What is isosorbide mononitrate? Isosorbide mononitrate is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. Isosorbide mononitrate is used to prevent angina attacks (chest pain). Isosorbide mononitrate will not treat an angina attack that has already begun. Warnings You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure. Seek emergency medical attention if you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, general ill feeling). Do not stop taking this medicine suddenly. Stopping suddenly could cause a severe angina attack. Isosorbide mononitrate can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use the medication. Do not stop taking isosorbide mononitrate. Ask your doctor before using any headache pain medication. Use this medicine regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. Before taking this medicine You should not use isosorbide mononitrate if: you are allergic to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin; or you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating). You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure. To make sure this medicine is safe for you, tell your doctor if you have: congestive heart failure; kidney disease; or low blood pressure. It is not known whether this medicine will harm an unborn baby, although animal studies have not shown harm. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether isosorbide mononitrate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding. How should I take isosorbide mononitrate? Take isosorbide mononitrate exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you use too much isosorbide mononitrate, it might stop working as well in controlling your condition. Try to rest or stay seated when you take this medicine (may cause dizziness or fainting). Do not crush, chew, or break an extended-release tablet. Swallow it whole. Not all brands and forms of isosorbide mononitrate are taken the same number of times per day. You may need to take the medicine only once daily, in the morning after getting out of bed. You may also need a second dose later in the day. Follow your doctor's dosing instructions very carefully. If your doctor changes your brand, strength, or type of isosorbide mononitrate, your dosage needs may change. Ask your pharmacist if you have any questions about the new brand of medicine you receive at the pharmacy. Use this medicine regularly to prevent an angina attack. Get your prescription refilled before you run out of medicine completely. You should not stop using isosorbide mononitrate suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times. Get your prescription refilled before you run out of medicine completely. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal. Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions). What to avoid This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. Alcohol may increase certain side effects of isosorbide mononitrate (dizziness, drowsiness, feeling light-headed, or fainting). Isosorbide mononitrate side effects Get emergency medical help if you have signs of an allergic reaction to isosorbide mononitrate: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; worsening angina pain; fast or slow heart rate; or pounding heartbeats or fluttering in your chest. Isosorbide mononitrate can cause severe headaches. These headaches may gradually become less severe as you continue to use nitroglycerin. Do not stop taking this medicine to avoid headaches. Ask your doctor before using any headache pain medication. Common isosorbide mononitrate side effects may include: headache; dizziness upon standing; or flushing (warmth, redness, or tingly feeling). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect isosorbide mononitrate? Taking isosorbide mononitrate with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary arterial hypertension. Serious, life-threatening side effects may occur. Tell your doctor about all your current medicines and any you start or stop using, especially: erectile dysfunction medication (including Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil, others); a diuretic or "water pill"; blood pressure medications including calcium channel blockers (such as nifedipine, Procardia); nitroglycerin; or riociguat (Adempas); This list is not complete. Other drugs may interact with isosorbide mononitrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is Jantoven? Jantoven is an anticoagulant (blood thinner). This medicine reduces the formation of blood clots. Jantoven is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions. Jantoven may also be used for purposes not listed in this medication guide. Warnings You should not take Jantoven if you are prone to bleeding because of a medical condition, if you have an upcoming surgery, or if you need a spinal tap or epidural. Do not take this medicine if you cannot take it on time every day. Jantoven increases your risk of severe or fatal bleeding, especially if you have certain medical conditions, if you are 65 or older, or if you have had a stroke, or bleeding in your stomach or intestines. Seek emergency help if you have any bleeding that will not stop. Call your doctor at once if you have other signs of bleeding such as: swelling, pain, feeling very weak or dizzy, unusual bruising, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Many other drugs can increase your risk of bleeding when used with Jantoven. Tell your doctor about all medicines you have recently used. Avoid making any changes in your diet without first talking to your doctor. Some foods can make Jantoven less effective. Before taking this medicine You should not take Jantoven if you are allergic to it, or if: you have very high blood pressure; you recently had or will have surgery on your brain, spine, or eye; you undergo a spinal tap or spinal anesthesia (epidural); or you cannot take Jantoven on time every day. You also should not take Jantoven if you are are prone to bleeding because of a medical condition, such as: a blood cell disorder (such as low red blood cells or low platelets); ulcers or bleeding in your stomach, intestines, lungs, or urinary tract; an aneurysm or bleeding in the brain; or an infection of the lining of your heart. Do not take Jantoven if you are pregnant, unless your doctor tells you to. This medicine can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking this medicine and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant. Jantoven can make you bleed more easily, especially if you have ever had: high blood pressure or serious heart disease; kidney disease; cancer or low blood cell counts; an accident or surgery; bleeding in your stomach or intestines; a stroke; or if you are 65 or older. To make sure Jantoven is safe for you, tell your doctor if you have ever had: diabetes; congestive heart failure; liver disease, kidney disease (or if you are on dialysis); a hereditary clotting deficiency; or low blood platelets after receiving heparin. It is not known whether warfarin passes into breast milk. Watch for signs of bruising or bleeding in the baby if you take warfarin while you are breast-feeding a baby. How should I take Jantoven? Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take Jantoven in larger or smaller amounts or for longer than your doctor tells you to. Take Jantoven at the same time every day, with or without food. Never take a double dose. Jantoven can make it easier for you to bleed. Seek emergency help if you have any bleeding that will not stop. You will need frequent "INR" or prothrombin time tests (to measure your blood-clotting time and determine your Jantoven dose). You must remain under the care of a doctor while taking this medicine. If you receive Jantoven in a hospital, call or visit your doctor 3 to 7 days after you leave the hospital. Your INR will need to be tested at that time. Do not miss any follow-up appointments. Tell your doctor if you are sick with diarrhea, fever, chills, or flu symptoms, or if your body weight changes. You may need to stop taking Jantoven 5 to 7 days before having any surgery, dental work, or a medical procedure. Call your doctor for instructions. Wear a medical alert tag or carry an ID card stating that you take Jantoven. Any medical care provider who treats you should know that you are taking Jantoven. Store at room temperature away from heat, moisture, and light.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause excessive bleeding. What should I avoid while taking Jantoven? Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. You may still bleed more easily for several days after you stop taking Jantoven. Avoid making any changes in your diet without first talking to your doctor. Foods that are high in vitamin K (liver, leafy green vegetables, or vegetable oils) can make Jantoven less effective. If these foods are part of your diet, eat a consistent amount on a weekly basis. Grapefruit juice, cranberry juice, noni juice, and pomegranate juice may interact with Jantoven and lead to unwanted side effects. Avoid the use of these juice products while taking this medicine. Avoid drinking alcohol. Ask your doctor before using any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. These medicines may affect blood clotting and may also increase your risk of stomach bleeding. Jantoven side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Jantoven increases your risk of bleeding, which can be severe or life-threatening. Call your doctor at once if you have any signs of bleeding such as: sudden headache, feeling very weak or dizzy; swelling, pain, unusual bruising; bleeding gums, nosebleeds; bleeding from wounds or needle injections that will not stop; heavy menstrual periods or abnormal vaginal bleeding; blood in your urine, bloody or tarry stools; or coughing up blood or vomit that looks like coffee grounds. Clots formed by Jantoven may block normal blood flow, which could lead to tissue death or amputation of the affected body part. Get medical help at once if you have: pain, swelling, hot or cold feeling, skin changes, or discoloration anywhere on your body; or sudden and severe leg or foot pain, foot ulcer, purple toes or fingers. Bleeding is the most common side effect of warfarin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Jantoven? Many drugs (including some over-the-counter medicines and herbal products) can affect your INR and may increase the risk of bleeding if you take them with Jantoven. Not all possible drug interactions are listed in this medication guide. It is very important to ask your doctor and pharmacist before you start or stop using any other medicine, especially: other medicines to prevent blood clots; an antibiotic or antifungal medicine; supplements that contain vitamin K; or herbal (botanical) products--coenzyme Q10, cranberry, echinacea, garlic, ginkgo biloba, ginseng, goldenseal, or St. John's wort. This list is not complete and many other drugs can interact with Jantoven. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

What is Kapvay? Kapvay (clonidine) is a prescription medicine supplied as an extended-release tablet and is used to treat attention deficit hyperactivity disorder (ADHD). Your doctor may prescribe Kapvay alone or together with certain other ADHD medicines. Kapvay is not a central nervous system (CNS) stimulant. Kapvay should be used as part of a total treatment program for ADHD that may include counseling or other therapies. Warnings Use Kapvay only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before you take Kapvay, tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, slow heartbeats, low blood pressure, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS). Before taking this medicine You should not take Kapvay if you are allergic to clonidine. To make sure Kapvay is safe for you, tell your doctor if you have: heart disease or severe coronary artery disease; a heart rhythm disorder, slow heartbeats; high or low blood pressure, or a history of fainting spells; a heart attack or stroke; pheochromocytoma (tumor of the adrenal gland); kidney disease; or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS). It is not known if clonidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonidine on the baby. Clonidine may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine. If you are breastfeeding, tell your doctor if you notice somnolence, tiredness, rapid breathing, and poor feeding in the nursing baby. Do not give Kapvay to a child younger than 6 years old. How should I take Kapvay? Take Kapvay exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Kapvay is usually taken in the morning and at bedtime. If you take different doses of this medicine at each dosing time, it may be best to take the larger dose at bedtime. Kapvay may be taken with or without food. Swallow the extended-release tablet whole and do not crush, chew, or break it. Tell your doctor if you have a planned surgery. You may have withdrawal symptoms if you stop using Kapvay suddenly. Ask your doctor before stopping the medicine. Call your doctor if you are sick with vomiting. Prolonged illness can make it harder for your body to absorb clonidine, which may lead to withdrawal symptoms. This is especially important for a child taking Kapvay. Store at room temperature away from moisture, heat, and light. Dosing information Usual Pediatric Dose for Attention Deficit Disorder: Extended release: 6 years and older: -Initial dose: 0.1 mg orally at bedtime -Titration: Increase in 0.1 mg/day increments every 7 days until desired response; doses should be administered twice daily (either split equally or with the higher split dosage given at bedtime) -Maximum dose: 0.4 mg/day in 2 divided doses Comments: -May be taken with or without food. -If a dose is missed, that dose should be skipped and take the next dose as scheduled. -Tablets should be swallowed whole, and not crushed, chewed, or broken to avoid increasing the rate of drug release. -When discontinuing therapy, taper daily dose by no more than 0.1 mg every 3 to 7 days. Use: For the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy or as adjunctive therapy to stimulant medications.   