What is hydrochlorothiazide and irbesartan? Hydrochlorothiazide is a diuretic (water pill). Irbesartan is an angiotensin II receptor blocker (sometimes called an ARB blocker). Hydrochlorothiazide and irbesartan is a combination medicine used to treat high blood pressure (hypertension). Hydrochlorothiazide and irbesartan may also be used for purposes not listed in this medication guide. Warnings You should not use hydrochlorothiazide and irbesartan if you are unable to urinate, or if you are allergic to sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to irbesartan or hydrochlorothiazide, or: if you are unable to urinate; or if you are allergic to sulfa drugs. If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and irbesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: liver disease; congestive heart failure; glaucoma; low or high levels of potassium in your blood; asthma or allergies; high cholesterol or triglyceride levels; gout; lupus; diabetes; or an allergy to penicillin. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Irbesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and irbesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and irbesartan with or without food. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and irbesartan. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and irbesartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol can further lower your blood pressure and may cause side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Hydrochlorothiazide and irbesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and irbesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: eye pain, vision problems; a light-headed feeling, like you might pass out; little or no urinating; jaundice (yellowing of the skin or eyes); easy bruising, unusual bleeding; or signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling. Common side effects may include: dizziness; muscle or joint pain; or feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.  

What is hydrochlorothiazide and lisinopril? Hydrochlorothiazide is a thiazide diuretic (water pill). Lisinopril is in an ACE inhibitor (ACE stands for angiotensin converting enzyme). Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and lisinopril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and lisinopril and tell your doctor right away. You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or lisinopril, or if: you have hereditary angioedema; you are unable to urinate; you recently took a heart medicine called sacubitril; you have an allergy to sulfa drugs; or you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, trandolapril). Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and lisinopril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); cirrhosis or other liver disease; glaucoma; heart disease or congestive heart failure; asthma or allergies; gout; lupus; an allergy to sulfa drugs or penicillin; or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using hydrochlorothiazide and lisinopril. Hydrochlorothiazide and lisinopril is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and lisinopril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and lisinopril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often, and you may need occasional blood tests. If you need surgery, tell your surgeon you currently use this medicine. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking hydrochlorothiazide and lisinopril? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and lisinopril. Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Hydrochlorothiazide and lisinopril side effects Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; eye pain, vision problems; little or no urination; weakness, drowsiness, or feeling restless; fever, chills, sore throat, mouth sores, trouble swallowing; jaundice (yellowing of the skin or eyes); high potassium--nausea, tingly feeling, chest pain, irregular heartbeats, loss of movement; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: cough; headache; dizziness; or tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and lisinopril dosing information Usual Adult Dose for Hypertension: Initial dose: Hydrochlorothiazide 12.5 mg-Lisinopril 10 to 20 mg orally once a day, depending on the current monotherapy dose Maximum dose: Hydrochlorothiazide 50 mg-Lisinopril 80 mg per day Comments: -May increase dose every 2 to 3 weeks. -If blood pressure is controlled with monotherapy hydrochlorothiazide 25 mg per day, but significant potassium loss occurs, then similar or greater blood pressure control without electrolyte disturbance may be achieved with hydrochlorothiazide 12.5 mg-lisinopril 10 mg orally once a day.   What other drugs will affect hydrochlorothiazide and lisinopril? Tell your doctor about all your other medicines, especially: any other blood pressure medication; lithium; everolimus, sirolimus, temsirolimus; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and lisinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is hydrochlorothiazide and losartan? Hydrochlorothiazide is a diuretic (water pill). Losartan is an angiotensin II receptor antagonist (sometimes called an ARB blocker). Hydrochlorothiazide and losartan is a combination medicine used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease. Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide. Warnings You should not use hydrochlorothiazide and losartan if you are unable to urinate. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or losartan, if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and losartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: lupus; liver or kidney disease; asthma or allergies; diabetes; gout; congestive heart failure; glaucoma; low or high levels of potassium in your blood; high cholesterol or triglyceride levels; or an allergy to penicillin or sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. Hydrochlorothiazide and losartan is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and losartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Your blood pressure will need to be checked often. