What is buprenorphine and naloxone? Buprenorphine and naloxone is a combination medicine used to treat opioid addiction. Buprenorphine and naloxone is not for use as a pain medication. Buprenorphine and naloxone may also be used for purposes not listed in this medication guide. Warnings MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Taking buprenorphine and naloxone during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Before taking this medicine You should not use this medicine if you are allergic to buprenorphine or naloxone (Narcan). Tell your doctor if you have ever had: breathing problems, sleep apnea; enlarged prostate, urination problems; liver or kidney disease; abnormal curvature of the spine that affects breathing; problems with your gallbladder, adrenal gland, or thyroid; a head injury, brain tumor, or seizures; or alcoholism or drug addiction. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Ask a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby. How should I take buprenorphine and naloxone? Follow the directions on your prescription label and read all medication guides. Never use buprenorphine and naloxone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of buprenorphine and naloxone. Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine in a place where others cannot get to it. Selling or giving away opioid medicine is against the law. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. If you switch between medicines containing buprenorphine, you may not use the same dose for each one. Follow all directions carefully. Do not stop using buprenorphine and naloxone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. You will need frequent blood tests to check your liver function. All your medical care providers should know that you are being treated for opioid addiction, and that you take buprenorphine and naloxone. Make sure your family members know how to provide this information in case they need to speak for you during an emergency. Never crush or break a buprenorphine and naloxone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death. Store this medicine in the foil pouch at room temperature, away from moisture and heat. Discard an empty pouch in a place children and pets cannot get to. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription. Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, remove any unused films from the foil pack and flush the films down the toilet. Throw the empty foil pack into the trash.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opioid overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing. What should I avoid while taking buprenorphine and naloxone? Do not drink alcohol. Dangerous side effects or death could occur. Avoid driving or operating machinery until you know how buprenorphine and naloxone will affect you. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries. Buprenorphine and naloxone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once or seek emergency medical attention if you have: weak or shallow breathing, breathing that stops during sleep; a light-headed feeling, like you might pass out; confusion, loss of coordination, extreme weakness; blurred vision, slurred speech; liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or opioid withdrawal symptoms--shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain. Serious breathing problems may be more likely in older adults and those who are debilitated or have wasting syndrome or chronic breathing disorders. Common side effects may include: dizziness, drowsiness, blurred vision, feeling drunk, trouble concentrating; withdrawal symptoms; tongue pain, redness or numbness inside your mouth; nausea, vomiting, constipation; headache, back pain; fast or pounding heartbeats, increased sweating; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect buprenorphine and naloxone? You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use: cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic ("water pill"); medicines for motion sickness, irritable bowel syndrome, or overactive bladder; other opioids--opioid pain medicine or prescription cough medicine; a sedative like Valium--diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and others; drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting. This list is not complete. Other drugs may affect buprenorphine and naloxone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is buprenorphine and naloxone? Buprenorphine and naloxone is a combination medicine used to treat opioid addiction. Buprenorphine and naloxone is not for use as a pain medication. Buprenorphine and naloxone may also be used for purposes not listed in this medication guide. Warnings MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Taking buprenorphine and naloxone during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Before taking this medicine You should not use this medicine if you are allergic to buprenorphine or naloxone (Narcan). Tell your doctor if you have ever had: breathing problems, sleep apnea; enlarged prostate, urination problems; liver or kidney disease; abnormal curvature of the spine that affects breathing; problems with your gallbladder, adrenal gland, or thyroid; a head injury, brain tumor, or seizures; or alcoholism or drug addiction. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Ask a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby. How should I take buprenorphine and naloxone? Follow the directions on your prescription label and read all medication guides. Never use buprenorphine and naloxone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of buprenorphine and naloxone. Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine in a place where others cannot get to it. Selling or giving away opioid medicine is against the law. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. If you switch between medicines containing buprenorphine, you may not use the same dose for each one. Follow all directions carefully. Do not stop using buprenorphine and naloxone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. You will need frequent blood tests to check your liver function. All your medical care providers should know that you are being treated for opioid addiction, and that you take buprenorphine and naloxone. Make sure your family members know how to provide this information in case they need to speak for you during an emergency. Never crush or break a buprenorphine and naloxone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death. Store this medicine in the foil pouch at room temperature, away from moisture and heat. Discard an empty pouch in a place children and pets cannot get to. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription. Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, remove any unused films from the foil pack and flush the films down the toilet. Throw the empty foil pack into the trash.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opioid overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing. What should I avoid while taking buprenorphine and naloxone? Do not drink alcohol. Dangerous side effects or death could occur. Avoid driving or operating machinery until you know how buprenorphine and naloxone will affect you. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries. Buprenorphine and naloxone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once or seek emergency medical attention if you have: weak or shallow breathing, breathing that stops during sleep; a light-headed feeling, like you might pass out; confusion, loss of coordination, extreme weakness; blurred vision, slurred speech; liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or opioid withdrawal symptoms--shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain. Serious breathing problems may be more likely in older adults and those who are debilitated or have wasting syndrome or chronic breathing disorders. Common side effects may include: dizziness, drowsiness, blurred vision, feeling drunk, trouble concentrating; withdrawal symptoms; tongue pain, redness or numbness inside your mouth; nausea, vomiting, constipation; headache, back pain; fast or pounding heartbeats, increased sweating; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect buprenorphine and naloxone? You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use: cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic ("water pill"); medicines for motion sickness, irritable bowel syndrome, or overactive bladder; other opioids--opioid pain medicine or prescription cough medicine; a sedative like Valium--diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and others; drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting. This list is not complete. Other drugs may affect buprenorphine and naloxone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is bupropion? Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Bupropion may also be used for purposes not listed in this medication guide. Warnings You should not take bupropion if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Bupropion may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Before taking this medicine Do not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. You should not take bupropion if you are allergic to it, or if you have ever had: a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others). Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take this medicine to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking. Bupropion may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. To make sure this medicine is safe for you, tell your doctor if you have ever had: a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); depression, bipolar disorder or other mental illness; or if you drink alcohol. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms. Ask your doctor about taking this medicine if you are pregnant. It is not known whether bupropion will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking bupropion without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Bupropion is not approved for use by anyone younger than 18 years old. How should I take bupropion? Take bupropion exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure. Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole. You should not change your dose or stop using bupropion suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using bupropion. If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 to 12 weeks. Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products. Some people taking bupropion (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with bupropion. You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban. Smoking cessation may also cause new or worsening mental health problems, such as depression. This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting. What to avoid Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. This medicine can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication. Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Bupropion side effects Get emergency medical help if you have any of these signs of an allergic reaction to bupropion: (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a seizure (convulsions); confusion, unusual changes in mood or behavior; blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; fast or irregular heartbeats; or a manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep. Common bupropion side effects may include: dry mouth, sore throat, stuffy nose; ringing in the ears; blurred vision; nausea, vomiting, stomach pain, loss of appetite, constipation; sleep problems (insomnia); tremors, sweating, feeling anxious or nervous; fast heartbeats; confusion, agitation, hostility; rash; weight loss; increased urination; headache, dizziness; or muscle or joint pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect bupropion? You may have a higher risk of seizures if you use certain other medicines while taking bupropion. Many drugs can interact with bupropion. Tell your doctor about all medicines you use, and those you start or stop using during your treatment. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is bupropion? Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Bupropion may also be used for purposes not listed in this medication guide. Warnings You should not take bupropion if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Bupropion may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Before taking this medicine Do not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. You should not take bupropion if you are allergic to it, or if you have ever had: a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others). Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take this medicine to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking. Bupropion may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. To make sure this medicine is safe for you, tell your doctor if you have ever had: a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); depression, bipolar disorder or other mental illness; or if you drink alcohol. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms. Ask your doctor about taking this medicine if you are pregnant. It is not known whether bupropion will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking bupropion without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Bupropion is not approved for use by anyone younger than 18 years old. How should I take bupropion? Take bupropion exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure. Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole. You should not change your dose or stop using bupropion suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using bupropion. If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 to 12 weeks. Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products. Some people taking bupropion (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with bupropion. You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban. Smoking cessation may also cause new or worsening mental health problems, such as depression. This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion. Store at room temperature away from moisture and heat. Detailed Bupropion dosage information What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting. What to avoid Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. This medicine can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication. Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Bupropion side effects Get emergency medical help if you have any of these signs of an allergic reaction to bupropion: (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a seizure (convulsions); confusion, unusual changes in mood or behavior; blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; fast or irregular heartbeats; or a manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep. Common bupropion side effects may include: dry mouth, sore throat, stuffy nose; ringing in the ears; blurred vision; nausea, vomiting, stomach pain, loss of appetite, constipation; sleep problems (insomnia); tremors, sweating, feeling anxious or nervous; fast heartbeats; confusion, agitation, hostility; rash; weight loss; increased urination; headache, dizziness; or muscle or joint pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Bupropion side effects (more detail) What other drugs will affect bupropion? You may have a higher risk of seizures if you use certain other medicines while taking bupropion. Many drugs can interact with bupropion. Tell your doctor about all medicines you use, and those you start or stop using during your treatment. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is bupropion? Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Bupropion may also be used for purposes not listed in this medication guide. Warnings You should not take bupropion if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Bupropion may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Before taking this medicine Do not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. You should not take bupropion if you are allergic to it, or if you have ever had: a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others). Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take this medicine to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking. Bupropion may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use. To make sure this medicine is safe for you, tell your doctor if you have ever had: a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); depression, bipolar disorder or other mental illness; or if you drink alcohol. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms. Ask your doctor about taking this medicine if you are pregnant. It is not known whether bupropion will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking bupropion without your doctor's advice. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Bupropion is not approved for use by anyone younger than 18 years old. How should I take bupropion? Take bupropion exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure. Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole. You should not change your dose or stop using bupropion suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using bupropion. If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 to 12 weeks. Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products. Some people taking bupropion (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with bupropion. You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban. Smoking cessation may also cause new or worsening mental health problems, such as depression. This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting. What to avoid Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. This medicine can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication. Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Bupropion side effects Get emergency medical help if you have any of these signs of an allergic reaction to bupropion: (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a seizure (convulsions); confusion, unusual changes in mood or behavior; blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; fast or irregular heartbeats; or a manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep. Common bupropion side effects may include: dry mouth, sore throat, stuffy nose; ringing in the ears; blurred vision; nausea, vomiting, stomach pain, loss of appetite, constipation; sleep problems (insomnia); tremors, sweating, feeling anxious or nervous; fast heartbeats; confusion, agitation, hostility; rash; weight loss; increased urination; headache, dizziness; or muscle or joint pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect bupropion? You may have a higher risk of seizures if you use certain other medicines while taking bupropion. Many drugs can interact with bupropion. Tell your doctor about all medicines you use, and those you start or stop using during your treatment. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is buspirone? Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety. Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms. Buspirone is not an anti-psychotic medication and should not be used in place of medication prescribed by your doctor for psychotic disorders. Warnings Do not use buspirone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Before taking this medicine You should not use buspirone if you are allergic to it. Do not use buspirone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. To make sure this medicine is safe for you, tell your doctor if you have any of these conditions: kidney disease; or liver disease. Buspirone is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether buspirone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Buspirone is not FDA-approved for use by anyone younger than 18 years old, but this medicine has been used in children and adolescents under close medical supervision and at the appropriate dosage. How should I take buspirone? Take buspirone exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take buspirone with or without food but take it the same way each time. Some buspirone tablets are scored so you can break the tablet into 2 or 3 pieces in order to take a smaller amount of the medicine at each dose. Do not use a tablet if it has not been broken correctly and the piece is too big or too small. Follow your doctor's instructions about how much of the tablet to take. If you have switched to buspirone from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use. This medication can cause false positive results with certain medical tests. You may need to stop using the medicine for at least 48 hours before your test. Tell any doctor who treats you that you are using buspirone. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol may increase certain side effects of buspirone. Grapefruit and grapefruit juice may interact with buspirone and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor. Buspirone side effects Get emergency medical help if you have any signs of an allergic reaction to buspirone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; shortness of breath; or a light-headed feeling, like you might pass out. Common buspirone side effects may include: headache; dizziness, drowsiness; sleep problems (insomnia); nausea, upset stomach; or feeling nervous or excited.  

What is calcitriol? Calcitriol is a form of vitamin D3. Vitamin D helps your body absorb calcium from the stomach. Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis. Calcitriol is also used to treat calcium deficiency in people with hypoparathyroidism (underactive parathyroid glands) caused by surgery, disease, or other conditions. Calcitriol is also used to treat calcium deficiency (hypocalcemia) and metabolic bone disease in people who are receiving dialysis. Calcitriol may also be used for purposes not listed in this medication guide. Warnings You should not use calcitriol if you have high levels of calcium or vitamin D in your blood, or if you have ever had an allergic reaction to calcitriol or other forms of vitamin D. Before taking this medicine You should not use calcitriol if: you have high levels of calcium or vitamin D in your blood; or you have had an allergic reaction to calcitriol or other forms of vitamin D. Tell your doctor about all your medical conditions or allergies. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using calcitriol. Do not give this medicine to a child without medical advice. How should I use calcitriol? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Calcitriol oral is taken by mouth. Measure oral liquid carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Calcitriol injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. You will need frequent medical tests. Drink plenty of fluids unless your doctor has told you to restrict your fluid intake. You may need to follow a special diet while using calcitriol. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking calcitriol. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. If you need major surgery or will be on long-term bed rest, your dose or testing needs may change. Follow your doctor's instructions. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Early signs of overdose may include headache, weakness, drowsiness, dry mouth, metallic taste, nausea, vomiting, constipation, stomach pain, loss of appetite, muscle pain, or bone pain. Late signs of overdose may include increased thirst, itching, increased urination (especially at night), severe stomach pain spreading to your back, irregular heartbeats, loss of appetite, weight loss, feeling hot, decreased interest in sex, or being unable to urinate. What should I avoid while using calcitriol? Do not take other vitamin or mineral supplements unless your doctor has told you to. Ask your doctor before using an antacid or laxative, especially if you are on dialysis. Taking antacids or laxatives that contain magnesium may increase your blood levels of magnesium, which could affect your heart or blood pressure. Calcitriol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using calcitriol and call your doctor at once if you have: dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; high calcium levels--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling; or low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Calcitriol can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using calcitriol. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect calcitriol? Tell your doctor about all your other medicines, especially: cholestyramine; digoxin, digitalis; ketoconazole; a diuretic or "water pill"--hydrochlorothiazide, HCTZ, Diovan HCT, Hyzaar, Maxzide, Tenoretic, Zestoretic, and others; seizure medicine--phenobarbital, phenytoin; or steroid medicine--prednisone, dexamethasone, fluticasone, and others. This list is not complete. Other drugs may affect calcitriol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is calcium acetate? Calcium is a mineral that is needed for many functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals such as phosphate, and aid in their removal from the body. Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure who are on dialysis. Calcium acetate may also be used for purposes not listed in this medication guide. Warnings You should not use calcium acetate if you have high levels of calcium in your blood. Before taking this medicine You should not use calcium acetate if you are allergic to it, or if you have high levels of calcium in your blood. Tell your doctor if: your kidney disease gets worse; or you also take digoxin (digitalis, Lanoxin). Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether calcium acetate will harm an unborn baby, but having kidney failure or developing hypercalcemia during pregnancy may cause complications in the baby and the mother. The benefit of using calcium acetate during pregnancy may outweigh any risks.. Tell your doctor if you are breastfeeding. Calcium acetate is not approved for use by anyone younger than 18 years old. How should I take calcium acetate? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Take the capsule with food. You may need to keep a food diary to measure how much calcium you are getting in your diet. You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if calcium acetate is effective. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking calcium acetate? Do not take additional calcium supplements unless your doctor has told you to. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids contain calcium. Calcium acetate side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using calcium acetate and call your doctor at once if you have: high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling. Common side effects may include: increased calcium in the blood nausea; or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Calcium acetate dosing information Usual Adult Dose for Hyperphosphatemia: Initial dose: 1334 mg (2 tablets/capsules, or 10 mL), orally, with each meal Maintenance dose: 2001 to 2668 mg (3 to 4 tablets/capsules, or 15 to 20 mL) with each meal Comments: -Titrate dose every 2 to 3 weeks until an acceptable serum phosphorous level is reached. Use: Reduce serum phosphorous levels in patients with end stage renal disease.   What other drugs will affect calcium acetate? If you take any of the following medicines, take them separately from your dose of calcium acetate: A fluoroquinolone antibiotic: Take your calcium acetate dose 6 hours before or 2 hours after you take an antibiotic such as ciprofloxacin, moxifloxacin, levofloxacin, Cipro, or Levaquin. A tetracycline antibiotic: Take your calcium acetate dose 1 hour before or 1 hour after you take an antibiotic such as doxycycline, minocycline, tetracycline, Doryx, or Oracea. Thyroid medication: Take your calcium acetate dose 4 hours before or 4 hours after you take the thyroid medicine. Other drugs may affect calcium acetate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is hydrochlorothiazide and candesartan? Hydrochlorothiazide and candesartan is a combination medicine used to treat high blood pressure (hypertension). Hydrochlorothiazide and candesartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and candesartan and tell your doctor right away. If you have diabetes, do not use hydrochlorothiazide and candesartan together with any medication that contains aliskiren (a blood pressure medicine). What should I with my healthcare provider before taking hydrochlorothiazide and candesartan? You should not use this medicine if you are allergic to candesartan or hydrochlorothiazide, or if: you are unable to urinate; or you are allergic to sulfa drugs. If you have diabetes, do not use hydrochlorothiazide and candesartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and candesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: liver disease; congestive heart failure; glaucoma; low or high levels of potassium in your blood; asthma or allergies; high cholesterol or triglyceride levels; gout; lupus; diabetes; or an allergy to penicillin. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. This medicine can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and candesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and candesartan with or without food. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and candesartan. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and candesartan? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and candesartan. Drinking alcohol can further lower your blood pressure and may cause side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Hydrochlorothiazide and candesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and candesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: eye pain, vision problems; a light-headed feeling, like you might pass out; little or no urinating; jaundice (yellowing of the skin or eyes); easy bruising, unusual bleeding; or signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling. Common side effects may include: dizziness; back pain; or cold or flu symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Candesartan / hydrochlorothiazide side effects (more detail) Hydrochlorothiazide and candesartan dosing information Usual Adult Dose for Hypertension: Candesartan 16 to 32 mg-Hydrochlorothiazide 12.5 to 50 mg orally daily in 1 to 2 divided doses Comments: -The recommended starting dose of candesartan is 16 mg orally once a day when used as monotherapy in patients who are not volume depleted; doses larger than 32 mg do not appear to have a greater blood pressure lowering effect. -A patient whose blood pressure remains uncontrolled on candesartan 32 mg can expect an incremental effect from candesartan 32 mg-hydrochlorothiazide 12.5 mg -A patient whose blood pressure remains uncontrolled on hydrochlorothiazide 25 mg can expect an incremental effect from candesartan 16 mg-hydrochlorothiazide 12.5 mg; a patient whose blood pressure is controlled on hydrochlorothiazide 25 mg but is experiencing decreases in serum potassium can expect the same or incremental blood pressure effects from candesartan 16 mg-hydrochlorothiazide 12.5 mg and serum potassium may improve. -Maximal antihypertensive effect can be expected within 4 weeks of treatment initiation.   What other drugs will affect hydrochlorothiazide and candesartan? Tell your doctor about all your other medicines, especially: lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and candesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is candesartan? Candesartan is an angiotensin II receptor blocker (sometimes called an ARB). Candesartan is used to treat high blood pressure (hypertension) in adults and children who are at least 1 year old. Lowering blood pressure may lower your risk of a stroke or heart attack. Candesartan is also used in adults to treat certain types of heart failure and lower your risk of death or needing to be hospitalized for heart damage. Candesartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using candesartan and tell your doctor right away if you become pregnant. If you have diabetes, do not take candesartan with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medication if you are allergic to candesartan. If you have diabetes, do not take candesartan with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking candesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: a heart condition other than one being treated with candesartan; kidney disease (or if you are on dialysis); liver disease; or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Candesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. If you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby. You should not breastfeed while using candesartan. How should I take candesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take candesartan with or without food. For a child who cannot swallow a tablet whole, a pharmacist can mix the medicine into a liquid. Shake the liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Candesartan doses are based on weight in children and/or teenagers. Your child's dose needs may change if the child gains or loses weight. Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking candesartan. It may take 2 to 4 weeks before your blood pressure is under control. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Treatment may also include diet, exercise, lowering cholesterol, not smoking, and controlling diabetes. If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include dizziness, fast heartbeats, or fainting. What should I avoid while taking candesartan? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Candesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: high potassium; headache, back pain; cold symptoms such as stuffy or runny nose, sneezing, sore throat; dizziness; or abnormal kidney test. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Candesartan dosing information Usual Adult Dose for Hypertension: Initial dose: 16 mg orally once a day Maintenance dose: 8 to 32 mg/day orally in 1 to 2 divided doses Maximum dose: 32 mg/day Comments: -Consider administration of a lower initial dose in volume depleted patients. -Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 to 6 weeks of starting that dose. Usual Adult Dose for Congestive Heart Failure: Initial dose: 4 mg orally once a day; double dose every 2 weeks, as tolerated, to target dose of 32 mg orally once a day Use: Treatment of New York Heart Association (NYHA) class II through IV heart failure Usual Pediatric Dose for Hypertension: 1 TO LESS THAN 6 YEARS: Initial dose: 0.2 mg/kg/day orally in 1 to 2 divided doses Maintenance dose: 0.05 to 0.4 mg/kg/day orally in 1 to 2 divided doses 6 TO LESS THAN 17 YEARS: Less than 50 kg: -Initial dose: 4 to 8 mg/day orally in 1 to 2 divided doses -Maintenance dose: 2 to 16 mg/day orally in 1 to 2 divided doses Greater than 50 kg: -Initial dose: 8 to 16 mg/day orally in 1 to 2 divided doses -Maintenance dose: 4 to 32 mg/day orally in 1 to 2 divided doses Comments: -For patients with possible intravascular volume depletion (e.g., patients treated with diuretics, especially those with renal impairment), initiate this drug under close supervision and consider administration of a lower dose. -Antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose. -For children unable to swallow tablets, an extemporaneous suspension may be used instead.   