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What is amantadine? Amantadine is an antiviral medicine that blocks the actions of viruses in your body. Amantadine is used to treat Parkinson's disease and "Parkinson-like" symptoms such as stiffness or tremors, shaking, and repetitive uncontrolled muscle movements that may be caused by the use of certain drugs. Amantadine is also used to treat or prevent influenza A in adults and children. It may not be effective during every flu season because certain strains of the virus may be resistant to amantadine. This medicine should not be used in place of getting a yearly flu shot. The Centers for Disease Control recommends an annual flu shot to help protect you each year from new strains of influenza virus. Amantadine is available as tablets, capsules, and oral solution. Warnings You should not use amantadine if you received a nasal flu vaccine in the past 14 days. Do not receive a nasal flu vaccine while taking amantadine, and for at least 48 hours after your last dose. You may receive a flu shot (injection) while taking amantadine. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this amantadine affects you. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs. Heat stroke has happened in people taking amantadine. Be careful in hot weather and during physical activity. If you have kidney problems, talk with your doctor. Your dose may need to be changed based on how well your kidneys work. Deaths have happened in people with kidney problems whose dose was too high for their kidney function. Do not stop taking amantadine all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop amantadine, you will want to slowly stop it as ordered by your doctor. Before taking this medicine You should not use amantadine if you are allergic to it, or if: you have severe kidney disease; or you received a "live" nasal flu vaccine (FluMist) within the past 14 days. To make sure amantadine is safe for you, tell your doctor if you have ever had: kidney disease; daytime drowsiness (caused by a sleep disorder or taking certain medicines); congestive heart failure; eczema; glaucoma; liver disease; a seizure; low blood pressure, fainting spells; alcoholism or drug addiction; or mental illness, psychosis, or suicidal thoughts or actions. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether amantadine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breast-feed while using this medicine. Amantadine is not approved for influenza in a child younger than 1 year old. Gocovri is not approved for use by anyone younger than 18 years old. How should I take amantadine? Take amantadine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. If you take amantadine to treat influenza A, start taking the medicine within 24 to 48 hours after flu symptoms begin. Keep taking this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. You may take amantadine with or without food. You may need to take this medicine only at bedtime. Follow your doctor's instructions. Measure liquid oral solution carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Swallow the capsule or tablet whole and do not crush, chew, or break it. If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use. Call your doctor if your symptoms do not improve, or if you have a fever with a headache, cough, skin rash, or other new symptoms. If you take amantadine for Parkinson symptoms: You should not stop using amantadine suddenly or your condition may become worse. Stopping suddenly may also cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. Call your doctor if you miss several doses in a row. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amantadine can be fatal. Overdose symptoms may include confusion, agitation, behavior changes, hallucinations, severe headache or pounding in your ears, muscle stiffness, problems with balance or walking, trouble breathing, fast heartbeats, or seizure. What to avoid Do not receive a nasal flu vaccine while using amantadine, and for at least 48 hours after your last dose. The vaccine may not work as well during this time, and may not protect you from influenza. You may receive a flu shot (injection) while taking amantadine. Do not drink alcohol. Dangerous side effects could occur. Avoid driving or operating machinery until you know how amantadine will affect you. Amantadine may impair your thinking or reactions. Some people taking this medicine have fallen asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with amantadine can increase your risk of unpleasant side effects. Amantadine side effects Get emergency medical help if you have signs of an allergic reaction to amantadine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: extreme drowsiness, falling asleep suddenly even after feeling alert; a light-headed feeling, like you might pass out; shortness of breath (even with mild exertion), swelling in your hands or feet; painful or difficult urination; depression, agitation, aggression, behavior changes, hallucinations, thoughts of hurting yourself; a seizure; or severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Side effects may be more likely in older adults. Common amantadine side effects may include: dizziness, falls; dry mouth; swelling in your legs or