What is atomoxetine? Atomoxetine is used to treat attention deficit hyperactivity disorder (ADHD). Atomoxetine may also be used for purposes not listed in this medication guide. Warnings Some people have thoughts about suicide while taking atomoxetine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Do not use atomoxetine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Atomoxetine may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder. Atomoxetine has caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect. Before taking this medicine Do not use atomoxetine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. You should not use atomoxetine if you are allergic to it, or if you have: severe heart or blood vessel problems; narrow-angle glaucoma; or pheochromocytoma (tumor of the adrenal gland). Atomoxetine has caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have: heart problems or a congenital heart defect; high blood pressure; or a family history of heart disease or sudden death. Tell your doctor if you have ever had: depression, mental illness, bipolar disorder, psychosis; suicidal thoughts or actions; low blood pressure; or liver disease. Some people have thoughts about suicide while taking atomoxetine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of atomoxetine on the baby. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Atomoxetine is not approved for use by anyone younger than 6 years old. How should I take atomoxetine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take the medicine at the same time each day, with a full glass of water. Atomoxetine is usually taken once daily in the morning, or two times per day in the morning and late afternoon. Follow your doctor's instructions. You may take atomoxetine with or without food. Swallow the capsule whole and do not crush, chew, break, or open it. Tell your doctor if you have trouble swallowing the capsules. Your doctor will need to check your progress on a regular basis. Your blood, heart rate, blood pressure, height and weight may also need to be checked often. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, dizziness, stomach problems, tremors, or unusual behavior. What should I avoid while taking atomoxetine? Avoid using or handling an open or broken capsule. If the powder from inside the capsule gets in your eyes, rinse them with water right away and call your doctor. Avoid driving or hazardous activity until you know how atomoxetine will affect you. Your reactions could be impaired. Atomoxetine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself. Atomoxetine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine. Call your doctor at once if you have: signs of heart problems--chest pain, trouble breathing, feeling like you might pass out; signs of psychosis--hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia; liver problems--stomach pain (upper right side), itching, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes); painful or difficult urination; or erection is painful or lasts longer than 4 hours (this is a rare side effect). Common side effects may include: nausea, vomiting, upset stomach, constipation; dry mouth, loss of appetite; mood changes, feeling tired; dizziness; urination problems; or impotence, trouble having an erection. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Atomoxetine dosing information Usual Adult Dose for Attention Deficit Disorder: -Initial Dose: 40 mg/day orally. -Maintenance Dose: Increase dose to 80 mg/day orally after a minimum of 3 days at the initial dose. -Maximum Dose: After 2 to 4 additional weeks, the dose may be increased up to 100 mg/day in patients who have not achieved an optimal response. Comments: Take dose once a day in the morning OR as evenly divided doses in the morning and late afternoon/early evening. Use: Treatment of Attention Deficit Hyperactivity Disorder (ADHD). Usual Pediatric Dose for Attention Deficit Disorder: 70 kg or Less: -Initial Dose: 0.5 mg/kg/day orally. -Maintenance dose: Increase dose to 1.2 mg/kg/day after a minimum of 3 days at the initial dose. -Maximum dose: 1.4 mg/kg/day or 100 mg/day, whichever is less. Over 70 kg: -Initial Dose: 40 mg/day orally. -Maintenance dose: Increase dose to 80 mg/day after a minimum of 3 days at the initial dose. -Maximum dose: After 2 to 4 additional weeks, the dose may be increased up to 100 mg/day in patients who have not achieved an optimal response. Comments: Take dose once a day in the morning OR as evenly divided doses in the morning and late afternoon/early evening. Use: Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in pediatric patients age 6 and older.   What other drugs will affect atomoxetine? Tell your doctor about all your current medicines and any you start or stop using, especially: an antidepressant; asthma medication; blood pressure medicine; or a cold or allergy medicine that contains a decongestant such as pseudoephedrine or phenylephrine. This list is not complete. Other drugs may affect atomoxetine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is dexmethylphenidate? Dexmethylphenidate is a stimulant that is used to treat attention deficit hyperactivity disorder (ADHD). Dexmethylphenidate may also be used for purposes not listed in this medication guide. Warnings Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect. Dexmethylphenidate may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder. Call your doctor right away if you have: signs of heart problems--chest pain, feeling light-headed or short of breath; or signs of psychosis--paranoia, aggression, new thought or behavior problems, seeing or hearing things that are not real. Dexmethylphenidate may be habit-forming. Tell your doctor if you have a history of drug or alcohol addiction. Keep the medication where others cannot get to it. Before taking this medicine You should not take dexmethylphenidate if you are allergic to dexmethylphenidate or methylphenidate (Ritalin, Concerta). Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have: heart problems or a congenital heart defect; high blood pressure; or a family history of heart disease or sudden death. Do not use dexmethylphenidate if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine. Tell your doctor if you also use opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with dexmethylphenidate could cause a serious condition called serotonin syndrome. Tell your doctor if you or anyone in your family has ever had: depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions; blood circulation problems in the hands or feet; or alcoholism or drug addiction. Becoming dependent on this medicine during pregnancy can cause premature birth or low birth weight. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dexmethylphenidate on the baby. Ask a doctor if it is safe to breastfeed while using this medicine. Not approved for use by anyone younger than 6 years old. How should I take dexmethylphenidate? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Dexmethylphenidate may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication where others cannot get to it. Selling or giving away this medicine is against the law. Dexmethylphenidate is usually taken twice per day, at least 4 hours apart. You may take dexmethylphenidate with or without food. Take the regular tablet twice daily, at least 4 hours apart. Take the extended-release capsule once daily in the morning. Swallow the extended-release capsule whole and do not crush, chew, break, or open it. If you cannot swallow a capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing. Your doctor will need to check your progress on a regular basis. Your heart and blood pressure may also need to be checked often. Tell your doctor if you have a planned surgery. Your treatment may also include counseling or other treatments. Store tightly closed at room temperature, away from moisture, heat, and light. Keep your medicine in a place where no one can use it improperly.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of dexmethylphenidate could be fatal. Overdose symptoms may include dry mouth, vomiting, agitation, tremor, muscle twitches, confusion, hallucinations, dilated pupils, muscle pain or weakness, fever, sweating, headache, pounding in your neck or ears, fast or pounding heartbeats, seizure (convulsions), or coma. What should I avoid while taking dexmethylphenidate? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Dexmethylphenidate side effects Get emergency medical help if you have signs of an allergic reaction: fever; hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: signs of heart problems--chest pain, trouble breathing, feeling like you might pass out; signs of psychosis--hallucinations (seeing or hearing things that are not real), new thought or behavior problems, aggression, hostility, paranoia; signs of circulation problems--numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes; or penis erection that is painful or lasts 4 hours or longer. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Dexmethylphenidate can affect growth in children. Your child's height and weight may need to be checked often. Tell your doctor if your child is not growing at a normal rate. Common side effects may include: loss of appetite; nausea, stomach pain; or fever. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect dexmethylphenidate? Tell your doctor about all your other medicines, especially: an antidepressant; or blood pressure medication. This list is not complete. Other drugs may affect dexmethylphenidate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Warning This medicine has a risk of abuse and misuse. Use this medicine (dextroamphetamine and amphetamine extended-release capsules) only as you were told by your doctor. Tell your doctor if you have ever abused or been addicted to any drugs or alcohol. Uses of Dextroamphetamine and Amphetamine Extended-Release Capsules: It is used to treat attention deficit problems with hyperactivity. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Dextroamphetamine and Amphetamine Extended-Release Capsules? If you have an allergy to dextroamphetamine, amphetamine, or any other part of this medicine (dextroamphetamine and amphetamine extended-release capsules). If you are allergic to this medicine (dextroamphetamine and amphetamine extended-release capsules); any part of this medicine (dextroamphetamine and amphetamine extended-release capsules); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you or a family member have any of these health problems: Blood vessel disease, high blood pressure, heart structure problems or other heart problems, or Tourette's syndrome or tics. If you have any of these health problems: Glaucoma, agitation, anxiety, or overactive thyroid. If you have ever had any of these health problems: Drug abuse or stroke. If you have kidney disease. If you are taking acetazolamide. If you are taking sodium bicarbonate. If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen. If you are taking any of these drugs: Linezolid or methylene blue. If you are breast-feeding. Do not breast-feed while you take this medicine (dextroamphetamine and amphetamine extended-release capsules). This is not a list of all drugs or health problems that interact with this medicine (dextroamphetamine and amphetamine extended-release capsules). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (dextroamphetamine and amphetamine extended-release capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Dextroamphetamine and Amphetamine Extended-Release Capsules? Tell all of your health care providers that you take this medicine (dextroamphetamine and amphetamine extended-release capsules). This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (dextroamphetamine and amphetamine extended-release capsules) affects you. If you have been taking this medicine (dextroamphetamine and amphetamine extended-release capsules) for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if this medicine (dextroamphetamine and amphetamine extended-release capsules) stops working well. Do not take more than ordered. This medicine may be habit-forming with long-term use. If you have been taking this medicine (dextroamphetamine and amphetamine extended-release capsules) for many weeks, talk with your doctor before stopping. You may want to slowly stop this medicine (dextroamphetamine and amphetamine extended-release capsules). You may need to have some heart tests before starting this medicine (dextroamphetamine and amphetamine extended-release capsules). If you have questions, talk with your doctor. This medicine may cause high blood pressure. Check blood pressure and heart rate as the doctor has told you. Have blood work checked as you have been told by the doctor. Talk with the doctor. This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (dextroamphetamine and amphetamine extended-release capsules). Do not take antacids with this medicine (dextroamphetamine and amphetamine extended-release capsules). Talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids. New or worse behavior and mood changes like change in thinking, anger, and hallucinations have happened with this medicine (dextroamphetamine and amphetamine extended-release capsules). Tell your doctor if you or a family member have any mental or mood problems like depression or bipolar illness, or if a family member has committed suicide. Call your doctor right away if you have hallucinations; change in the way you act; or signs of mood changes like depression, thoughts of suicide, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life. A severe and sometimes deadly problem called serotonin syndrome may happen if you take this medicine (dextroamphetamine and amphetamine extended-release capsules) with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache. This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor. Different brands of this medicine (dextroamphetamine and amphetamine extended-release capsules) may be for use in different ages of children. Talk with the doctor before giving this medicine (dextroamphetamine and amphetamine extended-release capsules) to a child. Avoid drinking alcohol while taking this medicine (dextroamphetamine and amphetamine extended-release capsules). Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (dextroamphetamine and amphetamine extended-release capsules) while you are pregnant. How is this medicine (Dextroamphetamine and Amphetamine Extended-Release Capsules) best taken? Use this medicine (dextroamphetamine and amphetamine extended-release capsules) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take with or without food but take the same way each time. Always take with food or always take on an empty stomach. Take in the morning. Swallow whole. Do not chew, break, or crush. You may sprinkle contents of capsule on applesauce. Do not chew. After mixing, take your dose right away. Do not store for future use. What do I do if I miss a dose? Skip the missed dose and go back to your normal time. Do not take it later in the day. Detailed Amphetamine / dextroamphetamine dosage information What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Not able to get or keep an erection. Change in sex interest. Seizures. Trouble controlling body movements. Restlessness. Change in eyesight. For males, erections (hard penis) that happen often or that last a long time. Change in color of hands or feet from pale to blue or red. Numbness, pain, tingling, or cold feeling of the hands or feet. Any sores or wounds on the fingers or toes. Muscle pain or weakness, dark urine, or trouble passing urine. Pain when passing urine. Heart attacks, strokes, and sudden deaths have happened in adults taking this medicine (dextroamphetamine and amphetamine extended-release capsules). Sudden deaths have also happened in children with some heart problems or heart defects. Call your doctor right away if you have a fast, slow, or abnormal heartbeat; weakness on 1 side of the body; trouble speaking or thinking; change in balance; drooping on 1 side of the face; change in eyesight; chest pain or pressure; shortness of breath; or severe dizziness or passing out. Amphetamine / dextroamphetamine side effects (more detail) What are some other side effects of Dextroamphetamine and Amphetamine Extended-Release Capsules? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Feeling nervous and excitable. Headache. Not hungry. Trouble sleeping. Diarrhea or constipation. Stomach pain. Feeling dizzy, tired, or weak. Dry mouth. Bad taste in your mouth. Weight loss. Upset stomach or throwing up. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch. If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out Dextroamphetamine and Amphetamine Extended-Release Capsules? Store at room temperature. Protect from light. Store in a dry place. Do not store in a bathroom. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area. Consumer information use If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine (dextroamphetamine and amphetamine extended-release capsules) is refilled. If you have any questions about this medicine (dextroamphetamine and amphetamine extended-release capsules), please talk with the doctor, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