What other drugs will affect candesartan? Tell your doctor about all your other medicines, especially: any other heart or blood pressure medications; a diuretic or "water pill"; lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect candesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is capecitabine? Capecitabine is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer. Capecitabine is sometimes used when cancer has spread to other parts of the body (metastatic). Capecitabine may also be used for purposes not listed in this medication guide. Warnings Taking a blood thinner (warfarin, Coumadin, Jantoven) can increase your risk of severe bleeding during and shortly after treatment with capecitabine. This risk is higher in adults older than 60. Before taking this medicine You should not take capecitabine if you are allergic to capecitabine or fluorouracil, or if you have: severe kidney disease. Tell your doctor if you have ever had: a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests. Capecitabine can harm an unborn baby if the mother or the father is using this medicine. If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs. Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby. Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose. How should I take capecitabine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Capecitabine is usually taken twice per day, and may be only part of a treatment program that may also include other medications taken on different schedules. Follow your doctor's dosing instructions very carefully. Take with food or within 30 minutes after eating a meal. Swallow the tablet whole with water and do not crush, chew, or break it. Tell your doctor if you have trouble swallowing the tablet. Capecitabine is given in a 3-week treatment cycle, and you may only need to take the medicine only on certain days of this cycle. You may get dehydrated during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea. You may need frequent medical tests and your cancer treatments may be delayed based on the results. Capecitabine can have long lasting effects on your body. You may also need medical tests for a short time after your last dose. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking capecitabine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Capecitabine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Diarrhea may occur and could be severe. Stop taking capecitabine and tell your doctor right away if the number of bowel movements you usually have per day increases by 4 or more, or if you have bowel movements at night. Stop using capecitabine and call your doctor at once if you have: severe diarrhea; bloody diarrhea with severe stomach pain and fever; severe nausea or loss of appetite that causes you to eat much less than usual; vomiting (more than once in 24 hours); fever above 100.5 degrees; sores or ulcers in your mouth, redness or swelling of your mouth or tongue, trouble eating or swallowing; jaundice (yellowing of the skin or eyes); dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; "hand and foot syndrome"--pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet; heart problems--chest pain, irregular heartbeats, swelling in your lower legs, rapid weight gain, feeling lightheaded or short of breath; or low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: nausea, vomiting, diarrhea, stomach pain; feeling weak or tired; hand and foot syndrome; or jaundice. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect capecitabine? Taking a blood thinner (warfarin, Coumadin, Jantoven) can increase your risk of severe bleeding during and shortly after treatment with capecitabine. This risk is higher in adults older than 60. Tell your doctor if you also take allopurinol. Other drugs may affect capecitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is capsaicin topical? Capsaicin is the active ingredient in chili peppers that makes them hot. Capsaicin is used in medicated creams and lotions to relieve muscle or joint pain. Capsaicin used on the body causes a sensation of heat that activates certain nerve cells. With regular use of capsaicin, this heating effect reduces the amount of substance P, a chemical that acts as a pain messenger in the body. Capsaicin topical is used for temporary relief of muscle or joint pain caused by strains, sprains, arthritis, bruising, or backaches. Capsaicin topical is also used to treat nerve pain (neuralgia) in people who have had herpes zoster, or "shingles." Qutenza is a prescription-strength form of capsaicin topical that is applied by a healthcare professional. Qutenza is used to treat nerve pain caused by herpes, and also to treat nerve pain in the feet (peripheral neuropathy) in people with diabetes. Capsaicin topical may also be used for purposes not listed in capsaicin topical guide. Warnings Do not use this medicine if you are allergic to chili peppers, or if you have ever had an allergic reaction to capsaicin topical. Capsaicin can cause a burning sensation wherever it is applied. If you have severe discomfort or skin redness, wash the treated skin area with soap and cool water. Get medical attention right away if you have severe burning, pain, swelling, or blistering of the skin where you applied this medicine. Before taking this medicine Do not use capsaicin topical if you are allergic to chili peppers, or if you have ever had an allergic reaction to capsaicin topical. Tell your doctor if you have ever had: any allergies (especially to plants); or a serious medical condition. Ask a doctor before using this medicine if you are pregnant or breastfeeding. Do not apply capsaicin topical to your breast area if you are breastfeeding a baby. Do not use this medicine on anyone younger than 18 years old without the advice of a doctor. How should I use capsaicin topical? Use exactly as directed on the label, or as prescribed by your doctor. The Qutenza brand of capsaicin is applied only by a healthcare professional and is not available over the counter. Do not take by mouth. Topical medicine is for use only on the skin. Capsaicin is available in different forms, such as a cream, lotion, liquid, and skin patch. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina, rinse with water. Make sure your skin is clean and dry before you apply capsaicin topical. Wash your hands with soap and water immediately after applying capsaicin topical or handling a topical skin patch. If you have applied the medicine to your hands or fingers to treat pain in those areas, wait at least 30 minutes before washing your hands. To prevent getting this medicine on your fingers, use a rubber glove, finger cot, cotton ball, or clean tissue to apply the medicine. Capsaicin can cause a burning sensation wherever it is applied. Even if the medicine gets on a surface other than your skin, you may feel burning when you later touch that surface. This sensation is usually mild and should gradually lessen over time with continued regular use of the medicine. If the burning sensation is painful or causes severe discomfort, wash the treated skin area with soap and cool water. Get medical attention right away if you have severe burning, pain, swelling, or blistering. Do not cover treated skin with a bandage or heating pad, which can increase the burning sensation. You may cover the skin with clothing. Avoid taking a bath or shower within 1 hour before or after you apply capsaicin to your skin. Also avoid swimming or vigorous exercise. Warm water or perspiration can increase the burning sensation caused by capsaicin. Avoid getting capsaicin topical in your eyes or near your nose where you might inhale it. If it does get into any of these areas, rinse thoroughly with water. Also avoid getting this medicine on contact lenses, dentures, and other items that come into contact with sensitive areas of your body. It may take up to 2 weeks of using this medicine regularly before your symptoms improve. For best results, keep using the medicine as directed. Pain relief should occur gradually as the substance P in your body is decreased in the nerve cells. Call your doctor if your pain does not improve after using this medicine for 7 days, or if your symptoms get worse or get better and then come back in a few days. Store capsaicin topical at room temperature away from moisture and heat, in a place where children and pets cannot get to it. Capsaicin topical liquid is flammable. Do not use or store near fire or open flame. What happens if I miss a dose? Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not apply capsaicin more than 4 times in one day, or use extra medicine to make up a missed dose. A missed dose of capsaicin topical will not cause harm but may make the medicine less effective reducing substance P and relieving your pain. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222, especially if anyone has accidentally swallowed it. Accidental swallowing of capsaicin can cause severe burning in or around the mouth, watery eyes, runny nose, and trouble swallowing or breathing. Applying too much capsaicin topical to the skin can cause severe burning or redness. What should I avoid while using capsaicin topical? Avoid inhaling the odor or dried residue of capsaicin topical. Inhaling capsaicin can cause coughing, sneezing, or watery eyes, and can irritate your throat or lungs. Avoid touching your eyes, mouth, nose, genitals, or rectum until the medicine has been washed off your hands. Also avoid handling food while the medicine is still on your hands. Avoid exposing treated skin to sunlight, sunlamps, tanning beds, or a hot tub. Capsaicin can cause a burning sensation that may be made worse by heat. Do not use other medicated skin products, including muscle pain creams or lotions, on areas where you have applied capsaicin, unless your doctor has told you to. Capsaicin topical side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Wash the skin and get medical attention right away if you have severe burning, pain, swelling, or blistering of the skin where you applied capsaicin topical. Stop using capsaicin topical and call your doctor at once if you have: severe pain or skin redness where the medicine was applied; loss of feeling; trouble breathing or swallowing (after accidental inhalation of capsaicin odor or dried residue). Common side effects may include pain or a burning sensation that can last for several hours or days (especially after your first use of capsaicin topical). