What is baclofen? Baclofen is a muscle relaxer and an antispasmodic agent. Baclofen is used to treat muscle pain, spasms, and stiffness in people with multiple sclerosis or spinal cord injury or disease. Baclofen is given intrathecally (directly into the spinal cord) or orally (by mouth). Warnings Do not use baclofen at a time when you need muscle tone for safe balance and movement during certain activities. Do not drive or operate heavy machinery until you know how this medicine affects you. Do not stop using baclofen suddenly, or you could have unpleasant withdrawal symptoms. Before taking this medicine You should not use baclofen if you are allergic to it. To make sure this medicine is safe for you, tell your doctor if you have ever had: mental illness or psychosis; a nervous system disorder; epilepsy or other seizure disorder; a stroke or blood clot; or kidney disease. Using baclofen may increase your risk of developing an ovarian cyst. Talk with your doctor about your specific risk. Tell your doctor if you are pregnant or breastfeeding. If you take baclofen during pregnancy, your newborn baby may have withdrawal symptoms such as tremors, rigid muscles, or a seizure. Follow your doctor's instructions about tapering your dose as your due date approaches. If you take baclofen while breastfeeding, withdrawal symptoms may occur in the nursing baby. Ask your doctor if it is safe for you to breastfeed while taking this medicine. Baclofen is not approved for use by anyone younger than 12 years old. How should I take baclofen? Take baclofen exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Call your doctor if your muscle symptoms do not improve, or if they get worse. You should not stop using baclofen suddenly or you could have serious or fatal withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include muscle weakness, vomiting, severe dizziness or drowsiness, dilated or pinpoint pupils, shallow breathing, seizure, or loss of consciousness. What to avoid Do not use baclofen at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone. Avoid drinking alcohol with baclofen. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Baclofen side effects Get emergency medical help if you have signs of an allergic reaction to baclofen: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe drowsiness, weak or shallow breathing; confusion, hallucinations; itching, tingling, or twitching in your hands, arms, feet, or legs; fever; or a seizure. Common baclofen side effects may include: drowsiness, dizziness, weakness, tiredness; headache; sleep problems (insomnia); nausea, constipation; or urinating more often than usual. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect baclofen? Using baclofen with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Tell your physician if you are taking any of the following medications: Opioid medications Sleeping pills Muscle relaxers Medication for depression, anxiety, or bipolar disorder Seizure medication Blood pressure medication Other drugs may interact with baclofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you  

What is chlorzoxazone? Chlorzoxazone is a muscle relaxer that is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Chlorzoxazone may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use chlorzoxazone if you are allergic to it. Tell your doctor if you have ever had: liver disease. Tell your doctor if you are pregnant or breast-feeding. Chlorzoxazone is not approved for use by anyone younger than 18 years old. How should I take chlorzoxazone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Chlorzoxazone is usually taken 3 or 4 times per day. Follow your doctor's dosing instructions very carefully. Chlorzoxazone is only part of a complete program of treatment that may also include rest, physical therapy, or other pain relief measures. Follow your doctor's instructions. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, diarrhea, severe drowsiness, headache, muscle weakness, shallow breathing, or fainting. What should I avoid while taking chlorzoxazone? Drinking alcohol with chlorzoxazone can cause side effects. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Chlorzoxazone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: a light-headed feeling, like you might pass out; skin rash, itching, or redness; liver problems--stomach pain (upper right side), loss of appetite, vomiting, fever, unusual tiredness, dark urine, or jaundice (yellowing of the skin or eyes); or signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Common side effects may include: drowsiness; dizziness; or general ill feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Chlorzoxazone dosing information Usual Adult Dose for Muscle Spasm: Initial dose: 250 to 500 mg orally 3 to 4 times a day -If inadequate response, may increase to 750 mg orally 3 or 4 times a day Comments: -The dose should be reduced as improvement occurs. Use: As an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.   What other drugs will affect chlorzoxazone? Using chlorzoxazone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect chlorzoxazone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is cyclobenzaprine? Cyclobenzaprine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Cyclobenzaprine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Cyclobenzaprine may also be used for purposes not listed in this medication guide. Warnings You should not use cyclobenzaprine if you have an allergy to the medication, a certain type of thyroid disorder (hyperthyroidism), heart block, congestive heart failure, a heart rhythm disorder, or you have recently had a heart attack. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Before taking this medicine You should not use cyclobenzaprine if you are allergic to it, or if you have: hyperthyroidism; heart block, heart rhythm disorder, congestive heart failure; or if you have recently had a heart attack. Cyclobenzaprine is not approved for use by anyone younger than 15 years old. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications. To make sure cyclobenzaprine is safe for you, tell your doctor if you have: thyroid disease; liver disease; glaucoma; enlarged prostate; or problems with urination. It is not known whether cyclobenzaprine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Older adults may be more sensitive to the effects of this medicine. How should I take cyclobenzaprine? Cyclobenzaprine is usually taken taken for up to 2 or 3 weeks. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Follow your doctor's dosing instructions very carefully. Swallow the capsule whole and do not crush, chew, break, or open it. Call your doctor if your symptoms do not improve after 3 weeks, or if they get worse. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of cyclobenzaprine can be fatal. Overdose symptoms may include severe drowsiness, vomiting, fast heartbeats, tremors, agitation, or hallucinations. What to avoid Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid drinking alcohol. Dangerous side effects could occur. Cyclobenzaprine side effects Get emergency medical help if you have signs of an allergic reaction to cyclobenzaprine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: fast or irregular heartbeats; chest pain or pressure, pain spreading to your jaw or shoulder; or sudden numbness or weakness (especially on one side of the body), slurred speech, balance problems. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Serious side effects may be more likely in older adults. Common cyclobenzaprine side effects may include: drowsiness, tiredness; headache, dizziness; dry mouth; or upset stomach, nausea, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect cyclobenzaprine? Using cyclobenzaprine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: MAO inhibitors, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine; Any antidepressant or anxiety medications; bupropion (Zyban, for smoking cessation or Wellbutrin, for depression); meperidine; tramadol; verapamil; cold or allergy medicine that contains an antihistamine (Benadryl and others); medicine to treat Parkinson's disease; medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome; medicine to treat overactive bladder; or bronchodilator asthma medication. This list is not complete. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is methocarbamol? Methocarbamol is a muscle relaxer. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Methocarbamol is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Methocarbamol injection is sometimes used in the treatment of tetanus, (lockjaw) which causes painful tightening of the muscles. Warnings You should not use this medication if you are allergic to methocarbamol. Before using methocarbamol, tell your doctor if you have myasthenia gravis. You may need to reduce your dose after the first 2 or 3 days of treatment. Follow your doctor's instructions regarding the number of tablets you take each day. Methocarbamol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of this medicine. Before taking this medicine You should not use methocarbamol if you are allergic to it. To make sure this medicine is safe for you, tell your doctor if you have: kidney disease; a seizure; or myasthenia gravis. Methocarbamol may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Methocarbamol is not approved for use by anyone younger than 16 years old unless to treat tetanus. Methocarbamol pregnancy and breastfeeding warnings (more detail) How should I use methocarbamol? Take methocarbamol exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Methocarbamol is only part of a complete treatment program that may also include rest, physical therapy, or other pain relief measures. Methocarbamol oral is taken by mouth. You may need to reduce your dose after the first 2 or 3 days of treatment. Carefully follow your doctor's dosing instructions. Methocarbamol injection is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection. The injection is usually given as a single dose before you start taking the oral form. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when methocarbamol is injected. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Dosing information Usual Adult Dose for Muscle Spasm: ORAL: Initial Dose: 1500 mg orally 4 times a day -Doses of 6000 mg per day are generally used for the first 48 to 72 hours -In severe cases, doses up to 8000 mg per day may be used Maintenance dose: 500 mg tablets: 1000 mg orally 4 times a day 750 mg Tablets: 750 mg orally every 4 hours OR 1500 mg orally 3 times a day PARENTERAL: -For the relief of moderate symptoms: 1 g IV or IM once, then switch to oral -For relief of severe symptoms or postoperative conditions: 1 g IV or IM every 8 hours Maximum Dose: 3 g in 24-hours Maximum Duration: 3 consecutive days; may repeat after a drug-free interval of 48 hours Comments: -Higher doses are recommended in the first 48 to 72 hours of treatment, then doses can usually be reduced to approximately 4000 mg per day. -Oral tablets should be administered whenever feasible; IV/IM therapy should not be administered for more than 3 consecutive days without a drug-free interval of 48 hours. Use: As an adjunct to rest and physical therapy for the relief of discomfort associated with acute, painful musculoskeletal conditions. Usual Adult Dose for Tetanus: Initial dose: 1 to 2 g IV followed by an additional 1 to 2 g via IV infusion Maximal Initial Dose: 3 g Repeat initial IV dose every 6 hours until NG tube or oral therapy is possible Once NG tube is in place, may crush tablets, suspend in water or saline and administer through tube -Total oral doses of up to 24 g may be needed based on patient response Comments: -There is clinical evidence to suggest this drug may have a beneficial effect in the control of the neuromuscular manifestations of tetanus. -This drug should not replace the