What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling cold, irritable, weak, drowsy, or light-headed, or having weak reflexes, pinpoint pupils, slow heartbeats, shallow breathing, or a seizure. What should I avoid while taking Kapvay? Avoid drinking alcohol. It may increase certain side effects of Kapvay. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid becoming overheated or dehydrated during exercise and in hot weather. Kapvay side effects Get emergency medical help if you have signs of an allergic reaction to Kapvay: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe chest pain, shortness of breath, irregular heartbeats; a very slow heart rate; or a light-headed feeling, like you might pass out. Common Kapvay side effects may include: drowsiness, dizziness; feeling tired or irritable; dry mouth; constipation, loss of appetite; or sleep problems (insomnia), nightmares. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Kapvay? Using Kapvay with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: other heart or blood pressure medications; an antidepressant; or any other medicine that contains clonidine. This list is not complete. Other drugs may interact with clonidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is ketotifen ophthalmic? Ketotifen is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Ketotifen ophthalmic (for use in the eyes) is used to treat itching of the eyes caused by allergy to dust, pollen, animals, or other allergens. Ketotifen ophthalmic may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use ketotifen ophthalmic if you are allergic to it, or if you have: an untreated eye infection; or eye irritation caused by wearing contact lenses. Ketotifen ophthalmic is not approved for use by anyone younger than 3 years old. How should I use ketotifen ophthalmic? Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Do not use ketotifen ophthalmic while wearing contact lenses. Ketotifen ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 10 minutes after using this medicine before putting in your contact lenses. Wash your hands before using the eye drops. To apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop. Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct. Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops. Wait at least 10 minutes before using any other eye drops your doctor has prescribed. Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems. Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine. Call your doctor if your eye itching does not improve, or if it lasts longer than 72 hours. Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? An overdose of ketotifen ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication. What should I avoid while using ketotifen ophthalmic? Do not use other eye medications unless your doctor tells you to. Ketotifen ophthalmic side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using ketotifen ophthalmic and call your doctor at once if you have: redness, drainage, eyelid swelling, or other signs of infection; eye pain; vision changes; or severe itching of the eyes worse than before using the medication. Common side effects may include: mild burning, stinging, or eye irritation; dryness of the eyes; or increased sensitivity to light. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Ketotifen ophthalmic dosing information Usual Adult Dose for Allergic Conjunctivitis: Instill 1 drop in the affected eye(s) 2 times a day Comments: May administer eye drops every 8 to 12 hours, but should not administer more than twice a day. Use: For the treatment of itching related to pollen, ragweed, grass, animal hair and dander. Usual Pediatric Dose for Allergic Conjunctivitis: Age: 3 years and older Instill 1 drop in the affected eye(s) 2 times a day Comments: May administer eye drops every 8 to 12 hours, but should not administer more than twice a day. Use: For the treatment of itching related to pollen, ragweed, grass, animal hair and dander.   What other drugs will affect ketotifen ophthalmic? It is not likely that other drugs you take orally or inject will have an effect on ketotifen used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products

What is Kapvay? Kapvay (clonidine) is a prescription medicine supplied as an extended-release tablet and is used to treat attention deficit hyperactivity disorder (ADHD). Your doctor may prescribe Kapvay alone or together with certain other ADHD medicines. Kapvay is not a central nervous system (CNS) stimulant. Kapvay should be used as part of a total treatment program for ADHD that may include counseling or other therapies. Warnings Use Kapvay only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before you take Kapvay, tell your doctor if you have heart disease or severe coronary artery disease, a heart rhythm disorder, slow heartbeats, low blood pressure, a history of heart attack or stroke, kidney disease, or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS). Before taking this medicine You should not take Kapvay if you are allergic to clonidine. To make sure Kapvay is safe for you, tell your doctor if you have: heart disease or severe coronary artery disease; a heart rhythm disorder, slow heartbeats; high or low blood pressure, or a history of fainting spells; a heart attack or stroke; pheochromocytoma (tumor of the adrenal gland); kidney disease; or if you have ever had an allergic reaction to a clonidine transdermal skin patch (Catapres TTS). It is not known if clonidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of clonidine on the baby. Clonidine may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine. If you are breastfeeding, tell your doctor if you notice somnolence, tiredness, rapid breathing, and poor feeding in the nursing baby. Do not give Kapvay to a child younger than 6 years old. How should I take Kapvay? Take Kapvay exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Kapvay is usually taken in the morning and at bedtime. If you take different doses of this medicine at each dosing time, it may be best to take the larger dose at bedtime. Kapvay may be taken with or without food. Swallow the extended-release tablet whole and do not crush, chew, or break it. Tell your doctor if you have a planned surgery. You may have withdrawal symptoms if you stop using Kapvay suddenly. Ask your doctor before stopping the medicine. Call your doctor if you are sick with vomiting. Prolonged illness can make it harder for your body to absorb clonidine, which may lead to withdrawal symptoms. This is especially important for a child taking Kapvay. Store at room temperature away from moisture, heat, and light. Dosing information Usual Pediatric Dose for Attention Deficit Disorder: Extended release: 6 years and older: -Initial dose: 0.1 mg orally at bedtime -Titration: Increase in 0.1 mg/day increments every 7 days until desired response; doses should be administered twice daily (either split equally or with the higher split dosage given at bedtime) -Maximum dose: 0.4 mg/day in 2 divided doses Comments: -May be taken with or without food. -If a dose is missed, that dose should be skipped and take the next dose as scheduled. -Tablets should be swallowed whole, and not crushed, chewed, or broken to avoid increasing the rate of drug release. -When discontinuing therapy, taper daily dose by no more than 0.1 mg every 3 to 7 days. Use: For the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy or as adjunctive therapy to stimulant medications.   What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling cold, irritable, weak, drowsy, or light-headed, or having weak reflexes, pinpoint pupils, slow heartbeats, shallow breathing, or a seizure. What should I avoid while taking Kapvay? Avoid drinking alcohol. It may increase certain side effects of Kapvay. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid becoming overheated or dehydrated during exercise and in hot weather. Kapvay side effects Get emergency medical help if you have signs of an allergic reaction to Kapvay: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe chest pain, shortness of breath, irregular heartbeats; a very slow heart rate; or a light-headed feeling, like you might pass out. Common Kapvay side effects may include: drowsiness, dizziness; feeling tired or irritable; dry mouth; constipation, loss of appetite; or sleep problems (insomnia), nightmares. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Kapvay? Using Kapvay with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: other heart or blood pressure medications; an antidepressant; or any other medicine that contains clonidine. This list is not complete. Other drugs may interact with clonidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is labetalol? Labetalol is a beta-blocker that is used to treat hypertension (high blood pressure). Labetalol oral is sometimes given with other blood pressure medications. Labetalol injection is used when hypertension is severe. Labetalol may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use labetalol if you are allergic to it, or if you have: asthma; "AV block" (2nd or 3rd degree); uncontrolled heart failure; very low blood pressure; slow heartbeats that have caused you to faint; or if your heart cannot pump blood properly. Tell your doctor if you have ever had: congestive heart failure; angina (chest pain); liver disease; emphysema, chronic bronchitis, or other breathing problems; pheochromocytoma (tumor of the adrenal gland); diabetes; coronary artery bypass surgery (sometimes called "CABG"); kidney disease; or allergies. Labetalol can affect your pupils. If you need eye surgery, tell the surgeon about your use of labetalol, even if you no longer take it. Labetalol may cause low blood pressure, low blood sugar, slow heartbeats, or breathing problems in a newborn if the mother uses labetalol during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant. Ask a doctor if it is safe to breastfeed while using this medicine. Not approved for use by anyone younger than 18 years old. How should I use labetalol? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Labetalol oral is taken by mouth. Labetalol injection is given in a vein by a healthcare provider when hypertension is severe. After the injection you may need to remain lying down for up to 3 hours. You may feel light-headed when you first stand up. Your blood pressure will need to be checked often, and you may need other medical tests. If you have diabetes, check your blood sugar regularly. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. Labetalol can cause false results with certain lab tests of the urine, including a drug-screening urine test. Tell the laboratory staff that you use labetalol. Tell your doctor if you have a planned surgery. You should not stop using labetalol suddenly. Stopping suddenly may make your condition worse. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include slow heart rate, wheezing, chest tightness, trouble breathing, extreme dizziness, seizure, or fainting. What should I avoid while using labetalol? Avoid driving or hazardous activity until you know how labetalol will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Drinking alcohol can further lower your blood pressure and may increase certain side effects of labetalol. Labetalol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); shortness of breath (even with mild exertion), swelling, rapid weight gain; severe headache, blurred vision, pounding in your neck or ears; or liver problems--loss of appetite, stomach pain (upper right side), flu-like symptoms, itching, dark urine, jaundice (yellowing of the skin or eyes). Severe dizziness or fainting may be more likely in older adults. Common side effects may include: dizziness, drowsiness, tiredness; nausea, vomiting; sudden warmth, skin redness, sweating; numbness; or tingly feeling in your scalp. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect labetalol? Tell your doctor about all your other medicines, especially: any other blood pressure medicine; aminophylline, theophylline; cimetidine; heart medication; insulin or oral diabetes medicine; an antidepressant--amitriptyline, doxepin, desipramine, imipramine, nortriptyline, and others; or a bronchodilator--albuterol, formoterol, levalbuterol, metaproterenol, olodaterol, salmeterol, and others. This list is not complete. Other drugs may affect labetalol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is lactulose? Lactulose is used to treat chronic constipation. Lactulose is sometimes used to treat or prevent certain conditions of the brain that are caused by liver failure. These conditions can lead to confusion, problems with memory or thinking, behavior changes, tremors, feeling irritable, sleep problems, loss of coordination, and loss of consciousness. Lactulose may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use lactulose if you are on a special diet low in galactose (milk sugar). Tell your doctor if you have ever had: diabetes; or if you need to have any type of intestinal test using a scope (such as a colonoscopy). Tell your doctor if you are pregnant or breastfeeding. How should I take lactulose? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Mix lactulose powder with at least 4 ounces of water, milk, or fruit juice. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). Lactulose should produce a bowel movement within 24 to 48 hours. If you use lactulose long-term, you may need frequent medical tests. Tell your doctor if you have a planned colonoscopy or proctoscopy procedure. Store tightly closed at room temperature, away from moisture and heat. Avoid freezing. The liquid may turn darker in color, but this will not affect the medicine. Do not use the medicine if it becomes very dark or gets thicker or thinner in texture. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose may cause nausea, vomiting, diarrhea, and stomach cramps, or symptoms of low blood potassium or low blood sodium (confusion, weakness, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling). What should I avoid while taking lactulose? Ask your doctor before taking any other laxative or an antacid, and take only the type your doctor recommends. Lactulose side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea. Common side effects may include: bloating, gas; stomach pain; diarrhea; or nausea, vomiting. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Lactulose dosing information Usual Adult Dose for Constipation -- Chronic: 15 mL orally once a day. Usual Adult Dose for Constipation -- Acute: Initial dose: 15 mL orally once a day. Therapy should be continued until normal bowel function resumes. Usual Adult Dose for Hepatic Encephalopathy: Initial dose: 30 mL orally 3 times a day or 300 mL in 700 mL water or normal saline as an enema retained for 30 to 60 minutes every 4 to 6 hours. Maintenance dose: 30 to 45 mL orally 3 times a day. Usual Pediatric Dose for Hepatic Encephalopathy: Infants: 1.7 to 6.7 g/day (2.5 to 10 mL) orally daily divided in 3 to 4 doses. Adjust dosage to produce 2 to 3 soft stools per day. Children: 26.7 to 60 g/day (40 to 90 mL) orally daily divided in 3 to 4 doses. Adjust dosage to produce 2 to 3 soft stools per day. Usual Pediatric Dose for Constipation -- Chronic: Children: 0.7 to 2 g/kg/day (1 to 3 mL/kg/day) orally in divided doses daily; generally recommended not to exceed the adult maximum of 40 g/day (60 mL/day).   What other drugs will affect lactulose? Other drugs may affect lactulose, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is lamivudine and zidovudine? Lamivudine and zidovudine are antiviral medications that prevent human immunodeficiency virus (HIV) from multiplying in your body. Lamivudine and zidovudine is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Lamivudine and zidovudine is not a cure for HIV or AIDS. Lamivudine and zidovudine may also be used for purposes not listed in this medication guide. Warnings Do not take lamivudine and zidovudine if you have ever had an allergic reaction to any medicine that contains lamivudine or zidovudine. Zidovudine can weaken your immune system and cause signs of infection (fever, mouth sores, skin sores, flu symptoms, pale skin). Your blood will need to be tested often. Long-term use of zidovudine can cause muscle weakness, or loss of muscle tissue similar to "wasting syndrome" caused by HIV. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired. If you've ever had hepatitis B, it may become active or get worse after you stop using this medicine. You may need frequent liver function tests for several months. Before taking this medicine You should not take this medicine if you are allergic to lamivudine. Do not take Combivir with any other medicine that contains lamivudine, zidovudine, or emtricitabine. This includes Atripla, Biktarvy, Cimduo, Combivir, Complera, Descovy, Emtriva, Epzicom, Genvoya, Odefsey, Retrovir, Stribild, Symfi, Triumeq, Trizivir, and Truvada. Lamivudine and zidovudine can also cause severe or fatal liver problems. Tell your doctor if you have liver disease, especially hepatitis B. Lamivudine and zidovudine should not be used to treat HIV in adolescents weighing less than 66 pounds. Tell your doctor if you have ever had: kidney disease; pancreas disorder (especially in a child taking this medicine); or if you take ribavirin to treat hepatitis C. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk. Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk. How should I take lamivudine and zidovudine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may take lamivudine and zidovudine with or without food. Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor. Store at room temperature away from moisture and heat. If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using lamivudine and zidovudine. You may need frequent liver function tests while using this medicine and for several months after your last dose. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking lamivudine and zidovudine? Avoid taking other medications that contain an ingredient called sorbitol, often used as a sweetener in liquid medicines. Ask your pharmacist if you are not sure a medicine contains this ingredient. Using lamivudine and zidovudine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Lamivudine and zidovudine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired. Call your doctor at once if you have: liver problems--swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting. Lamivudine and zidovudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have: signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects may include: headache; nausea, diarrhea; tiredness, general ill feeling; cold symptoms such as stuffy nose, sneezing, sinus pain, cough; or loss of body fat (especially in your arms, legs, face, and buttocks). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Lamivudine and zidovudine dosing information Usual Adult Dose for HIV Infection: 1 tablet orally twice a day Use: In combination with other antiretrovirals, for the treatment of HIV-1 infection Usual Adult Dose for Nonoccupational Exposure: US CDC recommendations: 1 tablet orally every twice a day Duration of therapy: 28 days Comments: -Recommended as part of a preferred NNRTI-based or protease inhibitor-based regimen for nonoccupational postexposure prophylaxis of HIV infection; also recommended as part of alternative regimens (NNRTI-based, protease inhibitor-based, or triple NRTI) -Prophylaxis should be started as soon as possible, within 72 hours of exposure. -Current guidelines should be consulted for additional information. Usual Adult Dose for Occupational Exposure: US Public Health Service working group recommendations: 1 tablet orally twice a day Duration of therapy: 28 days, if tolerated Comments: -Recommended as part of alternative regimens for HIV postexposure prophylaxis -Prophylaxis should be started as soon as possible, preferably within hours after exposure. -The optimal duration of prophylaxis is unknown and may differ based on the institution protocol. -Current guidelines should be consulted for additional information. Usual Pediatric Dose for HIV Infection: At least 30 kg: 1 tablet orally twice a day Comments: -Use of the individual components is recommended for patients less than 30 kg; the manufacturer product information for lamivudine and zidovudine should be consulted. Use: In combination with other antiretrovirals, for the treatment of HIV-1 infection   What other drugs will affect lamivudine and zidovudine? Tell your doctor about all your other medicines, especially: ganciclovir; interferon alfa; or ribavirin. This list is not complete. Other drugs may affect lamivudine and zidovudine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is lamotrigine? Lamotrigine is an anti-epileptic medication, also called an anticonvulsant. Lamotrigine is used alone or with other medications to treat epileptic seizures in adults and children. Lamotrigine is also used to delay mood episodes in adults with bipolar disorder (manic depression). Immediate-release lamotrigine can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form should not be used as a single medication in a child or teenager who is younger than 16 years old. Extended-release lamotrigine is for use only in adults and children who are at least 13 years old. Lamotrigine may also be used for purposes not listed in this medication guide. Warnings Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Seek emergency medical attention if you have a skin rash, hives, blistering, peeling, or sores in your mouth or around your eyes. Call your doctor at once if you have signs of other serious side effects, including: fever, swollen glands, severe muscle pain, bruising or unusual bleeding, yellowing of your skin or eyes, headache, neck stiffness, vomiting, confusion, or increased sensitivity to light. Some people have thoughts about suicide while taking lamotrigine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Before taking this medicine You should not take lamotrigine if you are allergic to it. Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Tell your doctor if you have ever had: a rash or allergic reaction after taking another seizure medication; kidney or liver disease; heart problems such as heart block or irregular heartbeats; depression, suicidal thoughts or actions; or meningitis (inflammation of the tissue that covers the brain and spinal cord) after taking lamotrigine. Some people have thoughts about suicide while taking lamotrigine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lamotrigine on the baby. Birth control pills can make lamotrigine less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills. Your lamotrigine dose may need to be changed. It may not be safe to breastfeed while using lamotrigine. Ask your doctor about any risk. How should I take lamotrigine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Taking too much lamotrigine at the start of treatment may increase your risk of a severe life-threatening skin rash. You may need frequent blood tests to help your doctor make sure you are taking the right dose. Extended-release and immediate-release lamotrigine may be used for different conditions. Always check your refills to make sure you have received the correct size, color, and shape of tablet. Avoid medication errors by using only the form and strength your doctor prescribes. If you switch to lamotrigine from another seizure medicine, carefully follow your doctor's instructions about the timing and dosage of your medicine. Swallow the tablet whole and do not crush, chew, or break it. Read and carefully follow any Instructions for Use provided with the orally disintegrating or dispersible tablets. Ask your doctor or pharmacist if you do not understand these instructions. Do not stop using lamotrigine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. In case of emergency, wear or carry medical identification to let others know you use seizure medication. Lamotrigine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use lamotrigine. Store at room temperature away from light and moisture.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include blurred vision, problems with coordination, increased seizures, feeling light-headed, or fainting. What should I avoid while taking lamotrigine? Avoid driving or hazardous activity until you know how lamotrigine will affect you. Your reactions could be impaired. Lamotrigine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). If you have to stop taking lamotrigine because of a serious skin rash, you may not be able to take it again in the future. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: fast, slow, or pounding heartbeats or fluttering in your chest; chest pain, shortness of breath; fever, swollen glands, weakness, severe muscle pain; any skin rash, especially with blistering or peeling; painful sores in your mouth or around your eyes; headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, drowsiness; jaundice (yellowing of the skin or eyes); or pale skin, cold hands and feet, easy bruising, unusual bleeding. Common side effects may include: headache, dizziness; blurred vision, double vision; tremor, loss of coordination; dry mouth, nausea, vomiting, stomach pain, diarrhea; fever, sore throat, runny nose; drowsiness, tired feeling; back pain; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect lamotrigine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Other drugs may affect lamotrigine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is lamotrigine? Lamotrigine is an anti-epileptic medication, also called an anticonvulsant. Lamotrigine is used alone or with other medications to treat epileptic seizures in adults and children. Lamotrigine is also used to delay mood episodes in adults with bipolar disorder (manic depression). Immediate-release lamotrigine can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form should not be used as a single medication in a child or teenager who is younger than 16 years old. Extended-release lamotrigine is for use only in adults and children who are at least 13 years old. Lamotrigine may also be used for purposes not listed in this medication guide. Warnings Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Seek emergency medical attention if you have a skin rash, hives, blistering, peeling, or sores in your mouth or around your eyes. Call your doctor at once if you have signs of other serious side effects, including: fever, swollen glands, severe muscle pain, bruising or unusual bleeding, yellowing of your skin or eyes, headache, neck stiffness, vomiting, confusion, or increased sensitivity to light. Some people have thoughts about suicide while taking lamotrigine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Before taking this medicine You should not take lamotrigine if you are allergic to it. Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Tell your doctor if you have ever had: a rash or allergic reaction after taking another seizure medication; kidney or liver disease; heart problems such as heart block or irregular heartbeats; depression, suicidal thoughts or actions; or meningitis (inflammation of the tissue that covers the brain and spinal cord) after taking lamotrigine. Some people have thoughts about suicide while taking lamotrigine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lamotrigine on the baby. Birth control pills can make lamotrigine less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills. Your lamotrigine dose may need to be changed. It may not be safe to breastfeed while using lamotrigine. Ask your doctor about any risk. How should I take lamotrigine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Taking too much lamotrigine at the start of treatment may increase your risk of a severe life-threatening skin rash. You may need frequent blood tests to help your doctor make sure you are taking the right dose. Extended-release and immediate-release lamotrigine may be used for different conditions. Always check your refills to make sure you have received the correct size, color, and shape of tablet. Avoid medication errors by using only the form and strength your doctor prescribes. If you switch to lamotrigine from another seizure medicine, carefully follow your doctor's instructions about the timing and dosage of your medicine. Swallow the tablet whole and do not crush, chew, or break it. Read and carefully follow any Instructions for Use provided with the orally disintegrating or dispersible tablets. Ask your doctor or pharmacist if you do not understand these instructions. Do not stop using lamotrigine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. In case of emergency, wear or carry medical identification to let others know you use seizure medication. Lamotrigine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use lamotrigine. Store at room temperature away from light and moisture.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include blurred vision, problems with coordination, increased seizures, feeling light-headed, or fainting. What should I avoid while taking lamotrigine? Avoid driving or hazardous activity until you know how lamotrigine will affect you. Your reactions could be impaired. Lamotrigine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). If you have to stop taking lamotrigine because of a serious skin rash, you may not be able to take it again in the future. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: fast, slow, or pounding heartbeats or fluttering in your chest; chest pain, shortness of breath; fever, swollen glands, weakness, severe muscle pain; any skin rash, especially with blistering or peeling; painful sores in your mouth or around your eyes; headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, drowsiness; jaundice (yellowing of the skin or eyes); or pale skin, cold hands and feet, easy bruising, unusual bleeding. Common side effects may include: headache, dizziness; blurred vision, double vision; tremor, loss of coordination; dry mouth, nausea, vomiting, stomach pain, diarrhea; fever, sore throat, runny nose; drowsiness, tired feeling; back pain; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect lamotrigine? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Other drugs may affect lamotrigine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

USES This package of Twist Top Lancets has been designed for use with Prodigy brand Blood Testing Glucometers but will work with most other lancing devices. Use these lancets as they are or with a lancing device (available separately). Each lancet features a twist-top, an ultra-fine gauge and tri-bevel tip. Please note, this is a package of 100 individual 28G twist-top lancets only. Lancers and Blood Testing Glucose Meters are available separately. To use, twist off the protective cap. After use, discard the lancet in a puncture-resistant container. Thanks to the tri-bevel tip, sampling is virtually painless with these lancets. These Prodigy Twist Top Lancets penetrate the skin every time and offer consistent depth penetration. Do not store lancets in lancing devices and do not reuse lancets. Lancets are packaged sterile with a protective cap. Do not use if protective cap is missing or damaged.

What is digoxin? Lanoxin (digoxin) is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm. Lanoxin is used to treat heart failure. Lanoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria (the upper chambers of the heart that allow blood to flow into the heart). Warnings You should not use Lanoxin if you have ventricular fibrillation (a heart rhythm disorder of the ventricles, or lower chambers of the heart that allow blood to flow out of the heart). Before taking this medicine You should not use Lanoxin if you are allergic to digoxin, or if you have ventricular fibrillation (a heart rhythm disorder of the ventricles, or lower chambers of the heart that allow blood to flow out of the heart). To make sure Lanoxin is safe for you, tell your doctor if you have ever had: a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); a heart attack; slow heartbeats that have caused you to faint; Wolff-Parkinson-White Syndrome (sudden fast heartbeats); kidney disease; an electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood); a thyroid disorder; or if you have recently been sick with vomiting or diarrhea. Tell your doctor if you are pregnant. It is not known whether digoxin will harm an unborn baby. However, having heart failure or atrial fibrillation during pregnancy may cause complications such as premature birth or low birth weight, or risk of death in both mother and baby. The benefit of treating heart problems with digoxin may outweigh any risks to the baby. It may not be safe to breast-feed while using Lanoxin. Ask your doctor about any risk. How should I use Lanoxin? Take Lanoxin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Try to take oral Lanoxin at the same time every day. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Take Lanoxin regularly even if you feel fine or have no symptoms. Get your prescription refilled before you run out of medicine completely. Lanoxin injection is given as a shot into a muscle, or as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. Your blood pressure and heart rate will need to be checked daily. You may need frequent blood tests. Your kidney function may also need to be checked. You should not stop taking Lanoxin suddenly. Stopping suddenly may make your condition worse. Store at room temperature away from moisture and heat. Dosing information Usual Adult Dose of Lanoxin for Congestive Heart Failure: Rapid Digitalization with a Loading Dose: Peak digoxin body stores of 8 to 12 mcg/kg generally provide a therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm. The loading dose should be administered in several fractions, with approximately half the total given as the first dose. Additional fractions of the total dose may be given at 6 to 8 hour intervals. Careful assessment of the patient's clinical response should be considered before each additional dose. If the patient's response necessitates a change from the calculated loading dose of digoxin, then calculation of the maintenance dose should be based upon the amount actually given. Tablets: Initial: 500 to 750 mcg usually produces a detectable effect in 0.5 to 2 hours with a maximal effect in 2 to 6 hours. Additional doses of 125 to 375 mcg may be given at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin tablets that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 750 to 1250 mcg. Injection: Initial: 400 to 600 mcg of digoxin intravenously usually produces a detectable effect in 5 to 30 minutes with a maximal effect in 1 to 4 hours. Additional doses of 100 to 300 mcg may be given cautiously at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin injection that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 600 to 1000 mcg. The injectable route is frequently used to achieve rapid digitalization, with conversion to digoxin tablets for maintenance therapy. Maintenance Dose: The doses of digoxin tablets used in controlled trials in patients with heart failure have ranged from 125 to 500 mcg once daily. In these studies, the digoxin dose has been generally titrated according to the patient's age, lean body weight, and renal function. Therapy is generally initiated at a dose of 250 mcg once daily in patients under age 70 with good renal function. Usual Adult Dose for Atrial Fibrillation: Peak digoxin body stores larger than the 8 to 12 mcg/kg required for most patients with heart failure and normal sinus rhythm have been used for control of ventricular rate in patients with atrial fibrillation. Doses of digoxin used for the treatment of chronic atrial fibrillation should be titrated to the minimum dose that achieves the desired ventricular rate control without causing undesirable side effects.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of digoxin can be fatal. Overdose symptoms may include nausea, vomiting, loss of appetite, and feeling tired. What should I avoid while using Lanoxin? Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Digoxin overdose can occur more easily if you are dehydrated. Lanoxin side effects Get emergency medical help if you have signs of an allergic reaction to Lanoxin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: nausea, vomiting, diarrhea, stomach pain; fast, slow, or uneven heart rate; a light-headed feeling, like you might pass out; bloody or black, tarry stools; confusion, weakness, hallucinations, unusual thoughts or behavior; breast swelling or tenderness; blurred vision, yellowed vision; or (in babies or children) stomach pain, weight loss, growth delay, behavior changes. Serious side effects may be more likely in older adults and those who are ill or debilitated. Common Lanoxin side effects may include: nausea, diarrhea; feeling weak or dizzy; headache, weakness, anxiety, depression; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Lanoxin? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with digoxin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is lansoprazole? Lansoprazole is a proton pump inhibitor. Lansoprazole decreases the amount of acid produced in the stomach. Lansoprazole is used to treat and prevent stomach and intestinal ulcers, erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Over-the-counter lansoprazole (Prevacid OTC) is used to treat frequent heartburn that happens 2 or more days per week. This medicine is not for the immediate relief of heartburn symptoms. Warnings Lansoprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. This medicine can cause diarrhea, which may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it. Lansoprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. You may be more likely to have a broken bone while taking this medicine long term or more than once per day. If you also take sucralfate (Carafate), avoid taking it at the same time you take this medicine. Sucralfate can make it harder for your body to absorb lansoprazole. Wait at least 30 minutes after taking this medicine before you take sucralfate. Before taking this medicine You should not use lansoprazole if you are allergic to it, or if you take any medicine that contains rilpivirine (Edurant, Complera, Odefsey). Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. Tell your doctor if you have ever had: liver disease; lupus; low levels of magnesium in your blood; or osteoporosis or low bone mineral density (osteopenia). Do not use over-the-counter lansoprazole (Prevacid OTC) without the advice of a doctor if you have: trouble or pain with swallowing; bloody or black stools; vomit that looks like blood or coffee grounds; heartburn that has lasted for over 3 months; frequent chest pain, heartburn with wheezing; unexplained weight loss; nausea or vomiting, stomach pain; or an electrolyte imbalance or metabolic disorder. Some forms of lansoprazole may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy. Some conditions are treated with a combination of lansoprazole and antibiotics. Use all medications as directed by your doctor Do not give lansoprazole to a child younger than 1 year old. Prevacid OTC is not approved for use by anyone younger than 18 years old. Ask a doctor before using this medicine if you are pregnant or breastfeeding. How should I take lansoprazole? Use lansoprazole exactly as directed on the label, or as prescribed by your doctor and read all medication guides or instruction sheets. Lansoprazole is usually taken before eating. Prevacid OTC should be taken in the morning before you eat breakfast. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Shake the lansoprazole oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Swallow the lansoprazole capsule whole and do not crush, chew, break, or open it. Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves. Use lansoprazole for the full prescribed length of time, even if your symptoms quickly improve. Prevacid OTC should be taken only once daily for 14 days. It may take up to 4 days for full effect. Allow at least 4 months to pass before you start another 14-day treatment with Prevacid OTC. Call your doctor if your symptoms do not improve or if they get worse while you are taking lansoprazole. If you take Prevacid OTC, call your doctor if your heartburn gets worse over the 14-day treatment, or if you need treatment more than once every 4 months. Some conditions are treated with a combination of lansoprazole and antibiotics. Use all medications as directed. If you use lansoprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Store at room temperature away from moisture, heat, and light. Do not freeze the liquid medicine.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine. Lansoprazole side effects Get emergency medical help if you have signs of an allergic reaction ro lansoprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; new or unusual pain in your wrist, back, hip, or thigh; a seizure (convulsions); kidney problems - fever, nausea, little or no urination, blood in your urine, swelling, rapid weight gain; low magnesium - dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Taking lansoprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk. If you use lansoprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Common lansoprazole side effects may include: nausea, stomach pain; diarrhea, constipation; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect lansoprazole? Sucralfate (Carafate) can make it harder for your body to absorb lansoprazole. Wait at least 30 minutes after taking lansoprazole before you take sucralfate. Tell your doctor if you use methotrexate. Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can affect lansoprazole, and some drugs should not be used at the same time. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is latanoprost ophthalmic? Latanoprost ophthalmic (for the eyes) is used to treat certain types of glaucoma and other causes of high pressure inside the eye. Latanoprost ophthalmic may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use latanoprost ophthalmic if you are allergic to latanoprost or benzalkonium chloride. Tell your doctor if you have ever had: swelling or an infection in your eye; herpes infection of the eyes; retinal detachment; or eye surgery or injury affecting the lens of your eye. Latanoprost ophthalmic is not approved for use by anyone younger than 18 years old. Latanoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, usually an increase in brown pigment. You may also notice increased growth or thickness of your eyelashes. These changes occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other. Tell your doctor if you are pregnant or breastfeeding. How should I use latanoprost ophthalmic? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. The usual dose of this medicine is 1 drop into the affected eye every evening. Follow your doctor's dosing instructions very carefully. Do not use while wearing soft contact lenses. A preservative in this medicine could permanently stain the lenses. Use the medicine at least 15 minutes before inserting your contact lenses. Wash your hands before using the eye drops. To apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop. Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct. Wait at least 5 minutes before using any other eye drops your doctor has prescribed. Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems. Tell your doctor right away if you have an eye injury or eye infection, or if you plan to have eye surgery. Store an unopened bottle of latanoprost eye drops in a refrigerator. Do not freeze. After your first use, store the eye drops at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Throw away the medicine after 6 weeks have passed since you first opened the bottle. What happens if I miss a dose? Skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose. What happens if I overdose? An overdose of latanoprost ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication. What should I avoid while using latanoprost ophthalmic? Avoid using too much of latanoprost ophthalmic, which can actually make it less effective in lowering the pressure inside the eye. Do not use other eye medications unless your doctor tells you to. Latanoprost ophthalmic side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using latanoprost and call your doctor at once if you have: eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection); red, swollen, or itchy eyelids; increased sensitivity to light; vision changes; or severe burning, stinging, or irritation after using this medicine. Common side effects may include: watery eyes; itchy eyes; puffy eyelids; stinging, burning, or redness of the eyes; blurred vision; feeling like something is in your eye; your eyes may be more sensitive to light; darkened eye color; or eyelash thickening. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Latanoprost ophthalmic dosing information Usual Adult Dose for Intraocular Hypertension: One eye drop in the affected eye(s) once a day in the evening Comments: -If one dose is missed, treatment should continue with the next dose as normal. -The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect. -Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours. -This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure. -If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart. Use: -Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension Usual Adult Dose for Glaucoma (Open Angle): One eye drop in the affected eye(s) once a day in the evening Comments: -If one dose is missed, treatment should continue with the next dose as normal. -The dose should not exceed one drop in the affected eye(s) daily as more frequent administration may lessen the intraocular pressure lowering effect. -Reduction of the intraocular pressure starts approximately 2 to 4 hours after the first administration with the maximum effect reached after 12 hours. -This drug may be used concomitantly with other topical ophthalmic drugs to lower intraocular pressure. -If more than one topical ophthalmic drug is being used, each one should be administered at least 5 minutes apart. Use: -Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension   What other drugs will affect latanoprost ophthalmic? Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What is leflunomide? Leflunomide affects the immune system and reduces swelling and inflammation in the body. Leflunomide is used to treat the symptoms of rheumatoid arthritis. Leflunomide may also be used for purposes not listed in this medication guide. Warnings Do not use leflunomide if you are pregnant, and stop taking leflunomide if you think you might be pregnant. Use birth control to prevent pregnancy while you are taking leflunomide, and until you complete a "drug elimination" procedure. Leflunomide can cause severe or fatal liver damage. Tell your doctor if you have a history of liver disease or if you also use other medicines such as: pain or arthritis medicine (including aspirin, Tylenol, and Advil/Motrin), medicines to treat tuberculosis or other infections, seizure medication, hormonal birth control or hormone replacement therapy, chemotherapy, cholesterol-lowering medicine, heart medication, or blood pressure medicine. Your liver function will need to be tested often, and you may need to stop taking leflunomide based on the results of these tests. Before taking this medicine You should not use this medicine if you are allergic to leflunomide or teriflunomide, or if: you are pregnant (you will need to have a negative pregnancy test before starting this treatment); you have severe liver disease; or you are also using teriflunomide. Do not use leflunomide if you are pregnant or may become pregnant. Avoid getting pregnant until after you stop taking leflunomide and undergo a "drug elimination" procedure to help rid your body of this medicine. Stop taking leflunomide and call your doctor right away if you miss a period or think you might be pregnant. To make sure leflunomide is safe for you, tell your doctor if you have: a history of liver disease or hepatitis (leflunomide can cause severe liver problems); a severe or uncontrolled infection; kidney disease; nerve problems, such as neuropathy caused by diabetes; a history of tuberculosis; a weak immune system or bone marrow disorder; or if you are using any drugs that weaken your immune system (such as cancer medicine or steroids). Use birth control to prevent pregnancy while you are taking this medicine. After you stop taking leflunomide, continue using birth control until you have received blood tests to make sure the drug has been eliminated from your body. Ask your doctor if you should use a barrier form of birth control (condom or diaphragm with spermicide). Using hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may increase your risk of liver damage while taking leflunomide. It is not known whether leflunomide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take leflunomide? Before you start treatment with leflunomide, your doctor may perform tests to make sure you do not have tuberculosis or other infections. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use leflunomide in larger or smaller amounts or for longer than recommended. Your blood pressure will need to be checked often. Leflunomide can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your leflunomide treatment may be stopped for a short time based on the results of these tests. Your liver function will also need to be tested often, and you may need to stop taking leflunomide based on the results of these tests. After you stop taking leflunomide, you may need to be treated with other medicines to help your body eliminate leflunomide quickly. If you do not undergo this drug elimination procedure, leflunomide could stay in your body for up to 2 years. Follow your doctor's instructions. You will also need to go through this drug elimination procedure if you plan to become pregnant after you stop taking leflunomide. Arthritis is often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include diarrhea, stomach pain, pale skin, easy bruising or bleeding, dark urine, or jaundice (yellowing of the skin or eyes). What should I avoid while taking leflunomide? Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection. Do not receive a "live" vaccine while using leflunomide, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine. Leflunomide side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: signs of infection--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; numbness, tingling, or burning pain in your hands or feet; liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Common side effects may include: nausea, diarrhea, stomach pain; headache; abnormal liver function tests; thinning hair; back pain; weakness; rash; or high blood pressure. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Leflunomide dosing information Usual Adult Dose for Rheumatoid Arthritis: Loading dose: 100 mg orally once a day for 3 days Maintenance: 20 mg orally once a day (If not well tolerated, the dose may be decreased to 10 mg orally once a day) Comment: -Hematology parameters and liver enzymes should be monitored. Use: For the treatment of active rheumatoid arthritis (RA): -To reduce signs and symptoms -To inhibit structural damage as evidenced by X-ray erosions and joint space narrowing -To improve physical function   What other drugs will affect leflunomide? Leflunomide can cause severe or fatal liver damage. This effect is increased when you also use certain other medicines, including: acetaminophen (Tylenol), aspirin, gout or arthritis medication (including gold injections); an NSAID (non-steroidal anti-inflammatory drug)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; an antibiotic, antifungal medicine, or sulfa drug; tuberculosis medicine; antiviral or HIV/AIDS medication; medicine to treat mental illness; seizure medication--carbamazepine, phenytoin, valproic acid, and others; birth control pills or hormone replacement therapy; anabolic steroids--methyltestosterone, "performance-enhancing drugs"; cancer medication; or cholesterol-lowering medication--Crestor, Lipitor, Vytorin, Zocor, and others; heart or blood pressure medication. This list is not complete and many other drugs can interact with leflunomide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Not all possible interactions are listed in this medication guide.

