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What is omega-3 polyunsaturated fatty acids? Omega-3 polyunsaturated fatty acids are used together with diet and exercise to help lower triglyceride levels in the blood. It is not known if omega-3 polyunsaturated fatty acids will prevent a heart attack or stroke. Talk to your doctor about your risk factors. Omega-3 polyunsaturated fatty acids may also be used for purposes not listed in this medication guide. Warnings Follow all directions on the label and package. Use exactly as directed. Before taking this medicine You should not use omega-3 polyunsaturated fatty acids if you are allergic to omega-3 polyunsaturated fatty acids or soybeans. Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: an allergy to fish or shellfish; diabetes; liver disease; a heart rhythm disorder; a pancreas disorder; or underactive thyroid. Tell your doctor if you are pregnant or breastfeeding. Not approved for use by anyone younger than 18 years old. How should I take omega-3 polyunsaturated fatty acids? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Swallow the capsule whole and do not crush, chew, break, or open it. Take with food. You may need frequent blood tests. You may need to follow a special diet. Follow all instructions of your doctor or dietitian. Learn about the foods you should eat or avoid. Tell your doctor if you have a planned surgery. Store at room temperature away from moisture and heat. Do not freeze. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking omega-3 polyunsaturated fatty acids? Avoid eating foods high in fat or cholesterol, or omega-3 polyunsaturated fatty acids will not be as effective. Avoid drinking alcohol. It can increase triglycerides and may make your condition worse. Omega-3 polyunsaturated fatty acids side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; or uneven heartbeats. Common side effects may include: loss of appetite; diarrhea, constipation, upset stomach, belching; back pain; or dry mouth, altered sense of taste. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Omega-3 polyunsaturated fatty acids side effects (more detail) Omega-3 polyunsaturated fatty acids dosing information Usual Adult Dose for Hypertriglyceridemia: 1 gram prescription only products: 4 grams orally daily; may be given as a single dose or 2 divided doses. Comments: -Assess triglyceride levels carefully before starting therapy and identify other possible causes (e.g. diabetes, hypothyroidism, medications) and manage appropriately. -Patients should be on a lipid lowering diet prior to using this medication, and continue the diet during use of this medication. -Capsules should be swallowed whole; do not break, crush, chew or dissolve capsules. -In clinical trials, the medication was administered with meals. What other drugs will affect omega-3 polyunsaturated fatty acids? Tell your doctor about all your other medicines, especially: a blood thinner--warfarin, Coumadin, Jantoven. This list is not complete. Other drugs may affect omega-3 polyunsaturated fatty acids, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.