usual procedure of debridement, tetanus antitoxin, penicillin, tracheotomy, attention to fluid balance, and supportive care; if used, this drug should be added to the regimen as soon as possible. Use: To control the neuromuscular manifestations of tetanus. Usual Pediatric Dose for Tetanus: Initial dose: 15 mg/kg or 500 mg/m2 IV; repeat initial dose every 6 hours as needed Maximum dose: 1.8 g/m2/day IV for 3 consecutive days Maintenance dose: May be given by injection into tubing or by IV infusion with an appropriate quantity of fluid Comments: -There is clinical evidence to suggest this drug may have a beneficial effect in the control of the neuromuscular manifestations of tetanus. -This drug should not replace the usual procedure of debridement, tetanus antitoxin, penicillin, tracheotomy, attention to fluid balance, and supportive care; if used, this drug should be added to the regimen as soon as possible. Use: To control the neuromuscular manifestations of tetanus. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Detailed Methocarbamol dosage information What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, extreme drowsiness, fainting, seizure, or coma. What to avoid Avoid driving or hazardous activity until you know how methocarbamol will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Drinking alcohol with this medicine can cause side effects. Methocarbamol side effects Get emergency medical help if you have signs of an allergic reaction to methocarbamol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using methocarbamol and call your doctor at once if you have: a light-headed feeling, like you might pass out; slow heartbeats; a seizure; jaundice (yellowing of your skin or eyes); or pain, bruising, swelling, or skin changes where the injection was given. Common methocarbamol side effects may include: headache, dizziness, drowsiness; fever; confusion, problems with memory; nausea, vomiting, upset stomach; blurred vision, double vision; flushing (warmth, redness, or tingly feeling); sleep problems (insomnia); or lack of coordination.    

What is tizanidine? Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain. Tizanidine is used to treat spasticity by temporarily relaxing muscle tone. Tizanidine may also be used for purposes not listed in this medication guide. Warnings Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity. You should not take tizanidine if you are also taking fluvoxamine (Luvox) or ciprofloxacin (Cipro). Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone. Switching between tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects. The recommended starting dose of tizanidine is 2 mg every 6 to 8 hours, up to a maximum of 3 doses in 24 hours. Do not take more than 36 mg of tizanidine in a 24-hour period. Too much of this medicine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Avoid drinking alcohol. It can increase some of the side effects of this medicine. Before taking this medicine You should not use tizanidine if you are allergic to it, or if: you also take the antidepressant fluvoxamine (Luvox); or you also take the antibiotic ciprofloxacin (Cipro). To make sure tizanidine is safe for you, tell your doctor if you have ever had: liver disease; kidney disease; or low blood pressure. It is not known whether tizanidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take tizanidine? Take tizanidine exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Tizanidine is usually taken up to 3 times in one day, starting at 2mg per dose. Allow 6 to 8 hours to pass between doses. Do not take more than 36 mg in a 24-hour period. Too much of this medicine can damage your liver. You may take tizanidine with or without food, but take it the same way each time. Switching between taking with food and taking it without food can make the medicine less effective or cause increased side effects. Switching between tablets and capsules may cause changes in side effects or how well the medicine works. Taking the tablets with food can increase your blood levels of tizanidine. Taking the capsules with food can decrease your blood levels of tizanidine. If you make any changes in how you take tizanidine, tell your doctor if you notice any change in side effects or in how well the medicine works. Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 3 hours after you take it. You should take this medicine only for daily activities that require relief from muscle spasms. You will need frequent blood tests to check your liver function. If you stop using this medicine suddenly after long-term use, you may have withdrawal symptoms such as dizziness, fast heartbeats, tremors, and anxiety. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting. What to avoid Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone. Drinking alcohol with this medicine can cause side effects. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Tizanidine side effects Get emergency medical help if you have signs of an allergic reaction to tizanidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; weak or shallow breathing; confusion, hallucinations; or pain or burning when you urinate. Common tizanidine side effects may include: drowsiness, dizziness, weakness; feeling nervous; blurred vision; flu-like symptoms; dry mouth, trouble speaking; abnormal liver function tests; runny nose, sore throat; urination problems, painful urination; vomiting, constipation; or uncontrolled muscle movements. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tizanidine? Taking tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: acyclovir; ticlopidine; zileuton; birth control pills; an antibiotic - ciprofloxacin, levofloxacin, moxifloxacin, or ofloxacin; blood pressure medicine - clonidine, guanfacine, methyldopa; heart rhythm medicine - amiodarone, mexiletine, propafenone, verapamil; or stomach acid medicine - cimetidine, famotidine. This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.