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and losartan. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and losartan. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking hydrochlorothiazide and losartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Drinking alcohol can further lower your blood pressure and may cause side effects. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Hydrochlorothiazide and losartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; irregular heartbeats; eye pain, vision problems; kidney problems--little or no urination, rapid weight gain, swelling in your hands, feet, or ankles; new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight; or signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain, leg cramps, irregular heartbeats, numbness or tingling, severe weakness, loss of movement, feeling jittery or unsteady. Common side effects may include: dizziness; back pain; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and losartan dosing information Usual Adult Dose for Hypertension: HYPERTENSION: Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Comments: -A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day. -May increase dose if blood pressure remains uncontrolled after about 3 weeks. Use: Treatment of hypertension. This drug is not indicated for initial therapy except when hypertension is severe enough that the benefit of achieving prompt blood pressure control exceeds the risk of initiating combination therapy. SEVERE HYPERTENSION: Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose. Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day HYPERTENSION WITH LEFT VENTRICULAR HYPERTROPHY: Initial therapy: Losartan monotherapy; if blood pressure remains uncontrolled, may initiate this drug. Add-on therapy: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled, initiate hydrochlorothiazide 12.5 mg-losartan 100 mg orally once a day, followed by hydrochlorothiazide 25 mg-losartan 100 mg orally once a day, if needed. Use: To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients.   What other drugs will affect hydrochlorothiazide and losartan? If you also take cholestyramine or colestipol, take your hydrochlorothiazide and losartan dose 4 hours before or 4 to 6 hours after you take the other medicine. Tell your doctor about all your other medicines, especially: a diuretic or "water pill"; other blood pressure medications; lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is metolazone? Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. Metolazone is also used to treat high blood pressure (hypertension). Metolazone may also be used for purposes not listed in this medication guide. Warnings You should not use metolazone if you are unable to urinate, or if you have severe liver disease. What should I discuss with my doctor before taking metolazone? You should not use metolazone if you are allergic to it, or if you have: severe liver disease; or if you are unable to urinate. To make sure metolazone is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); a heart rhythm disorder; an allergy to sulfa drugs; liver disease; kidney disease; diabetes; gout; or systemic lupus erythematosus. Using metolazone during pregnancy could cause side effects in the newborn baby, such as blood cell problems, or jaundice (yellowing of the skin or eyes). Tell your doctor if you are pregnant or if you become pregnant while using metolazone. Metolazone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. Metolazone is not approved for use by anyone younger than 18 years old. How should I take metolazone? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Metolazone is usually taken only once per day. You may need to limit salt in your diet while taking this medicine. Follow your doctor's instructions carefully. While using metolazone, you may need frequent blood tests. Your blood and urine may both be tested if you have been vomiting or are dehydrated. Metolazone can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using metolazone. If you need surgery, tell the surgeon ahead of time that you are using metolazone. You may need to stop using the medicine for a short time. If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store the tablets at room temperature away from heat, light, and moisture. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe dizziness or drowsiness, dry mouth, thirst, muscle weakness, feeling light-headed, or fainting. What should I avoid while taking metolazone? Drinking alcohol with metolazone can cause side effects. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Metolazone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; pounding heartbeats or fluttering in your chest; easy bruising or bleeding; a light-headed feeling, like you might pass out; liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; other signs of an electrolyte imbalance--dry mouth, nausea, vomiting, weakness, drowsiness, lack of energy, muscle pain, little or no urination, or feeling restless; or severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Common side effects may include: dizziness, spinning sensation; drowsiness, tiredness; depressed mood; muscle or joint pain; numbness or tingly feeling; nausea, stomach pain, loss of appetite; or diarrhea, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Metolazone dosing information Usual Adult Dose for Hypertension: Initial dose: 2.5 mg orally once a day (Zaroxolyn) or 0.5 mg orally once a day (Mykrox). Usual Adult Dose for Edema: Initial dose: 5 mg orally once a day (Zaroxolyn) or 0.5 mg orally once a day (Mykrox).   