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What is cevimeline? Cevimeline increases the secretions of the saliva and sweat glands in the body. Cevimeline is used to treat dry mouth in people with Sjögren's Syndrome. Cevimeline may also be used for purposes not listed in this medication guide. Warnings You should not take cevimeline if you have uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis. What should I tell my healthcare provider before taking cevimeline? You should not take cevimeline if you are allergic to it, or if you have: untreated or uncontrolled asthma; narrow-angle glaucoma; or an eye condition called iritis or uveitis. To make sure cevimeline is safe for you, tell your doctor if you have: asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD); heart disease, angina (chest pain), or a history of heart attack; a heart rhythm disorder; high blood pressure (hypertension); liver or kidney disease; or a history of kidney stones or gallstones. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether cevimeline passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Cevimeline is not approved for use by anyone younger than 18 years old. How should I take cevimeline? Follow all directions on your prescription label. Do not take cevimeline in larger or smaller amounts or for longer than recommended. Drink plenty of liquids while you are taking cevimeline. This will help keep your kidneys working properly, and can also prevent dehydration. Cevimeline is usually taken 3 times per day. Follow your doctor's dosing instructions. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include headache, vision problems, confusion, sweating, tremors, vomiting, diarrhea, feeling short of breath, and irregular heartbeats. What should I avoid while taking cevimeline? cevimeline may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Avoid becoming overheated or dehydrated during exercise and in hot weather. Cevimeline can decrease sweating and you may be more prone to heat stroke. Cevimeline side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using cevimeline and call your doctor at once if you have: severe pain in your stomach, side, or lower back; vomiting; fast, slow, or uneven heart rate; painful or difficult urination; a light-headed feeling, like you might pass out; or dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin. Common side effects may include: increased sweating; excessive salivation, drooling; nausea, diarrhea; dry mouth; headache; or stuffy nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Cevimeline dosing information Usual Adult Dose for Sjogren's Syndrome: 30 mg orally three times a day Comments: -There is insufficient safety information and insufficient evidence for additional efficacy to support doses greater than 30 mg three times a day. Use: Treatment of symptoms of dry mouth in patients with Sjögren's Syndrome. What other drugs will affect cevimeline? Tell your doctor about all your current medicines and any you start or stop using, especially: an antibiotic or antifungal medicine; an antidepressant; antiviral medicine to treat hepatitis C or HIV/AIDS; or heart or blood pressure medication. This list is not complete. Other drugs may interact with cevimeline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
What is Salagen? Salagen affects the nervous system and increases saliva secretion in the mouth. Salagen is used to treat dry mouth caused by Sjogren's syndrome, or by radiation to treat head and neck cancer. Salagen may also be used for purposes not listed in this medication guide. Warnings You should not use Salagen if you have narrow-angle glaucoma, or asthma that is untreated or uncontrolled. Before taking this medicine You should not use Salagen if you are allergic to it, or if you have: untreated or uncontrolled asthma; or narrow-angle glaucoma. To make sure Salagen is safe for you, tell your doctor if you have: asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), or other breathing disorder; glaucoma or vision problems; liver disease; kidney disease; heart disease; gallbladder problems; mental illness; if you take heart or blood pressure medicine; or if you use a bronchodilator to treat a breathing disorder. FDA pregnancy category C. It is not known whether Salagen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Salagen. It is not known whether pilocarpine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take Salagen? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Salagen with or without food. Drink plenty of liquids while you are taking Salagen. This medicine can cause increased sweating and you may get dehydrated easily. Use Salagen regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Salagen can be fatal at very high doses. What should I avoid while taking pilocarpine? Salagen may cause blurred vision, especially at night or in low light. Be careful if you drive or do anything that requires you to be able to see clearly. Avoid becoming overheated during exercise and in hot weather. Salagen can increase sweating and you may be more prone to dehydration. Salagen side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Salagen and call your doctor at once if you have: shortness of breath; fast or slow heart rate; severe headache, pounding in your neck or ears; confusion, tremors; or a light-headed feeling, like you might pass out. Common side effects may include: increased sweating, urinating more than usual; chills, or flushing (warmth, redness, or tingly feeling); headache, dizziness, weakness; nausea, vomiting, diarrhea; blurred vision, watery eyes; or runny nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect Salagen? Other drugs may interact with pilocarpine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using