What is tadalafil? Tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Warnings Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with tadalafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis. Get medical help at once if you have nausea, chest pain, or dizziness during sex. Stop using tadalafil and get emergency medical help if you have sudden vision loss. Before taking this medicine You should not take tadalafil if you are allergic to it. Taking tadalafil with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take this medicine if you also use: riociguat (to treat pulmonary arterial hypertension); or a nitrate drug (for chest pain or heart problems) such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as amyl nitrate or nitrite "poppers". Some tadalafil can remain in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). Avoid nitrate use during this time. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease or heart rhythm problems; a heart attack or stroke; angina (chest pain), high or low blood pressure; pulmonary hypertension (unless you are taking tadalafil for this); a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart); liver or kidney disease (or if you are on dialysis); vision loss, or retinitis pigmentosa (an inherited condition of the eye); a bleeding disorder; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a physical deformity of the penis (such as Peyronie's disease), or an erection lasting longer than 4 hours; a stomach ulcer; or health problems that make sexual activity unsafe. Sudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others). Most of these people already had certain eye problems or risk factors for blood vessel disorders (heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether the medicine was the actual cause of vision loss. Sudden hearing loss has also been reported with tadalafil. Stop tadalafil and call your doctor immediately for any hearing loss, decrease in hearing, or ringing in the ears. Do not start or stop taking tadalafil during pregnancy without your doctor's advice. Having pulmonary arterial hypertension (PAH) during pregnancy may cause heart failure, stroke, or other medical problems in both mother and baby. Tell your doctor right away if you become pregnant. It may not be safe to breastfeed while using tadalafil. Ask your doctor about any risk. Cialis is not for use in women. Tadalafil is not approved for use by anyone younger than 18 years old. How should I take tadalafil? Tadalafil is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Tadalafil can be taken with or without food. Do not break or split a Cialis tablet. Swallow it whole. For erectile dysfunction, take Cialis just before sexual activity but not more than once per day. It can be used up to 36 hours before sexual activity. Cialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions. Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension. Store at room temperature away from moisture and heat.   What happens if I miss a dose? If tadalafil is used as needed, you are not likely to be on a dosing schedule. If you take tadalafil every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol with this medicine can cause a drop in blood pressure, leading to dizziness or fainting. Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine. Tadalafil side effects Get emergency medical help if you have signs of an allergic reaction to tadalafil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex. You could be having a life-threatening side effect. Stop using tadalafil and call your doctor at once if you have: a light-headed feeling, like you might pass out; an erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis); vision changes or sudden vision loss; ringing in your ears or sudden hearing loss; or heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Common tadalafil side effects may include: headache; flushing (warmth, redness, or tingly feeling); nausea, upset stomach; stuffy nose; or muscle pain, back pain, pain in your arms, legs, or back. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tadalafil? Tell your doctor about all your current medicines and any you start or stop using, especially: medicines to treat erectile dysfunction or pulmonary arterial hypertension; an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis C or HIV/AIDS; drugs to treat high blood pressure or a prostate disorder; or seizure medicine. This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is tamoxifen? Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Warnings Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal. Do not use tamoxifen if you are pregnant. It could harm the unborn baby. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. You should not use tamoxifen if you are allergic to it, if you have a history of blood clots in your veins or your lungs, or if you are taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment. If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking this medicine, to make sure you are not pregnant. Follow your doctor's instructions. To make sure this medication is not causing harmful effects, your doctor may want you to have mammograms and to perform routine breast self-exams on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly. Before taking this medicine You should not use tamoxifen if you are allergic to it. Tamoxifen may harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using tamoxifen and for at least 2 months after your last dose. Tell your doctor if you become pregnant. To prevent pregnancy while using tamoxifen, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Avoid using hormonal birth control, including birth control pills, injections, implants, skin patches, and vaginal rings. You should not use tamoxifen to reduce your risk of breast cancer if you also take warfarin (Coumadin, Jantoven). To make sure tamoxifen is safe for you, tell your doctor if you have: a stroke or blood clot; liver disease; high cholesterol or triglycerides (a type of fat in the blood); cataracts; chemotherapy; or if you also use anastrozole or letrozole. Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your own risks. Do not breastfeed while using tamoxifen, and for at least 3 months after your last dose. This medicine is not approved for use by anyone younger than 18 years old. How should I take tamoxifen? Take tamoxifen exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Take with or without food. You may need to keep using this medicine for 5 to 10 years. Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using tamoxifen. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using tamoxifen. Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze. Throw away any leftover liquid medicine 3 months after you first opened the bottle. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tamoxifen? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Tamoxifen side effects Get emergency medical help if you have signs of an allergic reaction to tamoxifen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tamoxifen can increase your risk of stroke or blood clots. Call your doctor at once if you have: signs of a stroke - sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance; signs of a blood clot in the lung - chest pain, sudden cough or shortness of breath, dizziness, coughing up blood; or signs of a blood clot deep in the body - pain, swelling, or warmth in one leg. Also call your doctor at once if you have: unusual vaginal bleeding or discharge; blurred vision, eye pain or redness, seeing halos around lights; changes in your menstrual periods; pain or pressure in your pelvic area; a new breast lump; liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or high blood calcium - confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss. Common tamoxifen side effects may include: vaginal bleeding or discharge; hot flashes; swelling, weight gain; nausea; or mood changes. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Tamoxifen dosing information Usual Adult Dose for Breast Cancer: Metastatic breast cancer in women and men: 20 to 40 mg orally daily for 5 years; doses greater than 20 mg should be given in divided doses (morning and evening) DCIS following breast surgery and radiation: 20 mg orally daily for 5 years To reduce the incidence of breast cancer in women at high risk for breast cancer: 20 mg orally daily for 5 years Comments: -There are no data to support the use of this drug other than for 5 years. Uses: -Metastatic For metastatic breast cancer in women and men. In premenopausal women with metastatic breast cancer, this drug is an alternative to oophorectomy or ovarian irradiation. Patients whose tumors are estrogen receptor positive are more likely to benefit. -Ductal Carcinoma in Situ (DCIS): In women with DCIS, following breast surgery and radiation, to reduce the risk of invasive breast cancer. -Reduction in Breast Cancer Incidence in High Risk Women: To reduce the incidence of breast cancer in women at high risk. "High risk" is defined as women at least 35 years of age with a 5-year predicted risk of breast cancer greater than or equal to 1.67%, as calculated by the Gail Model. Usual Adult Dose for Breast Cancer -- Adjuvant: 20 mg orally once daily or 10 mg orally 2 times daily Duration of therapy: Up to 5 years Comments: -There are no data to support the use of this drug other than for 5 years. Use: For the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation Usual Pediatric Dose for McCune-Albright Syndrome: Girls 2 to 10 years with McCune-Albright Syndrome and precocious puberty: 20 mg orally once daily Duration of therapy: Up to 12 months Use: McCune-Albright Syndrome; precocious puberty Usual Pediatric Dose for Precocious Puberty: Girls 2 to 10 years with McCune-Albright Syndrome and precocious puberty: 20 mg orally once daily Duration of therapy: Up to 12 months Use: McCune-Albright Syndrome; precocious puberty   What other drugs will affect tamoxifen? Many drugs can interact with tamoxifen, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is tamsulosin? Tamsulosin (Flomax) is an alpha-blocker that relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Tamsulosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Tamsulosin is not FDA approved for use in women or children. Warnings You should not use this medication if you are allergic to tamsulosin. Do not take tamsulosin with other similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin). Tamsulosin may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. If you stop taking this medicine for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using tamsulosin before surgery unless your surgeon tells you to. There are many other drugs that can interact with this medicine. Tell your doctor about all medications you use. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use tamsulosin if you are allergic to it. Do not take tamsulosin together with similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin). To make sure tamsulosin is safe for you, tell your doctor if you have: liver or kidney disease; a history of prostate cancer; low blood pressure; or an allergy to sulfa drugs. Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine. Do not stop using tamsulosin before surgery unless your surgeon tells you to. Although this medicine is not for use in women, tamsulosin is not expected to harm an unborn baby. If you are a woman using this medication, tell your doctor if you are pregnant or breast-feeding. This medicine is not approved for use by anyone younger than 18 years old. How should I take tamsulosin? Take tamsulosin exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Tamsulosin is usually taken once a day, approximately 30 minutes after a meal. Try to take this medication at the same time each day. Do not crush, chew, or open a capsule. Swallow the capsule whole. Tamsulosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. Call your doctor if you have severe dizziness or feel like you might pass out. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Your blood pressure will need to be checked often. You will also need to be checked for prostate cancer before and during treatment with tamsulosin. You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position. If you stop taking tamsulosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Store at room temperature away from moisture and heat. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. Dosing information Usual Adult Dose for Benign Prostatic Hyperplasia: Initial Dose: 0.4 mg orally once a day Maximum Dose: 0.8 mg orally once a day Comments: -If use is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, treatment should be initiated again with the 0.4 mg once a day dose. Use: Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss your doses for several days in a row, contact your doctor before restarting the medication. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Tamsulosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries. To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Drinking alcohol can increase certain side effects of tamsulosin. Tamsulosin side effects Get emergency medical help if you have signs of an allergic reaction to tamsulosin: hives, rash, itching; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: a light-headed feeling, like you might pass out; penis erection that is painful or lasts 4 hours or longer; or severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Common tamsulosin side effects may include: low blood pressure; dizziness, drowsiness, weakness; nausea, diarrhea; headache, chest pain; abnormal ejaculation, decreased amount of semen; back pain; blurred vision; tooth problems; fever, chills, body aches, flu symptoms; runny or stuffy nose, sinus pain, sore throat, cough; sleep problems (insomnia); or decreased interest in sex. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tamsulosin? Tell your doctor about all medicines you use, and those you start or stop using during your treatment with, especially: blood pressure medicine. This list is not complete. Other drugs may interact with tamsulosin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is tazarotene topical? Tazarotene is a compound similar to vitamin A. It helps the skin to renew itself more quickly and may improve the appearance and texture of skin. Tazarotene topical is available in a cream, gel, lotion, or foam. The Avage brand of tazarotene cream is used to reduce the appearance of fine wrinkles on the face, mottled light and dark skin patches on the face, and benign facial lentigines (non-cancerous freckles) in adults and adolescents who are at least 17 years old. The Fabior and Tazorac brands of tazarotene topical are used to treat acne vulgaris in adults and adolescents who are at least 12 years old. The Arazlo brand of tazarotene topical is used to treat acne vulgaris in adults and adolescents who are at least 9 years old. Tazorac is also used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults. Warnings Tazarotene can cause birth defects. Do not use if you are pregnant. Use effective birth control to prevent pregnancy. Stop using tazarotene and tell your doctor right away if you become pregnant, if you stop using birth control, or if you miss a menstrual period. You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun. Some weather conditions may irritate the skin. Your skin may look worse before it looks better. Tazarotene may cause harm if swallowed. If tazarotene cream is swallowed, call a doctor or poison control center right away. Before taking this medicine You should not use tazarotene topical if you are allergic to it, or if you are pregnant or may become pregnant. You must have a negative pregnancy test within 2 weeks before starting this treatment. To make sure tazarotene is safe for you, tell your doctor if you have ever had: eczema, sunburn, or another skin condition; skin cancer; lentigo maligna (a type of skin cancer); an allergic reaction to a skin product; or if you work outdoors. Do not use tazarotene if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. Stop using tazarotene and tell your doctor right away if you become pregnant, if you stop using birth control, or if you miss a menstrual period. It may not be safe to breastfeed while using tazarotene. Ask your doctor about any risk. Avage should not be used on anyone younger than 17 years old. Fabior or Tazorac should not be used to treat acne in a child younger than 12 years old. Fabior should not be used to treat psoriasis in anyone under 18 years old. How should I use tazarotene topical? Tazarotene is usually applied once daily in the evening or at bedtime. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Do not take by mouth. Topical medicine is for use only on the skin. Do not use tazarotene topical on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina, rinse with water. Also avoid using this medicine in wounds or on areas of eczema. Wait until these conditions have fully healed before using tazarotene. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Women who use tazarotene topical should start the medication during a menstrual period. Avoid applying the medication to unaffected areas. If medication accidentally gets on areas that do not need treatment, wash it off. Shake the Fabior foam well just before each use. Your skin may be more sensitive to weather extremes such as cold and wind during treatment with tazarotene. Protect your skin with clothing and use a moisturizing cream or lotion as needed. Store at room temperature, away from moisture and heat. Do not freeze. Fabior foam is flammable. Do not use near high heat or open flame. The canister may explode if it gets too hot. Do not puncture or burn an empty foam canister. Store the bottle in an upright position. Tazarotene dosing information Usual Adult Dose of Tazarotene for Plaque Psoriasis: Initial dose: Apply a thin film of 0.05% gel or cream once a day in the evening to cover only the psoriatic lesions -Increase to 0.1% if tolerated and medically indicated Comments: -Apply to dry skin; if a bath or shower is taken prior to application, allow time for skin to dry before applying; if emollients are used, they should be applied at least 1 hour prior. -Avoid applying gel or cream on unaffected skin as it may be more susceptible to irritation. -The safety of gel use on more than 20% body surface area has not been established and is not recommended. Uses: -For the topical treatment of plaque psoriasis Usual Adult Dose of Tazarotene for Acne: Apply a thin layer of 0.1% gel/cream/foam once a day in the evening to cover acne lesions Comments: -Cleanse the face gently and dry before application. -Use sunscreen and wear protective clothing while using this drug. Use: For the topical treatment of acne vulgaris Usual Adult Dose of Tazarotene for Skin Pigmentation Disorder: Apply pea-sized amount once a day at bedtime to lightly cover entire face, including the eyelids, if desired Comments: -Remove makeup and after washing face and allow skin to completely dry before applying; emollients/moisturizers may be applied before this cream, however, allow to absorb and completely dry before applying this cream; facial moisturizers may be used as frequently as desired. -This cream does not eliminate or prevent wrinkles or restore more youthful skin. -This cream does not reverse photoaging or repair sun damaged skin; it does not mitigate coarse or deep wrinkling, tactile roughness, telangiectasia, skin laxity, keratinocytic atypia, melanocytic atypia, or dermal elastosis. -The safety and effectiveness for the prevention and treatment of actinic keratoses, skin neoplasms, or lentigo maligna have not been established. Use: As an adjunctive agent for use in the mitigation (palliation) of facial fine wrinkling, facial, mottled hyper and hypopigmentation and benign facial lentigines in patients who use comprehensive skin care and sunlight avoidance programs. Usual Pediatric Dose for Acne: Age: 12 years or older: Apply a thin layer of 0.1% gel/cream/foam once a day in the evening to cover acne lesions Comments: -Cleanse the face gently and dry before application. -Use sunscreen and wear protective clothing while using this drug. Use: For the topical treatment of acne vulgaris Usual Pediatric Dose for Plaque Psoriasis: Age: 12 years or older: Initial dose: Apply a thin film of 0.05% gel or cream once a day in the evening to cover only the psoriatic lesions -Increase to 0.1% if tolerated and medically indicated Comments: -Apply to dry skin; if a bath or shower is taken prior to application, allow time for skin to dry before applying; if emollients are used, they should be applied at least 1 hour prior. -Avoid applying gel or cream on unaffected skin as it may be more susceptible to irritation. -The safety of gel use on more than 20% body surface area has not been established and is not recommended. Uses: -For the topical treatment of plaque psoriasis   What happens if I miss a dose? Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time. What happens if I overdose? An overdose of tazarotene may cause severe skin discomfort. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine. What should I avoid while using tazarotene? Avoid applying the medication to unaffected areas. If medication accidentally gets on areas that do not need treatment, wash it off. Avoid using other skin medications on the areas you treat with tazarotene topical unless your doctor tells you to. Avoid exposure to sunlight or tanning beds. tazarotene can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Rinse with water if tazarotene gets in your eyes. Tazarotene topical side effects Get emergency medical help if you have signs of an allergic reaction to tazarotene: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using tazarotene and call your doctor at once if you have: severe skin irritation (pain, dryness, flaking, peeling, burning, stinging, itching) after applying the medicine; blistering or peeling skin; severe redness or discomfort; or swelling, warmth, oozing, or other signs of skin infection. Common tazarotene side effects may include: dry, scaly, or peeling skin; skin pain, redness or burning; or itching or other irritation of treated skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tazarotene topical? If you also use a benzoyl peroxide acne medication, do not use it at the same time you use tazarotene topical. Apply one medication only in the morning and the other only in the evening. Tell your doctor about all your other medicines, especially: an antibiotic or other medicine that can make your skin more sensitive to sunlight. This list is not complete. Other drugs may interact with tazarotene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is telmisartan? Telmisartan is an angiotensin II receptor blocker (sometimes called an ARB) that is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Telmisartan is also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders. Telmisartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using telmisartan and tell your doctor right away if you become pregnant. If you have diabetes, do not take telmisartan with any medicine that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use telmisartan if you are allergic to it. If you have diabetes, do not take telmisartan with any medicine that contains aliskiren (a blood pressure medicine). You may also need to avoid taking telmisartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: a heart condition other than one being treated with telmisartan; liver disease; kidney disease (or if you are on dialysis); or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. If you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby. You should not breastfeed while using telmisartan. How should I take telmisartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take telmisartan at the same time each day, with or without food. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking telmisartan. It may take 2 to 4 weeks before your blood pressure is under control. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Treatment may also include diet, exercise, lowering cholesterol, not smoking, and controlling diabetes. Your blood pressure will need to be checked often. Your liver or kidney function may also need to be checked. Store at room temperature away from moisture and heat. Keep the tablets in their original package or container, along with any packet or canister of moisture-absorbing preservative. Keep this medicine in its original packaging until you're ready to take a tablet. Tear or cut one tablet blister from the package, peel back the paper liner, and push the tablet through the foil. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking telmisartan? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Telmisartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Also call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; swelling in your feet or ankles, rapid weight gain; unusual pain or tightness in your lower body; a skin ulcer; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: stuffy nose, sinus pain; back pain; or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Telmisartan dosing information Usual Adult Dose for Hypertension: Initial dose: 40 mg orally once a day Maintenance dose: 40 to 80 mg orally once a day Comments: Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose. Usual Adult Dose for Cardiovascular Risk Reduction: 80 mg orally once a day Comments: -It is unknown whether doses lower than 80 mg are effective in reducing the risk of cardiovascular morbidity and mortality. -When initiating this drug for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of other medications that lower blood pressure. Use: Reduction of risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years or older at high risk of developing major cardiovascular events who are unable to take angiotensin-converting enzyme (ACE) inhibitors. High risk for cardiovascular events can be evidenced by a history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage.   What other drugs will affect telmisartan? Tell your doctor about all your other medicines, especially: digoxin; lithium; a diuretic or "water pill" or other blood pressure medicine; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; This list is not complete. Other drugs may affect telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here,  

What is hydrochlorothiazide and telmisartan? Hydrochlorothiazide is a diuretic (water pill). Telmisartan is an angiotensin II receptor blocker (sometimes called an ARB blocker). Hydrochlorothiazide and telmisartan is a combination medicine is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and telmisartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. You should not use hydrochlorothiazide and telmisartan if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and telmisartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or telmisartan, if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and telmisartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and telmisartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease; liver disease; glaucoma; low or high levels of magnesium or potassium in your blood; asthma or allergies; lupus; diabetes; or an allergy to penicillin or sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and telmisartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and telmisartan with or without food. Your blood pressure will need to be checked often. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and telmisartan. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. If you need surgery or medical tests, tell the surgeon ahead of time that you are using this medicine. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. Keep each tablet in its blister pack until you are ready to take it. Gently push the tablet through the foil to remove it. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heart rate, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and telmisartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Drinking alcohol can further lower your blood pressure and may cause side effects. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Hydrochlorothiazide and telmisartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: eye pain, vision problems; a light-headed feeling, like you might pass out; jaundice (yellowing of the skin or eyes); swelling in your hands or feet, unusual weight gain; easy bruising, unusual bleeding; or signs of an electrolyte imbalance--dry mouth, increased thirst, drowsiness, confusion, feeling restless, vomiting, muscle pain or weakness, lack of energy, fast heartbeats, little or no urine, or a seizure. Common side effects may include: dizziness, feeling tired; nausea, diarrhea; back pain; or cold or flu symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and telmisartan dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-Telmisartan 80 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Telmisartan 160 mg orally once a day Comments: -This drug may be substituted for the individual titrated components. -If blood pressure remains uncontrolled by hydrochlorothiazide 25 mg orally once a day monotherapy, may switch to hydrochlorothiazide 12.5 to 25 mg-telmisartan 80 mg orally once a day. Reassess after 2 to 4 weeks; may increase up to hydrochlorothiazide 25 mg-telmisartan 160 mg orally once a day. -If blood pressure is controlled by hydrochlorothiazide 25 mg orally once a day monotherapy, but hypokalemia occurs, may switch to hydrochlorothiazide 12.5 mg-telmisartan 80 mg orally once a day. -If blood pressure remains uncontrolled by telmisartan 80 mg orally once a day monotherapy, may switch to hydrochlorothiazide 12.5 mg-telmisartan 80 mg orally once a day; may titrate up to hydrochlorothiazide 25 mg-telmisartan 160 mg orally once a day, if necessary. Use: Treatment of hypertension; not indicated for initial therapy.   What other drugs will affect hydrochlorothiazide and telmisartan? If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and telmisartan. Tell your doctor about all your other medicines, especially: any other heart or blood pressure medications; digoxin; lithium; a diuretic or "water pill"; insulin or oral diabetes medicine; opioid pain medicine; a sleeping pill; steroid medicine or adrenocorticotrophic hormone (ACTH); a barbiturate such as butabarbital, phenobarbital, or secobarbital; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is temazepam? Temazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It affects chemicals in the brain that may be unbalanced in people with sleep problems (insomnia). Temazepam is used short term to treat insomnia (trouble falling or staying asleep). Temazepam works by slowing down the central nervous system (brain), causing drowsiness which helps patients fall asleep. Warnings Temazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. Never take this medicine if you do not have at least 7 to 8 hours to sleep before being active again. Do not use temazepam if you are pregnant. It can cause birth defects or life-threatening withdrawal symptoms in a newborn. Use effective birth control to prevent pregnancy while taking this medicine. Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking temazepam and talk with your doctor about another treatment for your sleep disorder. Temazepam may be habit-forming and should be used only by the person it was prescribed for. This medicine should never be shared with another person, especially someone who has a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Temazepam may cause a severe allergic reaction. Stop taking this medicine and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Take this medication only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine. Before taking this medicine You should not use temazepam if you are allergic to it. Do not use temazepam if you are pregnant or may become pregnant. This medicine could harm the unborn baby. To make sure temazepam is safe for you, tell your doctor if you have ever had: lung disease or breathing problems; depression, mental illness, suicidal thoughts; alcoholism or drug addiction; or liver or kidney disease. Ask a doctor if it is safe to breastfeed while using this medicine. Valtoco is not approved for use by anyone younger than 18 years old. How should I take temazepam? Take temazepam exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides or instruction sheets. Never use temazepam in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law. Take this medicine only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine. Call your doctor if your insomnia does not improve after taking temazepam for 7 to 10 nights, or if you have any mood or behavior changes. Insomnia can be a symptom of depression, mental illness, or certain medical conditions. Temazepam should be used for only a short time. Do not take this medicine for longer than 2 weeks without your doctor's advice. Do not stop using this medicine without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly. Store at room temperature away from moisture and heat. Keep your medicine in a place where no one can use it improperly. Dosing information Usual Adult Dose for Insomnia: 7.5 to 30 mg orally once a day at bedtime Comments: -In transient insomnia, a 7.5 mg dose may be sufficient to improve sleep latency. -In elderly or debilitated patients, therapy should be initiated at 7.5 mg until individual responses are determined. Use: Short-term treatment of insomnia (generally 7 to 10 days)   What happens if I miss a dose? Temazepam is used when needed. If you are on a dosing schedule, skip any missed dose. Take temazepam only when you have time for several hours of sleep. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of temazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing. Overdose symptoms may include extreme drowsiness, confusion, or coma. What should I avoid while taking temazepam? Do not drink alcohol. Dangerous side effects or death could occur. You may still feel sleepy the morning after taking temazepam. Wait until you are fully awake before you drive, operate machinery, or do anything that requires you to be awake and alert. Your reactions may be impaired. Temazepam side effects Temazepam may cause a severe allergic reaction. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; nausea, vomiting; swelling of your face, lips, tongue, or throat. Temazepam can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once if you have: confusion, agitation, hallucinations; depressed mood; or thoughts of suicide or hurting yourself. Some people using temazepam have engaged in activity such as driving, eating, walking, making phone calls, or having sex and later having no memory of the activity. Tell your doctor if this happens to you. Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury. Common temazepam side effects may include: drowsiness, tiredness; dizziness; headache; nausea; or feeling nervous. After you stop using temazepam, get medical help right away if you have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, suicidal thoughts or actions. Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect temazepam? Taking temazepam with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may interact with temazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is tenofovir? Tenofovir is an antiviral medicine that is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Tenofovir is not a cure for HIV or AIDS. Tenofovir is also used to treat chronic hepatitis B. Tenofovir is for use in adults and children at least 2 years old and weighing at least 22 pounds (10 kilograms). Tenofovir may also be used for purposes not listed in this medication guide. Warnings If you've had hepatitis B, it may come back or get worse after you stop using tenofovir. You may need liver function tests for several months. Do not change your dose or stop using a medicine without your doctor's advice. Before taking this medicine You should not take tenofovir if you are allergic to it. Do not take tenofovir together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Biktarvy, Cimduo, Complera, Descovy, Genvoya, Odefsey, Stribild, Symfi, or Truvada). Tell your doctor if you have ever had: liver disease (especially hepatitis B if you also have HIV); HIV (if you are taking tenofovir to treat hepatitis B); kidney disease; or low bone mineral density. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Ask your doctor about your risk. To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry. Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk. How should I take tenofovir? Before you start treatment with tenofovir, your doctor may perform tests to make sure you do not have HIV (if you are being treated for hepatitis B) or hepatitis B (if you are being treated for HIV). Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take tenofovir at the same time each day. Some forms of tenofovir should be taken with food. Carefully follow all instructions on your medicine label. Tenofovir oral powder should be mixed with soft food such as applesauce, yogurt, or baby food. Do not mix the oral powder with liquid. Swallow the tablet whole and do not crush, chew, or break it. Tell your doctor if you or your the child taking tenofovir has trouble swallowing a tablet. Doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. You will need medical tests. Use all HIV medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Remain under the care of a doctor. Store tightly closed at room temperature, away from moisture and heat. If you've had hepatitis B, it may come back or get worse after you stop using tenofovir. You may need liver function tests while using this medicine and for several months after you stop.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tenofovir? Drinking alcohol may increase your risk of liver damage. Using tenofovir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Ask your doctor how to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe. Tenofovir side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, fast/slow or irregular heartbeats, dizziness, feeling cold, or feeling very weak or tired. Call your doctor at once if you have: sore throat, flu symptoms, easy bruising or unusual bleeding; kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or liver problems--swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Tenofovir can affect your immune system (even weeks or months after you've used this medicine). Tell your doctor if you have: signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects may include: stomach pain, nausea, vomiting, diarrhea; fever, pain; weakness, dizziness; headache; depressed mood; itching, rash; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tenofovir? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tenofovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Many drugs can affect tenofovir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

What is terazosin? Terazosin is in a group of drugs called alpha-adrenergic blockers. Terazosin relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Terazosin is used to treat hypertension (high blood pressure), or to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Terazosin may also be used for other purposes not listed in this medication guide. Warnings Terazosin may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. You may wish to take this medication only at bedtime if it causes you to feel light-headed. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. You should not use this medication if you are allergic to terazosin. If you stop taking terazosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Terazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using terazosin. Do not stop using terazosin before surgery unless your surgeon tells you to. Tell your doctor about all other medications you use, especially other blood pressure medications including diuretics (water pills). Before taking this medicine You should not use this medication if you are allergic to terazosin. If you have a history of prostate cancer, you may need a dose adjustment or special tests to safely take terazosin. Terazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using terazosin before surgery unless your surgeon tells you to. FDA pregnancy category C. It is not known whether terazosin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether terazosin passes into breast milk or if it could harm a nursing baby. Do not use terazosin without telling your doctor if you are breast-feeding a baby. Terazosin pregnancy and breastfeeding warnings (more detail) How should I take terazosin? Take terazosin exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your terazosin dose to make sure you get the best results. Terazosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. You may wish to take this medication only at bedtime if it causes you to feel light-headed. Call your doctor if you have severe dizziness or feel like you might pass out. You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position. If you stop taking terazosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Your blood pressure or prostate will need to be checked often. Visit your doctor regularly. If you are being treated for