feet; nausea, constipation; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect amantadine? Using amantadine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: glaucoma medication; or medicine that contains sodium bicarbonate (such as Alka-Seltzer). This list is not complete. Other drugs may interact with amantadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What is benztropine? Benztropine is used with other medicines to treat symptoms of Parkinson's disease, such as stiffness or tremors. Benztropine is also used to treat Parkinson-like symptoms caused by using certain medicines. Benztropine may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use benztropine if you are allergic to it. Not approved for use by anyone younger than 3 years old. Tell your doctor if you have ever had: an enlarged prostate; urination problems; glaucoma; or muscle problems. Older adults may be more sensitive to the effects of benztropine. It is not known if benztropine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Tell your doctor if you are breastfeeding. How should I take benztropine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Benztropine oral is taken by mouth. Benztropine is usually taken at bedtime. Benztropine injection is given in a muscle or vein if you are unable to take the medicine by mouth. Drink plenty of water to prevent dry mouth while taking benztropine. Dry mouth may lead to gum disease or cavities. Brush and floss your teeth regularly and visit your dentist for routine dental care. Call your doctor if your symptoms do not improve, or if they get worse. Your symptoms may get worse if you stop using benztropine suddenly. Ask your doctor before stopping any of your anti-Parkinson medications. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose may cause drowsiness, confusion, nervousness, hallucinations, fast heart rate, vomiting, numbness in your fingers, hot or dry skin, or fainting. What should I avoid while taking benztropine? Avoid driving or hazardous activity until you know how benztropine will affect you. Your reactions could be impaired. Avoid becoming overheated or dehydrated during exercise and in hot weather. Benztropine can decrease sweating and you may be more prone to heat stroke. Benztropine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: dry mouth that causes trouble talking or swallowing; little or no urination; uncontrolled muscle movements; vomiting, severe constipation; fast heartbeats; muscle weakness; blurred vision, tunnel vision, eye pain, or seeing halos around lights; confusion, hallucinations; or severe skin rash. Common side effects may include: dry mouth; blurred vision; constipation; or nausea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect benztropine? Tell your doctor about all your other medicines, especially: other medicine to treat Parkinson's disease; medicine to treat depression, anxiety, mood disorders, or mental illness; cold or allergy medicine (Benadryl and others); medicine to treat stomach problems, motion sickness, or irritable bowel syndrome; medicine to treat overactive bladder; or bronchodilator asthma medication. This list is not complete. Other drugs may affect benztropine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What is bromocriptine (Parlodel)? This medication guide provides information about the Parlodel brand of bromocriptine. Cycloset is another brand of bromocriptine that is not covered in this medication guide. The Parlodel brand of bromocriptine is used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia). High prolactin levels may cause sexual problems, hot flashes, menstrual problems or infertility in women, muscle loss in men, breast enlargement in men and women, and lack of sexual development in adolescents. Parlodel is also used to treat these disorders when they are caused by a noncancerous tumor of the pituitary gland that can overproduce prolactin. Parlodel is sometimes used together with surgery or radiation in treating acromegaly, a condition caused by a pituitary gland tumor that produces too much growth hormone. Parlodel is also used to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Bromocriptine may also be used for purposes not listed in this medication guide. Warnings You should not use Parlodel if you have uncontrolled high blood pressure, if you have high blood pressure caused by pregnancy (eclampsia or preeclampsia), or if you recently had a baby and you have a history of coronary artery disease or severe heart disease. You may need to stop taking Parlodel if you become pregnant during treatment. Follow your doctor's instructions. Parlodel may cause you to fall asleep suddenly, even after feeling alert. Avoid driving or other hazardous activity until you know how this medicine will affect you. Do not breastfeed. Tell your doctor right away if you become pregnant while taking bromocriptine. Before taking this medicine You should not use this medicine if you are allergic to bromocriptine or to an ergot medicine (dihydroergotamine, ergotamine, ergonovine, methylergonovine). You should not use Parlodel if: you are breastfeeding; you have uncontrolled high blood pressure (hypertension); you have hypertension caused by pregnancy (including eclampsia and preeclampsia); or you recently had a baby and you have a history of coronary artery disease or severe heart disease. Bromocriptine may contain lactose. Before taking Parlodel, tell your doctor if you have a hereditary form of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption. Tell your doctor if you have ever had: high or low blood pressure, heart disease, or a heart attack; liver or kidney disease; a tumor of the pituitary gland; a stomach ulcer, stomach or intestinal bleeding; or mental illness or psychosis. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. A pituitary tumor in the mother can expand during pregnancy. High blood pressure can also occur during pregnancy and bromocriptine could be dangerous if taken by a pregnant woman with high blood pressure. Some women take Parlodel in order to normalize menstrual periods and increase their chances of becoming pregnant. Tell your doctor as soon as you become pregnant. You may need to stop taking Parlodel. If you are not taking Parlodel to help you get pregnant, use a barrier form of birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy during treatment. Your doctor may also want you to have a pregnancy test every 4 weeks during treatment. Do not breastfeed while using this medicine. Parlodel should not be given to a child younger than 11 years old. How should I take Parlodel? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take Parlodel with food, even if you take it at bedtime. You will need frequent medical tests. You should not stop using Parlodel suddenly. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine with food as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, constipation, sweating, pale skin, dizziness, drowsiness, yawning, confusion, hallucinations, and fainting. What should I avoid while taking Parlodel? Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol with this medicine can cause side effects. Parlodel side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: numbness, pain, and paleness or discoloration in your fingers or toes (especially in cold weather); vision problems, constant runny nose; chest pain, pain when you breathe, fast heart rate, rapid breathing, feeling short of breath (especially when lying down); back pain, swelling in your ankles or feet, urinating less than usual or not at all; confusion, hallucinations, feeling like you might pass out; muscle movements you cannot control, loss of balance or coordination; or bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Parlodel may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Common side effects may include: dizziness; headache; hallucinations; nausea, constipation; or abnormal involuntary movements. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect Parlodel? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tell your doctor about all your current medicines. Many drugs can affect Parlodel, especially medicines to treat: migraine headaches; infections; psychotic conditions such as bipolar disorder or schizophrenia; Parkinson's disease; restless leg syndrome; or acromegaly (too much growth hormone). This list is not complete and many other drugs may affect Parlodel. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Parlodel can make certain migraine headache medicines less effective when taken at the same time. Avoid taking Parlodel within 6 hours before or 6 hours after you take an ergot headache medicine (such as dihydroergotamine, ergotamine, ergonovine, methylergonovine). Many other drugs can interact with bromocriptine. Below is just a partial list. Tell your doctor if you are using: an antidepressant, a sedative or opioid medication, medicines to treat psychiatric disorders; an antibiotic or antifungal medication, anti-malaria drugs; asthma or allergy medication; cancer medicine, medicines used to prevent organ transplant rejection; cholesterol-lowering drugs such as simvastatin (Zocor); an oral diabetes medication; heart or blood pressure medications, heart rhythm medication; HIV or AIDS medications; seizure medications; sildenafil (Viagra) and other erectile dysfunction medicines; or stomach acid reducers. This list is not complete and there are many other drugs that can interact with bromocriptine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
What is carbidopa and levodopa? Carbidopa and levodopa is a combination medicine used to treat symptoms of Parkinson's disease, such as stiffness or tremors. Carbidopa and levodopa is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication. Carbidopa and levodopa may also be used for purposes not listed in this medication guide. Warnings Do not use carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. Before taking this medicine You should not use this medicine if you are allergic to carbidopa or levodopa, or if you have: narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Tell your doctor if you have ever had: heart disease, high blood pressure, or heart attack; liver or kidney disease; an endocrine (hormonal) disorder; asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder; a stomach or intestinal ulcer; open-angle glaucoma; or depression, mental illness, or psychosis. The disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. Tell your doctor if you are pregnant or breastfeeding. How should I take carbidopa and levodopa? If you already take levodopa, you must stop taking it at least 12 hours before you start taking carbidopa and levodopa. