What is atorvastatin? Atorvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. Warnings You should not take atorvastatin if you are pregnant or breastfeeding, or if you have liver disease. Stop taking this medication and tell your doctor right away if you become pregnant. Serious drug interactions can occur when certain medicines are used together with atorvastatin. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using. In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Avoid eating foods that are high in fat or cholesterol. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Atorvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Before taking this medicine You should not use atorvastatin if you are allergic to it, or if you have: liver disease; or if you are pregnant or breastfeeding. Atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Stop taking this medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine. Atorvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking this medicine. To make sure this medicine is safe for you, tell your doctor if you have ever had: liver problems; muscle pain or weakness; kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily. Atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). Atorvastatin is approved for use in adults and children who are at least 10 years old. How should I take atorvastatin? Take atorvastatin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Atorvastatin is usually taken once a day, with or without food. Take the medicine at the same time each day. Do not break a tablet before taking it, unless your doctor has told you to. You may need to stop using this medicine for a short time if you have: uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; or surgery or a medical emergency. It may take up to 2 weeks before your cholesterol levels improve, and you may need regular blood tests. You may not notice any change in your symptoms, but keep using the medication as directed. Your blood work will help your doctor determine how long to treat you with this medicine. You may need to take atorvastatin for a long time or for life depending on your medical history. Atorvastatin is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid eating foods that are high in fat or cholesterol. Atorvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Minimize drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Grapefruit and grapefruit juice may interact with atorvastatin and lead to potentially dangerous effects. Avoid drinking more than 1 liter per day of grapefruit juice while taking this medicine. Atorvastatin side effects Get emergency medical help if you have signs of an allergic reaction to atorvastatin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: muscle weakness in your hips, shoulders, neck, and back trouble lifting your arms, trouble climbing or standing; liver problems - upper stomach pain, weakness, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); or kidney problems - little or no urinating, swelling in your feet or ankles, feeling tired or short of breath. Common atorvastatin side effects may include: joint pain; stuffy nose, sore throat; diarrhea; or pain in your arms or legs. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect atorvastatin? Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them. Tell your doctor about all your current medicines and any you start or stop using, especially: other cholesterol-lowering medication; antibiotic or antifungal medicine; birth control pills; medicine to prevent organ transplant rejection; heart medication; or medicine to treat hepatitis C or HIV. This list is not complete. Many other drugs may interact with atorvastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is colesevelam? Colesevelam lowers "bad" cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering your LDL cholesterol may reduce your risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems. Colesevelam is used to treat high cholesterol in adults and children at least 10 years old. Colesevelam is sometimes used together with "statin" cholesterol medications such as atorvastatin, lovastatin, simvastatin, Crestor, Lipitor, Pravachol, Zocor, and others. Colesevelam is also used to improve blood sugar control in adults with type 2 diabetes mellitus. This medication is not for treating type 1 diabetes. Colesevelam may also be used for purposes not listed in this medication guide. Warnings You should not take colesevelam if you have diabetic ketoacidosis, very high triglycerides, a history of bowel obstruction, or a history of pancreatitis caused by high triglycerides. Before taking this medicine You should not take colesevelam if you are allergic to it, or if you have: very high levels of triglycerides (a type of fat) in your blood; diabetic ketoacidosis (call your doctor for treatment); a history of bowel obstruction; or a history of pancreatitis caused by high triglycerides. Colesevelam may increase your triglycerides, which can increase your risk of pancreatitis (inflammation of the pancreas). Your doctor will perform blood tests to make sure your triglycerides are not too high for you to safely use colesevelam. Colesevelam is not for use in girls who have not yet started having menstrual periods. Colesevelam should not be given to a child younger than 10 years old. Tell your doctor if you have ever had: trouble swallowing; blockage in your digestive tract (stomach or intestines); slow digestion; surgery on your stomach or intestines; or a vitamin A, D, E, or K deficiency. Tell your doctor if you are pregnant or if you become pregnant. The powder form of colesevelam may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). How should I take colesevelam? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take colesevelam with a meal and a full glass of water or other liquid. You may have to take several tablets at a time each time you take colesevelam. Tell your doctor if you have trouble swallowing the tablet whole. Colesevelam powder must be mixed with 8 ounces of water, fruit juice, or a diet soft drink. Stir and drink this mixture right away. Add a little more water to the glass, swirl gently and drink right away. Do not change the dose or timing of any other cholesterol or diabetes medications without your doctor's advice. You will need frequent blood tests. Colesevelam is only part of a complete treatment program that may also include diet, exercise, and weight control. You may need to follow a special diet to prevent constipation while using colesevelam. Follow all instructions of your doctor or dietitian. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine (with food and a full glass of water) as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking colesevelam? Avoid eating foods high in fat or cholesterol, or colesevelam will not be as effective. Colesevelam side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using colesevelam and call your doctor at once if you have: severe constipation; severe stomach pain; or pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting. Common side effects may include: constipation; nausea; or upset stomach. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect colesevelam? Colesevelam can make it harder for your body to absorb other medicines you take, which could make those medicines less effective. If you take any of the following medicines, take them 4 hours before you take colesevelam: cyclosporine; olmesartan; phenytoin; levothyroxine or other thyroid medication; birth control pills; multivitamins; warfarin (Coumadin, Jantoven); or oral diabetes medication--chlorpropamide, glimepiride, glipizide, or glyburide, tolazamide, tolbutamide. This list is not complete and many other drugs may affect colesevelam. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is colestipol? Colestipol is a cholesterol-lowering drug. Colestipol lowers "bad" cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering your LDL cholesterol may reduce your risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems. Lowering high cholesterol levels is an important part of preventing heart disease and arteriosclerosis (hardening of the arteries). Colestipol may also be used for purposes not listed in this medication guide. Warnings Do not take colestipol granules without mixing them with water or another liquid. Taking the granules dry could cause you to accidentally inhale or choke on the granules. Before taking this medicine You should not take colestipol if you are allergic to it. To make sure colestipol is safe for you, tell your doctor if you have: trouble swallowing; constipation or hemorrhoids; blockage in your intestines; a stomach or digestive disorder; liver disease; a thyroid disorder; a bleeding disorder; a history of major stomach or bowel surgery; or if you have a vitamin A, D, E, or K deficiency. Colestipol is not expected to harm an unborn baby when taken at recommended doses. However, taking colestipol can make it harder for your body to absorb certain vitamins that are needed during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while taking colestipol. Taking colestipol can make it harder for your body to absorb certain vitamins that are important if you are nursing a baby. Do not take colestipol without telling your doctor if you are breast-feeding a baby. Some forms of colestipol may contain phenylalanine. Talk to your doctor before using colestipol if you have phenylketonuria (PKU). Colestipol is not approved for use by anyone younger than 18 years old. How should I take colestipol? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Do not crush, chew, or break colestipol tablet. Swallow it whole. Swallow only one tablet at a time. Take the tablet with a full glass of water. Call your doctor if you have have trouble swallowing the tablet, or if it feels like it gets stuck in your esophagus after you swallow it. Dissolve the colestipol granules in a small amount of water, milk, broth soup, applesauce, hot or cold cereal, or crushed fruit (such as pineapple, pears, peaches, or fruit cocktail). Stir this mixture and drink or eat all of it right away. Swallow the mixture without chewing or holding it in your mouth. Colestipol can damage your teeth if left in contact with them for too long. Do not take colestipol granules without mixing them with water, other liquid, or food. Taking the granules dry could cause you to accidentally inhale or choke on the granules. Use only the dosing scoop that comes with your supply of colestipol granules. Do not keep it for later use. The scoop may not be the right size for use with a different brand of colestipol granules. While using colestipol, you may need frequent blood tests. It may take 2 weeks to several months of using this medicine before your cholesterol levels improve. For best results, keep using the medication as directed. Colestipol is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking colestipol? Avoid taking other medicines at the same time you take colestipol. Taking colestipol can make it harder for your body to absorb certain drugs, making them less effective. Take your other medicines at least 1 hour before or 4 hours after you take colestipol. Avoid constipation by drinking 8 to 12 full glasses (8 ounces each) every day while taking colestipol. Ask your doctor before using a laxative or stool softener. Colestipol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: trouble swallowing; severe constipation or stomach pain; or black, bloody, or tarry stools. Common side effects may include: constipation; or hemorrhoids. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Colestipol dosing information Usual Adult Dose for Hyperlipoproteinemia: Tablets: -Initial dose: 2 g orally once or twice a day -Maintenance dose: 2 to 16 g once a day or in divided doses Comments: -Dose increases of 2 g once or twice a day should occur at 1 to 2 month intervals. -If desired therapeutic effect on low density lipoprotein (LDL) cholesterol is not obtained at a dose of 2 to 16 g per day with good compliance and acceptable side effects, combined therapy or alternate treatment should be considered. Granules: -Initial dose: 5 g (1 packet or 1 level scoop) orally once or twice a day -Maintenance dose: 5 to 30 g (1 to 6 packets or level scoops) orally once a day or in divided doses Comments: -Incremental dose increases should occur at a rate of 1 dose per day at 1 to 2 month intervals. -If desired therapeutic effect is not obtained at 1 to 6 doses per day with good compliance and acceptable side effects, combined therapy or alternate treatment should be considered. Use: For use as adjunctive treatment to diet for the reduction of elevated serum total and low-density lipoprotein (LDL) cholesterol in patients with primary hypercholesterolemia (elevated LDL) who do not respond adequately to diet   What other drugs will affect colestipol? Other drugs may interact with colestipol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is digoxin? Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm. Digoxin is used to treat heart failure. Digoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria (the upper chambers of the heart that allow blood to flow into the heart). Warnings You should not use digoxin if you have ventricular fibrillation (a heart rhythm disorder of the ventricles, or lower chambers of the heart that allow blood to flow out of the heart). Before taking this medicine You should not use digoxin if you are allergic to it, or if you have ventricular fibrillation (a heart rhythm disorder of the ventricles, or lower chambers of the heart that allow blood to flow out of the heart). To make sure digoxin is safe for you, tell your doctor if you have ever had: a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); a heart attack; slow heartbeats that have caused you to faint; Wolff-Parkinson-White Syndrome (sudden fast heartbeats); kidney disease; an electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood); a thyroid disorder; or if you have recently been sick with vomiting or diarrhea. Tell your doctor if you are pregnant. It is not known whether digoxin will harm an unborn baby. However, having heart failure or atrial fibrillation during pregnancy may cause complications such as premature birth or low birth weight, or risk of death in both mother and baby. The benefit of treating heart problems with digoxin may outweigh any risks to the baby. It may not be safe to breast-feed while using digoxin. Ask your doctor about any risk. How should I use digoxin? Take digoxin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Try to take oral digoxin at the same time every day. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Take digoxin regularly even if you feel fine or have no symptoms. Get your prescription refilled before you run out of medicine completely. Digoxin injection is given as a shot into a muscle, or as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. Your blood pressure and heart rate will need to be checked daily. You may need frequent blood tests. Your kidney function may also need to be checked. You should not stop taking this medicine suddenly. Stopping suddenly may make your condition worse. Store at room temperature away from moisture and heat. Dosing information Usual Adult Dose of Digoxin for Congestive Heart Failure: Rapid Digitalization with a Loading Dose: Peak digoxin body stores of 8 to 12 mcg/kg generally provide a therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm. The loading dose should be administered in several fractions, with approximately half the total given as the first dose. Additional fractions of the total dose may be given at 6 to 8 hour intervals. Careful assessment of the patient's clinical response should be considered before each additional dose. If the patient's response necessitates a change from the calculated loading dose of digoxin, then calculation of the maintenance dose should be based upon the amount actually given. Tablets: Initial: 500 to 750 mcg usually produces a detectable effect in 0.5 to 2 hours with a maximal effect in 2 to 6 hours. Additional doses of 125 to 375 mcg may be given at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of tablets that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 750 to 1250 mcg. Capsules: Initial: 400 to 600 mcg of digoxin capsules generally produces a detectable effect in 0.5 to 2 hours with a maximal effect in 2 to 6 hours. Additional doses of 100 to 300 mcg may be given cautiously at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of capsules that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 600 to 1000 mcg. Injection: Initial: 400 to 600 mcg of digoxin intravenously usually produces a detectable effect in 5 to 30 minutes with a maximal effect in 1 to 4 hours. Additional doses of 100 to 300 mcg may be given cautiously at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin injection that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 600 to 1000 mcg. The injectable route is frequently used to achieve rapid digitalization, with conversion to digoxin tablets or digoxin capsules for maintenance therapy. Maintenance Dose: The doses of digoxin tablets used in controlled trials in patients with heart failure have ranged from 125 to 500 mcg once daily. In these studies, the dose has been generally titrated according to the patient's age, lean body weight, and renal function. Therapy is generally initiated at a dose of 250 mcg once daily in patients under age 70 with good renal function. Usual Adult Dose for Atrial Fibrillation: Peak digoxin body stores larger than the 8 to 12 mcg/kg required for most patients with heart failure and normal sinus rhythm have been used for control of ventricular rate in patients with atrial fibrillation. Doses used for the treatment of chronic atrial fibrillation should be titrated to the minimum dose that achieves the desired ventricular rate control without causing undesirable side effects. Usual Pediatric Dose for Atrial Fibrillation: Do not give full total digitalizing dose at once. Administer loading doses in several portions, give roughly half the total as the first dose. Give additional fractions of the total dose at 6 to 8 hour intervals (oral) or 4 to 8 hour intervals (parenteral). Divided daily dosing is recommended for infants and young children under 10 years of age. Parenteral administration should be used only when the need for rapid digitalization is urgent or when the drug cannot be taken orally. Intravenous administration is preferred over intramuscular injection as it can lead to severe pain