What other drugs will affect metolazone? Taking metolazone with other drugs that make you make you light-headed can worsen this effect. Ask your doctor before taking metolazone with a narcotic pain medicine, muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your current medicines and any you start or stop using, especially: any other blood pressure medication; digoxin, digitalis; furosemide or other diuretics (water pills); insulin or oral diabetes medicine; lithium; methenamine; vitamin D (at high doses); a blood thinner--warfarin, Coumadin, Jantoven; NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; salicylates--aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others; or steroid medicine--prednisone and others. This list is not complete. Other drugs may interact with metolazone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is hydrochlorothiazide and metoprolol? Hydrochlorothiazide is a thiazide diuretic (water pill). Metoprolol is a beta-blocker. Hydrochlorothiazide and metoprolol is a combination medicine used to treat high blood pressure (hypertension). Hydrochlorothiazide and metoprolol may also be used for purposes not listed in this medication guide. Warnings You should not use hydrochlorothiazide and metoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly. You should not use hydrochlorothiazide and metoprolol if you are unable to urinate. Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose. Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or metoprolol, or if you have: a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), or if your heart cannot pump blood properly; slow heartbeats that have caused you to faint; severe or uncontrolled heart failure; an allergy to sulfa drugs; or if you are unable to urinate. Tell your doctor if you have ever had: congestive heart failure; slow heartbeats; blood circulation problems; asthma or other breathing disorder; peripheral vascular disease such as Raynaud's syndrome; diabetes; a thyroid disorder; kidney disease (or if you are on dialysis); pheochromocytoma (tumor of the adrenal gland); glaucoma; lupus; gout; or high cholesterol or triglycerides. Tell your doctor if you are pregnant or breastfeeding. Hydrochlorothiazide and metoprolol is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and metoprolol? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and metoprolol with or without food. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea. Your blood pressure will need to be checked often. You may also need frequent blood tests. If you are diabetic, check your blood sugar carefully. Taking hydrochlorothiazide and metoprolol can make it harder for you to tell when you have low blood sugar. Do not change your medication dose or schedule without your doctor's advice. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and metoprolol. Keep using hydrochlorothiazide and metoprolol as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Do not stop using hydrochlorothiazide and metoprolol suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heart rate, trouble breathing, or fainting. What should I avoid while taking hydrochlorothiazide and metoprolol? Avoid driving or hazardous activity until you know how hydrochlorothiazide and metoprolol will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol with this medicine can cause side effects. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Hydrochlorothiazide and metoprolol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: bronchospasm (wheezing, chest tightness, trouble breathing); slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); blurred vision, tunnel vision, eye pain, or seeing halos around lights; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: tired feeling; or stuffy nose, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.  

What is hydrochlorothiazide and olmesartan? Hydrochlorothiazide is a diuretic (water pill). Olmesartan is an angiotensin II receptor blocker (sometimes called an ARB blocker). Hydrochlorothiazide and olmesartan is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and olmesartan is usually given after other blood pressure medicines did not work or have stopped working. Hydrochlorothiazide and olmesartan may also be used for purposes not listed in this medication guide. Warnings You should not use hydrochlorothiazide and olmesartan if you are unable to urinate. Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment. If you have diabetes, do not use hydrochlorothiazide and olmesartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or olmesartan, or if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and olmesartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and olmesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease; liver disease; congestive heart failure; glaucoma; low or high levels of potassium in your blood; asthma or allergies; high cholesterol or triglyceride levels; gout; lupus; diabetes; or an allergy to penicillin or sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and olmesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Your blood pressure will need to be checked often. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and olmesartan. It may take up to 4 weeks for this medication to control your blood pressure. Keep using hydrochlorothiazide and olmesartan as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heart rate, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and olmesartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Drinking alcohol can further lower your blood pressure and may cause side effects. Avoid driving or hazardous activity until you know how hydrochlorothiazide and olmesartan will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Hydrochlorothiazide and olmesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, this medicine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: a light-headed feeling, like you might pass out; eye pain, vision problems; an unusual skin rash; easy bruising, unusual bleeding; jaundice (yellowing of the skin or eyes); kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; high potassium--slow or unusual heart rate, weakness, loss of movement; or low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. Common side effects include: nausea; dizziness; cold symptoms such as stuffy nose, sneezing, sore throat; or high levels of uric acid in your blood. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and olmesartan dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-Olmesartan 20 to 40 mg orally once a day Comments: -If blood pressure is not controlled by olmesartan alone, hydrochlorothiazide may be added starting with a dose of 12.5 mg once a day; if blood pressure is not controlled by hydrochlorothiazide alone, olmesartan may be added starting with a dose of 20 mg once a day. -If large doses of hydrochlorothiazide have been used as monotherapy and volume depletion or hyponatremia is present, use caution when adding olmesartan as marked decreases in blood pressure may occur. Consider reducing the dose of hydrochlorothiazide to 12.5 mg before adding olmesartan. -May be titrated every 2 to 4 weeks.   What other drugs will affect hydrochlorothiazide and olmesartan? If you also take cholestyramine or colestipol, take your hydrochlorothiazide and olmesartan dose 4 hours before or 4 hours after you take the other medicine. Tell your doctor about all your other medicines, especially: steroids; any other blood pressure medications; insulin or oral diabetes medicine; lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and olmesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and quinapril? Hydrochlorothiazide is a thiazide diuretic (water pill). Quinapril is in an ACE inhibitor (ACE stands for angiotensin converting enzyme). Hydrochlorothiazide and quinapril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and quinapril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and quinapril and tell your doctor right away. You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and quinapril together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or quinapril, or if: you have a history of angioedema; you are unable to urinate; you recently took a heart medicine called sacubitril; or you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril). Do not take hydrochlorothiazide and quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use hydrochlorothiazide and quinapril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and quinapril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); cirrhosis or other liver disease; glaucoma; congestive heart failure; gout; lupus; an allergy to sulfa drugs or penicillin; or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Quinapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using hydrochlorothiazide and quinapril. Hydrochlorothiazide and quinapril is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and quinapril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and quinapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Your blood pressure will need to be checked often, and you may need occasional blood tests. If you need surgery, tell your surgeon you currently use this medicine. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking hydrochlorothiazide and quinapril? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and quinapril. Do not use salt substitutes or potassium supplements while taking this medicine, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Hydrochlorothiazide and quinapril side effects Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; blurred vision, tunnel vision, eye pain, or seeing halos around lights; swelling, weight gain, shortness of breath; sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, trouble swallowing; high potassium--nausea, tingly feeling, chest pain, irregular heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low levels of sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: cough; headache, dizziness; tired feeling; or muscle pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and quinapril dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-quinapril 10 to 20 mg orally once a day Comments: -The initial dosage of hydrochlorothiazide-quinapril should be based on the patient requirements for each drug individually.   What other drugs will affect hydrochlorothiazide and quinapril? Tell your doctor about all your other medicines, especially: any other blood pressure medication; lithium; everolimus, sirolimus, temsirolimus; an antibiotic--demeclocycline, doxycycline, minocycline, eravacycline, omadacycline, sarecycline, tetracycline; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is spironolactone? Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Spironolactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. Warnings You should use spironolactone with caution if you have kidney problems, high levels of potassium in your blood, Addison's disease, if you are unable to urinate, or if you are also taking eplerenone. Spironolactone has caused tumors in animals but it is not known whether this could occur in people. Do not use this medicine for any condition that has not been checked by your doctor. Before taking this medicine You should not use spironolactone if you are allergic to it, or if you have: Addison's disease (an adrenal gland disorder); high levels of potassium in your blood (hyperkalemia); if you are unable to urinate; or if you are also taking eplerenone. To make sure spironolactone is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of calcium, magnesium, or sodium in your blood); kidney disease; liver disease; or heart disease. Tell your doctor if you are pregnant or plan to become pregnant. Having congestive heart failure, cirrhosis, or uncontrolled high blood pressure during pregnancy may lead to medical problems in the mother or the baby. Your doctor should decide whether you take spironolactone if you are pregnant. It may not be safe to breastfeed while using spironolactone. Ask your doctor about any risk. How should I take spironolactone? Take spironolactone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Do not share this medicine with another person, even if they have the same symptoms you have. You may take spironolactone with or without food, but take it the same way each time. You will need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using spironolactone. If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from heat, light, and moisture. Dosing information Usual Adult Dose for Edema: 25 to 200 mg orally per day in single or divided doses Duration of therapy: When given as the sole diuretic, continue the initial dose for at least 5 days, after which the initial dose may be adjusted to an optimal maintenance dose.Comments:-A second diuretic that acts more proximally at the renal tubule may be added if adequate diuresis has not been achieved after 5 days. The dose of this drug should remain unchanged if a second diuretic is added.Uses:-Treatment of edematous conditions in patients with congestive heart failure who are only partially responsive to or intolerant of other therapeutic measures or who are taking digitalis when other therapies are considered inappropriate.