and bloody diarrhea; severe chest pain, shortness of breath, irregular heartbeats; a seizure (convulsions); blood circulation problems in your legs or feet--cramps, tight or heavy feeling, numbness or tingling, muscle weakness, burning pain, cold feeling, color changes (pale or blue), hip pain; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: numbness, tingling, warmth, redness, or burning sensation; pressure or heavy feeling in any part of your body; dizziness, drowsiness, feeling weak or tired; neck pain or stiffness; or pain or redness where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sumatriptan injection? Using sumatriptan while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use: medicine to treat depression or a psychiatric disorder; medicine for Parkinson's disease; medicine for serious infections; herbal products; stimulant medicine; opioid medicine; or medicine to prevent nausea and vomiting. This list is not complete. Other drugs may affect sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.