at the injection site. If it is necessary to administer the drug by the intramuscular route, it should be injected deep into the muscle followed by massage. No more than 500 mcg should be injected into a single site. Calculated doses should be based on lean body weight. Premature: Digitalizing (Loading) dose: Oral elixir: 20 to 30 mcg/kg; Intravenous: 15 to 25 mcg/kg Maintenance dose: oral 5 to 7.5 mcg/kg; intravenous 4 to 6 mcg/kg Full Term: Digitalizing (Loading) dose: Oral elixir: 25 to 35 mcg/kg; Intravenous: 20 to 30 mcg/kg Maintenance dose: oral 6 to 10 mcg/kg; intravenous 5 to 8 mcg/kg 1-24 months: Digitalizing (Loading) dose: Oral elixir: 35 to 60 mcg/kg; Intravenous: 30 to 50 mcg/kg Maintenance dose: 10 to 15 mcg/kg oral; intravenous 7.5 to 12 mcg/kg 3 to 5 years: Digitalizing (Loading) dose: Oral elixir: 30 to 40 mcg/kg; Intravenous: 25 to 35 mcg/kg Maintenance dose: oral 7.5 to 10 mcg/kg; intravenous 6 to 9 mcg/kg 6 to 10 years: Digitalizing (Loading) dose: Oral elixir: 20 to 35 mcg/kg; Intravenous: 15 to 30 mcg/kg Maintenance dose: oral 5 to 10 mcg/kg; intravenous 4 to 8 mcg/kg 11 years and older: Digitalizing (Loading) dose: Oral elixir: 10 to 15 mcg/kg; Intravenous: 8 to 12 mcg/kg Maintenance dose: oral 2.5 to 5 mcg/kg; intravenous 2 to 3 mcg/kg   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of digoxin can be fatal. Overdose symptoms may include nausea, vomiting, loss of appetite, and feeling tired. What should I avoid while using digoxin? Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Digoxin overdose can occur more easily if you are dehydrated. Digoxin side effects Get emergency medical help if you have signs of an allergic reaction to digoxin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: nausea, vomiting, diarrhea, stomach pain; fast, slow, or uneven heart rate; a light-headed feeling, like you might pass out; bloody or black, tarry stools; confusion, weakness, hallucinations, unusual thoughts or behavior; breast swelling or tenderness; blurred vision, yellowed vision; or (in babies or children) stomach pain, weight loss, growth delay, behavior changes. Serious side effects may be more likely in older adults and those who are ill or debilitated. Common digoxin side effects may include: nausea, diarrhea; feeling weak or dizzy; headache, weakness, anxiety, depression; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect digoxin? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with digoxin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is dofetilide? Dofetilide is a heart rhythm medicine, also called an antiarrhythmic. Dofetilide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). Dofetilide is used in people with atrial fibrillation or atrial flutter. Dofetilide may also be used for purposes not listed in this medication guide. Warnings You should not take dofetilide if you have severe kidney disease or a history of Long QT syndrome. Serious drug interactions can occur when certain medicines are used together with dofetilide. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using. You will need to spend at least 3 days in a hospital setting when you first start taking dofetilide. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects. Before taking this medicine You should not take dofetilide if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); or a history of Long QT syndrome. Some medicines can cause unwanted or dangerous effects when used with dofetilide, and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs: cimetidine; dolutegravir; ketoconazole; megestrol; prochlorperazine; trimethoprim (Proloprim, Trimpex, Bactrim, Septra); verapamil; or a diuretic (water pill) that contains hydrochlorothiazide (HCTZ), such as Accuretic, Aldactazide, Atacand HCT, Benicar HCT, Diovan HCT, Dyazide, Exforge HCT, Hyzaar, Lopressor HCT, Maxzide, Micardis HCT, Monopril HCT, Prinzide, Tekturna HCT, Vaseretic, and others. To make sure dofetilide is safe for you, tell your doctor if you have: heart disease, high blood pressure; liver or kidney disease; depression, mental illness; asthma or allergies; any active infection; skin problems; or an electrolyte imbalance (such as low levels of potassium or magnesium in your blood). It is not known whether dofetilide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. It is not known whether dofetilide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using dofetilide. How should I take dofetilide? Dofetilide is available only from a hospital or specialty pharmacy. You will need to spend at least 3 days in a hospital setting when you first start taking dofetilide. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take dofetilide with or without food. You should not skip doses or stop using dofetilide suddenly. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose. Tell your doctor if you have a prolonged illness that causes severe diarrhea, vomiting, or heavy sweating. These conditions can cause an electrolyte imbalance, making it dangerous for you to use dofetilide. Your blood pressure will need to be checked often. Your kidney function may also need to be checked with frequent blood tests. Store at room temperature away from moisture and heat. Detailed Dofetilide dosage information What happens if I miss a dose? Skip the missed dose and take your next dose at the usual time to stay on schedule. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking dofetilide? Grapefruit and grapefruit juice may interact with dofetilide and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor. Dofetilide side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; loss of appetite, vomiting or severe diarrhea; or low magnesium or potassium--confusion, uneven heart rate, increased thirst or urination, sweating, jerking muscle movements, leg discomfort, muscle weakness or limp feeling. Common side effects may include: mild headache; mild dizziness; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Dofetilide side effects (more detail) What other drugs will affect dofetilide? Other drugs may interact with dofetilide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is fenofibrate? Fenofibrate belongs to a group of drugs known as "fibrates." It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate is used along with a proper diet to help to treat high cholesterol and high triglyceride levels. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help fenofibrate work better include exercising, losing weight if overweight, and stopping smoking. Warnings You should not take fenofibrate if you have liver disease, gallbladder disease, severe kidney disease, or if you are breast-feeding a baby. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine. Before taking this medicine You should not take fenofibrate if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); liver disease; or gallbladder disease. Do not breast-feed while using this medicine, and for at least 5 days after your last dose. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; or gallbladder problems. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid). It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Fenofibrate is not approved for use by anyone younger than 18 years old. How should I take fenofibrate? Take fenofibrate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Some brands of fenofibrate should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label. Swallow the tablet or capsule whole and do not crush, chew, dissolve, or open it. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Fenofibrate is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IIa (Elevated LDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IV (Elevated VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Geriatric Dose of Fenofibrate for Hyperlipoproteinemia: Tricor: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours. Lofibra and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Antara: 43 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Triglide: 50 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Lipofen: 50 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Fenoglide: 40 mg to 120 mg orally once a day with food   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Fenofibrate side effects Get emergency medical help if you have signs of an allergic reaction to fenofibrate (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: sharp stomach pain spreading to your back or shoulder blade; loss of appetite, stomach pain just after eating a meal; jaundice (yellowing of the skin or eyes); fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or swelling, warmth, or redness in an arm or leg. Common fenofibrate side effects may include: runny nose, sneezing; or abnormal laboratory tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect fenofibrate? Some medicines can make fenofibrate much less effective when taken at the same time. If you take any of the following medicines, take your dose 1 hour before or 4 to 6 hours after you take the other medicine. cholestyramine; colesevelam; or colestipol. Tell your doctor about all your other medicines, especially: other cholesterol lowering medicines; colchicine; a blood thinner such as warfarin, Coumadin, Jantoven; or drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection. This list is not complete. Other drugs may affect fenofibrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is fenofibrate? Fenofibrate belongs to a group of drugs known as "fibrates." It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate is used along with a proper diet to help to treat high cholesterol and high triglyceride levels. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help fenofibrate work better include exercising, losing weight if overweight, and stopping smoking. Warnings You should not take fenofibrate if you have liver disease, gallbladder disease, severe kidney disease, or if you are breast-feeding a baby. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine. Before taking this medicine You should not take fenofibrate if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); liver disease; or gallbladder disease. Do not breast-feed while using this medicine, and for at least 5 days after your last dose. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; or gallbladder problems. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid). It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Fenofibrate is not approved for use by anyone younger than 18 years old. How should I take fenofibrate? Take fenofibrate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Some brands of fenofibrate should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label. Swallow the tablet or capsule whole and do not crush, chew, dissolve, or open it. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Fenofibrate is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IIa (Elevated LDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IV (Elevated VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Geriatric Dose of Fenofibrate for Hyperlipoproteinemia: Tricor: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours. Lofibra and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Antara: 43 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Triglide: 50 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Lipofen: 50 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Fenoglide: 40 mg to 120 mg orally once a day with food   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Fenofibrate side effects Get emergency medical help if you have signs of an allergic reaction to fenofibrate (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: sharp stomach pain spreading to your back or shoulder blade; loss of appetite, stomach pain just after eating a meal; jaundice (yellowing of the skin or eyes); fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or swelling, warmth, or redness in an arm or leg. Common fenofibrate side effects may include: runny nose, sneezing; or abnormal laboratory tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is fenofibrate? Fenofibrate belongs to a group of drugs known as "fibrates." It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Fenofibrate is used along with a proper diet to help to treat high cholesterol and high triglyceride levels. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help fenofibrate work better include exercising, losing weight if overweight, and stopping smoking. Warnings You should not take fenofibrate if you have liver disease, gallbladder disease, severe kidney disease, or if you are breast-feeding a baby. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark urine. Before taking this medicine You should not take fenofibrate if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); liver disease; or gallbladder disease. Do not breast-feed while using this medicine, and for at least 5 days after your last dose. To make sure this medicine is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; or gallbladder problems. Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid). It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Fenofibrate is not approved for use by anyone younger than 18 years old. How should I take fenofibrate? Take fenofibrate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Some brands of fenofibrate should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label. Swallow the tablet or capsule whole and do not crush, chew, dissolve, or open it. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Fenofibrate is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IIa (Elevated LDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food. Usual Adult Dose of Fenofibrate for Hyperlipoproteinemia Type IV (Elevated VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food. Usual Geriatric Dose of Fenofibrate for Hyperlipoproteinemia: Tricor: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours. Lofibra and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Antara: 43 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Triglide: 50 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Lipofen: 50 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals. Fenoglide: 40 mg to 120 mg orally once a day with food   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Fenofibrate side effects Get emergency medical help if you have signs of an allergic reaction to fenofibrate (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: sharp stomach pain spreading to your back or shoulder blade; loss of appetite, stomach pain just after eating a meal; jaundice (yellowing of the skin or eyes); fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or swelling, warmth, or redness in an arm or leg. Common fenofibrate side effects may include: runny nose, sneezing; or abnormal laboratory tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is flecainide? Flecainide is a Class IC anti-arrhythmic that is used in certain situations to prevent serious heart rhythm disorders. Flecainide may also be used for purposes not listed in this medication guide. Warnings You should not use flecainide if you have a serious heart condition such as bundle branch block or AV block (without a pacemaker), or if your heart cannot pump blood properly. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects. Before taking this medicine You should not use flecainide if you are allergic to it, or if: you have a serious heart condition such as bundle branch block or AV block (unless you have a pacemaker); or your heart cannot pump blood properly. Tell your doctor if you have ever had: a heart attack; chronic atrial fibrillation, or "AFib"; congestive heart failure; a heart condition called "sick sinus syndrome"; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or liver disease. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. How should I take flecainide? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may receive your first few doses in a hospital or clinic setting to quickly treat any serious side effects. Your heart rate will be monitored using an electrocardiograph or ECG (sometimes called an EKG). This will help your doctor determine how long to treat you with flecainide. You may also need frequent blood tests to check your liver or kidney function. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, slow heart rate, fainting, or seizure (convulsions). What should I avoid while taking flecainide? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Flecainide side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: fast or pounding heartbeats; fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); slow heart rate, weak pulse, slow breathing (breathing may stop); feeling short of breath; swelling, rapid weight gain; pale skin, easy bruising or bleeding, unusual weakness; fever, flu-like symptoms; or jaundice (yellowing of the skin or eyes). Common side effects may include: dizziness; vision problems; trouble breathing; headache; nausea; or feeling weak or tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Flecainide dosing information Usual Adult Dose for Ventricular Tachycardia: Initial dose: 100 mg orally every 12 hours. Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Most patients with SUSTAINED VT do not require more than 150 mg every 12 hours (300 mg/day), and the maximum dose recommended is 400 mg/day. Usual Adult Dose for Atrial Fibrillation: Initial dose: 50 mg orally every 12 hours. Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Usual Adult Dose for Atrial Flutter: Initial dose: 50 mg orally every 12 hours. Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Usual Adult Dose for Wolff-Parkinson-White Syndrome: Initial dose: 50 mg orally every 12 hours. Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Usual Adult Dose for Paroxysmal Supraventricular Tachycardia: Initial dose: 50 mg orally every 12 hours. Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Usual Pediatric Dose for Supraventricular Tachycardia: less than 1 month: Supraventricular tachycardia: Limited data available: Initial: 2 mg/kg/day orally divided every 12 hours; titrate to clinical response, monitor serum concentration; mean dose required to suppress SVT: 3.35 ± 1.35 mg/kg/day in 17 neonates (n=20 treated neonates; mean PNA: 11.5 days; mean GA: 36.8 weeks; mean birthweight: 2.8 kg); study did not report resultant serum concentrations. 