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take carbidopa and levodopa at regular intervals, with or without food. Swallow the capsule whole and do not crush, chew, break, or open it. The tablet is sometimes broken in half to give the correct dose. Always swallow a whole or half tablet without chewing or crushing. Place the orally disintegrating tablet in your mouth and allow it to dissolve, without chewing. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if the effects of this medicine wear off quickly between doses. If you use this medicine long-term, you may need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using carbidopa and levodopa. Do not stop using carbidopa and levodopa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light. Detailed Carbidopa / levodopa dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking carbidopa and levodopa? Avoid driving or hazardous activity until you know how carbidopa and levodopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking iron supplements or eating a diet high in protein. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid. Carbidopa and levodopa side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); worsening of tremors (uncontrolled shaking); severe or ongoing vomiting or diarrhea; confusion, hallucinations, unusual changes in mood or behavior; depression or suicidal thoughts; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Some people taking carbidopa and levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: jerky or twisting muscle movements; headache, dizziness; low blood pressure (feeling light-headed); sleep problems, strange dreams; dry mouth; muscle contractions; or nausea, vomiting, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Carbidopa / levodopa side effects (more detail) What other drugs will affect carbidopa and levodopa? Other drugs may affect carbidopa and levodopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
What is carbidopa? Carbidopa is used with another medicine called levodopa to treat symptoms of Parkinson's disease, such as stiffness or tremors. Carbidopa and levodopa are also used to treat Parkinson-like symptoms caused by taking certain medicines or by exposure to poisonous gases or minerals such as carbon monoxide or manganese. Carbidopa is only used in combination with levodopa and has no effect when used alone. Carbidopa may also be used for purposes not listed in this medication guide. Warnings Do not use carbidopa if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. Before taking this medicine You should not use carbidopa if you are allergic to it, or if you have: narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Tell your doctor if you have ever had: nausea and vomiting while taking levodopa; heart disease, high blood pressure; liver or kidney disease; a stomach or intestinal ulcer; glaucoma; or depression, mental illness, or psychosis. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. It is not known if carbidopa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using carbidopa. Not approved for use by anyone younger than 18 years old. How should I take carbidopa? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you already take levodopa but have never taken carbidopa, start taking both medicines at least 12 hours after you last took levodopa by itself. Take both carbidopa and levodopa together at regular intervals, to keep steady amounts in your body at all times. You may need frequent medical tests. Your symptoms may not improve for several weeks. Call your doctor if your symptoms do not improve or if the effects of carbidopa wear off quickly between doses. You may have withdrawal symptoms if you stop using carbidopa suddenly. Ask your doctor before stopping the medicine. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using carbidopa. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking carbidopa? Avoid driving or hazardous activity until you know how carbidopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking iron supplements or eating a diet high in protein. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid. Carbidopa side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The following side effects may occur when carbidopa is taken with levodopa. Call your doctor at once if you have: severe drowsiness; uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); worsening of tremors (uncontrolled shaking); severe nausea, vomiting, or diarrhea; confusion, hallucinations, unusual changes in mood or behavior; depression or suicidal thoughts; seizure (convulsions); or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Some people taking carbidopa with levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: nausea, upset stomach; headache, dizziness; sleep problems (insomnia), dreaming more than usual; dry mouth, burning feeling in your tongue; weight changes; or abnormal liver function tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Carbidopa dosing information Usual Adult Dose for Parkinsonian Tremor: Patients on carbidopa-levodopa therapy requiring additional carbidopa: Initial dose: 25 mg orally with the first dose of carbidopa-levodopa each day Maintenance dose: Additional doses of 