What is guanfacine? Guanfacine reduces nerve impulses in your heart and blood vessels. Guanfacine works by relaxing blood vessels, which lowers blood pressure and improves blood flow. The Tenex brand of guanfacine is used to treat high blood pressure (hypertension). It is sometimes given with other blood pressure medications. The Intuniv brand of guanfacine is used to treat attention deficit hyperactivity disorder (ADHD). Guanfacine may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use guanfacine if you are allergic to it. Intuniv is not approved for use by anyone younger than 6 years old. Tenex is not approved for use by anyone younger than 12 years old. Tell your doctor if you have ever had: heart problems, coronary artery disease (clogged arteries); a heart rhythm disorder; a heart attack or stroke; high or low blood pressure; liver disease; or kidney disease. It is not known whether guanfacine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks. How should I take guanfacine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take Intuniv with a full glass of water, milk, or other liquid. Take Tenex at bedtime to ease drowsiness. Swallow the Intuniv tablet whole and do not crush, chew, or break it. If a child is using this medicine, tell your doctor if the child has any changes in weight. Intuniv doses are based on weight in children, and any changes may affect your child's dose. You should not stop using guanfacine suddenly. Stopping suddenly can raise your blood pressure and cause unpleasant symptoms. Call your doctor if you are sick with vomiting and cannot take your medicine as usual. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes. Your doctor will need to check your progress on a regular basis. Your blood pressure and heart rate may also need to be checked. If you have high blood pressure, keep using Tenex even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Avoid taking guanfacine with high-fat foods, or your body could absorb the medicine too quickly. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Call your doctor for instructions if you miss more than 2 doses in a row. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe drowsiness, slow heart rate, and feeling like you might pass out. What should I avoid while taking guanfacine? Avoid driving or hazardous activity until you know how guanfacine will affect you. Your reactions could be impaired. Drinking alcohol can increase certain side effects of guanfacine. Guanfacine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: anxiety, nervousness; hallucinations (especially in children); severe drowsiness; slow heartbeats; or a light-headed feeling, like you might pass out; If you stop taking guanfacine, tell your doctor if you have headaches, confusion, rapid heartbeats, tremors, increased blood pressure, or if you feel nervous or agitated. If left untreated, these symptoms could lead to very high blood pressure, vision problems, or seizures. Common side effects may include: dizziness, drowsiness; low blood pressure, slow heartbeats; feeling tired or irritable; trouble sleeping; dry mouth; or stomach pain, nausea, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Guanfacine dosing information Usual Adult Dose for Hypertension: Initial dose: 1 mg orally once a day at bedtime; may increase to 2 mg once a day if satisfactory result not achieved after 3 to 4 weeks. Comments: Adverse reactions increase significantly with doses above 3 mg/day. Usual Pediatric Dose for Attention Deficit Disorder: 6 YEARS TO LESS THAN 18 YEARS: Initial dose: 1 mg orally once a day, either in the morning or evening, at approximately the same time each day; may adjust in increments of no more than 1 mg/week. Recommended target dose: 0.05 to 0.12 mg/kg/day (total daily dose between 1 and 7 mg) once a day, depending on clinical response and tolerability Maximum dose: 6 to 12 years: Doses above 4 mg/day have not been evaluated; 13 to 17 years: Doses above 7 mg/day have not been evaluated. Comments: Attention Deficit Hyperactivity Disorder (ADHD) may require treatment for an extended period of time; healthcare providers should periodically reevaluate treatment and adjust dose as needed. Use: Treatment of ADHD as monotherapy and as adjunctive therapy to stimulant medications. Usual Pediatric Dose for Hypertension: 12 YEARS OR OLDER: Initial dose: 1 mg orally once a day at bedtime; may increase to 2 mg once a day if satisfactory result not achieved after 3 to 4 weeks. Comments: Adverse reactions increase significantly with doses above 3 mg/day.   