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Capsaicin topical side effects (more detail) Capsaicin topical dosing information Usual Adult Dose for Postherpetic Neuralgia: Qutenza(R): Up to 4 patches applied to intact, non-irritated, dry skin, and allowed to remain in place for 60 minutes Comments: -Treatment may be repeated not more frequently than every three months. -The patch should be applied by a physician or by a health care professional under the supervision of a physician. Use: Management of neuropathic pain associated with postherpetic neuralgia Usual Adult Dose for Pain: Salonpas(R)/Capsaicin(R)/Capzasin(R): Apply to affected area not more than 3 to 4 times a day Uses: For the temporary relief of minor aches and pains of the muscles and joints associated with simple backache, strains, sprains, bruises, arthritis Zostrix(R): Apply a thin film to the affected area two to four times daily, and gently rub in until fully absorbed Comments: Unless being treated, hands should be washed thoroughly with soap and water immediately after use. Uses: For the temporary relief of minor aches and pains of the muscles and joints associated with strains, sprains, bruises, arthritis Usual Adult Dose for Diabetic Nephropathy: Qutenza(R): Up to 4 patches applied to intact, non-irritated, dry skin on the feet, and allowed to remain in place for 30 minutes Comments: -Treatment may be repeated not more frequently than every three months. -The patch should be applied by a physician or by a health care professional under the supervision of a physician. Use: Management of neuropathic pain in the feet associated with diabetic peripheral neuralgia Usual Pediatric Dose for Pain: Salonpas(R)/Capsaicin(R): -Adolescents 12 years and older: Apply to affected area not more than 3 to 4 times a day Uses: For the temporary relief of minor aches and pains of the muscles and joints associated with simple backache, strains, sprains, bruises, arthritis   What other drugs will affect capsaicin topical? It is not likely that other drugs you take orally or inject will have an effect on topically applied capsaicin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What is captopril? Captopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Captopril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack. Captopril may also be used for purposes not listed in this medication guide. Warnings Do not use captopril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. If you have diabetes, do not use captopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo). Before taking this medicine You should not use this medicine if you are allergic to captopril or to any other ACE inhibitor, such as benazepril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril. You may also need to avoid taking captopril with aliskiren if you have kidney disease. To make sure captopril is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis); liver disease; diabetes; a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis; or if you have had an organ transplant. Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Captopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Captopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using captopril. How should I take captopril? Take captopril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended. Captopril is usually taken 1 hour before meals. Follow your doctor's instructions. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking captopril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. Drink plenty of water each day while you are taking captopril. Your blood pressure will need to be checked often, and you may need frequent blood tests. This medication can cause false results with certain medical tests. Tell any doctor who treats you that you are using captopril. If you need surgery, tell the surgeon ahead of time that you are using captopril. You may need to stop using the medicine for a short time. If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Detailed Captopril dosage information What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol can further lower your blood pressure and may increase certain side effects of captopril. Do not use salt substitutes or potassium supplements while taking captopril, unless your doctor has told you to. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. Avoid strenuous exercise without your doctor's approval if you are being treated for heart failure. Captopril side effects Get emergency medical help if you have signs of an allergic reaction to captopril: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination, or urinating more than usual; shortness of breath (even with mild exertion), swelling, rapid weight gain; chest pain or pressure, pounding heartbeats or fluttering in your chest; high potassium - nausea, slow or unusual heart rate, weakness, loss of movement; or sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms. Common captopril side effects may include: cough; flushing (warmth, redness, or tingly feeling); numbness, tingling, or burning pain in your hands or feet; loss of taste sensation; or mild skin itching or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Captopril side effects (more detail) What other drugs will affect captopril? Other drugs may interact with captopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is carbamazepine? Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Carbamazepine may also be used for purposes not listed in this medication guide. Warnings You should not take carbamazepine if you have a history of bone marrow suppression, if you are allergic to it, or take an antidepressant such as amitriptyline, desipramine, doxepin, imipramine, or nortriptyline. TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE. Some drugs can raise or lower your blood levels of carbamazepine, which may cause side effects or make this medicine less effective. Carbamazepine can also affect blood levels of certain other drugs, making them less effective or increasing side effects. Carbamazepine may cause serious blood problems or a life-threatening skin rash or allergic reaction. Call your doctor if you have a fever, unusual weakness, bleeding, bruising, or a skin rash that causes blistering and peeling. Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Do not stop taking this medicine without asking your doctor first, even if you feel fine. If you are pregnant, do not start or stop taking carbamazepine without your doctor's advice. Before taking this medicine You should not take carbamazepine if you have a history of bone marrow suppression, or if you are allergic to carbamazepine or to an antidepressant such as amitriptyline, desipramine, doxepin, imipramine, or nortriptyline. Do not use carbamazepine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Carbamazepine may cause severe or life-threatening skin rash, and especially in people of Asian ancestry. Your doctor may recommend a blood test before you start the medication to determine your risk. Tell your doctor if you have ever had: heart problems; liver or kidney disease; glaucoma; porphyria; low sodium levels; depression, mood disorder; or suicidal thoughts or actions. You may have thoughts about suicide while taking carbamazepine. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Carbamazepine may harm an unborn baby, but having a seizure during pregnancy could harm both mother and baby. The benefit of preventing seizures may outweigh any risks to the baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of this medicine on the baby. Carbamazepine can make birth control pills or implants less effective. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy. You should not breastfeed while you are using carbamazepine. How should I take carbamazepine? Take carbamazepine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Take with food. Swallow the extended-release tablet or capsule whole and do not crush, chew, or break it. Tell your doctor if you cannot swallow a pill whole. The chewable tablet must be chewed before you swallow it. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and call your doctor promptly if this medicine seems to stop working as well in preventing your seizures. You will need frequent medical tests. Store at room temperature away from moisture, heat, and light. Do not stop using carbamazepine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe drowsiness, weak or shallow breathing, and loss of consciousness. What to avoid Drinking alcohol with this medicine can cause side effects, and can also increase your risk of seizures. Grapefruit may interact with carbamazepine and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Carbamazepine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Carbamazepine side effects Get emergency medical help if you have signs of an allergic reaction to carbamazepine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Report any new or worsening symptoms to your doctor, such as: sudden mood or behavior changes, depression, anxiety, insomnia, or if you feel agitated, hostile, restless, irritable, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a skin rash, no matter how mild; loss of appetite, right-sided upper stomach pain, dark urine; slow, fast, or pounding heartbeats; anemia or other blood problems - fever, chills, sore throat, mouth sores, bleeding gums, nosebleeds, pale skin, easy bruising, unusual tiredness, feeling light-headed or short of breath; or low levels of sodium in the body - headache, confusion, severe weakness, feeling unsteady, increased seizures. Common carbamazepine side effects may include: dizziness, loss of coordination, problems with walking; nausea, vomiting; or drowsiness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect carbamazepine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Using carbamazepine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Many drugs can interact with carbamazepine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is carbamazepine? Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Carbamazepine may also be used for purposes not listed in this medication guide. Warnings You should not take carbamazepine if you have a history of bone marrow suppression, if you are allergic to it, or take an antidepressant such as amitriptyline, desipramine, doxepin, imipramine, or nortriptyline. TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE. Some drugs can raise or lower your blood levels of carbamazepine, which may cause side effects or make this medicine less effective. Carbamazepine can also affect blood levels of certain other drugs, making them less effective or increasing side effects. Carbamazepine may cause serious blood problems or a life-threatening skin rash or allergic reaction. Call your doctor if you have a fever, unusual weakness, bleeding, bruising, or a skin rash that causes blistering and peeling. Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Do not stop taking this medicine without asking your doctor first, even if you feel fine. If you are pregnant, do not start or stop taking carbamazepine without your doctor's advice. Before taking this medicine You should not take carbamazepine if you have a history of bone marrow suppression, or if you are allergic to carbamazepine or to an antidepressant such as amitriptyline, desipramine, doxepin, imipramine, or nortriptyline. Do not use carbamazepine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Carbamazepine may cause severe or life-threatening skin rash, and especially in people of Asian ancestry. Your doctor may recommend a blood test before you start the medication to determine your risk. Tell your doctor if you have ever had: heart problems; liver or kidney disease; glaucoma; porphyria; low sodium levels; depression, mood disorder; or suicidal thoughts or actions. You may have thoughts about suicide while taking carbamazepine. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Carbamazepine may harm an unborn baby, but having a seizure during pregnancy could harm both mother and baby. The benefit of preventing seizures may outweigh any risks to the baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of this medicine on the baby. Carbamazepine can make birth control pills or implants less effective. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy. You should not breastfeed while you are using carbamazepine. How should I take carbamazepine? Take carbamazepine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Take with food. Swallow the extended-release tablet or capsule whole and do not crush, chew, or break it. Tell your doctor if you cannot swallow a pill whole. The chewable tablet must be chewed before you swallow it. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and call your doctor promptly if this medicine seems to stop working as well in preventing your seizures. You will need frequent medical tests. Store at room temperature away from moisture, heat, and light. Do not stop using carbamazepine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe drowsiness, weak or shallow breathing, and loss of consciousness. What to avoid Drinking alcohol with this medicine can cause side effects, and can also increase your risk of seizures. Grapefruit may interact with carbamazepine and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Carbamazepine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Carbamazepine side effects Get emergency medical help if you have signs of an allergic reaction to carbamazepine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Report any new or worsening symptoms to your doctor, such as: sudden mood or behavior changes, depression, anxiety, insomnia, or if you feel agitated, hostile, restless, irritable, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a skin rash, no matter how mild; loss of appetite, right-sided upper stomach pain, dark urine; slow, fast, or pounding heartbeats; anemia or other blood problems - fever, chills, sore throat, mouth sores, bleeding gums, nosebleeds, pale skin, easy bruising, unusual tiredness, feeling light-headed or short of breath; or low levels of sodium in the body - headache, confusion, severe weakness, feeling unsteady, increased seizures. Common carbamazepine side effects may include: dizziness, loss of coordination, problems with walking; nausea, vomiting; or drowsiness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect carbamazepine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Using carbamazepine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Many drugs can interact with carbamazepine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is carbidopa and levodopa? Carbidopa and levodopa is a combination medicine used to treat symptoms of Parkinson's disease, such as stiffness or tremors. Carbidopa and levodopa is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication. Carbidopa and levodopa may also be used for purposes not listed in this medication guide. Warnings Do not use carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. Before taking this medicine You should not use this medicine if you are allergic to carbidopa or levodopa, or if you have: narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Tell your doctor if you have ever had: heart disease, high blood pressure, or heart attack; liver or kidney disease; an endocrine (hormonal) disorder; asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder; a stomach or intestinal ulcer; open-angle glaucoma; or depression, mental illness, or psychosis. The disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. Tell your doctor if you are pregnant or breastfeeding. How should I take carbidopa and levodopa? If you already take levodopa, you must stop taking it at least 12 hours before you start taking carbidopa and levodopa. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take carbidopa and levodopa at regular intervals, with or without food. Swallow the capsule whole and do not crush, chew, break, or open it. The tablet is sometimes broken in half to give the correct dose. Always swallow a whole or half tablet without chewing or crushing. Place the orally disintegrating tablet in your mouth and allow it to dissolve, without chewing. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if the effects of this medicine wear off quickly between doses. If you use this medicine long-term, you may need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using carbidopa and levodopa. Do not stop using carbidopa and levodopa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light. Detailed Carbidopa / levodopa dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking carbidopa and levodopa? Avoid driving or hazardous activity until you know how carbidopa and levodopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking iron supplements or eating a diet high in protein. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid. Carbidopa and levodopa side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); worsening of tremors (uncontrolled shaking); severe or ongoing vomiting or diarrhea; confusion, hallucinations, unusual changes in mood or behavior; depression or suicidal thoughts; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Some people taking carbidopa and levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: jerky or twisting muscle movements; headache, dizziness; low blood pressure (feeling light-headed); sleep problems, strange dreams; dry mouth; muscle contractions; or nausea, vomiting, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Carbidopa / levodopa side effects (more detail) What other drugs will affect carbidopa and levodopa? Other drugs may affect carbidopa and levodopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is carbidopa? Carbidopa is used with another medicine called levodopa to treat symptoms of Parkinson's disease, such as stiffness or tremors. Carbidopa and levodopa are also used to treat Parkinson-like symptoms caused by taking certain medicines or by exposure to poisonous gases or minerals such as carbon monoxide or manganese. Carbidopa is only used in combination with levodopa and has no effect when used alone. Carbidopa may also be used for purposes not listed in this medication guide. Warnings Do not use carbidopa if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. Before taking this medicine You should not use carbidopa if you are allergic to it, or if you have: narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Tell your doctor if you have ever had: nausea and vomiting while taking levodopa; heart disease, high blood pressure; liver or kidney disease; a stomach or intestinal ulcer; glaucoma; or depression, mental illness, or psychosis. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. It is not known if carbidopa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using carbidopa. Not approved for use by anyone younger than 18 years old. How should I take carbidopa? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. If you already take levodopa but have never taken carbidopa, start taking both medicines at least 12 hours after you last took levodopa by itself. Take both carbidopa and levodopa together at regular intervals, to keep steady amounts in your body at all times. You may need frequent medical tests. Your symptoms may not improve for several weeks. Call your doctor if your symptoms do not improve or if the effects of carbidopa wear off quickly between doses. You may have withdrawal symptoms if you stop using carbidopa suddenly. Ask your doctor before stopping the medicine. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using carbidopa. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking carbidopa? Avoid driving or hazardous activity until you know how carbidopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking iron supplements or eating a diet high in protein. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid. Carbidopa side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The following side effects may occur when carbidopa is taken with levodopa. Call your doctor at once if you have: severe drowsiness; uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); worsening of tremors (uncontrolled shaking); severe nausea, vomiting, or diarrhea; confusion, hallucinations, unusual changes in mood or behavior; depression or suicidal thoughts; seizure (convulsions); or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Some people taking carbidopa with levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: nausea, upset stomach; headache, dizziness; sleep problems (insomnia), dreaming more than usual; dry mouth, burning feeling in your tongue; weight changes; or abnormal liver function tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Carbidopa dosing information Usual Adult Dose for Parkinsonian Tremor: Patients on carbidopa-levodopa therapy requiring additional carbidopa: Initial dose: 25 mg orally with the first dose of carbidopa-levodopa each day Maintenance dose: Additional doses of 12.5 mg or 25 mg may be given with each dose of carbidopa-levodopa Maximum dose: 200 mg orally per day Patients requiring individual titration of carbidopa and levodopa: Initial dose: 25 mg orally 3 to 4 times a day, given at the same time as levodopa Maximum dose: 200 mg orally per day Comments: -Most patients respond to a 1:10 proportion of carbidopa and levodopa, provided the daily dosage of carbidopa is 70 mg or more a day; for patients taking carbidopa-levodopa, the amount of carbidopa in carbidopa-levodopa should be considered when calculating the maximum daily carbidopa dose. -In patients already on levodopa, allow 12 hours between the last dose of levodopa and the initiation of therapy with carbidopa and levodopa. Uses: With carbidopa-levodopa or with levodopa in the treatment of symptoms of idiopathic Parkinson's disease (paralysis agitans), postencephalitic parkinsonism, and symptomatic parkinsonism   What other drugs will affect carbidopa? Using carbidopa with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect carbidopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is carbidopa, entacapone, and levodopa (Stalevo)? Carbidopa, entacapone, and levodopa (Stalevo) is a combination medicine used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control. Stalevo may also be used for purposes not listed in this medication guide. Warnings You should not use carbidopa, entacapone, and levodopa if you have narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Before taking this medicine You should not take this medicine if you are allergic to carbidopa, entacapone, or levodopa, or if you have: narrow-angle glaucoma. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: glaucoma; depression or other mental illness; a stomach ulcer; or liver disease. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Ask your doctor about skin symptoms to watch for. Tell your doctor if you are pregnant or breastfeeding. How should I take Stalevo? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Swallow the tablet whole and do not crush, chew, or break it. Take only a single tablet at each dosing time. Do not take more than 1 tablet at a time or take a portion of a broken tablet. Combining more than one tablet or tablet portions may cause an overdose. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times. Ask your doctor about whether you should take Stalevo with or without food. Tell your doctor if the effects of carbidopa, entacapone, and levodopa seem to wear off quickly in between doses. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated from vomiting or diarrhea. Drink plenty of liquids if you are ill. Do not take any other medications for Parkinson's disease that your doctor has not prescribed. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Stalevo. Do not stop using Stalevo suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include rapid heartbeats and feeling light-headed. What should I avoid while taking Stalevo? Avoid driving or hazardous activity until you know how carbidopa, entacapone, and levodopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid taking iron supplements without your doctor's advice. Also avoid increasing the amount of protein in your diet (protein sources include meat, eggs, and cheese). Taking iron or eating too much protein can make it harder for your body to digest and absorb Stalevo. Stalevo side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: worsening symptoms such as tremors, twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; depressed mood, thoughts about hurting yourself; hallucinations, unusual behaviors; severe nausea and vomiting; severe or ongoing diarrhea, diarrhea that is watery; unexplained muscle pain, tenderness, or weakness; a light-headed feeling, like you might pass out; fluid build-up in or around the lungs--pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats. This medicine may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: involuntary muscle movement; diarrhea; nausea, vomiting, stomach pain; discolored urine; or dry mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Carbidopa, entacapone, and levodopa dosing information Usual Adult Dose for Parkinson's Disease: Converting from Carbidopa, Levodopa, and Entacapone: -Switch to combination tablet that provides equivalent dose Converting from Carbidopa and Levodopa: -Patients with moderate to severe dyskinesias taking levodopa doses of 600 mg or more are likely to require a reduction in levodopa dose when entacapone is added -Titrate patients to a dose using separate carbidopa/levodopa tablets plus entacapone, then switch to corresponding single combination tablet -When less levodopa is required, reduce dose by either decreasing tablet strength or extending time between doses Concomitant Administration with Other Anti-Parkinson Drugs: -Dose adjustment of concomitant medications or this drug may be needed MAXIMUM DAILY DOSE: -Stalevo(R) 50, 75, 100, 125 and 150: Do not exceed 8 tablets in 24-hours -Stalevo (R) 200: Do not exceed 6 tablets in 24-hours Comments: -Conversions from carbidopa/levodopa are based on carbidopa/levodopa products combined in a 1:4 ratio; there is no experience switching patients from products that are not combined in a 1:4 ratio or from extended-release formulations. -Optimum dose should be determined by careful titration; therapy should be individualized and adjusted according to the desired therapeutic response. Use: For the treatment of Parkinson's disease: --As a substitute for equivalent strengths of each component; --Or to replace carbidopa/levodopa therapy in patients experiencing signs and symptoms of end-of-dose "wearing-off" when the total daily dose of levodopa is 600 mg or less and dyskinesias are not present.   