12.5 mg or 25 mg may be given with each dose of carbidopa-levodopa Maximum dose: 200 mg orally per day Patients requiring individual titration of carbidopa and levodopa: Initial dose: 25 mg orally 3 to 4 times a day, given at the same time as levodopa Maximum dose: 200 mg orally per day Comments: -Most patients respond to a 1:10 proportion of carbidopa and levodopa, provided the daily dosage of carbidopa is 70 mg or more a day; for patients taking carbidopa-levodopa, the amount of carbidopa in carbidopa-levodopa should be considered when calculating the maximum daily carbidopa dose. -In patients already on levodopa, allow 12 hours between the last dose of levodopa and the initiation of therapy with carbidopa and levodopa. Uses: With carbidopa-levodopa or with levodopa in the treatment of symptoms of idiopathic Parkinson's disease (paralysis agitans), postencephalitic parkinsonism, and symptomatic parkinsonism What other drugs will affect carbidopa? Using carbidopa with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect carbidopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
What is carbidopa, entacapone, and levodopa (Stalevo)? Carbidopa, entacapone, and levodopa (Stalevo) is a combination medicine used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control. Stalevo may also be used for purposes not listed in this medication guide. Warnings You should not use carbidopa, entacapone, and levodopa if you have narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Before taking this medicine You should not take this medicine if you are allergic to carbidopa, entacapone, or levodopa, or if you have: narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: glaucoma; depression or other mental illness; a stomach ulcer; or liver disease. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. Tell your doctor if you are pregnant or breastfeeding. How should I take Stalevo? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Swallow the tablet whole and do not crush, chew, or break it. Take only a single tablet at each dosing time. Do not take more than 1 tablet at a time or take a portion of a broken tablet. Combining more than one tablet or tablet portions may cause an overdose. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times. Ask your doctor about whether you should take Stalevo with or without food. Tell your doctor if the effects of carbidopa, entacapone, and levodopa seem to wear off quickly in between doses. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated from vomiting or diarrhea. Drink plenty of liquids if you are ill. Do not take any other medications for Parkinson's disease that your doctor has not prescribed. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Stalevo. Do not stop using Stalevo suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include rapid heartbeats and feeling light-headed. What should I avoid while taking Stalevo? Avoid driving or hazardous activity until you know how carbidopa, entacapone, and levodopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking iron supplements without your doctor's advice. Also avoid increasing the amount of protein in your diet (protein sources include meat, eggs, and cheese). Taking iron or eating too much protein can make it harder for your body to digest and absorb Stalevo. Stalevo side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: worsening symptoms such as tremors, twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; depressed mood, thoughts about hurting yourself; hallucinations, unusual behaviors; severe nausea and vomiting; severe or ongoing diarrhea, diarrhea that is watery; unexplained muscle pain, tenderness, or weakness; a light-headed feeling, like you might pass out; fluid build-up in or around the lungs--pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats. This medicine may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: involuntary muscle movement; diarrhea; nausea, vomiting, stomach pain; discolored urine; or dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Carbidopa, entacapone, and levodopa dosing information Usual Adult Dose for Parkinson's Disease: Converting from Carbidopa, Levodopa, and Entacapone: -Switch to combination tablet that provides equivalent dose Converting from Carbidopa and Levodopa: -Patients with moderate to severe dyskinesias taking levodopa doses of 600 mg or more are likely to require a reduction in levodopa dose when entacapone is added -Titrate patients to a dose using separate carbidopa/levodopa tablets plus entacapone, then switch to corresponding single combination tablet -When less levodopa is required, reduce dose by either decreasing tablet strength or extending time between doses Concomitant Administration with Other Anti-Parkinson Drugs: -Dose adjustment of concomitant medications or this drug may be needed MAXIMUM DAILY DOSE: -Stalevo(R) 50, 75, 100, 125 and 150: Do not exceed 8 tablets in 24-hours -Stalevo (R) 200: Do not exceed 6 tablets in 24-hours Comments: -Conversions from carbidopa/levodopa are based on carbidopa/levodopa products combined in a 1:4 ratio; there is no experience switching patients from products that are not combined in a 1:4 ratio or from extended-release formulations. -Optimum dose should be determined by careful titration; therapy should be individualized and adjusted according to the desired therapeutic response. Use: For the treatment of Parkinson's disease: --As a substitute for equivalent strengths of each component; --Or to replace carbidopa/levodopa therapy in patients experiencing signs and symptoms of end-of-dose "wearing-off" when the total daily dose of levodopa is 600 mg or less and dyskinesias are not present. What other drugs will affect Stalevo? Using Stalevo with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Many drugs can affect Stalevo. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