-Treatment of edematous conditions in patients with liver cirrhosis accompanied by edema and/or ascites. -Treatment of edematous conditions in patients with nephrotic syndrome when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response. Usual Adult Dose for Hypertension: Initial dose: 50 to 100 mg orally per day in single or divided doses Duration of therapy: Treatment should be continued for at least 2 weeks to achieve a maximum response. Subsequently, the dose may be adjusted according to patient response. Usual Adult Dose for Congestive Heart Failure: Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL Maintenance dose:-Patients tolerant of initial dose: May increase to 50 mg orally once a day as clinically indicated-Patients intolerant of initial dose: May decrease to 25 mg orally every other dayUse: To increase survival and reduce the need for hospitalization of severe heart failure patients (New York Heart Association [NYHA] class III to IV) when used in addition to standard therapy. Usual Adult Dose for Primary Hyperaldosteronism: Diagnostic dose: -Long test: 400 mg orally per day for 3 to 4 weeks-Short test: 400 mg orally per day for 4 daysMaintenance dose: 100 to 400 mg orally per day until surgery; may be used long-term at the lowest effective dose in patients deemed unsuitable for surgery.Comments:-For the long test, correction of hypokalemia and hypertension provides presumptive evidence of primary hyperaldosteronism.-For the short test, increased serum potassium with this drug and a decrease upon discontinuation provide presumptive evidence of primary hyperaldosteronism.Uses:-Initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets.-Short-term preoperative treatment of patients with primary hyperaldosteronism.-Long-term maintenance therapy for patients deemed unsuitable for surgery or those with idiopathic hyperaldosteronism. Usual Adult Dose for Hypokalemia: 25 to 100 mg orally per day Uses:-Treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate.-Prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate. Detailed Spironolactone dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol can increase certain side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Avoid driving or hazardous activity until you know how spironolactone will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Spironolactone side effects Get emergency medical help if you have signs of an allergic reaction to spironolactone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; high potassium level - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; o signs of other electrolyte imbalances - increased thirst or urination, confusion, vomiting, muscle pain, slurred speech, severe weakness, numbness, loss of coordination, feeling unsteady. Common spironolactone side effects may include: breast swelling or tenderness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect spironolactone? Using spironolactone with other drugs that make you dizzy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Tell your doctor about all your other medicines, especially: colchicine; digoxin; lithium; loperamide; trimethoprim; heart or blood pressure medicine (especially another diuretic); medicine to prevent a blood clot; or NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may interact with spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and spironolactone? Hydrochlorothiazide is a thiazide diuretic (water pill). Spironolactone is a potassium-sparing diuretic. Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. hydrochlorothiazide and spironolactone also treats high blood pressure (hypertension), or low potassium levels (hypokalemia) caused by using a diuretic. Do not use this medicine for any condition that has not been checked by your doctor. Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you have kidney problems, Addison's disease, high blood levels of calcium or potassium, an allergy to sulfa drugs, or if you are unable to urinate. Before taking this medicine You should not use hydrochlorothiazide and spironolactone if you are allergic to hydrochlorothiazide or spironolactone, or if you have: kidney disease or urination problems; liver disease; high levels of calcium or potassium in your blood; an allergy to sulfa drugs; or Addison's disease (an adrenal gland disorder). Tell your doctor if you have ever had: cirrhosis or other liver disease; severe kidney disease; asthma or allergies; glaucoma; gout; diabetes; or lupus. In animal studies, spironolactone caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine. This medicine is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and spironolactone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Do not share this medicine with another person, even if they have the same symptoms you have. You may need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using hydrochlorothiazide and spironolactone. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and spironolactone. You may need to stop using the medicine for a short time. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion, skin rash, nausea, vomiting, diarrhea, dizziness, and drowsiness. What should I avoid while taking hydrochlorothiazide and spironolactone? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol with hydrochlorothiazide and spironolactone can cause side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Hydrochlorothiazide and spironolactone side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if you have: a light-headed feeling, like you might pass out; blurred vision, tunnel vision, eye pain, or seeing halos around lights; breast swelling and tenderness; low blood cell counts--easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: drowsiness, dizziness, lack of energy; leg cramps; weakness; feeling like you might pass out; severe pain in your upper stomach spreading to your back, nausea and vomiting; or electrolyte imbalance. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and spironolactone dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 50 to 100 mg-Spironolactone 50 to 100 mg orally daily in 1 to 2 divided doses Uses: -Treatment of essential hypertension when other measures are considered inadequate or inappropriate. -Treatment of diuretic-induced hypokalemia in hypertensive patients when other measures are considered inappropriate. -Treatment of hypertension. Usual Adult Dose for Edema: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Usual Adult Dose for Congestive Heart Failure: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Uses: -Management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. -Treatment of diuretic-induced hypokalemia in patients with congestive heart failure (CHF) when other measures are considered inappropriate. -Treatment of patients with CHF taking digitalis when other therapies are considered inadequate or inappropriate. Usual Adult Dose for Ascites: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Use: Maintenance therapy together with bed rest and fluid and sodium restriction for cirrhosis of the liver accompanied by edema and/or ascites. Usual Adult Dose for Nephrotic Syndrome: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Use: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response.   What other drugs will affect hydrochlorothiazide and spironolactone? Using hydrochlorothiazide and spironolactone with other drugs that make you drowsy or lower your blood pressure can worsen these effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cholestyramine; digoxin; lithium; heart or blood pressure medicine, especially another diuretic; insulin or oral diabetes medicine; medicine to prevent a blood clot; NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or steroid medicine--dexamethasone, prednisone, or others. This list is not complete. Other drugs may affect hydrochlorothiazide and spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and telmisartan? Hydrochlorothiazide is a diuretic (water pill). Telmisartan is an angiotensin II receptor blocker (sometimes called an ARB blocker). Hydrochlorothiazide and telmisartan is a combination medicine is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and telmisartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. You should not use hydrochlorothiazide and telmisartan if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and telmisartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or telmisartan, if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and telmisartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and telmisartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease; liver disease; glaucoma; low or high levels of magnesium or potassium in your blood; asthma or allergies; lupus; diabetes; or an allergy to penicillin or sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and telmisartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and telmisartan with or without food. Your blood pressure will need to be checked often. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and telmisartan. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. If you need surgery or medical tests, tell the surgeon ahead of time that you are using this medicine. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. Keep each tablet in its blister pack until you are ready to take it. Gently push the tablet through the foil to remove it. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heart rate, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and telmisartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Drinking alcohol can further lower your blood pressure and may cause side effects. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Hydrochlorothiazide and telmisartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: eye pain, vision problems; a light-headed feeling, like you might pass out; jaundice (yellowing of the skin or eyes); swelling in your hands or feet, unusual weight gain; easy bruising, unusual bleeding; or signs of an electrolyte imbalance--dry mouth, increased thirst, drowsiness, confusion, feeling restless, vomiting, muscle pain or weakness, lack of energy, fast heartbeats, little or no urine, or a seizure. Common side effects may include: dizziness, feeling tired; nausea, diarrhea; back pain; or cold or flu symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and telmisartan dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-Telmisartan 80 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Telmisartan 160 mg orally once a day Comments: -This drug may be substituted for the individual titrated components. -If blood pressure remains uncontrolled by hydrochlorothiazide 25 mg orally once a day monotherapy, may switch to hydrochlorothiazide 12.5 to 25 mg-telmisartan 80 mg orally once a day. Reassess after 2 to 4 weeks; may increase up to hydrochlorothiazide 25 mg-telmisartan 160 mg orally once a day. -If blood pressure is controlled by hydrochlorothiazide 25 mg orally once a day monotherapy, but hypokalemia occurs, may switch to hydrochlorothiazide 12.5 mg-telmisartan 80 mg orally once a day. -If blood pressure remains uncontrolled by telmisartan 80 mg orally once a day monotherapy, may switch to hydrochlorothiazide 12.5 mg-telmisartan 80 mg orally once a day; may titrate up to hydrochlorothiazide 25 mg-telmisartan 160 mg orally once a day, if necessary. Use: Treatment of hypertension; not indicated for initial therapy.   