What is atenolol? Atenolol (Tenormin) is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins). Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). Atenolol is also used to lower the risk of death after a heart attack. Warnings You should not use this atenolol if you have a serious heart condition such as "AV block," very slow heartbeats, or heart failure. Do not stop taking atenolol without first talking to your doctor. Stopping suddenly may make your condition worse. If you are having any type of surgery, be sure the surgeon knows ahead of time that you are using this medicine. Atenolol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking this medicine. Atenolol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension. If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Before taking this medicine You should not use atenolol if you are allergic to it, or if you have: a serious heart condition such as "AV block" (second or third degree); slow heartbeats; heart failure; or if your heart cannot pump blood properly. To make sure atenolol is safe for you, tell your doctor if you have: congestive heart failure; coronary artery disease (hardened arteries); asthma, bronchitis, emphysema; diabetes; overactive thyroid; liver or kidney disease; pheochromocytoma (tumor of the adrenal gland); peripheral vascular disease such as Raynaud's syndrome; or allergies (or if you are undergoing allergy treatments or skin-testing). Atenolol may harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine. Atenolol can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby. Atenolol is not approved for use by anyone younger than 18 years old. How should I take atenolol? Take atenolol exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Your blood pressure will need to be checked often. If you need surgery, tell the surgeon ahead of time that you are using atenolol. You may need to stop using the medicine for a short time. Keep using the medication as directed and tell your doctor if your symptoms do not improve. You should not stop taking atenolol suddenly. Stopping suddenly may make your condition worse. If you are being treated for high blood pressure: Keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Your condition may need to be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Atenolol dosing information Usual Adult Dose of Atenolol for Hypertension: Initial dose: 50 mg orally once a day Maintenance dose: 50 to 100 mg orally once a day Maximum dose: 100 mg per day Comments: -If desired response not achieved after 1 to 2 weeks, increase to 100 mg may be beneficial. -Doses greater than 100 mg once a day did not result in significant additional antihypertensive effects. Use: For the treatment of hypertension alone or in combination with other antihypertensive agents. Usual Adult Dose of Atenolol for Angina Pectoris Prophylaxis: Initial dose: 50 mg orally once a day -Increase to 100 mg orally once a day after 1 week if optimal response not achieved Maintenance dose: 50 to 200 mg orally once a day Maximum dose: 200 mg per day Comments: -Some patients may require 200 mg per day to attain optimal effect. Use: For the long-term management of angina pectoris due to coronary atherosclerosis. Usual Adult Dose of Atenolol for Angina Pectoris: Initial dose: 50 mg orally once a day -Increase to 100 mg orally once a day after 1 week if optimal response not achieved Maintenance dose: 50 to 200 mg orally once a day Maximum dose: 200 mg per day Comments: -Some patients may require 200 mg per day to attain optimal effect. Use: For the long-term management of angina pectoris due to coronary atherosclerosis. Usual Adult Dose of Atenolol for Myocardial Infarction: 50 mg orally twice a day or 100 mg orally once a day Comments: -If IV beta blockers are contraindicated or inappropriate, oral therapy should continue for at least 7 days post-myocardial infarction (MI). -Treatment with beta blockers post MI should generally continue for 1 to 3 years if there are no contraindications. Use: For the management of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality. Usual Geriatric Dose of Atenolol for Hypertension: Initial dose: Consider reducing the starting dose to 25 mg orally once a day   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme weakness or lack of energy, very slow heart rate, shortness of breath, or fainting. What should I avoid while taking atenolol? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Atenolol side effects Get emergency medical help if you have signs of an allergic reaction to atenolol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: new or worsening chest pain; slow or uneven heartbeats; a light-headed feeling, like you might pass out; shortness of breath (even with mild exertion), swelling, rapid weight gain; or a cold feeling in your hands and feet. Common atenolol side effects may include include: cold hands or feet; dizziness; tiredness; or depressed mood. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect atenolol? Tell your doctor about all your current medicines and any you start or stop using, especially: digoxin, digitalis; indomethacin; any other beta-blocker--bisoprolol, carvedilol, labetalol, metoprolol, nebivolol, propranolol, sotalol, timolol, and others; or heart or blood pressure medication--amiodarone, clonidine, diltiazem, disopyramide, nicardipine, nifedipine, reserpine, verapamil, and others. This list is not complete. Other drugs may interact with atenolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is hydrochlorothiazide and benazepril? Hydrochlorothiazide is a thiazide diuretic (water pill) and benazepril is an ACE inhibitor (ACE stands for angiotensin converting enzyme). Hydrochlorothiazide and benazepril is a combination medicine used to treat hypertension (high blood pressure). Hydrochlorothiazide and benazepril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and benazepril and tell your doctor right away. You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take hydrochlorothiazide and benazepril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and benazepril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or benazepril, or if: you are unable to urinate; you have ever had angioedema; you recently took a heart medicine called sacubitril; you are allergic to sulfa drugs; or you are allergic to any ACE inhibitor (captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril). Do not take hydrochlorothiazide and benazepril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and benazepril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and benazepril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: asthma or allergies; kidney disease (or if you are on dialysis); cirrhosis or other liver disease; glaucoma; congestive heart failure; gout; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); lupus; if you are allergic to penicillin; or if you are on a low salt diet. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while you are using this medicine. How should I take hydrochlorothiazide and benazepril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and benazepril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and benazepril. Keep using hydrochlorothiazide and benazepril as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased thirst, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and benazepril? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol may increase certain side effects of hydrochlorothiazide and benazepril. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Hydrochlorothiazide and benazepril side effects Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; jaundice (yellowing of the skin or eyes); blurred vision, tunnel vision, eye pain, or seeing halos around lights; fever, chills, flu-like symptoms, sore throat, mouth sores; signs of an electrolyte imbalance--leg cramps, constipation, muscle pain or weakness, irregular heartbeats, feeling jittery, increased thirst or urination, numbness or tingling, loss of movement; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Common side effects may include: dizziness; cough; headache; or feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and benazepril dosing information Usual Adult Dose for Hypertension: Benazepril 5 to 20 mg-Hydrochlorothiazide 6.25 to 25 mg orally once a day Maximum dose: Benazepril 20 mg-Hydrochlorothiazide 25 mg Comments: May increase dose after 2 to 3 weeks as needed to achieve blood pressure goal.   What other drugs will affect hydrochlorothiazide and benazepril? Tell your doctor about all your current medicines. Many drugs can affect hydrochlorothiazide and benazepril, especially: other blood pressure medications, including another diuretic or "water pill"; digoxin; lithium; cancer medicine; gold injections to treat arthritis; insulin or oral diabetes medicine; a muscle relaxer; medicine to prevent organ transplant rejection--cyclosporine, everolimus, sirolimus, tacrolimus; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

What is hydrochlorothiazide and bisoprolol? Hydrochlorothiazide is a thiazide diuretic (water pill). Bisoprolol is a beta-blocker. Hydrochlorothiazide and bisoprolol is a combination medicine used to treat high blood pressure (hypertension). Hydrochlorothiazide and bisoprolol may also be used for purposes not listed in this medication guide. Warnings You should not use hydrochlorothiazide and bisoprolol if you are unable to urinate. You should not use hydrochlorothiazide and bisoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block," severe heart failure, or slow heartbeats that have caused you to faint. Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or bisoprolol, or if you have: severe or uncontrolled heart failure; slow heartbeats that have caused you to faint; a serious heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree); an allergy to sulfa drugs; or if you are unable to urinate. Tell your doctor if you have ever had: congestive heart failure; asthma or other breathing disorder; diabetes; a thyroid disorder; glaucoma; peripheral vascular disease such as Raynaud's syndrome; kidney disease; liver disease (or cirrhosis); lupus; gout; or an allergy to sulfa drugs or penicillin. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine. This medicine is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and bisoprolol? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and bisoprolol. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated. If you are diabetic, check your blood sugar carefully. Taking bisoprolol may make it harder for you to tell when you have low blood sugar. Your insulin or diabetes medication needs may change while you are taking hydrochlorothiazide and bisoprolol. Do not change your medication dose or schedule without your doctor's advice. If you need surgery or medical tests, tell the doctor you currently use hydrochlorothiazide and bisoprolol. You may need to stop for a short time. Do not skip doses or stop using hydrochlorothiazide and bisoprolol suddenly. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature, away from heat and moisture. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion, leg cramps, numbness and tingling, slow heartbeats or fainting. What should I avoid while taking hydrochlorothiazide and bisoprolol? Avoid drinking alcohol. It may increase your blood levels of bisoprolol. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Hydrochlorothiazide and bisoprolol side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Call your doctor at once if you have: chest pain; fast, slow, or uneven heartbeats; a light-headed feeling, like you might pass out; blurred vision, tunnel vision, eye pain, or seeing halos around lights; shortness of breath (even with mild exertion), swelling, rapid weight gain; liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); signs of an electrolyte imbalance--increased thirst or urination, constipation, muscle pain or weakness, leg cramps, numbness or tingling, feeling jittery, irregular heartbeats, fluttering in your chest, or a choking feeling; low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky. Common side effects may include: dizziness; feeling weak or tired; diarrhea, nausea, indigestion; headache; or cough. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and bisoprolol dosing information Usual Adult Dose for Hypertension: Initial dose: Bisoprolol 2.5 mg-Hydrochlorothiazide 6.25 mg orally once a day Maximum dose: Bisoprolol 20 mg-Hydrochlorothiazide 12.5 mg orally once a day Comments: -Increase the dose every 14 days if optimal response not achieved. -This drug may be substituted for titrated individual components (e.g., inadequate control on bisoprolol 2.5 to 20 mg or adequate control on hydrochlorothiazide 50 mg but with significant potassium loss). -Abrupt discontinuation should be avoided; taper therapy gradually over approximately 2 weeks. -If withdrawal symptoms occur, therapy may be temporarily reinstituted.   What other drugs will affect hydrochlorothiazide and bisoprolol? Tell your doctor about all your other medicines, especially: colestipol or cholestyramine; insulin or oral diabetes medicine; lithium; sedatives or narcotic medicine; heart or blood pressure medicine--clonidine, digoxin, diltiazem, disopyramide, reserpine, verapamil, and others; NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or steroid medicine--prednisone and others. This list is not complete. Other drugs may affect hydrochlorothiazide and bisoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is bumetanide? Bumetanide is diuretic that is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Bumetanide may also be used for purposes not listed in this medication guide. Warnings You should not use bumetanide if you are unable to urinate, if you have severe kidney or liver disease, if you are severely dehydrated, or if you have an electrolyte imbalance (low potassium or magnesium). Before taking this medicine You should not use bumetanide if you are allergic to it, or if you have: severe kidney disease or are unable to urinate; severe liver disease or cirrhosis; severe dehydration; or an electrolyte imbalance (such as low levels of potassium or magnesium in your blood). Tell your doctor if you have ever had: a heart rhythm disorder; liver disease; kidney disease (or if you are on dialysis); gout; an allergy to sulfa drugs; or if you are on a low-salt diet. Tell your doctor if you are pregnant or breast-feeding. Bumetanide is not approved for use by anyone younger than 18 years old. How should I take bumetanide? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Bumetanide injection is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. Bumetanide will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about taking potassium supplements or getting enough salt and potassium in your diet. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking bumetanide. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. You will need frequent medical tests. Store at room temperature away from heat, moisture, and light.   What happens if I miss a dose? Bumetanide is sometimes used only once, so you may not be on a dosing schedule. If you are on a dosing schedule, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme dizziness or weakness, confusion, loss of appetite, stomach cramps, and vomiting. What should I avoid while taking bumetanide? Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking bumetanide. What are the possible side effects of bumetanide? Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: hearing problems; confusion, hallucinations, problems with thought or memory; trouble speaking or understanding what is said to you; unusual weakness; twitching, or a seizure; weak or shallow breathing; easy bruising, unusual bleeding, purple or red spots under your skin; low magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin. Common side effects may include: muscle cramps; dizziness; low blood presure; nausea; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect bumetanide? Bumetanide can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Tell your doctor about all your other medicines, especially: lithium; digoxin; probenecid; indomethacin; blood pressure medication; or any other diuretic. This list is not complete. Other drugs may affect bumetanide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and candesartan? Hydrochlorothiazide and candesartan is a combination medicine used to treat high blood pressure (hypertension). Hydrochlorothiazide and candesartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and candesartan and tell your doctor right away. If you have diabetes, do not use hydrochlorothiazide and candesartan together with any medication that contains aliskiren (a blood pressure medicine). What should I with my healthcare provider before taking hydrochlorothiazide and candesartan? You should not use this medicine if you are allergic to candesartan or hydrochlorothiazide, or if: you are unable to urinate; or you are allergic to sulfa drugs. If you have diabetes, do not use hydrochlorothiazide and candesartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and candesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: liver disease; congestive heart failure; glaucoma; low or high levels of potassium in your blood; asthma or allergies; high cholesterol or triglyceride levels; gout; lupus; diabetes; or an allergy to penicillin. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. This medicine can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and candesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and candesartan with or without food. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and candesartan. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and candesartan? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and candesartan. Drinking alcohol can further lower your blood pressure and may cause side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Hydrochlorothiazide and candesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and candesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: eye pain, vision problems; a light-headed feeling, like you might pass out; little or no urinating; jaundice (yellowing of the skin or eyes); easy bruising, unusual bleeding; or signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling. Common side effects may include: dizziness; back pain; or cold or flu symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Candesartan / hydrochlorothiazide side effects (more detail) Hydrochlorothiazide and candesartan dosing information Usual Adult Dose for Hypertension: Candesartan 16 to 32 mg-Hydrochlorothiazide 12.5 to 50 mg orally daily in 1 to 2 divided doses Comments: -The recommended starting dose of candesartan is 16 mg orally once a day when used as monotherapy in patients who are not volume depleted; doses larger than 32 mg do not appear to have a greater blood pressure lowering effect. -A patient whose blood pressure remains uncontrolled on candesartan 32 mg can expect an incremental effect from candesartan 32 mg-hydrochlorothiazide 12.5 mg -A patient whose blood pressure remains uncontrolled on hydrochlorothiazide 25 mg can expect an incremental effect from candesartan 16 mg-hydrochlorothiazide 12.5 mg; a patient whose blood pressure is controlled on hydrochlorothiazide 25 mg but is experiencing decreases in serum potassium can expect the same or incremental blood pressure effects from candesartan 16 mg-hydrochlorothiazide 12.5 mg and serum potassium may improve. -Maximal antihypertensive effect can be expected within 4 weeks of treatment initiation.   What other drugs will affect hydrochlorothiazide and candesartan? Tell your doctor about all your other medicines, especially: lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and candesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is chlorthalidone? Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Chlorthalidone is also used to treat high blood pressure (hypertension). Chlorthalidone may also be used for purposes not listed in this medication guide. Warnings You should not use chlorthalidone if you are unable to urinate, or if you are allergic to sulfa drugs. Before taking this medicine You should not use chlorthalidone if you are allergic to it, or if: you are unable to urinate; or you are allergic to sulfa drugs. Tell your doctor if you have ever had: kidney disease; heart failure; gout; high cholesterol or triglycerides; diabetes; or if you are on a low-salt diet. Tell your doctor if you are pregnant or plan to become pregnant. Taking chlorthalidone during pregnancy may cause side effects in the newborn baby, such as jaundice (yellowing of the skin or eyes), bruising or bleeding, low blood sugar, or an electrolyte imbalance. Do not start or stop taking chlorthalidone during pregnancy without your doctor's advice. Although chlorthalidone may cause side effects in a newborn, having high blood pressure during pregnancy can cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby. You should not breastfeed while using chlorthalidone. How should I take chlorthalidone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking chlorthalidone. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated. chlorthalidone can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorthalidone. If you need surgery, tell your surgeon you currently use this medicine. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store this medicine at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, weakness, dizziness, drowsiness, extreme thirst, muscle pain, or rapid heartbeats. What should I avoid while taking chlorthalidone? Drinking alcohol with chlorthalidone can cause side effects. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Chlorthalidone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; low sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; low magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath. Common side effects may include: low blood pressure (feeling light-headed); kidney problems; dizziness; or an electrolyte imbalance (such as low levels of potassium, sodium, or magnesium in your blood). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Chlorthalidone dosing information Usual Adult Dose for Hypertension: -Initial dose: 25 mg orally once a day -Titration: Increase to 50 mg orally once a day if response is inadequate; if response is still inadequate, increase to 100 mg orally once a day, or a second antihypertensive drug (step 2 therapy) may be added -Maintenance dose: 25 to 100 mg orally once a day -Maximum dose: 100 mg orally once a day Comments: -Doses should be taken in the morning with food. -Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response. -Effectiveness is well sustained during continued use. Use: Hypertension (alone or with another antihypertensive drug) Usual Adult Dose for Edema: -Initial dose: 50 to 100 mg orally once a day, or 100 mg orally every other day; some patients may require 150 to 200 mg orally at these intervals -Maximum dose: 200 mg orally once a day Comments: -Doses should be taken in the morning with food. -Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response. -Effectiveness is well sustained during continued use. Use: For edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure   What other drugs will affect chlorthalidone? Using chlorthalidone with other drugs that make you light-headed can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: other blood pressure medications; lithium; digoxin, digitalis; insulin or oral diabetes medicine; or steroid medicine. This list is not complete. Other drugs may affect chlorthalidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is Dyrenium? Dyrenium is a potassium-sparing diuretic (water pill) that is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney condition called nephrotic syndrome. Dyrenium is also used to treat edema caused by using steroid medicine or having too much aldosterone in your body. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in your body. Dyrenium may also be used for purposes not listed in this medication guide. Warnings You should not use Dyrenium if you have severe kidney or liver disease, urination problems, or high levels of potassium in your blood. You should not take Dyrenium if you also take potassium supplements, or other diuretics such as amiloride or spironolactone. Call your doctor right away if you have signs of hyperkalemia (high potassium), such as nausea, irregular heartbeats, weakness, or loss of movement. High potassium may be more likely in older adults, or in people with kidney disease, diabetes, or severe illness. Before taking this medicine You should not use Dyrenium if you are allergic to it, or if you have: severe kidney disease, or if you are unable to urinate; severe liver disease; high potassium levels (hyperkalemia); or if you take potassium supplements, or another potassium-sparing diuretic such as amiloride, eplerenone, or spironolactone. Tell your doctor if you have ever had: diabetes; heart disease; kidney disease; liver disease; gout; or kidney stones. Using Dyrenium may increase your risk of developing hyperkalemia (high levels of potassium in your blood). High potassium may be more likely in older adults, or in people with kidney disease, diabetes, or severe illness. Tell your doctor if you are pregnant or if you become pregnant. Dyrenium may harm an unborn baby. However, the benefit of treating edema during pregnancy may outweigh the risk to the baby. You should not breastfeed while using Dyrenium. Dyrenium is not approved for use by anyone younger than 18 years old. How should I take Dyrenium? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take Dyrenium after eating a meal to avoid stomach upset. Taking a diuretic can make you urinate more often, which could disrupt your sleep. If you take Dyrenium only once per day, take it in the morning to reduce the chance of night-time urination. You may need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Dyrenium. If you need surgery, tell the surgeon ahead of time that you are using Dyrenium. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased nausea, vomiting, unusual heart rate, muscle weakness, or loss of movement. What should I avoid while taking Dyrenium? Avoid driving or hazardous activity until you know how Dyrenium will affect you. Your reactions could be impaired. Drinking alcohol with this medicine can cause side effects. Dyrenium could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Dyrenium side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Dyrenium and call your doctor at once if you have: pale skin, easy bruising or bleeding; slow, fast, or uneven heartbeat; jaundice (yellowing of the skin or eyes); little or no urinating; signs of a kidney stone--sudden pain in your back or side, vomiting, fever, chills, painful urination, and urine that looks, red, pink, brown, or cloudy; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: nausea, diarrhea; dizziness, headache; dry mouth; or feeling weak or tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Dyrenium? Tell your doctor about all your other medicines, especially: any other diuretic; lithium; insulin or oral diabetes medicine; heart or blood pressure medicine; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect Dyrenium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and enalapril? Hydrochlorothiazide is a thiazide diuretic (water pill) and enalapril is an ACE inhibitor (ACE stands for angiotensin converting enzyme). Hydrochlorothiazide and enalapril is a combination medicine used to treat hypertension (high blood pressure). Hydrochlorothiazide and enalapril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and enalapril and tell your doctor right away. You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or enalapril, or if: you are unable to urinate; you have ever had angioedema; you recently took a heart medicine called sacubitril; you are allergic to sulfa drugs; or you are allergic to any ACE inhibitor (benazepril, captopril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril). Do not take hydrochlorothiazide and enalapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and enalapril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and enalapril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: asthma or allergies; kidney disease (or if you are on dialysis); cirrhosis or other liver disease; glaucoma; congestive heart failure; gout; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); lupus; if you are allergic to penicillin; or if you are on a low salt diet. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Enalapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while you are using this medicine. How should I take hydrochlorothiazide and enalapril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and enalapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and enalapril. Keep using hydrochlorothiazide and enalapril as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased thirst, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and enalapril? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol may increase certain side effects of hydrochlorothiazide and enalapril. Hydrochlorothiazide and enalapril side effects Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; jaundice (yellowing of the skin or eyes); blurred vision, tunnel vision, eye pain, or seeing halos around lights; fever, chills, flu-like symptoms, sore throat, mouth sores; signs of an electrolyte imbalance--leg cramps, constipation, muscle pain or weakness, irregular heartbeats, feeling jittery, increased thirst or urination, numbness or tingling, loss of movement; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Common side effects may include: dizziness; cough; headache; or nausea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and enalapril dosing information Usual Adult Dose for Hypertension: Enalapril 5 to 10 mg-Hydrochlorothiazide 12.5 to 25 mg orally once a day Maximum dose: Enalapril 20 mg-Hydrochlorothiazide 50 mg per day Comments: Hydrochlorothiazide may be increased after 2 to 3 weeks. Use: Treatment of hypertension only after failure to achieve the desired effect with monotherapy or the titrated components.   