What other drugs will affect guanfacine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Using guanfacine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Tell your doctor about all your other medicines. Some may affect guanfacine, especially: ketoconazole; a barbiturate, such as phenobarbital; blood pressure medications; medicine to treat mental illness; or a sedative, such as Valium or Xanax. This list is not complete. Other drugs may affect guanfacine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is Kapvay? Kapvay (clonidine) is a prescription medicine supplied as an extended-release tablet and is used to treat attention deficit hyperactivity disorder (ADHD). Your doctor may prescribe Kapvay alone or together with certain other ADHD medicines. Kapvay is not a central nervous system (CNS) stimulant. Kapvay should be used as part of a total treatment program for ADHD that may include counseling or other therapies. Warnings Use Kapvay only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before you take Kapvay, tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, slow heartbeats, low blood pressure, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS). Before taking this medicine You should not take Kapvay if you are allergic to clonidine. To make sure Kapvay is safe for you, tell your doctor if you have: heart disease or severe coronary artery disease; a heart rhythm disorder, slow heartbeats; high or low blood pressure, or a history of fainting spells; a heart attack or stroke; pheochromocytoma (tumor of the adrenal gland); kidney disease; or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS). It is not known if clonidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonidine on the baby. Clonidine may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine. If you are breastfeeding, tell your doctor if you notice somnolence, tiredness, rapid breathing, and poor feeding in the nursing baby. Do not give Kapvay to a child younger than 6 years old. How should I take Kapvay? Take Kapvay exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Kapvay is usually taken in the morning and at bedtime. If you take different doses of this medicine at each dosing time, it may be best to take the larger dose at bedtime. Kapvay may be taken with or without food. Swallow the extended-release tablet whole and do not crush, chew, or break it. Tell your doctor if you have a planned surgery. You may have withdrawal symptoms if you stop using Kapvay suddenly. Ask your doctor before stopping the medicine. Call your doctor if you are sick with vomiting. Prolonged illness can make it harder for your body to absorb clonidine, which may lead to withdrawal symptoms. This is especially important for a child taking Kapvay. Store at room temperature away from moisture, heat, and light. Dosing information Usual Pediatric Dose for Attention Deficit Disorder: Extended release: 6 years and older: -Initial dose: 0.1 mg orally at bedtime -Titration: Increase in 0.1 mg/day increments every 7 days until desired response; doses should be administered twice daily (either split equally or with the higher split dosage given at bedtime) -Maximum dose: 0.4 mg/day in 2 divided doses Comments: -May be taken with or without food. -If a dose is missed, that dose should be skipped and take the next dose as scheduled. -Tablets should be swallowed whole, and not crushed, chewed, or broken to avoid increasing the rate of drug release. -When discontinuing therapy, taper daily dose by no more than 0.1 mg every 3 to 7 days. Use: For the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy or as adjunctive therapy to stimulant medications.   What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling cold, irritable, weak, drowsy, or light-headed, or having weak reflexes, pinpoint pupils, slow heartbeats, shallow breathing, or a seizure. What should I avoid while taking Kapvay? Avoid drinking alcohol. It may increase certain side effects of Kapvay. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid becoming overheated or dehydrated during exercise and in hot weather. Kapvay side effects Get emergency medical help if you have signs of an allergic reaction to Kapvay: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe chest pain, shortness of breath, irregular heartbeats; a very slow heart rate; or a light-headed feeling, like you might pass out. Common Kapvay side effects may include: drowsiness, dizziness; feeling tired or irritable; dry mouth; constipation, loss of appetite; or sleep problems (insomnia), nightmares. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Kapvay? Using Kapvay with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: other heart or blood pressure medications; an antidepressant; or any other medicine that contains clonidine. This list is not complete. Other drugs may interact with clonidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is methylphenidate? Methylphenidate is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control. Methylphenidate is used to treat attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), and narcolepsy. Methylphenidate should be used as a part of a total treatment program for ADHD that may include counseling or other therapies. Warnings Methylphenidate may be habit-forming. Misuse can cause addiction, overdose, or death. Tell your doctor if you have had problems with drug or alcohol abuse. Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect. Do not use methylphenidate if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Methylphenidate may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder. You may have blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes. Call your doctor right away if you have: signs of heart problems - chest pain, feeling light-headed or short of breath; signs of psychosis - paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems - unexplained wounds on your fingers or toes. Tell your doctor if you have a history of drug or alcohol addiction. Keep the medication where others cannot get to it. Before taking this medicine You should not use methylphenidate if you are allergic to it. You should not take Concerta if you have: glaucoma; a personal or family history of tics (muscle twitches) or Tourette's syndrome; or severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse). Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have: heart problems or a congenital heart defect; high blood pressure; or a family history of heart disease or sudden death. Do not use methylphenidate if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine. Tell your doctor if you also use opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with methylphenidate could cause a serious condition called serotonin syndrome. Tell your doctor if you or anyone in your family has ever had: depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions; blood circulation problems in the hands or feet; alcoholism or drug addiction; or if you take Adhansia - an allergy to aspirin or yellow food dye. To make sure methylphenidate is safe for you, tell your doctor if you have:: problems with the esophagus, stomach, or intestines; `motor tics (muscle twitches) or Tourette's syndrome; or seizures, epilepsy, or an abnormal brain wave test (EEG). Becoming dependent on methylphenidate during pregnancy can cause premature birth or low birth weight. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of methylphenidate on the baby. Ask a doctor if it is safe to breastfeed while using this medicine. If you are breastfeeding, tell your doctor if you notice symptoms in the baby such as agitation, sleep problems, feeding problems, or reduced weight gain. methylphenidate is not approved for use by anyone younger than 6 years old. How should I take methylphenidate? Take methylphenidate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Methylphenidate may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication where others cannot get to it. Selling or giving away this medicine is against the law. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes. Most brands of methylphenidate are taken 1 or 2 times during the day. Jornay PM is for use only at night between 6:30 and 9:30 pm. You may take methylphenidate with or without food, but take it the same way each time. Swallow the extended-release capsule or tablet whole and do not crush, chew, or break it. If you cannot swallow an extended-release capsule whole, open it and mix the medicine with soft food such as applesauce, pudding or yogurt. Swallow the mixture right away without chewing. You must chew the chewable tablet before you swallow it. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). Allow the orally disintegrating tablet to dissolve in your mouth without chewing. Tell your doctor if you have a planned surgery. Your treatment may also include counseling or other treatments. Your doctor will need to check your progress on a regular basis. Your heart and blood pressure may also need to be checked often. Store tightly closed at room temperature, away from moisture, heat, and light. Keep your medicine in a place where no one can use it improperly. Do not keep leftover medicine. Ask your pharmacist about a drug take-back program. You may also mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag and throw the bag in the trash.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methylphenidate could be fatal. Overdose symptoms may include nausea, dry mouth, vomiting, diarrhea, anxiety, agitation, restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, dilated pupils, muscle pain or weakness, fever, sweating, headache, pounding in your neck or ears, fast or pounding heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma. What should I avoid while taking methylphenidate? Avoid drinking alcohol. Avoid driving or hazardous activity until you know how methylphenidate will affect you. Your reactions could be impaired. Methylphenidate side effects Get emergency medical help if you have signs of an allergic reaction to methylphenidate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: signs of heart problems - chest pain, trouble breathing, feeling like you might pass out; signs of psychosis - hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia; signs of circulation problems - numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes; or penis erection that is painful or lasts 4 hours or longer. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Methylphenidate can affect growth in children. Your child's height and weight may need to be checked often. Tell your doctor if your child is not growing at a normal rate. Common methylphenidate side effects may include: sweating, increased blood pressure; mood changes, anxiety, feeling nervous or irritable, trouble sleeping; fast heart rate, pounding heartbeats or fluttering in your chest; loss of appetite, weight loss; dry mouth, nausea, vomiting, stomach pain, indigestion; or headache, dizziness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect methylphenidate? Tell your doctor about all your other medicines, especially: an antidepressant; or blood pressure medication; This list is not complete. Other drugs may interact with methylphenidate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is methylphenidate? Methylphenidate is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control. Methylphenidate is used to treat attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), and narcolepsy. Methylphenidate should be used as a part of a total treatment program for ADHD that may include counseling or other therapies. Warnings Methylphenidate may be habit-forming. Misuse can cause addiction, overdose, or death. Tell your doctor if you have had problems with drug or alcohol abuse. Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect. Do not use methylphenidate if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Methylphenidate may cause new or worsening psychosis (unusual thoughts or behavior), especially if you have a history of depression, mental illness, or bipolar disorder. You may have blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes. Call your doctor right away if you have: signs of heart problems - chest pain, feeling light-headed or short of breath; signs of psychosis - paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems - unexplained wounds on your fingers or toes. Tell your doctor if you have a history of drug or alcohol addiction. Keep the medication where others cannot get to it. Before taking this medicine You should not use methylphenidate if you are allergic to it. You should not take Concerta if you have: glaucoma; a personal or family history of tics (muscle twitches) or Tourette's syndrome; or severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse). Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have: heart problems or a congenital heart defect; high blood pressure; or a family history of heart disease or sudden death. Do not use methylphenidate if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine. Tell your doctor if you also use opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with methylphenidate could cause a serious condition called serotonin syndrome. Tell your doctor if you or anyone in your family has ever had: depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions; blood circulation problems in the hands or feet; alcoholism or drug addiction; or if you take Adhansia - an allergy to aspirin or yellow food dye. To make sure methylphenidate is safe for you, tell your doctor if you have:: problems with the esophagus, stomach, or intestines; `motor tics (muscle twitches) or Tourette's syndrome; or seizures, epilepsy, or an abnormal brain wave test (EEG). Becoming dependent on methylphenidate during pregnancy can cause premature birth or low birth weight. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of methylphenidate on the baby. Ask a doctor if it is safe to breastfeed while using this medicine. If you are breastfeeding, tell your doctor if you notice symptoms in the baby such as agitation, sleep problems, feeding problems, or reduced weight gain. methylphenidate is not approved for use by anyone younger than 6 years old. How should I take methylphenidate? Take methylphenidate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Methylphenidate may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication where others cannot get to it. Selling or giving away this medicine is against the law. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes. Most brands of methylphenidate are taken 1 or 2 times during the day. Jornay PM is for use only at night between 6:30 and 9:30 pm. You may take methylphenidate with or without food, but take it the same way each time. Swallow the extended-release capsule or tablet whole and do not crush, chew, or break it. If you cannot swallow an extended-release capsule whole, open it and mix the medicine with soft food such as applesauce, pudding or yogurt. Swallow the mixture right away without chewing. You must chew the chewable tablet before you swallow it. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). Allow the orally disintegrating tablet to dissolve in your mouth without chewing. Tell your doctor if you have a planned surgery. Your treatment may also include counseling or other treatments. Your doctor will need to check your progress on a regular basis. Your heart and blood pressure may also need to be checked often. Store tightly closed at room temperature, away from moisture, heat, and light. Keep your medicine in a place where no one can use it improperly. Do not keep leftover medicine. Ask your pharmacist about a drug take-back program. You may also mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag and throw the bag in the trash.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of methylphenidate could be fatal. Overdose symptoms may include nausea, dry mouth, vomiting, diarrhea, anxiety, agitation, restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, dilated pupils, muscle pain or weakness, fever, sweating, headache, pounding in your neck or ears, fast or pounding heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma. What should I avoid while taking methylphenidate? Avoid drinking alcohol. Avoid driving or hazardous activity until you know how methylphenidate will affect you. Your reactions could be impaired. Methylphenidate side effects Get emergency medical help if you have signs of an allergic reaction to methylphenidate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: signs of heart problems - chest pain, trouble breathing, feeling like you might pass out; signs of psychosis - hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia; signs of circulation problems - numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes; or penis erection that is painful or lasts 4 hours or longer. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Methylphenidate can affect growth in children. Your child's height and weight may need to be checked often. Tell your doctor if your child is not growing at a normal rate. Common methylphenidate side effects may include: sweating, increased blood pressure; mood changes, anxiety, feeling nervous or irritable, trouble sleeping; fast heart rate, pounding heartbeats or fluttering in your chest; loss of appetite, weight loss; dry mouth, nausea, vomiting, stomach pain, indigestion; or headache, dizziness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect methylphenidate? Tell your doctor about all your other medicines, especially: an antidepressant; or blood pressure medication; This list is not complete. Other drugs may interact with methylphenidate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.