What is anastrozole? Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox). Anastrozole may also be used for purposes not listed in this medication guide. Warnings Anastrozole may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries). Seek medical attention if you have new or worsening chest pain, or if you feel short of breath. Before taking this medicine You should not use anastrozole if you are allergic to it, or if you have not yet completed menopause. Anastrozole is not approved for use in men or children. You should not take anastrozole if you also take tamoxifen. Tell your doctor if you have ever had: heart problems; coronary artery disease (clogged artery disease); high cholesterol; or osteoporosis or low bone mineral density. Hormonal cancer treatment can weaken your bones. You may be more likely to have a broken bone while using anastrozole. Talk with your doctor about ways to keep your bones healthy. Although it is not likely that a postmenopausal woman would be pregnant, anastrozole may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control if you are not past menopause. Keep using birth control for at least 3 weeks after your last dose of anastrozole. Tell your doctor if you become pregnant. Do not breastfeed while using anastrozole, and for at least 2 weeks after your last dose. How should I take anastrozole? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Anastrozole is usually taken once per day. Follow your doctor's dosing instructions very carefully. You may take anastrozole with or without food. You may need to keep taking this medication for up to 5 years. Follow your doctor's instructions. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking anastrozole? Avoid driving or hazardous activity until you know how anastrozole will affect you. Your reactions could be impaired. Anastrozole side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Anastrozole may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries). Seek medical attention if you have new or worsening chest pain, or if you feel short of breath. Call your doctor at once if you have: shortness of breath (even with mild exertion), swelling, rapid weight gain; numbness, prickly feeling, pain, or weakness in your hands or wrists; symptoms of bone fracture--bruising, swelling, tenderness, pain that worsens with movement; liver problems--right-sided upper stomach pain, yellowing of your skin or eyes, and not feeling well; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: numbness, tingling, or tickling feeling in your skin; hot flashes; weakness; joint pain or stiffness; bone pain, risk of fracture; swelling in your arms, legs, or feet; sore throat, cough, shortness of breath; headache, back pain; depression, sleep problems (insomnia); high blood pressure; nausea, vomiting; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Anastrozole dosing information Usual Adult Dose for Breast Cancer: Initial dose: 1 mg orally taken once a day Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer) Uses: -Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer; -First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer; -Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.   What other drugs will affect anastrozole? Anastrozole may not work as well if you take it together with an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings or vaginal suppositories). Other drugs may affect anastrozole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is capecitabine? Capecitabine is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer. Capecitabine is sometimes used when cancer has spread to other parts of the body (metastatic). Capecitabine may also be used for purposes not listed in this medication guide. Warnings Taking a blood thinner (warfarin, Coumadin, Jantoven) can increase your risk of severe bleeding during and shortly after treatment with capecitabine. This risk is higher in adults older than 60. Before taking this medicine You should not take capecitabine if you are allergic to capecitabine or fluorouracil, or if you have: severe kidney disease. Tell your doctor if you have ever had: a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests. Capecitabine can harm an unborn baby if the mother or the father is using this medicine. If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs. Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby. Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose. How should I take capecitabine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Capecitabine is usually taken twice per day, and may be only part of a treatment program that may also include other medications taken on different schedules. Follow your doctor's dosing instructions very carefully. Take with food or within 30 minutes after eating a meal. Swallow the tablet whole with water and do not crush, chew, or break it. Tell your doctor if you have trouble swallowing the tablet. Capecitabine is given in a 3-week treatment cycle, and you may only need to take the medicine only on certain days of this cycle. You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea. You may need frequent medical tests and your cancer treatments may be delayed based on the results. Capecitabine can have long lasting effects on your body. You may also need medical tests for a short time after your last dose. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking capecitabine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Capecitabine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Diarrhea may occur and could be severe. Stop taking capecitabine and tell your doctor right away if the number of bowel movements you usually have per day increases by 4 or more, or if you have bowel movements at night. Stop using capecitabine and call your doctor at once if you have: severe diarrhea; bloody diarrhea with severe stomach pain and fever; severe nausea or loss of appetite that causes you to eat much less than usual; vomiting (more than once in 24 hours); fever above 100.5 degrees; sores or ulcers in your mouth, redness or swelling of your mouth or tongue, trouble eating or swallowing; jaundice (yellowing of the skin or eyes); dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; "hand and foot syndrome"--pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet; heart problems--chest pain, irregular heartbeats, swelling in your lower legs, rapid weight gain, feeling lightheaded or short of breath; or low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: nausea, vomiting, diarrhea, stomach pain; feeling weak or tired; hand and foot syndrome; or jaundice. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect capecitabine? Taking a blood thinner (warfarin, Coumadin, Jantoven) can increase your risk of severe bleeding during and shortly after treatment with capecitabine. This risk is higher in adults older than 60. Tell your doctor if you also take allopurinol. Other drugs may affect capecitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is exemestane? Exemestane is used to treat breast cancer in postmenopausal women. Exemestane is sometimes given after you have taken tamoxifen for 2 or 3 years, or if tamoxifen did not work or has stopped working. Exemestane may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use exemestane if you are allergic to it, or if: you are pregnant or able to become pregnant; or you have not yet completed menopause, and are still having menstrual periods. Some drugs should not be used together with exemestane. Your doctor may change your treatment plan if you also use medicines that contain estrogen, such as: birth control pills, patches, injections, or implants; or hormone replacement therapy. Tell your doctor if you have ever had: liver or kidney disease; or if you are still having menstrual periods. Exemestane can decrease bone mineral density, which may increase your risk of developing osteoporosis. Talk to your doctor about your individual risk of bone loss. exemestane is for use only in women who can no longer get pregnant. Exemestane can harm an unborn baby. Do not take this medicine if you are pregnant or may become pregnant. You may need to have a negative pregnancy test before starting this treatment. If you are not past menopause, use effective birth control to prevent pregnancy while you are taking exemestane and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant. This medicine may affect fertility (your ability to have children). However, if you are not past menopause you should still use birth control to prevent pregnancy because exemestane can harm an unborn baby. You should not breastfeed while using this medicine and for 1 month after your last dose. How should I take exemestane? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Exemestane is usually taken once per day, after a meal. Try to take the medicine at the same time each day. You will need frequent medical tests. Your doctor may have you take extra vitamin D while you are taking exemestane. Take only the amount of vitamin D that your doctor has prescribed. Use exemestane regularly to get the most benefit. You may need to keep taking take this medication for up to 5 years. Store in the original container at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking exemestane? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Exemestane side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain or pressure; new or unusual bone pain; swelling in your hands or feet; feeling short of breath, even with mild exertion; or signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg. Common side effects may include: hot flashes; headache, feeling tired; joint pain; nausea; increased appetite; sleep problems (insomnia); or increased sweating. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Exemestane dosing information Usual Adult Dose for Breast Cancer: 25 mg orally once a day Comment: -This drug is not indicated for the treatment of breast cancer in premenopausal women. Uses: -Adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to exemestane for completion of a total of five consecutive years of adjuvant hormonal therapy. -Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.   What other drugs will affect exemestane? When you start or stop taking exemestane, your doctor may need to adjust the doses of any other medicines you take on a regular basis. Many drugs can affect exemestane, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is imatinib? Imatinib interferes with the growth of some cancer cells. Imatinib is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer. Imatinib is also used to treat certain tumors of the stomach and digestive system. Warnings Imatinib can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches). Imatinib may increase the risk of liver problems. Tell your doctor if you have upper stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Imatinib may increase the risk of fluid retention or heart problems. Tell your doctor if you have swelling or rapid weight gain, shortness of breath, fast or slow heart rate, weak pulse, or fainting. Before taking this medicine You should not use imatinib if you are allergic to it. To make sure imatinib is safe for you, tell your doctor if you have ever had: liver disease (especially hepatitis B); kidney disease; underactive thyroid, recent or upcoming thyroid surgery; heart disease, high blood pressure, congestive heart failure; a stomach ulcer or bleeding; diabetes; or chemotherapy. You may need to have a negative pregnancy test before starting this treatment. Do not use imatinib if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using imatinib and for at least 14 days after your last dose. Do not breast-feed a baby while you are using this medicine and for at least 1 month after your last dose. How should I take imatinib? Take imatinib exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Take imatinib with a meal and a large glass of water. Do not take imatinib on an empty stomach. If you cannot swallow a tablet whole, you may dissolve it in a glass of water or apple juice to make the pill easier to swallow. Use about 2 ounces of liquid for each 100-milligram tablet, or 7 ounces of liquid for each 400-milligram tablet. Stir the mixture and drink all of it right away. Do not use a broken tablet. The medicine from a broken pill can be dangerous if it gets in your mouth, eyes, or nose, or on your skin. If this happens, wash your skin with soap and water or rinse your eyes with water. Ask