What other drugs will affect hydrochlorothiazide and telmisartan? If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and telmisartan. Tell your doctor about all your other medicines, especially: any other heart or blood pressure medications; digoxin; lithium; a diuretic or "water pill"; insulin or oral diabetes medicine; opioid pain medicine; a sleeping pill; steroid medicine or adrenocorticotrophic hormone (ACTH); a barbiturate such as butabarbital, phenobarbital, or secobarbital; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and triamterene? Hydrochlorothiazide is a thiazide diuretic (water pill). Triamterene is a potassium-sparing diuretic. Hydrochlorothiazide and triamterene is a combination medicine that is used to treat fluid retention (edema) and high blood pressure (hypertension). hydrochlorothiazide and triamterene is usually given to people in whom other diuretics have caused hypokalemia (low potassium levels in your blood). Hydrochlorothiazide and triamterene may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if have kidney disease, urination problems, high levels of potassium in your blood, or if you are taking other diuretics similar to triamterene. This medicine can raise your blood potassium to dangerous levels, especially if you have kidney disease, diabetes, severe illness, or if you are an older adult. Call your doctor right away if you have signs of high potassium: nausea, tingly feeling, feeling weak or tired, slow heartbeats, or loss of movement. Before taking this medicine You should not use hydrochlorothiazide and triamterene if you are allergic to hydrochlorothiazide or triamterene, or if: you have kidney disease or are unable to urinate; you have high potassium levels (hyperkalemia); you are taking diuretics similar to triamterene, such as amiloride or spironolactone; or you are taking potassium supplements (unless your doctor tells you to). Diuretics such as triamterene can raise your blood potassium to dangerous levels. This is more likely to occur if you have kidney disease, diabetes, severe illness, or if you are an older adult. Ask your doctor about your individual risk. Tell your doctor if you have ever had: diabetes; cirrhosis or other liver disease; heart disease, heart rhythm disorder; gout; cataracts or glaucoma; an allergy to sulfa drugs or penicillin; kidney stones; o if you are on a low-salt diet. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine. This medicine is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and triamterene? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Hydrochlorothiazide and triamterene is usually taken once per day. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Your heart function may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Severe illness can affect your potassium levels. Call your doctor if you have a serious illness, injury, or medical emergency. If you need surgery or medical tests, tell the doctor you currently use this medicine. You may need to stop for a short time. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased urination, nausea, vomiting, weakness, fever, warmth or flushing in your face, or muscle spasms. What should I avoid while taking hydrochlorothiazide and triamterene? Do not use potassium supplements, salt substitutes, or low-sodium milk unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make hydrochlorothiazide and triamterene less effective. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Hydrochlorothiazide and triamterene side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Stop taking this medicine and call your doctor at once if you have: blurred vision, tunnel vision, eye pain, or seeing halos around lights; a light-headed feeling, like you might pass out; fast, slow, or uneven heart rate; signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes); high potassium level--nausea, weakness, tingly feeling, feeling weak or tired, slow heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight; or other signs of an electrolyte imbalance--thirst, dry mouth, stomach pain, drowsiness, weakness, fast heart rate, muscle pain or weakness, feeling restless or light-headed. Common side effects may include: stomach pain, nausea, diarrhea, constipation; dizziness, headache; blurred vision; or dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Hydrochlorothiazide / triamterene side effects (more detail) Hydrochlorothiazide and triamterene dosing information Usual Adult Dose for Edema: Hydrochlorothiazide 25 to 50 mg-Triamterene 37.5 to 100 mg orally once a day Comments: -Patients who become hypokalemic on 50 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 50 mg-triamterene 75 mg orally once a day. Patients who become hypokalemic on 25 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. -Patients in whom hypokalemia cannot be risked may be initiated on hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. Uses: -Treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone. -Initial therapy of hypertension or edema for patients in whom hypokalemia cannot be risked (e.g., patients on concomitant digitalis preparations or with a history of cardiac arrhythmias, etc.). Usual Adult Dose for Hypertension: Hydrochlorothiazide 25 to 50 mg-Triamterene 37.5 to 100 mg orally once a day Comments: -Patients who become hypokalemic on 50 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 50 mg-triamterene 75 mg orally once a day. Patients who become hypokalemic on 25 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. -Patients in whom hypokalemia cannot be risked may be initiated on hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. Uses: -Treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone. -Initial therapy of hypertension or edema for patients in whom hypokalemia cannot be risked (e.g., patients on concomitant digitalis preparations or with a history of cardiac arrhythmias, etc.). Detailed Hydrochlorothiazide / triamterene dosage information What other drugs can affect hydrochlorothiazide and triamterene? Tell your doctor about all your other medicines, especially: any other blood pressure medicine; amphotericin B; chlorpropamide; digoxin; laxatives; lithium; methenamine; a blood thinner; oral diabetes medicine; steroid medication (prednisone and others); an ACE