What is pramipexole? Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Pramipexole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS). Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. Pramipexole may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use pramipexole if you are allergic to it. Tell your doctor if you have ever had: low blood pressure; dizziness after getting up too fast; daytime drowsiness; kidney disease; or problems controlling your muscle movements. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether pramipexole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using pramipexole. It is not known whether pramipexole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take pramipexole? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you are taking immediate-release pramipexole (Mirapex) you should not take extended-release pramipexole (Mirapex ER) at the same time. The dose and timing of pramipexole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of pramipexole you receive at the pharmacy. Pramipexole can be taken with or without food. Take the medication with food if it upsets your stomach. Do not crush, chew, or break an extended-release tablet (Mirapex ER). Swallow it whole. If you are taking this medication for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms. Do not stop using pramipexole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking pramipexole? Do not drink alcohol. Dangerous side effects can occur when alcohol is combined with pramipexole. Avoid driving or hazardous activity until you know how pramipexole will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Pramipexole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking pramipexole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. Call your doctor at once if you have: a light-headed feeling, like you might pass out; hallucinations (seeing or hearing things that are not real); extreme drowsiness, falling asleep suddenly, even after feeling alert; tremors, twitching or uncontrollable muscle movements; unexplained muscle pain, tenderness, or weakness; vision problems; or posture changes you cannot control, such as involuntary bending forward of your neck, bending forward at the waist, or tilting sideways when you sit, stand, or walk. Side effects such as confusion or hallucinations may be more likely in older adults. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Common side effects may include: muscle spasm or muscle weakness; drowsiness, dizziness, weakness; confusion, memory problems; dry mouth; nausea, constipation; increased urination; or sleep problems (insomnia), unusual dreams. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Pramipexole dosing information Usual Adult Dose for Parkinson's Disease: Immediate-release: Initial dose: 0.125 mg orally three times a day Titration: Increase gradually in small dose increments no more frequently than ever 5 to 7 days Maintenance dose: 1.5 to 4.5 mg per day based on efficacy and tolerability Maximum dose: 4.5 mg per day Comment: The following dose titration was used in clinical trials: Week 2, 0.25 mg 3 times a day Week 3, 0.5 mg 3 times a day Week 4, 0.75 mg 3 times a day Week 5, 1 mg 3 times a day Week 6, 1.25 mg 3 times a day Week 7, 1.5 mg 3 times a day. -When used in combination with levodopa, the levodopa dose was reduced by an average of 27% from baseline providing a concomitant dose of approximately 800 mg per day. Extended-release: Initial dose: 0.375 mg orally once a day Titration: Increase gradually no more frequently than every 5 to 7 days, first dose increase should be to 0.75 mg once a day followed by incremental increases of 0.75 mg; assess therapeutic response and tolerability at a minimum of 5 days after each dose increase. Maximum dose: 4.5 mg per day SWITCHING FROM IMMEDIATE-RELEASE TO EXTENDED-RELEASE: -Patients may be switched overnight from immediate-release tablets to extended-release tablets at the same daily dose; monitor closely to determine if dose adjustments may be necessary. Comments: -If a significant interruption in therapy occurs, re-titration may be necessary; upon discontinuation, doses should be tapered. Use: Treatment of Parkinson's disease Usual Adult Dose for Restless Legs Syndrome: Immediate-release: Initial dose: 0.125 mg orally once a day 2 to 3 hours before bedtime Titration: If needed, dose may be titrated upwards by increments of 0.125 mg every 4 to 7 days. Maximum dose: 0.5 mg orally once a day Comments: -Extended-release tablets are not indicated for Restless Legs Syndrome. -Doses of 0.75 mg once a day were used in clinical trials, but were not found to provide additional benefit as compared to the 0.5 mg dose. Use: For the treatment of moderate to severe primary Restless Legs Syndrome. What other drugs will affect pramipexole? Using pramipexole with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cimetidine; metoclopramide; or medicine to treat mental illness, such as chlorpromazine, droperidol, fluphenazine, haloperidol, perphenazine, prochlorperazine, thioridazine, and others. This list is not complete. Other drugs may affect pramipexole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What is pramipexole? Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Pramipexole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS). Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. Pramipexole may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use pramipexole if you are allergic to it. Tell your doctor if you have ever had: low blood pressure; dizziness after getting up too fast; daytime drowsiness; kidney disease; or problems controlling your muscle movements. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether pramipexole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using pramipexole. It is not known whether pramipexole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take pramipexole? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you are taking immediate-release pramipexole (Mirapex) you should not take extended-release pramipexole (Mirapex ER) at the same time. The dose and timing of pramipexole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of pramipexole you receive at the pharmacy. Pramipexole can be taken with or without food. Take the medication with food if it upsets your stomach. Do not crush, chew, or break an extended-release tablet (Mirapex ER). Swallow it whole. If you are taking this medication for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms. Do not stop using pramipexole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking pramipexole? Do not drink alcohol. Dangerous side effects can occur when alcohol is combined with pramipexole. Avoid driving or hazardous activity until you know how pramipexole will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Pramipexole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking pramipexole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. Call your doctor at once if you have: a light-headed feeling, like you might pass out; hallucinations (seeing or hearing things that are not real); extreme drowsiness, falling asleep suddenly, even after feeling alert; tremors, twitching or uncontrollable muscle movements; unexplained muscle pain, tenderness, or weakness; vision problems; or posture changes you cannot control, such as involuntary bending forward of your neck, bending forward at the waist, or tilting sideways when you sit, stand, or walk. Side effects such as confusion or hallucinations may be more likely in older adults. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Common side effects may include: muscle spasm or muscle weakness; drowsiness, dizziness, weakness; confusion, memory problems; dry mouth; nausea, constipation; increased urination; or sleep problems (insomnia), unusual dreams. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Pramipexole dosing information Usual Adult Dose for Parkinson's Disease: Immediate-release: Initial dose: 0.125 mg orally three times a day Titration: Increase gradually in small dose increments no more frequently than ever 5 to 7 days Maintenance dose: 1.5 to 4.5 mg per day based on efficacy and tolerability Maximum dose: 4.5 mg per day Comment: The following dose titration was used in clinical trials: Week 2, 0.25 mg 3 times a day Week 3, 0.5 mg 3 times a day Week 4, 0.75 mg 3 times a day Week 5, 1 mg 3 times a day Week 6, 1.25 mg 3 times a day Week 7, 1.5 mg 3 times a day. -When used in combination with levodopa, the levodopa dose was reduced by an average of 27% from baseline providing a concomitant dose of approximately 800 mg per day. Extended-release: Initial dose: 0.375 mg orally once a day Titration: Increase gradually no more frequently than every 5 to 7 days, first dose increase should be to 0.75 mg once a day followed by incremental increases of 0.75 mg; assess therapeutic response and tolerability at a minimum of 5 days after each dose increase. Maximum dose: 4.5 mg per day SWITCHING FROM IMMEDIATE-RELEASE TO EXTENDED-RELEASE: -Patients may be switched overnight from immediate-release tablets to extended-release tablets at the same daily dose; monitor closely to determine if dose adjustments may be necessary. Comments: -If a significant interruption in therapy occurs, re-titration may be necessary; upon discontinuation, doses should be tapered. Use: Treatment of Parkinson's disease Usual Adult Dose for Restless Legs Syndrome: Immediate-release: Initial dose: 0.125 mg orally once a day 2 to 3 hours before bedtime Titration: If needed, dose may be titrated upwards by increments of 0.125 mg every 4 to 7 days. Maximum dose: 0.5 mg orally once a day Comments: -Extended-release tablets are not indicated for Restless Legs Syndrome. -Doses of 0.75 mg once a day were used in clinical trials, but were not found to provide additional benefit as compared to the 0.5 mg dose. Use: For the treatment of moderate to severe primary Restless Legs Syndrome. What other drugs will affect pramipexole? Using pramipexole