1 month or older: Initial: 1 to 3 mg/kg/day orally or 50 to 100 mg/m2/day orally in 3 divided doses; usual: 3 to 6 mg/kg/day or 100 to 150 mg/m2/day in 3 divided doses; up to 8 mg/kg/day or 200 mg/m2/day for uncontrolled patients with subtherapeutic levels; higher doses have been reported, however they may be associated with an increased risk of proarrhythmias; a review of world literature reports the average effective dose to be 4 mg/kg/day or 140 mg/m2/day.   What other drugs will affect flecainide? Tell your doctor about all your other medicines, especially: digoxin; a diuretic or "water pill"; a beta-blocker (atenolol, metoprolol, propranolol, sotalol, and others); other heart medications such as amiodarone, diltiazem, disopyramide, nifedipine, quinidine, or verapamil; or seizure medication. This list is not complete. Other drugs may affect flecainide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is gemfibrozil? Gemfibrozil helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Gemfibrozil is used together with diet to treat very high cholesterol and triglyceride levels in people with pancreatitis. Gemfibrozil is also used to lower the risk of stroke, heart attack, or other heart complications in certain people with high cholesterol and triglycerides who have not been helped by other treatment methods. Warnings You should not take gemfibrozil if you have severe liver or kidney disease, gallbladder disease, or if you are also taking repaglinide, dasabuvir, or simvastatin. Before taking this medicine You should not use gemfibrozil if you are allergic to it, if you have: severe liver disease; severe kidney disease; gallbladder disease; or if you are also taking repaglinide, dasabuvir, or simvastatin. To make sure gemfibrozil is safe for you, tell your doctor if you have ever had:: gallstones; or if you also take warfarin (Coumadin, Jantoven). It is not known whether gemfibrozil will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take gemfibrozil? Take gemfibrozil exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Gemfibrozil is usually taken 30 minutes before breakfast and dinner. Follow your doctor's dosing instructions very carefully. Gemfibrozil is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose of Gemfibrozil for Hyperlipidemia: 600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides Usual Adult Dose of Gemfibrozil for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): 600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides Usual Adult Dose of Gemfibrozil for Hyperlipoproteinemia Type IV (Elevated VLDL): 600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): 600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides Usual Adult Dose for Hypertriglyceridemia: 600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides Usual Adult Dose for Prevention of Cardiovascular Disease: 600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking gemfibrozil? Avoid eating foods high in fat or cholesterol, or gemfibrozil will not be as effective. Avoid drinking alcohol. It may interfere with your treatment. Gemfibrozil side effects Get emergency medical help if you have signs of an allergic reaction to gemfibrozil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, gemfibrozil can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: sharp pain in your upper stomach (especially after eating); jaundice (yellowing of your skin or eyes); pain or burning when you urinate; blurred vision, eye pain, or seeing halos around lights; or low blood cell counts - pale skin, easy bruising, unusual bleeding, unusual tiredness, feeling light-headed or short of breath, cold hands and feet. Common gemfibrozil side effects may include: stomach pain, indigestion, diarrhea; numbness or tingly feeling; dizziness, drowsiness; blurred vision; muscle or joint pain; or loss of interest in sex, impotence. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect gemfibrozil? Using certain medicines together with gemfibrozil can increase your risk of serious muscle problems. It is very important to tell your doctor about all medicines you use, and those you start or stop using, especially: colchicine; or a "statin" cholesterol-lowering medicine - atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, Crestor, Lipitor, Zocor, Vytorin, and others. This list is not complete and many other drugs may interact with gemfibrozil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is isosorbide mononitrate? Isosorbide mononitrate is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. Isosorbide mononitrate is used to prevent angina attacks (chest pain). Isosorbide mononitrate will not treat an angina attack that has already begun. Warnings You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure. Seek emergency medical attention if you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, general ill feeling). Do not stop taking this medicine suddenly. Stopping suddenly could cause a severe angina attack. Isosorbide mononitrate can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use the medication. Do not stop taking isosorbide mononitrate. Ask your doctor before using any headache pain medication. Use this medicine regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. Before taking this medicine You should not use isosorbide mononitrate if: you are allergic to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin; or you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating). You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure. To make sure this medicine is safe for you, tell your doctor if you have: congestive heart failure; kidney disease; or low blood pressure. It is not known whether this medicine will harm an unborn baby, although animal studies have not shown harm. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether isosorbide mononitrate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding. How should I take isosorbide mononitrate? Take isosorbide mononitrate exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition. Try to rest or stay seated when you take this medicine (may cause dizziness or fainting). Do not crush, chew, or break an extended-release tablet. Swallow it whole. Not all brands and forms of isosorbide mononitrate are taken the same number of times per day. You may need to take the medicine only once daily, in the morning after getting out of bed. You may also need a second dose later in the day. Follow your doctor's dosing instructions very carefully. If your doctor changes your brand, strength, or type of isosorbide mononitrate, your dosage needs may change. Ask your pharmacist if you have any questions about the new brand of medicine you receive at the pharmacy. Use this medicine regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. You should not stop using isosorbide mononitrate suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times. Get your prescription refilled before you run out of medicine completely. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal. Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions). What to avoid This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. Alcohol may increase certain side effects of isosorbide mononitrate (dizziness, drowsiness, feeling light-headed, or fainting). Isosorbide mononitrate side effects Get emergency medical help if you have signs of an allergic reaction to isosorbide mononitrate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; worsening angina pain; fast or slow heart rate; or pounding heartbeats or fluttering in your chest. Isosorbide mononitrate can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication. Common isosorbide mononitrate side effects may include: headache; dizziness upon standing; or flushing (warmth, redness, or tingly feeling). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect isosorbide mononitrate? Taking isosorbide mononitrate with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary arterial hypertension. Serious, life-threatening side effects may occur. Tell your doctor about all your current medicines and any you start or stop using, especially: erectile dysfunction medication (including Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil, others); a diuretic or "water pill"; blood pressure medications including calcium channel blockers (such as nifedipine, Procardia); nitroglycerin; or riociguat (Adempas); This list is not complete. Other drugs may interact with isosorbide mononitrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is isosorbide mononitrate? Isosorbide mononitrate is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. Isosorbide mononitrate is used to prevent angina attacks (chest pain). Isosorbide mononitrate will not treat an angina attack that has already begun. Warnings You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure. Seek emergency medical attention if you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, general ill feeling). Do not stop taking this medicine suddenly. Stopping suddenly could cause a severe angina attack. Isosorbide mononitrate can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use the medication. Do not stop taking isosorbide mononitrate. Ask your doctor before using any headache pain medication. Use this medicine regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. Before taking this medicine You should not use isosorbide mononitrate if: you are allergic to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin; or you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating). You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure. To make sure this medicine is safe for you, tell your doctor if you have: congestive heart failure; kidney disease; or low blood pressure. It is not known whether this medicine will harm an unborn baby, although animal studies have not shown harm. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether isosorbide mononitrate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding. How should I take isosorbide mononitrate? Take isosorbide mononitrate exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition. Try to rest or stay seated when you take this medicine (may cause dizziness or fainting). Do not crush, chew, or break an extended-release tablet. Swallow it whole. Not all brands and forms of isosorbide mononitrate are taken the same number of times per day. You may need to take the medicine only once daily, in the morning after getting out of bed. You may also need a second dose later in the day. Follow your doctor's dosing instructions very carefully. If your doctor changes your brand, strength, or type of isosorbide mononitrate, your dosage needs may change. Ask your pharmacist if you have any questions about the new brand of medicine you receive at the pharmacy. Use this medicine regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. You should not stop using isosorbide mononitrate suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times. Get your prescription refilled before you run out of medicine completely. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal. Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions). What to avoid This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. Alcohol may increase certain side effects of isosorbide mononitrate (dizziness, drowsiness, feeling light-headed, or fainting). Isosorbide mononitrate side effects Get emergency medical help if you have signs of an allergic reaction to isosorbide mononitrate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; worsening angina pain; fast or slow heart rate; or pounding heartbeats or fluttering in your chest. Isosorbide mononitrate can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication. Common isosorbide mononitrate side effects may include: headache; dizziness upon standing; or flushing (warmth, redness, or tingly feeling). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect isosorbide mononitrate? Taking isosorbide mononitrate with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary arterial hypertension. Serious, life-threatening side effects may occur. Tell your doctor about all your current medicines and any you start or stop using, especially: erectile dysfunction medication (including Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil, others); a diuretic or "water pill"; blood pressure medications including calcium channel blockers (such as nifedipine, Procardia); nitroglycerin; or riociguat (Adempas); This list is not complete. Other drugs may interact with isosorbide mononitrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.