inhibitor--benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and triamterene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and triamterene? Hydrochlorothiazide is a thiazide diuretic (water pill). Triamterene is a potassium-sparing diuretic. Hydrochlorothiazide and triamterene is a combination medicine that is used to treat fluid retention (edema) and high blood pressure (hypertension). hydrochlorothiazide and triamterene is usually given to people in whom other diuretics have caused hypokalemia (low potassium levels in your blood). Hydrochlorothiazide and triamterene may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if have kidney disease, urination problems, high levels of potassium in your blood, or if you are taking other diuretics similar to triamterene. This medicine can raise your blood potassium to dangerous levels, especially if you have kidney disease, diabetes, severe illness, or if you are an older adult. Call your doctor right away if you have signs of high potassium: nausea, tingly feeling, feeling weak or tired, slow heartbeats, or loss of movement. Before taking this medicine You should not use hydrochlorothiazide and triamterene if you are allergic to hydrochlorothiazide or triamterene, or if: you have kidney disease or are unable to urinate; you have high potassium levels (hyperkalemia); you are taking diuretics similar to triamterene, such as amiloride or spironolactone; or you are taking potassium supplements (unless your doctor tells you to). Diuretics such as triamterene can raise your blood potassium to dangerous levels. This is more likely to occur if you have kidney disease, diabetes, severe illness, or if you are an older adult. Ask your doctor about your individual risk. Tell your doctor if you have ever had: diabetes; cirrhosis or other liver disease; heart disease, heart rhythm disorder; gout; cataracts or glaucoma; an allergy to sulfa drugs or penicillin; kidney stones; o if you are on a low-salt diet. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine. This medicine is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and triamterene? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Hydrochlorothiazide and triamterene is usually taken once per day. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Your heart function may also need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Severe illness can affect your potassium levels. Call your doctor if you have a serious illness, injury, or medical emergency. If you need surgery or medical tests, tell the doctor you currently use this medicine. You may need to stop for a short time. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include increased urination, nausea, vomiting, weakness, fever, warmth or flushing in your face, or muscle spasms. What should I avoid while taking hydrochlorothiazide and triamterene? Do not use potassium supplements, salt substitutes, or low-sodium milk unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make hydrochlorothiazide and triamterene less effective. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Hydrochlorothiazide and triamterene side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Stop taking this medicine and call your doctor at once if you have: blurred vision, tunnel vision, eye pain, or seeing halos around lights; a light-headed feeling, like you might pass out; fast, slow, or uneven heart rate; signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes); high potassium level--nausea, weakness, tingly feeling, feeling weak or tired, slow heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight; or other signs of an electrolyte imbalance--thirst, dry mouth, stomach pain, drowsiness, weakness, fast heart rate, muscle pain or weakness, feeling restless or light-headed. Common side effects may include: stomach pain, nausea, diarrhea, constipation; dizziness, headache; blurred vision; or dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Hydrochlorothiazide / triamterene side effects (more detail) Hydrochlorothiazide and triamterene dosing information Usual Adult Dose for Edema: Hydrochlorothiazide 25 to 50 mg-Triamterene 37.5 to 100 mg orally once a day Comments: -Patients who become hypokalemic on 50 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 50 mg-triamterene 75 mg orally once a day. Patients who become hypokalemic on 25 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. -Patients in whom hypokalemia cannot be risked may be initiated on hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. Uses: -Treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone. -Initial therapy of hypertension or edema for patients in whom hypokalemia cannot be risked (e.g., patients on concomitant digitalis preparations or with a history of cardiac arrhythmias, etc.). Usual Adult Dose for Hypertension: Hydrochlorothiazide 25 to 50 mg-Triamterene 37.5 to 100 mg orally once a day Comments: -Patients who become hypokalemic on 50 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 50 mg-triamterene 75 mg orally once a day. Patients who become hypokalemic on 25 mg of hydrochlorothiazide may be transferred directly to hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. -Patients in whom hypokalemia cannot be risked may be initiated on hydrochlorothiazide 25 mg-triamterene 37.5 mg orally once a day. Uses: -Treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide alone. -Initial therapy of hypertension or edema for patients in whom hypokalemia cannot be risked (e.g., patients on concomitant digitalis preparations or with a history of cardiac arrhythmias, etc.). Detailed Hydrochlorothiazide / triamterene dosage information What other drugs can affect hydrochlorothiazide and triamterene? Tell your doctor about all your other medicines, especially: any other blood pressure medicine; amphotericin B; chlorpropamide; digoxin; laxatives; lithium; methenamine; a blood thinner; oral diabetes medicine; steroid medication (prednisone and others); an ACE inhibitor--benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and triamterene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.