with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cimetidine; metoclopramide; or medicine to treat mental illness, such as chlorpromazine, droperidol, fluphenazine, haloperidol, perphenazine, prochlorperazine, thioridazine, and others. This list is not complete. Other drugs may affect pramipexole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What is rasagiline? Rasagiline is used to treat symptoms of Parkinson's disease (stiffness, tremors, spasms, poor muscle control). Rasagiline is sometimes used with another medicine called levodopa. Rasagiline may also be used for purposes not listed in this medication guide. Warnings Tell your doctor about all medicines you have used in the 2-week period before you start taking rasagiline. Many drugs can interact with rasagiline, and some drugs should not be used together. Before taking this medicine You should not take rasagiline if you are allergic to it. Do not use rasagiline if you have used any other MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, tranylcypromine, and others. Many drugs can interact and cause dangerous effects. Some drugs should not be used together with rasagiline. Your doctor may change your treatment plan if you also use: cyclobenzaprine (a muscle relaxer); dextromethorphan (contained in many over-the-counter cough medicines); meperidine (Demerol); methadone; St. John's wort; or tramadol (Ultram, Ultracet). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rasagiline and cause a serious condition called serotonin syndrome. Tell your doctor if you have ever had: high or low blood pressure; liver or kidney disease; or if you take ciprofloxacin (an antibiotic). People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. Tell your doctor if you are pregnant or breastfeeding. How should I take rasagiline? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you take rasagiline alone, your dose may be different than if you take rasagiline with other Parkinson's medications. Follow your doctor's dosing instructions very carefully. Rasagiline may be only part of a complete program of treatment that also includes a special diet. Follow the diet plan created for you by your doctor or nutrition counselor. Get familiar with the list of foods you should avoid to help prevent certain side effects of rasagiline. Call your doctor if your Parkinson's symptoms do not improve, or if they get worse while using rasagiline. Store at room temperature away from moisture and heat. Do not stop using rasagiline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using rasagiline. What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of rasagiline can be fatal. Overdose symptoms may include drowsiness, dizziness, severe headache, rapid pulse, feeling agitated or irritable, muscle spasms in your neck or jaw, sweating, cold or clammy skin, shallow breathing, fainting, or seizure (convulsions). These symptoms may be delayed for 12 to 24 hours after an overdose. What should I avoid while taking rasagiline? Avoid driving or hazardous activity until you know how rasagiline will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid drinking alcohol, especially red wine, vermouth, and tap beers or ale. Also avoid eating foods that are high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats and fish, and meats that are aged, dried, smoked, or fermented. Eating tyramine while you are taking rasagiline can raise your blood pressure to dangerous levels which could cause life-threatening side effects. Rasagiline side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe headache, blurred vision, pounding in your neck or ears; extreme drowsiness or falling asleep suddenly, even after feeling alert; unusual changes in mood or behavior; hallucinations; a light-headed feeling, like you might pass out; or worsening symptoms of Parkinson's disease (especially uncontrolled muscle movements). Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Some people taking rasagiline with levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Common side effects may include: depressed mood; sleep problems (insomnia), strange dreams; involuntary muscle movements; loss of appetite, weight loss; indigestion, stomach pain, nausea, vomiting, constipation; joint pain or stiffness; rash; cough or other flu symptoms; dry mouth; or swelling in your hands or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Rasagiline side effects (more detail) Rasagiline dosing information Usual Adult Dose for Parkinson's Disease: Monotherapy: Recommended dose: 1 mg orally once a day Adjunct therapy: Initial dose (in patients on concomitant levodopa): 0.5 mg orally once a day Initial dose (in patients not on concomitant levodopa): 1 mg orally once a day Maintenance dose: 0.5 mg to 1 mg orally once a day Maximum dose: 1 mg orally once a day Comments: May be used as adjunct therapy in patients on levodopa therapy, with or without other drugs used in the treatment of Parkinson's disease. Detailed Rasagiline dosage information What other drugs will affect rasagiline? Using rasagiline with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor if you have taken an antidepressant during the 2-week period before you start taking rasagiline. Many drugs can affect rasagiline, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.