What other drugs will affect hydrochlorothiazide and enalapril? Tell your doctor about all your current medicines. Many drugs can affect hydrochlorothiazide and enalapril, especially: other blood pressure medications, including another diuretic or "water pill"; digoxin; lithium; cancer medicine; gold injections to treat arthritis; insulin or oral diabetes medicine; a muscle relaxer; medicine to prevent organ transplant rejection--cyclosporine, everolimus, sirolimus, tacrolimus; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete and many other drugs may affect hydrochlorothiazide and enalapril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is furosemide? Furosemide is a loop diuretic (water pill) that prevents your body from absorbing too much salt. This allows the salt to instead be passed in your urine. Furosemide is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Furosemide is also used to treat high blood pressure (hypertension). Warnings You should not use furosemide if you are unable to urinate. Do not take more than your recommended dose. High doses of furosemide may cause irreversible hearing loss. Before using furosemide, tell your doctor if you have kidney disease, enlarged prostate, urination problems, cirrhosis or other liver disease, an electrolyte imbalance, high cholesterol, gout, lupus, diabetes, or an allergy to sulfa drugs. Tell your doctor if you have recently had an MRI (magnetic resonance imaging) or any type of scan using a radioactive dye that is injected into your veins. Do not take more of this medication than is recommended. If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms. Before taking this medicine You should not use furosemide if you are allergic to it, or if you are unable to urinate. Tell your doctor if you have ever had: kidney disease; enlarged prostate, bladder obstruction, urination problems; cirrhosis or other liver disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); gout; lupus; diabetes; or a sulfa drug allergy. Tell your doctor if you have an MRI (magnetic resonance imaging) or any type of scan using a radioactive dye that is injected into your veins. Both contrast dyes and furosemide can harm your kidneys. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Furosemide may slow breast milk production. How should I take furosemide? Take furosemide exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Furosemide oral is taken by mouth. The injection is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. You may receive your first dose in a hospital or clinic setting if you have severe liver disease. Do not take more than your recommended dose. High doses of furosemide may cause irreversible hearing loss. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Furosemide doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. Furosemide will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about using potassium supplements or getting enough salt and potassium in your diet. Your blood pressure will need to be checked often and you may need other medical tests. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. If you need surgery, tell the surgeon ahead of time that you are using this medicine. Store at room temperature away from moisture, heat, and light. Throw away any unused oral liquid after 90 days.   What happens if I miss a dose? Furosemide is sometimes used only once, so you may not be on a dosing schedule. If you are using the medication regularly, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling very thirsty or hot, heavy sweating, hot and dry skin, extreme weakness, or fainting. What to avoid Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking furosemide. Drinking alcohol with furosemide can cause side effects. If you have high blood pressure, ask a doctor or pharmacist before taking any medicines that can raise your blood pressure, such as diet pills or cough-and-cold medicine. Furosemide side effects Get emergency medical help if you have signs of an allergic reaction to furosemide (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). To make sure this medicine is safe for you, tell your doctor if you have: a light-headed feeling, like you might pass out; ringing in your ears, hearing loss; muscle spasms or contractions; pale skin, easy bruising, unusual bleeding; high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; signs of liver or pancreas problems - loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, dark urine, jaundice (yellowing of the skin or eyes); or signs of an electrolyte imbalance - dry mouth, thirst, weakness, drowsiness, feeling jittery or unsteady, vomiting, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle cramps, muscle weakness or limp feeling. Common furosemide side effects may include: diarrhea, constipation, loss of appetite; numbness or tingling; headache, dizziness; or blurred vision. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect furosemide? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. If you also take sucralfate, take your furosemide dose 2 hours before or 2 hours after you take sucralfate. Tell your doctor about all your other medicines, especially: another diuretic, especially ethacrynic acid; chloral hydrate; lithium; phenytoin; an injected antibiotic; cancer medicine, such as cisplatin; heart or blood pressure medicine; or salicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others. This list is not complete. Other drugs may interact with furosemide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is HCTZ? HCTZ (hydrochlorothiazide) is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. HCTZ is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. HCTZ is also used to treat high blood pressure (hypertension). Warnings You should not use HCTZ if you are allergic to hydrochlorothiazide or if you are unable to urinate. Before using HCTZ, tell your doctor if you have liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs or penicillin. Avoid drinking alcohol, which can increase some of the side effects of HCTZ. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. There are many other drugs that can interact with HCTZ. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. If you are being treated for high blood pressure, keep using HCTZ even if you feel fine. High blood pressure often has no symptoms. Before taking this medicine You should not use HCTZ if you are allergic to hydrochlorothiazide, or if you are unable to urinate. To make sure HCTZ is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; gout; glaucoma; low levels of potassium or sodium in your blood; high levels of calcium in your blood; a parathyroid gland disorder; diabetes; or an allergy to sulfa drugs or penicillin. Tell your doctor if you are pregnant or plan to become pregnant. If you take HCTZ during pregnancy, your newborn baby may develop jaundice or other problems. You should not breastfeed while using HCTZ. HCTZ is not approved for use by anyone younger than 18 years old. How should I take HCTZ? Take HCTZ exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking HCTZ, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your blood pressure will need to be checked often. Your blood and urine may be tested if you have been vomiting or are dehydrated. If you need surgery, tell your surgeon you currently use HCTZ. You may need to stop for a short time. Keep using HCTZ as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store HCTZ at room temperature away from moisture, heat, and freezing. Keep the bottle tightly closed when not in use. HCTZ dosing information Usual Adult Dose of HCTZ for Edema: Usual dose: 25 mg to 100 mg orally once or twice daily Comments: -Some patients respond to intermittent therapy, (i.e., administration on alternate days or on 3 to 5 days each week). Excessive response and undesirable electrolyte imbalance are less likely to occur with intermittent dosing. Usual Adult Dose of HCTZ for Hypertension: Initial dose: 25 mg orally once daily Maintenance dose: May increase to 50 mg orally daily, as a single or 2 divided doses Comments: -Patients usually do not require doses in excess of 50 mg daily when used concomitantly with other antihypertensive agents. Usual Adult Dose of HCTZ for Nephrocalcinosis: Initial: 25 mg orally once daily Maintenance dose: May increase to 50 mg twice daily Usual Adult Dose Dose of HCTZ for Osteoporosis: Initial: 25 mg orally once daily Maintenance dose: May increase to 50 mg daily Usual Adult Dose Dose of HCTZ for Diabetes Insipidus: Initial: 50 mg orally once daily Maintenance dose: May increase to 100 mg orally daily Usual PediatricDose of HCTZ Dose for Edema: Less than 6 months: Up to 3 mg/kg/day (up to 1.5 mg/pound) orally in 2 divided doses Less than 2 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day Usual Pediatric Dose Dose of HCTZ for Hypertension: Less than 6 months: Up to 3 mg/kg/day (up to 1.5 mg/pound) orally in 2 divided doses Less than 2 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day   What happens if I miss a dose? Take HCTZ as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, dizziness, dry mouth, thirst, and muscle pain or weakness. What should I avoid while taking HCTZ? HCTZ may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol with HCTZ can cause side effects. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. HCTZ side effects Get emergency medical help if you have signs of an allergic reaction to hydrochlorothiazide (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Call your doctor at once if you have: a light-headed feeling; eye pain, vision problems; jaundice (yellowing of the skin or eyes); pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum); shortness of breath, wheezing, cough with foamy mucus, chest pain; dehydration symptoms - feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or signs of an electrolyte imbalance - increased thirst or urination, confusion, vomiting, constipation, muscle pain, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling. Common hydrochlorothiazide side effects may include: weakness; feeling like you might pass out; severe pain in your upper stomach spreading to your back, nausea and vomiting; fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or electrolyte imbalance. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect HCTZ? Taking HCTZ with other drugs that make you light-headed can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cholestyramine, colestipol; insulin or oral diabetes medicine; lithium; other blood pressure medications; steroid medicine; or NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is HCTZ? HCTZ (hydrochlorothiazide) is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. HCTZ is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. HCTZ is also used to treat high blood pressure (hypertension). Warnings You should not use HCTZ if you are allergic to hydrochlorothiazide or if you are unable to urinate. Before using HCTZ, tell your doctor if you have liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs or penicillin. Avoid drinking alcohol, which can increase some of the side effects of HCTZ. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. There are many other drugs that can interact with HCTZ. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. If you are being treated for high blood pressure, keep using HCTZ even if you feel fine. High blood pressure often has no symptoms. Before taking this medicine You should not use HCTZ if you are allergic to hydrochlorothiazide, or if you are unable to urinate. To make sure HCTZ is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; gout; glaucoma; low levels of potassium or sodium in your blood; high levels of calcium in your blood; a parathyroid gland disorder; diabetes; or an allergy to sulfa drugs or penicillin. Tell your doctor if you are pregnant or plan to become pregnant. If you take HCTZ during pregnancy, your newborn baby may develop jaundice or other problems. You should not breastfeed while using HCTZ. HCTZ is not approved for use by anyone younger than 18 years old. How should I take HCTZ? Take HCTZ exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking HCTZ, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your blood pressure will need to be checked often. Your blood and urine may be tested if you have been vomiting or are dehydrated. If you need surgery, tell your surgeon you currently use HCTZ. You may need to stop for a short time. Keep using HCTZ as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store HCTZ at room temperature away from moisture, heat, and freezing. Keep the bottle tightly closed when not in use. HCTZ dosing information Usual Adult Dose of HCTZ for Edema: Usual dose: 25 mg to 100 mg orally once or twice daily Comments: -Some patients respond to intermittent therapy, (i.e., administration on alternate days or on 3 to 5 days each week). Excessive response and undesirable electrolyte imbalance are less likely to occur with intermittent dosing. Usual Adult Dose of HCTZ for Hypertension: Initial dose: 25 mg orally once daily Maintenance dose: May increase to 50 mg orally daily, as a single or 2 divided doses Comments: -Patients usually do not require doses in excess of 50 mg daily when used concomitantly with other antihypertensive agents. Usual Adult Dose of HCTZ for Nephrocalcinosis: Initial: 25 mg orally once daily Maintenance dose: May increase to 50 mg twice daily Usual Adult Dose Dose of HCTZ for Osteoporosis: Initial: 25 mg orally once daily Maintenance dose: May increase to 50 mg daily Usual Adult Dose Dose of HCTZ for Diabetes Insipidus: Initial: 50 mg orally once daily Maintenance dose: May increase to 100 mg orally daily Usual PediatricDose of HCTZ Dose for Edema: Less than 6 months: Up to 3 mg/kg/day (up to 1.5 mg/pound) orally in 2 divided doses Less than 2 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day Usual Pediatric Dose Dose of HCTZ for Hypertension: Less than 6 months: Up to 3 mg/kg/day (up to 1.5 mg/pound) orally in 2 divided doses Less than 2 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day   What happens if I miss a dose? Take HCTZ as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, dizziness, dry mouth, thirst, and muscle pain or weakness. What should I avoid while taking HCTZ? HCTZ may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol with HCTZ can cause side effects. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. HCTZ side effects Get emergency medical help if you have signs of an allergic reaction to hydrochlorothiazide (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Call your doctor at once if you have: a light-headed feeling; eye pain, vision problems; jaundice (yellowing of the skin or eyes); pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum); shortness of breath, wheezing, cough with foamy mucus, chest pain; dehydration symptoms - feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or signs of an electrolyte imbalance - increased thirst or urination, confusion, vomiting, constipation, muscle pain, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling. Common hydrochlorothiazide side effects may include: weakness; feeling like you might pass out; severe pain in your upper stomach spreading to your back, nausea and vomiting; fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or electrolyte imbalance. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect HCTZ? Taking HCTZ with other drugs that make you light-headed can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cholestyramine, colestipol; insulin or oral diabetes medicine; lithium; other blood pressure medications; steroid medicine; or NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is indapamide? Indapamide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Indapamide treats fluid retention (edema) in people with congestive heart failure. indapamide is also used to treat high blood pressure (hypertension). Indapamide may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you are allergic to sulfa drugs or if you are unable to urinate. Before taking this medicine You should not use indapamide if you are allergic to it, or if: you are unable to urinate; or you are allergic to sulfa drugs. To make sure indapamide is safe for you, tell your doctor if you have: cirrhosis or other liver disease; kidney disease; low levels of potassium or sodium in your blood; gout; diabetes; lupus; or if you are on a low-salt diet. Indapamide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether indapamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using indapamide. Indapamide is not approved for use by anyone younger than 18 years old. How should I take indapamide? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Indapamide is usually taken once per day in the morning. Follow your doctor's dosing instructions very carefully. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine, which can lead to severely low blood pressure or a serious electrolyte imbalance. While using indapamide, you may need frequent medical tests and blood pressure checks. Your blood and urine may both be tested if you have been vomiting or are dehydrated. If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include vomiting, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness. What should I avoid while taking indapamide? Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Indapamide side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have signs of an electrolyte imbalance, such as: drowsiness, lack of energy, feeling tired; leg cramps, muscle weakness or limp feeling; severe weakness, loss of coordination, feeling unsteady; fast or irregular heartbeats, fluttering in your chest, feeling restless; numbness or tingling; vomiting, constipation; headache, confusion, slurred speech; a light-headed feeling, like you might pass out; dry mouth, increased thirst; or little or no urinating. Common side effects may include: dizziness; weakness, tiredness; back pain, muscle cramps; feeling anxious or agitated; headache; or runny nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Indapamide dosing information Usual Adult Dose for Edema: Initial dose: 2.5 mg orally once a day. Usual Adult Dose for Hypertension: Initial dose: 1.25 mg orally once a day.   What other drugs will affect indapamide? Tell your doctor about all your current medicines and any you start or stop using, especially: digoxin, digitalis; lithium; blood pressure medication; or steroids (prednisone and others). This list is not complete. Other drugs may interact with indapamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.