What other drugs will affect Stalevo? Using Stalevo with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Many drugs can affect Stalevo. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is carvedilol? Carvedilol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Carvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used after a heart attack that has caused your heart not to pump as well. Carvedilol may also be used for purposes not listed in this medication guide. Warnings You should not take carvedilol if you have asthma, bronchitis, emphysema, severe liver disease, or a serious heart condition such as heart block, "sick sinus syndrome," or slow heart rate (unless you have a pacemaker). Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body. If you are being treated for high blood pressure, keep using carvedilol even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Before taking this medicine You should not take carvedilol if you are allergic to it, or if you have: asthma, bronchitis, emphysema; severe liver disease; or a serious heart condition such as heart block, "sick sinus syndrome," or slow heart rate (unless you have a pacemaker). To make sure carvedilol is safe for you, tell your doctor if you have: diabetes (taking carvedilol can make it harder for you to tell when you have low blood sugar); angina (chest pain); liver or kidney disease; a thyroid disorder; pheochromocytoma (tumor of the adrenal gland); circulation problems (such as Raynaud's syndrome); or a history of allergies. FDA pregnancy category C. It is not known whether carvedilol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether carvedilol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking carvedilol.   How should I take carvedilol? Take carvedilol exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Carvedilol works best if you take it with food. You may open the carvedilol capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule. Take carvedilol at the same time every day. Do not skip doses or stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse. If you are switched from carvedilol tablets to carvedilol extended-release capsules (Coreg CR), your daily total dose of this medicine may be higher or lower than before. Older adults may be more likely to become dizzy or feel faint when switching from tablets to extended-release capsules. Follow your doctor's instructions. Your blood pressure will need to be checked often. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. If you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time. You should not stop using carvedilol suddenly. Stopping suddenly may make your condition worse. Carvedilol can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using carvedilol before surgery unless your surgeon tells you to. Carvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, and seizure (convulsions). What to avoid Carvedilol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can further lower your blood pressure and may increase certain side effects of carvedilol. You should especially avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Carvedilol side effects Get emergency medical help if you have any of these signs of an allergic reaction to carvedilol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as: a light-headed feeling, like you might pass out; slow or uneven heartbeats; swelling, rapid weight gain, feeling short of breath (even with mild exertion); cold feeling or numbness in your fingers or toes; chest pain, dry cough, wheezing, chest tightness, trouble breathing; or high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss). Common carvedilol side effects may include: weakness, dizziness; diarrhea; dry eyes; tired feeling; or weight gain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect carvedilol? Other drugs may interact with carvedilol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is celecoxib? Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is used to treat juvenile rheumatoid arthritis in children who are at least 2 years old. It is also used in the treatment of hereditary polyps in the colon. Elyxyb is used to treat migraine headaches with or without aura in adults. Elyxyb will only treat migraine headaches, but it will not prevent a headache that has already begun. Warnings Celecoxib can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Celecoxib may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults. You should not take this medicine if you already have bleeding in your stomach or intestines. Before taking this medicine You should not use celecoxib if you are allergic to it, or if you have: an allergy to sulfa drugs; or a history of asthma attack or severe allergic reaction after taking aspirin or an NSAID. To make sure celecoxib is safe for you, tell your doctor if you have ever had: a stomach ulcer, bleeding in your stomach or intestines; heart disease, high blood pressure; asthma; bleeding problems; liver or kidney disease; or if you smoke or drink alcohol. If you are pregnant, you should not take celecoxib unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy. This medicine may affect fertility (ability to have children) in women. Ask your doctor about this risk. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Do not give this medicine to a child without medical advice. How should I take celecoxib? Take celecoxib exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition. You may take celecoxib with or without food. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture with water. You may save this applesauce mixture for later use in a refrigerator for up to 6 hours. Store at room temperature away from moisture and heat. Dosing information Usual Adult Dose for Pain: Acute pain: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed. Usual Adult Dose for Dysmenorrhea: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed. Usual Adult Dose for Osteoarthritis: 200 mg orally once daily or 100 mg orally twice daily. Usual Adult Dose for Rheumatoid Arthritis: 100 to 200 mg orally twice daily. Usual Adult Dose for Familial Adenomatous Polyposis: 400 mg orally twice daily with food. Usual Adult Dose for Ankylosing Spondylitis: 200 mg orally once daily or 100 mg orally twice daily. If after 6 weeks of therapy no results are observed, a trial dose of 400 mg orally daily may be worthwhile. If no response is seen after 6 weeks, consideration should be given to alternate treatment options. Usual Pediatric Dose for Juvenile Rheumatoid Arthritis: 2 years or older: 10 to less than or equal to 25 kg: 50 mg orally twice daily Greater than 25 kg: 100 mg orally twice daily   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Avoid taking aspirin or other NSAIDs while you are taking celecoxib, unless your doctor tells you to. Avoid drinking alcohol. It may increase your risk of stomach bleeding. Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to celecoxib (such as aspirin, ibuprofen, ketoprofen, or naproxen). Celecoxib side effects Get emergency medical help if you have signs of an allergic reaction to celecoxib (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Stop using this medicine and call your doctor at once if you have: the first sign of any skin rash, no matter how mild; heart problems - swelling, rapid weight gain, feeling short of breath; signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; liver problems - nausea, stomach pain (upper right side), itching, tiredness, dark urine, jaundice (yellowing of the skin or eyes); kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet. Common celecoxib side effects may include: stomach pain, heartburn, gas, diarrhea, constipation, nausea, vomiting; swelling in your hands or feet; dizziness; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect celecoxib? Ask your doctor before using celecoxib if you take an antidepressant, steroid medicine, or medicine to treat or prevent blood clots. Taking certain medicines with an NSAID may increase your risk of a stomach ulcer or bleeding. Many drugs can interact with celecoxib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is cetirizine? Cetirizine is a second generation antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose. Cetirizine is also used to treat an allergic reaction, itching and swelling caused by chronic urticaria (hives) and minimizes or eliminates the symptoms of perennial allergic rhinitis, seasonal allergic rhinitis, chronic idiopathic urticaria, allergic asthma, physical urticaria, and atopic dermatitis. Warnings Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of cetirizine. Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine. Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Before taking this medicine You should not use this medication if you are allergic to or had an adverse reaction to cetirizine. Before taking cetirizine, tell your doctor about all of your medical conditions or if you have ever had kidney or liver disease. Cetirizine is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cetirizine can pass into breast milk and may harm a nursing baby. Do not use cetirizine without telling your doctor if you are breast-feeding a baby. Cetirizine is indicated for chronic idiopathic urticaria in adults and children 6 months of age and older. Older adults may need to take a lower than normal dose. Follow your doctor's instructions. How should I take cetirizine? Take cetirizine exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. You may take cetirizine with or without food. The chewable tablet must be chewed before you swallow it. Oral doses: measure liquid medicine (oral solution) with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store cetirizine at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine or add extra doses to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include feeling restless or nervous, and then feeling drowsy. What should I avoid? Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine. Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of cetirizine. Cetirizine acute and common side effects Get emergency medical help if you have any serious adverse effects or any of these signs of an allergic reaction: chronic idiopathic urticaria (hives); difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using cetirizine and call your doctor at once if you have any of these serious side effects: fast, pounding, or uneven heartbeat; weakness, tremors (uncontrolled shaking), or sleep problems (insomnia); severe restless feeling, hyperactivity; confusion; problems with vision; or urinating less than usual or not at all. Less serious cetirizine side effects may include: dizziness, drowsiness; tired feeling; dry mouth; sore throat, cough; nausea, constipation; or headache. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.   What other drugs will affect cetirizine? There may be other drugs that can interact with cetirizine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