What is letrozole? Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. Letrozole is used to treat breast cancer in postmenopausal women. It is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. Letrozole may also be used for purposes not listed in this medication guide. Warnings You should not use letrozole if you are pregnant. Before taking this medicine You should not use letrozole if you are allergic to it. letrozole is for use only in women who can no longer get pregnant. Letrozole can harm an unborn baby. Do not use if you are pregnant. Use effective birth control if you are not past menopause. Keep using birth control for at least 3 weeks after your last dose of letrozole. Tell your doctor if you think you may be pregnant. Tell your doctor if you have ever had: liver disease (especially cirrhosis); osteoporosis, osteopenia (low bone mineral density); high cholesterol; or if you also take tamoxifen. You should not breastfeed while you are using letrozole and for at least 3 weeks after your last dose. How should I take letrozole? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may take letrozole with or without food. You will need frequent medical tests, and your bone mineral density may also need to be checked. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking letrozole? Avoid driving or hazardous activity until you know how letrozole will affect you. Your reactions could be impaired. Letrozole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Common side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or increased cholesterol in your blood. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Letrozole dosing information Usual Adult Dose for Breast Cancer: 2.5 mg orally once a day Duration of therapy: -Adjuvant and extended adjuvant settings: Optimal duration is unknown; discontinue therapy at relapse. -Advanced disease: Until tumor progression is evident. Uses: -Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer -Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy -First-line treatment of advanced breast cancer in postmenopausal women with hormone receptor positive or unknown locally advanced or metastatic breast cancer; second-line treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy Usual Adult Dose for Breast Cancer -- Adjuvant: 2.5 mg orally once a day Duration of therapy: -Adjuvant and extended adjuvant settings: Optimal duration is unknown; discontinue therapy at relapse. -Advanced disease: Until tumor progression is evident. Uses: -Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer -Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy -First-line treatment of advanced breast cancer in postmenopausal women with hormone receptor positive or unknown locally advanced or metastatic breast cancer; second-line treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy   What other drugs will affect letrozole? Other drugs may affect letrozole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is levalbuterol inhalation? Levalbuterol is a short-acting bronchodilator that relaxes muscles in the airways and increases air flow to the lungs. Levalbuterol inhalation is used to treat or prevent asthma attacks in adults and children who are at least 4 years old. Levalbuterol inhalation may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Seek medical attention if you think your asthma medications are not working as well. Before taking this medicine You should not use levalbuterol inhalation if you are allergic to levalbuterol or albuterol (Accuneb, ProAir, Proventil, Ventolin). To make sure levalbuterol is safe for you, tell your doctor if you have: heart disease, high blood pressure, or congestive heart failure; a seizure disorder; diabetes; or a thyroid disorder. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether levalbuterol inhalation passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding. A levalbuterol inhaler should not be given to a child younger than 4 years old. Levalbuterol solution in a nebulizer should not be given to a child younger than 6 years old. How should I use levalbuterol inhalation? Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. Any child using levalbuterol inhalation should be supervised by an adult while using this medicine. Prime the inhaler device before your first use. Pump 4 test sprays into the air, away from your face. Shake the inhaler for at least 5 seconds before each spray. Prime again whenever the inhaler has not been used in longer than 3 days. To use the inhaler: Shake the canister well just before each spray. Uncap the mouthpiece of the inhaler. Breathe out fully. Put the mouthpiece into your mouth and close your lips. Breathe in slowly while pushing down on the canister. Hold your breath for 10 seconds, then breathe out slowly. If you use more than one inhalation at a time, wait at least 1 minute before using the second inhalation and shake the inhaler again. Keep your inhaler clean and dry, and store it with the cap on the mouthpiece. Clean your inhaler once a week by removing the canister and placing the mouthpiece under warm running water for at least 30 seconds. Shake out the excess water and allow the parts to air dry completely before putting the inhaler back together. Store the levalbuterol inhaler with the mouthpiece down. Keep the inhaler at room temperature away from heat, sunlight, or freezing temperatures. If your inhaler has a dose number indicator on it, throw away the inhaler when the number displays "0" to show that all sprays have been used. Keep the inhaler canister away from open flame or high heat, such as in a car on a hot day. The canister may explode if it gets too hot. Do not puncture or burn an empty inhaler canister. Levalbuterol concentrate solution is given with a nebulizer. The concentrate must be mixed with a liquid (diluent) before using it. Ask your pharmacist about which diluent to use and where you can buy it. Be sure you understand how to properly mix the medicine and place it into the nebulizer. To use the solution with a nebulizer: Open the foil pouch and empty the medicine into the chamber of the nebulizer. Add the correct amount of diluent as directed by your doctor. Attach the mouthpiece or face mask, then attach the drug chamber to the compressor. Sit upright in a comfortable position. Place the mouthpiece into your mouth or put on the face mask, covering your nose and mouth. Turn on the compressor. Breathe in slowly and evenly until no more mist is formed by the nebulizer and the drug chamber is empty. Clean the nebulizer after each use. Follow the cleaning directions that came with your nebulizer. Do not use the nebulizer solution if it does not appear clear and colorless. Store the levalbuterol concentrate vials in the protective foil pouch at room temperature, away from moisture, heat, and light. Keep each vial in the foil pouch until you are ready to prepare a dose in the nebulizer. Each single-use plastic vial of levalbuterol concentrate is for one use only. Throw away after one use, even if there is still some medicine left in it after inhaling your dose. Asthma is often treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Using too much levalbuterol or using it too often can cause life-threatening side effects. Seek medical attention if you think your asthma medications are not working as well. An increased need for medication could be an early sign of a serious asthma attack.   What happens if I miss a dose? Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. Use levalbuterol inhalation regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of levalbuterol can be fatal. What should I avoid while using levalbuterol inhalation? Avoid situations that may make your condition worse such as exercising in cold, dry air; smoking; breathing in dust; and exposure to allergens such as pet fur. Levalbuterol inhalation side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: wheezing, choking, or other breathing problems after using levalbuterol inhalation; pounding heartbeats or fluttering in your chest; worsening asthma symptoms; or low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling. Common side effects may include: dizziness, nervousness, tremors; runny nose, sore throat; chest pain or tightness, irregular heartbeats; pain; or vomiting. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect levalbuterol inhalation? Tell your doctor if you have used an MAO inhibitor in the past 14 days. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor about all your current medicines and any you start or stop using, especially: any other inhaled medicines to treat asthma or COPD (chronic obstructive pulmonary disease); an antidepressant; a diuretic or "water pill"; or medicine to treat a heart condition. This list is not complete. Other drugs may interact with levalbuterol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is levetiracetam? Levetiracetam is used to treat certain types of seizures in people with epilepsy, including partial onset seizures, myoclonic seizures, and tonic-clonic seizures. When used for partial onset seizures: Extended-release (XR) levetiracetam is for adults and children at least 12 years old. Spritam is for children at least 4 years old who weigh at least 44 pounds (20 kilograms). Roweepra and Keppra may be used in children as young as 1 month old. Levetiracetam is also used with other seizure medications to treat tonic-clonic seizures in people who are at least 6 years old, and myoclonic seizures in people at least 12 years old. Levetiracetam injection is for use only in people who are least 16 years old. Levetiracetam may also be used for purposes not listed in this medication guide. Warnings Some people have thoughts about suicide while taking levetiracetam. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Seizures may increase if you stop using levetiracetam suddenly. Before taking this medicine You should not use levetiracetam if you are allergic to it. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); depression or other mood problems; mental illness or psychosis; or suicidal thoughts or actions. Do not give levetiracetam to a child without medical advice. Different brands of this medicine are for use only in children of certain ages. Some people have thoughts about suicide while taking levetiracetam. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor if you become pregnant. Your dose needs may be different during pregnancy. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of levetiracetam on the baby. Ask a doctor if it is safe to breastfeed while using this medicine. How should I take levetiracetam? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Levetiracetam oral is taken by mouth at the same time each day, with or without food. Levetiracetam injection is given in a vein if you are unable to take the medicine by mouth. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. A child's dose needs may change if the child gains or loses weight. Avoid medication errors by using only the brand, form, and strength your doctor prescribes. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Swallow the extended-release tablet whole and do not crush, chew, or break it. Do not swallow or chew a Spritam dispersible tablet for oral suspension. Place the tablet on your tongue and take a sip of liquid. Do not swallow until the tablet has completely dissolved on your tongue. Your kidney function may need to be tested. Use all seizure medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Seizures may increase if you stop using levetiracetam suddenly.. Ask your doctor before stopping the medicine. Wear a medical alert tag or carry an ID card to let others know you have seizures. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme drowsiness, agitation, aggression, shallow breathing, weakness, or fainting. What should I avoid while taking levetiracetam? Avoid driving or hazardous activity until you know how levetiracetam will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Levetiracetam side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel agitated, hostile, irritable, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: unusual changes in mood or behavior (unusual risk-taking behavior, being irritable or talkative); confusion, hallucinations, extreme drowsiness, feeling very weak or tired; loss of balance or coordination, problems with walking or movement; a skin rash, no matter how mild; easy bruising, unusual bleeding; or fever, chills, weakness, or other signs of infection. Common side effects may include: dizziness, drowsiness, tiredness, weakness; feeling aggressive or irritable; loss of appetite; stuffy nose; or infection. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is levetiracetam? Levetiracetam is used to treat certain types of seizures in people with epilepsy, including partial onset seizures, myoclonic seizures, and tonic-clonic seizures. When used for partial onset seizures: Extended-release (XR) levetiracetam is for adults and children at least 12 years old. Spritam is for children at least 4 years old who weigh at least 44 pounds (20 kilograms). Roweepra and Keppra may be used in children as young as 1 month old. Levetiracetam is also used with other seizure medications to treat tonic-clonic seizures in people who are at least 6 years old, and myoclonic seizures in people at least 12 years old. Levetiracetam injection is for use only in people who are least 16 years old. Levetiracetam may also be used for purposes not listed in this medication guide. Warnings Some people have thoughts about suicide while taking levetiracetam. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Seizures may increase if you stop using levetiracetam suddenly. Before taking this medicine You should not use levetiracetam if you are allergic to it. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); depression or other mood problems; mental illness or psychosis; or suicidal thoughts or actions. Do not give levetiracetam to a child without medical advice. Different brands of this medicine are for use only in children of certain ages. Some people have thoughts about suicide while taking levetiracetam. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor if you become pregnant. Your dose needs may be different during pregnancy. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of levetiracetam on the baby. Ask a doctor if it is safe to breastfeed while using this medicine. How should I take levetiracetam? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Levetiracetam oral is taken by mouth at the same time each day, with or without food. Levetiracetam injection is given in a vein if you are unable to take the medicine by mouth. Your dose needs may change if you switch to a different brand, strength, or form of this medicine. A child's dose needs may change if the child gains or loses weight. Avoid medication errors by using only the brand, form, and strength your doctor prescribes. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Swallow the extended-release tablet whole and do not crush, chew, or break it. Do not swallow or chew a Spritam dispersible tablet for oral suspension. Place the tablet on your tongue and take a sip of liquid. Do not swallow until the tablet has completely dissolved on your tongue. Your kidney function may need to be tested. Use all seizure medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Seizures may increase if you stop using levetiracetam suddenly.. Ask your doctor before stopping the medicine. Wear a medical alert tag or carry an ID card to let others know you have seizures. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme drowsiness, agitation, aggression, shallow breathing, weakness, or fainting. What should I avoid while taking levetiracetam? Avoid driving or hazardous activity until you know how levetiracetam will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Levetiracetam side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel agitated, hostile, irritable, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: unusual changes in mood or behavior (unusual risk-taking behavior, being irritable or talkative); confusion, hallucinations, extreme drowsiness, feeling very weak or tired; loss of balance or coordination, problems with walking or movement; a skin rash, no matter how mild; easy bruising, unusual bleeding; or fever, chills, weakness, or other signs of infection. Common side effects may include: dizziness, drowsiness, tiredness, weakness; feeling aggressive or irritable; loss of appetite; stuffy nose; or infection. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect levetiracetam? Other drugs may affect levetiracetam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is levocetirizine? Levocetirizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms such as a runny nose or hives. Levocetirizine is used to treat symptoms of year-round (perennial) allergies in children who are at least 6 months old. Levocetirizine is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old. Levocetirizine may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use levocetirizine if you are allergic to levocetirizine or cetirizine (Zyrtec). You should not take levocetirizine if you have end-stage kidney disease or if you are on dialysis. Any child younger than 12 years old with kidney disease should not take levocetirizine. Tell your doctor if you have ever had: kidney disease; liver disease; urination problems (caused by conditions such as enlarged prostate or spinal cord lesion); or gallbladder problems. Levocetirizine is not expected to harm an unborn baby. Tell your doctor if you are pregnant. You should not breast-feed while using this medicine. Levocetirizine is not approved for use by anyone younger than 6 months old. How should I take levocetirizine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. A child's dose of levocetirizine is based on the age of the child. Follow your doctor's dosing instructions very carefully. Do not give a child more than the prescribed dose of this medicine. A child's body absorbs twice as much of the same dose size of levocetirizine as an adult's body. Taking more of this medication will not make it more effective, and may cause severe drowsiness. Levocetirizine is usually taken in the evening, with or without food. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking levocetirizine? Avoid driving or hazardous activity until you know how levocetirizine will affect you. Your reactions could be impaired. Drinking alcohol with this medicine can cause side effects. Levocetirizine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using levocetirizine and call your doctor at once if you have: worsening allergy or urticaria symptoms; painful or difficult urination; little or no urination; a light-headed feeling, like you might pass out; fever; or signs of an ear infection--ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child. Common side effects may include: drowsiness, tiredness; sinus pain; ear infection; cough; fever; nosebleed; vomiting, diarrhea, constipation; dry mouth; or weight gain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Levocetirizine dosing information Usual Adult Dose for Urticaria: 5 mg orally once a day in the evening Comments: Some patients may be adequately controlled on 2.5 mg orally once a day in the evening. Use: For the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria Usual Adult Dose for Allergic Rhinitis: Seasonal Allergic Rhinitis (OTC): 5 mg orally once a day in the evening; some patients may be adequately controlled on 2.5 mg once a day Usual Pediatric Dose for Allergic Rhinitis: Perennial Allergic Rhinitis: 6 months to 2 years: 1.25 mg orally once a day in the evening Comments: The recommended dose in pediatric patients 6 months to 2 years should not be exceeded. Use: For the relief of symptoms associated with perennial allergic rhinitis Seasonal Allergic Rhinitis (OTC): 6 to 11 years: 2.5 mg orally once a day in the evening 12 years or older: 5 mg orally once a day in the evening; some patients may be adequately controlled on 2.5 mg once a day Comments: Avoid use in patients less than 6 years. Usual Pediatric Dose for Urticaria: 6 months to 5 years: 1.25 mg orally once a day in the evening 6 to 11 years: 2.5 mg orally once a day in the evening 12 years or older: 5 mg orally once a day in the evening; some patients may be adequately controlled on 2.5 mg once a day Comments: The recommended doses in pediatric patients 6 months to 12 years should not be exceeded. Use: For the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria   What other drugs will affect levocetirizine? Using levocetirizine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: ritonavir; or theophylline. This list is not complete. Other drugs may affect levocetirizine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is levothyroxine? Levothyroxine is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body's energy and metabolism. Levothyroxine is used to treat hypothyroidism (low thyroid hormone). This medicine is given when your thyroid does not produce enough of this hormone on its own. Levothyroxine is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer. Warnings You may not be able to take levothyroxine if you have certain medical conditions. Tell your doctor if you have an untreated or uncontrolled adrenal gland disorder, a thyroid disorder called thyrotoxicosis, or if you have any recent or current symptoms of a heart attack. Levothyroxine should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of this medicine, especially if you are taking any other weight-loss medications or appetite suppressants. Before taking this medicine Levothyroxine should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from the misuse of levothyroxine, especially if you are taking any other weight-loss medications or appetite suppressants. Since thyroid hormone occurs naturally in the body, almost anyone can take levothyroxine. However, you may not be able to take this medicine if you have certain medical conditions. Tell your doctor if you have: an untreated or uncontrolled adrenal gland disorder; a thyroid disorder called thyrotoxicosis; or symptoms of a heart attack (chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling). To make sure levothyroxine is safe for you, tell your doctor if you have ever had: a thyroid nodule; heart disease, a blood clot, or a blood-clotting disorder; diabetes (insulin or oral diabetes medication doses may need to be changed when you start taking this medicine); kidney disease; anemia (lack of red blood cells); osteoporosis, or low bone mineral density; problems with your pituitary gland; or any food or drug allergies. Tell your doctor if you have recently received radiation therapy with iodine (such as I-131). If you become pregnant while taking levothyroxine, do not stop taking the medicine without your doctor's advice. Having low thyroid hormone levels during pregnancy could harm both mother and baby. Your dose needs may be different during pregnancy. Tell your doctor if you are breastfeeding. Your dose needs may be different while you are nursing. Do not give this medicine to a child without medical advice. Tirosint is not approved for use by anyone younger than 6 years old. How should I take levothyroxine? Take levothyroxine exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Levothyroxine oral is taken by mouth. The injection is given as an infusion into a vein. Levothyroxine is usually given by injection only if you are unable to take the medicine by mouth. Levothyroxine oral works best if you take it on an empty stomach, 30 to 60 minutes before breakfast. Follow your doctor's dosing instructions and try to take the medicine at the same time each day. Swallow the tablet or capsule whole, with a full glass (8 ounces) of water. The tablet may dissolve very quickly and could swell in your throat. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Levothyroxine doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. It may take several weeks before your body starts to respond to levothyroxine. Keep using this medicine even if you feel well. You may need to use this medicine for the rest of your life. You may need frequent medical tests. Tell any doctor, dentist, or surgeon who treats you that you are using this medicine. Store at room temperature away from moisture and heat. Do not share this medicine with another person, even if they have the same symptoms you have.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include headache, leg cramps, tremors, feeling nervous or irritable, chest pain, shortness of breath, and fast or pounding heartbeats. What to avoid Avoid the following food products, which can make your body absorb less levothyroxine: grapefruit juice, infant soy formula, soybean flour, cotton seed meal, walnuts, and high-fiber foods. Levothyroxine side effects Get emergency medical help if you have signs of an allergic reaction to levothyroxine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: fast or irregular heartbeats; chest pain, pain spreading to your jaw or shoulder; shortness of breath; fever, hot flashes, sweating; tremors, or if you feel unusually cold; weakness, tiredness, sleep problems (insomnia); memory problems, feeling depressed or irritable; headache, leg cramps, muscle aches; feeling nervous or irritable; dryness of your skin or hair, hair loss; irregular menstrual periods; or vomiting, diarrhea, appetite changes, weight changes. Certain side effects may be more likely in older adults. Common levothyroxine side effects may include: chest pain, irregular heartbeats; shortness of breath; headache, leg cramps, muscle pain or weakness; tremors, feeling nervous or irritable, trouble sleeping; increased appetite; feeling hot; weight loss; changes in your menstrual periods; diarrhea; or skin rash, partial hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect levothyroxine? Many other medicines can be affected by your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of levothyroxine. Certain medicines can make this medicine less effective if taken at the same time. If you use any of the following drugs, avoid taking them within 4 hours before or 4 hours after you take levothyroxine: calcium carbonate (Alka-Mints, Caltrate, Os-Cal, Oyster Shell Calcium, Rolaids Soft Chew, Tums, and others); cholestyramine, colesevelam, colestipol; ferrous sulfate iron supplement; sucralfate; sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex); stomach acid reducers - esomeprazole, lansoprazole, omeprazole, rabeprazole, Nexium, Prilosec, Prevacid, Protonix, Zegerid, and others; or antacids that contain aluminum or magnesium - Gaviscon, Maalox, Milk of Magnesia, Mintox, Mylanta, Pepcid Complete, and others. Many drugs can interact with levothyroxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is lidocaine injection? Lidocaine is a local anesthetic (numbing medication) that is used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube. Lidocaine injection is sometimes used to treat irregular heart rhythms that may signal a possible heart attack. Lidocaine injection is also given in an epidural (spinal block) to reduce the discomfort of contractions during labor. Lidocaine injection may also be used for purposes not listed in this medication guide. Warnings You should not receive lidocaine injection if you have severe heart block, or a heart rhythm disorder called Stokes-Adams syndrome or Wolff-Parkinson-White Syndrome. Before taking this medicine You should not receive this medicine if you are allergic to lidocaine injection or any other type of numbing medicine, or if you have: severe heart block; a heart rhythm disorder called Stokes-Adams syndrome (sudden slow heart beats that can cause you to faint); or a heart rhythm disorder called Wolff-Parkinson-White Syndrome (sudden fast heartbeats that can cause you to faint or become easily tired). Tell your doctor if you have ever had: an allergy to corn products; liver disease; kidney disease; heart disease (unless you are being treated with lidocaine injection for a heart condition); coronary artery disease, circulation problems; or malignant hyperthermia. Tell your doctor if you are pregnant or breastfeeding. How is lidocaine injection given? A healthcare provider will give you this injection. When used to treat heart rhythm problems, lidocaine is given as an infusion into a vein. When used as a local anesthetic, lidocaine is injected through the skin directly into the body area to be numbed. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving lidocaine injection in a hospital setting. If you are being treated for irregular heart rhythm, your heart rate will be constantly monitored using an electrocardiograph or ECG (sometimes called an EKG). This will help your doctor determine how long to treat you with lidocaine injection.   What happens if I miss a dose? Since lidocaine injection is used only when needed in a clinical setting, you are not likely to miss a dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid after receiving lidocaine injection? Lidocaine injection can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after receiving lidocaine injection. Avoid eating or chewing within 1 hour after lidocaine injection is used to numb your mouth or throat. You may have trouble swallowing which could lead to choking. You may also accidentally bite the inside of your mouth if you are still numb an hour after treatment with lidocaine injection. Lidocaine injection side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregiver right away if you have: twitching, tremors, seizure (convulsions); a light-headed feeling, like you might pass out; slow heart rate, weak pulse, weak or shallow breathing; sudden feeling of heat, cold, or numbness; muscle stiffness and pain; weak or shallow breathing; blue appearance of the skin; or severe anxiety, unusual fear or uneasy feeling. Common side effects may include: drowsiness, dizziness; nausea, vomiting; feeling hot or cold; confusion, ringing in your ears, blurred vision, double vision; or numbness in places where the medicine is accidentally applied. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is lidocaine injection? Lidocaine is a local anesthetic (numbing medication) that is used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube. Lidocaine injection is sometimes used to treat irregular heart rhythms that may signal a possible heart attack. Lidocaine injection is also given in an epidural (spinal block) to reduce the discomfort of contractions during labor. Lidocaine injection may also be used for purposes not listed in this medication guide. Warnings You should not receive lidocaine injection if you have severe heart block, or a heart rhythm disorder called Stokes-Adams syndrome or Wolff-Parkinson-White Syndrome. Before taking this medicine You should not receive this medicine if you are allergic to lidocaine injection or any other type of numbing medicine, or if you have: severe heart block; a heart rhythm disorder called Stokes-Adams syndrome (sudden slow heart beats that can cause you to faint); or a heart rhythm disorder called Wolff-Parkinson-White Syndrome (sudden fast heartbeats that can cause you to faint or become easily tired). Tell your doctor if you have ever had: an allergy to corn products; liver disease; kidney disease; heart disease (unless you are being treated with lidocaine injection for a heart condition); coronary artery disease, circulation problems; or malignant hyperthermia. Tell your doctor if you are pregnant or breastfeeding. How is lidocaine injection given? A healthcare provider will give you this injection. When used to treat heart rhythm problems, lidocaine is given as an infusion into a vein. When used as a local anesthetic, lidocaine is injected through the skin directly into the body area to be numbed. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving lidocaine injection in a hospital setting. If you are being treated for irregular heart rhythm, your heart rate will be constantly monitored using an electrocardiograph or ECG (sometimes called an EKG). This will help your doctor determine how long to treat you with lidocaine injection.   What happens if I miss a dose? Since lidocaine injection is used only when needed in a clinical setting, you are not likely to miss a dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid after receiving lidocaine injection? Lidocaine injection can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after receiving lidocaine injection. Avoid eating or chewing within 1 hour after lidocaine injection is used to numb your mouth or throat. You may have trouble swallowing which could lead to choking. You may also accidentally bite the inside of your mouth if you are still numb an hour after treatment with lidocaine injection. Lidocaine injection side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregiver right away if you have: twitching, tremors, seizure (convulsions); a light-headed feeling, like you might pass out; slow heart rate, weak pulse, weak or shallow breathing; sudden feeling of heat, cold, or numbness; muscle stiffness and pain; weak or shallow breathing; blue appearance of the skin; or severe anxiety, unusual fear or uneasy feeling. Common side effects may include: drowsiness, dizziness; nausea, vomiting; feeling hot or cold; confusion, ringing in your ears, blurred vision, double vision; or numbness in places where the medicine is accidentally applied. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect lidocaine injection? Tell your doctor about all your other medicines, especially: cimetidine, fluvoxamine, nefazodone, St John's wort; antibiotic or antifungal medicine; antiviral medicine to treat hepatitis or HIV/AIDS; heart or blood pressure medicine--amiodarone, digoxin, nicardipine, procainamide, propranolol; seizure medicine--carbamazepine, phenytoin; or tuberculosis medicine--isoniazid, rifampin. This list is not complete. Other drugs may affect lidocaine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is liothyronine? Liothyronine is a man-made form of a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. Liothyronine is given when the thyroid does not produce enough of this hormone on its own. Liothyronine treats hypothyroidism (low thyroid hormone). Liothyronine is also given as part of a medical test for thyroid disorders. Liothyronine is also used together with surgery and radioactive iodine therapy in people with thyroid cancer. Liothyronine should not be used to treat obesity or weight problems. Liothyronine may also be used for purposes not listed in this medication guide. Warnings Liothyronine should not be used to treat obesity or weight problems. You may not be able to use liothyronine if you have an adrenal gland problem that is not controlled by treatment. Stop taking liothyronine and call your doctor if you have symptoms of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual. Before taking this medicine Since thyroid hormone occurs naturally in the body, almost anyone can take liothyronine. However, you may not be able to use this medicine if you have an adrenal gland problem that is not controlled by treatment. Tell your doctor if you have ever had: problems with your pituitary or adrenal gland; heart disease, angina (chest pain); a bleeding or blood clotting disorder; diabetes; or osteoporosis or low bone mineral density. Tell your doctor if you are pregnant or breastfeeding. Follow your doctor's instructions about using this medicine if you are pregnant. Controlling your thyroid hormone levels is very important during pregnancy, and your dose needs may be different during each trimester. How should I take liothyronine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Older adults may be more sensitive to the effects of liothyronine, and doses are generally lower for people in this age group. If you are switching to liothyronine from any other thyroid medicine, stop using the other medicine before you start taking liothyronine. Liothyronine doses are based on weight (especially in children and teenagers). Your dose needs may change if you gain or lose weight. When given as part of a thyroid suppression test, you will need to take liothyronine for several days in a row in preparation for the test. Tell your doctor if you miss any doses during this time. Your thyroid function will need to be tested often. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using liothyronine. Keep using this medicine as directed, even if you feel well. You may need to take thyroid medication for the rest of your life. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include headache, sweating, diarrhea, irregular menstrual periods, confusion, weakness, swelling in your hands or feet, fast heart rate, chest pain, feeling short of breath, fainting, or feeling nervous, restless, or irritable. What should I avoid while taking liothyronine? Do not change brands or change to a generic product without first asking your doctor. Different brands of liothyronine may not work the same. If you get a prescription refill and your new pills look different, talk with your pharmacist or doctor. Liothyronine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using liothyronine and call your doctor if you have symptoms of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual. Also call your doctor at once if you have: weak or shallow breathing; confusion; a feeling of being cold all the time; changes in weight or appetite; chest pressure spreading to your jaw or shoulder; a light-headed feeling, like you might pass out; severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes; a seizure; or (in a child or teenager) pain, stiffness, and trouble moving the legs. Common side effects may include: trouble breathing; headache; tremors, feeling nervous or irritable; muscle weakness; increased appetite; diarrhea; irregular menstrual periods; weight loss; feeling hot; rash; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect liothyronine? Some medicines can make liothyronine much less effective when taken at the same time. If you take any of the following medicines, take your liothyronine dose 4 hours before you take the other medicine. cholestyramine; colesevelam; colestipol; or sevelamer. Tell your doctor about all your current medicines. Many drugs can affect liothyronine, especially: cancer medicine; birth control pills or hormone replacement therapy; cough or cold medicine; an antidepressant; steroid medicine; seizure medicine; insulin or oral diabetes medicine; or a blood thinner (warfarin, Coumadin, Jantoven). This list is not complete and many other drugs may affect liothyronine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.