your pharmacist how to safely dispose of a broken pill. Imatinib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. You will also need frequent tests to check your liver function. Do not stop using imatinib without your doctor's advice. Store at room temperature away from moisture and heat. Dosing information Usual Adult Dose of Imatinib for Chronic Myelogenous Leukemia: Chronic phase: 400 mg orally once a day Accelerated phase or blast crisis: 600 mg orally once a day A dose increase may be considered in the absence of a severe adverse drug reaction and severe non-leukemia related neutropenia or thrombocytopenia in the following circumstances: disease progression (at any time), failure to achieve a satisfactory hematologic response after at least 3 months of treatment, failure to achieve a cytogenetic response after 6 to 12 months of treatment, or loss of a previously achieved hematologic or cytogenetic response: -Disease progression chronic phase: 600 mg orally once a day -Disease progression accelerated phase or blast crisis: 400 mg orally 2 times a day Uses: -Newly diagnosed patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML) in chronic phase -Patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML) in blast crisis (BC), accelerated phase (AP), or in chronic phase (CP) after failure of interferon-alpha therapy Usual Adult Dose of Imatinib for Acute Lymphoblastic Leukemia: 600 mg orally daily Use: For relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) Usual Adult Dose of Imatinib for Myeloproliferative Disorder: 400 mg orally once a day Comments: -Determine PDGFRb gene rearrangements status prior to initiating therapy. Use: For patients with myelodysplastic/myeloproliferative (MDS/MPD) diseases associated with PDGFR (platelet-derived growth factor receptor) gene rearrangements Usual Adult Dose of Imatinib for Myelodysplastic Disease: 400 mg orally once a day Comments: -Determine PDGFRb gene rearrangements status prior to initiating therapy. Use: For patients with myelodysplastic/myeloproliferative (MDS/MPD) diseases associated with PDGFR (platelet-derived growth factor receptor) gene rearrangements Usual Adult Dose of Imatinib for Systemic Mastocytosis: -For patients with ASM without the D816V c-Kit mutation: 400 mg orally daily -If c-Kit mutational status is not known or unavailable: 400 mg orally daily may be considered for patients with ASM not responding satisfactorily to other therapies. -For patients with ASM associated with eosinophilia, a clonal hematological disease related to the fusion kinase FIP1L1-PDGFR alpha, a starting dose of 100 mg/day is recommended. Dose increase from 100 mg to 400 mg for these patients may be considered in the absence of adverse drug reactions if assessments demonstrate an insufficient response to therapy. -For patients with ASM associated with eosinophilia (a clonal hematological disease related to the fusion kinase FIP1L1-PDGFR alpha: 100 mg orally daily; a dose increase from 100 mg to 400 mg for these patients may be considered in the absence of adverse drug reactions if assessments demonstrate an insufficient response to therapy Comments: -Determine D816V c-Kit mutation status prior to initiating treatment. Use: For patients with aggressive systemic mastocytosis without the D816V c-Kit mutation Usual Adult Dose of Imatinib for Hypereosinophilic Syndrome: -For patients with HES/CEL: 400 mg orally daily -For patients with HES/CEL with demonstrated FIP1L1-PDGFR alpha fusion kinase: 100 mg orally daily; dose increase from 100 mg to 400 mg for these patients may be considered in the absence of adverse drug reactions if assessments demonstrate an insufficient response to therapy Use: For patients with hypereosinophilic syndrome and/or chronic eosinophilic leukemia who have the FIP1L1-PDGFR alpha fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-PDGFR alpha fusion kinase negative or unknown Usual Adult Dose of Imatinib for Chronic Eosinophilic Leukemia: -For patients with HES/CEL: 400 mg orally daily -For patients with HES/CEL with demonstrated FIP1L1-PDGFR alpha fusion kinase: 100 mg orally daily; dose increase from 100 mg to 400 mg for these patients may be considered in the absence of adverse drug reactions if assessments demonstrate an insufficient response to therapy Use: For patients with hypereosinophilic syndrome and/or chronic eosinophilic leukemia who have the FIP1L1-PDGFR alpha fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-PDGFR alpha fusion kinase negative or unknown Usual Adult Dose of Imatinib for Dermatofibrosarcoma Protuberans: 100 mg orally daily Use: For patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans (DFSP) Usual Pediatric Dose of Imatinib for Chronic Myelogenous Leukemia: 1 year and older: 340 mg/m2 orally once a day or 170 mg/m2 orally 2 times a day Maximum Dose: 600 mg daily Comments: -Therapy can be given as a once daily dose or the daily dose may be split into 2 doses, with one portion dosed in the morning and one portion in the evening. -There is no experience with this drug in children under 1 year of age. Use: -Newly diagnosed patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML) in chronic phase.   What happens if I miss a dose? Take your dose as soon as you can, making sure you also eat a meal and drink a large glass of water. Skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking imatinib? imatinib may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries. Grapefruit may interact with imatinib and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. Imatinib side effects Get emergency medical help if you have signs of an allergic reaction to imatinib (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Call your doctor at once if you have: fluid retention - shortness of breath (even while lying down), swelling, rapid weight gain; kidney problems - little or no urination, swelling in your feet or ankles; fluid build-up in the lungs - pain when you breathe, wheezing, gasping for breath, cough with foamy mucus; liver problems - upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); low blood cell counts - fever, cold or flu symptoms, easy bruising, unusual bleeding, mouth sores, pale skin, unusual tiredness, feeling light-headed, cold hands and feet; signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; signs of tumor cell breakdown - confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth; or thyroid symptoms - tiredness, dry skin, hair loss, constipation, depression, slow heart rate, weight gain, feeling more sensitive to cold temperatures. Imatinib can affect growth in children and teenagers. Tell your doctor if your child is not growing at a normal rate while using this medicine. Common imatinib side effects may include: fluid retention; nausea, vomiting, stomach pain, diarrhea; joint or muscle pain; skin rash; or feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect imatinib? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tell your doctor about all your current medicines. Many drugs can interact with imatinib, especially: an antibiotic, antifungal, or antiviral medicine; seizure medicine; a blood thinner such as warfarin (Coumadin, Jantoven); or a vitamin or mineral supplement that contains iron. This list is not complete and many other drugs may affect imatinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is letrozole? Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. Letrozole is used to treat breast cancer in postmenopausal women. It is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. Letrozole may also be used for purposes not listed in this medication guide. Warnings You should not use letrozole if you are pregnant. Before taking this medicine You should not use letrozole if you are allergic to it. letrozole is for use only in women who can no longer get pregnant. Letrozole can harm an unborn baby. Do not use if you are pregnant. Use effective birth control if you are not past menopause. Keep using birth control for at least 3 weeks after your last dose of letrozole. Tell your doctor if you think you may be pregnant. Tell your doctor if you have ever had: liver disease (especially cirrhosis); osteoporosis, osteopenia (low bone mineral density); high cholesterol; or if you also take tamoxifen. You should not breastfeed while you are using letrozole and for at least 3 weeks after your last dose. How should I take letrozole? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may take letrozole with or without food. You will need frequent medical tests, and your bone mineral density may also need to be checked. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking letrozole? Avoid driving or hazardous activity until you know how letrozole will affect you. Your reactions could be impaired. Letrozole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Common side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or increased cholesterol in your blood. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Letrozole dosing information Usual Adult Dose for Breast Cancer: 2.5 mg orally once a day Duration of therapy: -Adjuvant and extended adjuvant settings: Optimal duration is unknown; discontinue therapy at relapse. -Advanced disease: Until tumor progression is evident. Uses: -Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer -Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy -First-line treatment of advanced breast cancer in postmenopausal women with hormone receptor positive or unknown locally advanced or metastatic breast cancer; second-line treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy Usual Adult Dose for Breast Cancer -- Adjuvant: 2.5 mg orally once a day Duration of therapy: -Adjuvant and extended adjuvant settings: Optimal duration is unknown; discontinue therapy at relapse. -Advanced disease: Until tumor progression is evident. Uses: -Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer -Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy -First-line treatment of advanced breast cancer in postmenopausal women with hormone receptor positive or unknown locally advanced or metastatic breast cancer; second-line treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy   What other drugs will affect letrozole? Other drugs may affect letrozole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is Nilandron? Nilandron is used to treat prostate cancer that has spread to other parts of the body. Nilandron is for use in men who have undergone surgical castration. Nilandron may also be used for purposes not listed in this medication guide. Warnings You should not use Nilandron if you have severe liver disease or severe breathing problems. Nilandron can cause serious lung problems. Call your doctor right away if you have chest pain, wheezing, dry cough, fever, and new or worsening shortness of breath. Before taking this medicine You should not use Nilandron if you are allergic to it, or if you have: severe liver disease; or severe breathing problems. Tell your doctor if you have ever had: liver disease; or asthma or another lung disease. Nilandron is not for use in women, and the effects of Nilandron during pregnancy or in breastfeeding women are unknown. How should I take Nilandron? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Treatment with Nilandron should be started on the day of or on the day after surgical castration. You may take Nilandron with or without food. Do not stop taking this medication without first talking to your doctor. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Nilandron? Nilandron may cause a delay in your ability to see in the dark after you have been in a lighted area. Be careful when driving at night, when entering a tunnel, and in similar situations. Wearing tinted glasses may help lessen this effect. Drinking alcohol with Nilandron may cause dizziness, flushing (warmth, redness, or tingly feeling), or other unpleasant symptoms. Nilandron side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain, wheezing, dry cough, fever; new or worsening shortness of breath; flu symptoms, pale skin, feeling tired; or liver problems--nausea, vomiting, loss of appetite, right-sided upper stomach pain, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: hot flashes; dizziness; constipation; nausea or vomiting, loss of appetite; skin rash; decreased libido, impotence; or vision changes. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Nilandron? Other drugs may affect Nilandron, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.