What is cevimeline? Cevimeline increases the secretions of the saliva and sweat glands in the body. Cevimeline is used to treat dry mouth in people with Sjögren's Syndrome. Cevimeline may also be used for purposes not listed in this medication guide. Warnings You should not take cevimeline if you have uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis. What should I tell my healthcare provider before taking cevimeline? You should not take cevimeline if you are allergic to it, or if you have: untreated or uncontrolled asthma; narrow-angle glaucoma; or an eye condition called iritis or uveitis. To make sure cevimeline is safe for you, tell your doctor if you have: asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD); heart disease, angina (chest pain), or a history of heart attack; a heart rhythm disorder; high blood pressure (hypertension); liver or kidney disease; or a history of kidney stones or gallstones. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether cevimeline passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Cevimeline is not approved for use by anyone younger than 18 years old. How should I take cevimeline? Follow all directions on your prescription label. Do not take cevimeline in larger or smaller amounts or for longer than recommended. Drink plenty of liquids while you are taking cevimeline. This will help keep your kidneys working properly, and can also prevent dehydration. Cevimeline is usually taken 3 times per day. Follow your doctor's dosing instructions. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include headache, vision problems, confusion, sweating, tremors, vomiting, diarrhea, feeling short of breath, and irregular heartbeats. What should I avoid while taking cevimeline? cevimeline may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Avoid becoming overheated or dehydrated during exercise and in hot weather. Cevimeline can decrease sweating and you may be more prone to heat stroke. Cevimeline side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using cevimeline and call your doctor at once if you have: severe pain in your stomach, side, or lower back; vomiting; fast, slow, or uneven heart rate; painful or difficult urination; a light-headed feeling, like you might pass out; or dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin. Common side effects may include: increased sweating; excessive salivation, drooling; nausea, diarrhea; dry mouth; headache; or stuffy nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Cevimeline dosing information Usual Adult Dose for Sjogren's Syndrome: 30 mg orally three times a day Comments: -There is insufficient safety information and insufficient evidence for additional efficacy to support doses greater than 30 mg three times a day. Use: Treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.   What other drugs will affect cevimeline? Tell your doctor about all your current medicines and any you start or stop using, especially: an antibiotic or antifungal medicine; an antidepressant; antiviral medicine to treat hepatitis C or HIV/AIDS; or heart or blood pressure medication. This list is not complete. Other drugs may interact with cevimeline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is chlordiazepoxide? Chlordiazepoxide is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat anxiety disorders. Chlordiazepoxide may also be used short-term to treat symptoms of alcohol withdrawal, or anxiety you may have before a surgery. Chlordiazepoxide may also be used for purposes not listed in this medication guide. Warnings Chlordiazepoxide can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. MISUSE OF chlordiazepoxide CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep this medicine where others cannot get to it. Do not stop using chlordiazepoxide without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use. Some withdrawal symptoms may last up to 12 months or longer. Get medical help right away if you stop using chlordiazepoxide and have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, or thoughts about suicide. Before taking this medicine You should not use chlordiazepoxide if you are allergic to it. Tell your doctor if you have ever had: depression, a mood disorder, suicidal thoughts or actions; alcoholism or drug addiction; or liver or kidney disease. Tell your doctor if you are pregnant or plan to become pregnant. Chlordiazepoxide may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy. Ask a doctor if it is safe to breastfeed while using this medicine. Not approved for use by anyone younger than 6 years old. How should I take chlordiazepoxide? Follow the directions on your prescription label and read all medication guides or instruction sheets. Never use chlordiazepoxide in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of chlordiazepoxide. Never share this medicine with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law. Chlordiazepoxide is usually taken for no longer than 4 months. Follow your doctor's dosing instructions very carefully. Do not stop using chlordiazepoxide without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use. Store at room temperature away from moisture and heat. Keep your medicine in a place where no one can use it improperly.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of chlordiazepoxide can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing. Overdose symptoms may include dry mouth, blurred vision, urinating less, constipation, extreme drowsiness, confusion, muscle weakness, or loss of consciousness. What should I avoid while taking chlordiazepoxide? Avoid drinking alcohol. Dangerous side effects or death could occur. Avoid driving or hazardous activity until you know how chlordiazepoxide will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Chlordiazepoxide side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Chlordiazepoxide can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once if you have: severe drowsiness, slurred speech; slow heart rate, slow breathing (breathing may stop); problems with memory or concentration; unusual changes in mood or behavior, thoughts of suicide or hurting yourself; problems with balance or muscle movement; confusion, excitement, paranoia, anger, aggression; or stomach pain, loss of appetite. Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury. Common side effects may include: drowsiness; confusion; or balance problems. After you stop using chlordiazepoxide, get medical help right away if you have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, suicidal thoughts or actions. Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect chlordiazepoxide? Using chlordiazepoxide with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect chlordiazepoxide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is chlorpromazine? Chlorpromazine is a phenothiazine (FEEN-oh-THYE-a-zeen) that is used to treat psychotic disorders such as schizophrenia or manic-depression in adults. Chlorpromazine is also used in adults to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. In children ages 1 through 12 years, chlorpromazine is used to treat severe behavioral problems (such as combative or explosive behavior) or hyperactivity with excessive motor activity. Chlorpromazine may also be used for purposes not listed in this medication guide. Warnings Call your doctor at once if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Chlorpromazine is not approved for use in older adults with dementia-related psychosis. Before taking this medicine You should not use chlorpromazine if you are allergic to chlorpromazine or other phenothiazines (such as fluphenazine, perphenazine, prochlorperazine, promethazine, thioridazine, or trifluoperazine). Do not use chlorpromazine if you have recently used large amounts of alcohol or medicine that makes you sleepy. Chlorpromazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Tell your doctor if you have ever had: severe asthma, emphysema, or other breathing problem; a sulfite allergy; bone marrow suppression; heart disease; liver or kidney disease; breast cancer; glaucoma; Parkinson's disease; seizures; a blockage in your intestines; a brain tumor; or pheochromocytoma (tumor of the adrenal gland). Tell your doctor if you will be exposed to extreme heat, or to insecticide poisons while you are using chlorpromazine. Do not give this medicine to a child without medical advice. Talk with your doctor before giving chlorpromazine to a child who has been ill with a fever or flu symptoms. Using antipsychotic medicine in the last 3 months of pregnancy may cause medical problems, breathing problems, feeding problems, or withdrawal symptoms in the newborn. However, you may have withdrawal symptoms or other problems if you stop using your medicine during pregnancy. If you get pregnant, tell your doctor right away. Do not stop using chlorpromazine without your doctor's advice. You should not breast-feed while using this medicine. How should I use chlorpromazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Chlorpromazine oral is taken by mouth. Chlorpromazine injection is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection. You may be asked to lie down for a short time after you receive a chlorpromazine injection. This medicine can lower your blood pressure and you may feel light-headed after an injection. Your doctor will need to check your progress on a regular basis. Your vision may also need to be checked. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorpromazine. If you need to have a spinal tap (lumbar puncture) or any type of x-ray scan or MRI of your spinal cord, tell the doctor ahead of time that you are using chlorpromazine. Do not stop using chlorpromazine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include dry mouth, bloating or stomach cramps, feeling restless, fever, muscle stiffness, jerky muscle movements, changes in heart rate, fainting, or seizure (convulsions). What should I avoid while using chlorpromazine? Avoid driving or hazardous activity until you know how chlorpromazine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol with this medicine can cause side effects. Avoid exposure to sunlight or tanning beds. Chlorpromazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Chlorpromazine side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Long-term use of chlorpromazine can cause a serious movement disorder that may not be reversible. The longer you use chlorpromazine, the more likely you are to develop this disorder, especially if you are a an older adult. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); stiffness in your neck, tightness in your throat, trouble breathing or swallowing; a light-headed feeling, like you might pass out; confusion, agitation, feeling jittery, trouble sleeping; weakness; breast swelling or discharge; a seizure; jaundice (yellowing of the skin or eyes); low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Some side effects may be more likely in older adults. Common side effects may include: drowsiness; dry mouth or stuffy nose; blurred vision; constipation; or impotence, trouble having an orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect chlorpromazine? Using chlorpromazine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect chlorpromazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.