high blood pressure, keep using terazosin even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Store terazosin at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme dizziness or fainting. What should I avoid? Terazosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of terazosin. Terazosin side effects Get emergency medical help if you have any of these signs of an allergic reaction to terazosin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: fast or pounding heartbeats or fluttering in your chest; feeling like you might pass out; swelling in your hands, ankles, or feet; or penis erection that is painful or lasts 4 hours or longer. Less serious terazosin side effects may include: mild dizziness; weakness, drowsiness; blurred vision; nausea; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Terazosin side effects (more detail) Dosing information Usual Adult Dose for Hypertension: Initial dose: 1 mg orally once a day at bedtime Maintenance dose: 1-5 mg orally once a day. Maximum dose: 20 mg per day. Usual Adult Dose for Benign Prostatic Hyperplasia: Initial dose: 1 mg orally once a day at bedtime. Maintenance dose: Increased in a stepwise fashion to 2 mg, 5 mg, or 10 mg once a day to achieve desired improvement of symptoms. Detailed Terazosin dosage information What other drugs will affect terazosin? Tell your doctor about all other medications you use, especially: sildenafil (Viagra, Revatio); tadalafil (Cialis); vardenafil (Levitra); verapamil (Calan, Covera, Isoptin, Verelan); or other blood pressure medications, including diuretics (water pills). This list is not complete and other drugs may interact with terazosin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems. Theophylline may also be used for purposes not listed in this medication guide. Warnings Never use theophylline in larger amounts, or for longer than prescribed. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well. Overdose can occur if you take too much theophylline at one time, or if your daily doses are too high. Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with theophylline. Before taking this medicine You should not use theophylline if you are allergic to it. Tell your doctor if you have ever had: a gastric or peptic ulcer; a serious infection called sepsis; liver disease (especially cirrhosis or hepatitis); fluid in your lungs; heart problems; a thyroid disorder; seizures; or kidney disease. Tell your doctor if you drink alcohol, or if you smoke or have recently quit smoking cigarettes or marijuana. Also tell your doctor if you have been sick with a high fever (102 degrees or higher) for 24 hours or longer. Tell your doctor if you are pregnant or breastfeeding.   Do not give theophylline to a child without medical advice. How should I take theophylline? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Never use theophylline in larger amounts, or for longer than prescribed. Theophylline is not a rescue medicine for asthma or bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well. Swallow the capsule or tablet whole and do not crush or chew it. You may break a scored tablet in half if needed to get the correct dose. Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Your dose and the number of times you take theophylline daily will depend on the reason you are taking this medication. Follow your doctor's instructions about whether to take your medication with food or on an empty stomach. Your dose needs may change if you are ill, or if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes. You will need regular medical tests to be sure you are using the right dose. Do not change your dose or dosing schedule without your doctor's advice. Theophylline doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using theophylline. Store at room temperature away from moisture, heat, and light.

What is tizanidine? Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain. Tizanidine is used to treat spasticity by temporarily relaxing muscle tone. Tizanidine may also be used for purposes not listed in this medication guide. Warnings Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity. You should not take tizanidine if you are also taking fluvoxamine (Luvox) or ciprofloxacin (Cipro). Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone. Switching between tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects. The recommended starting dose of tizanidine is 2 mg every 6 to 8 hours, up to a maximum of 3 doses in 24 hours. Do not take more than 36 mg of tizanidine in a 24-hour period. Too much of this medicine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Avoid drinking alcohol. It can increase some of the side effects of this medicine. Before taking this medicine You should not use tizanidine if you are allergic to it, or if: you also take the antidepressant fluvoxamine (Luvox); or you also take the antibiotic ciprofloxacin (Cipro). To make sure tizanidine is safe for you, tell your doctor if you have ever had: liver disease; kidney disease; or low blood pressure. It is not known whether tizanidine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take tizanidine? Take tizanidine exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Tizanidine is usually taken up to 3 times in one day, starting at 2mg per dose. Allow 6 to 8 hours to pass between doses. Do not take more than 36 mg in a 24-hour period. Too much of this medicine can damage your liver. You may take tizanidine with or without food, but take it the same way each time. Switching between taking with food and taking it without food can make the medicine less effective or cause increased side effects. Switching between tablets and capsules may cause changes in side effects or how well the medicine works. Taking the tablets with food can increase your blood levels of tizanidine. Taking the capsules with food can decrease your blood levels of tizanidine. If you make any changes in how you take tizanidine, tell your doctor if you notice any change in side effects or in how well the medicine works. Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 3 hours after you take it. You should take this medicine only for daily activities that require relief from muscle spasms. You will need frequent blood tests to check your liver function. If you stop using this medicine suddenly after long-term use, you may have withdrawal symptoms such as dizziness, fast heartbeats, tremors, and anxiety. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting. What to avoid Do not use tizanidine at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone. Drinking alcohol with this medicine can cause side effects. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Tizanidine side effects Get emergency medical help if you have signs of an allergic reaction to tizanidine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; weak or shallow breathing; confusion, hallucinations; or pain or burning when you urinate. Common tizanidine side effects may include: drowsiness, dizziness, weakness; feeling nervous; blurred vision; flu-like symptoms; dry mouth, trouble speaking; abnormal liver function tests; runny nose, sore throat; urination problems, painful urination; vomiting, constipation; or uncontrolled muscle movements. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tizanidine? Taking tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: acyclovir; ticlopidine; zileuton; birth control pills; an antibiotic - ciprofloxacin, levofloxacin, moxifloxacin, or ofloxacin; blood pressure medicine - clonidine, guanfacine, methyldopa; heart rhythm medicine - amiodarone, mexiletine, propafenone, verapamil; or stomach acid medicine - cimetidine, famotidine. This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is tolterodine? Tolterodine is used in adults to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence (urine leakage). Tolterodine may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use tolterodine if you are allergic to tolterodine or fesoterodine (Toviaz), or if you have: trouble emptying your bladder; a blockage in your stomach, slow digestion; or uncontrolled narrow-angle glaucoma. Tell your doctor if you have ever had: a stomach or intestinal disorder; problems with constipation; liver disease; kidney disease; myasthenia gravis; trouble emptying your bladder, or a weak stream of urine; glaucoma; or long QT syndrome (in you or a family member). Tell your doctor if you are pregnant or breastfeeding. How should I take tolterodine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take with water. Take tolterodine with or without food, at the same times each day. Swallow the capsule whole and do not crush, chew, break, or open it. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use 2 doses in one day What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tolterodine? Avoid driving or hazardous activity until you know how tolterodine will affect you. Your reactions could be impaired. Tolterodine side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tolterodine and call your doctor at once if you have: confusion, hallucinations; severe stomach pain or constipation; or painful or difficult urination. Common side effects may include: dry mouth; dizziness; constipation; stomach pain; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Tolterodine dosing information Usual Adult Dose for Urinary Incontinence: Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency Usual Adult Dose for Urinary Frequency: Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency   What other drugs will affect tolterodine? Tolterodine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Tell your doctor about all your other medicines, especially: cyclosporine; or vinblastine. This list is not complete. Other drugs may affect tolterodine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is tolterodine? Tolterodine is used in adults to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence (urine leakage). Tolterodine may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use tolterodine if you are allergic to tolterodine or fesoterodine (Toviaz), or if you have: trouble emptying your bladder; a blockage in your stomach, slow digestion; or uncontrolled narrow-angle glaucoma. Tell your doctor if you have ever had: a stomach or intestinal disorder; problems with constipation; liver disease; kidney disease; myasthenia gravis; trouble emptying your bladder, or a weak stream of urine; glaucoma; or long QT syndrome (in you or a family member). Tell your doctor if you are pregnant or breastfeeding. How should I take tolterodine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take with water. Take tolterodine with or without food, at the same times each day. Swallow the capsule whole and do not crush, chew, break, or open it. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use 2 doses in one day What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tolterodine? Avoid driving or hazardous activity until you know how tolterodine will affect you. Your reactions could be impaired. Tolterodine side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tolterodine and call your doctor at once if you have: confusion, hallucinations; severe stomach pain or constipation; or painful or difficult urination. Common side effects may include: dry mouth; dizziness; constipation; stomach pain; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Tolterodine dosing information Usual Adult Dose for Urinary Incontinence: Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency Usual Adult Dose for Urinary Frequency: Immediate release tablets: -Initial dose: 2 mg orally 2 times a day -Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability Extended release capsules: -Initial dose: 4 mg orally once a day -Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability Comments: -This drug can be taken with or without food. -The extended release formulation should be swallowed whole. Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency   What other drugs will affect tolterodine? Tolterodine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Tell your doctor about all your other medicines, especially: cyclosporine; or vinblastine. This list is not complete. Other drugs may affect tolterodine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is topiramate? Topiramate is a seizure medicine, also called an anticonvulsant. Topiramate is used to treat certain types of seizures in adults and children who are at least 2 years old. Trokendi XR is for use in adults and children who are at least 6 years old. Some brands of topiramate are also used to prevent migraine headaches in adults and teenagers who are at least 12 years old. These medicines will only prevent migraine headaches or reduce the number of attacks, but will not treat a headache that has already begun. Topiramate may also be used for purposes not listed in this medication guide. Warnings Topiramate may cause vision problems that can be permanent if not treated quickly. Call your doctor right away if you have a sudden decrease in vision. Topiramate can increase body temperature and decrease sweating, which may lead to life-threatening dehydration. Tell your doctor if you have decreased sweating, high fever, and hot dry skin. Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Before taking this medicine You should not use topiramate if you are allergic to it. Do not take Trokendi XR within 6 hours before or 6 hours after drinking alcohol. Tell your doctor if you are sick with diarrhea, or if you have ever had: glaucoma or other eye problems; metabolic acidosis (high levels of acid in your blood); kidney disease, kidney stones, or dialysis; lung disease, breathing problems; mood problems, depression, or suicidal thoughts or actions; liver disease; a growth disorder; or soft or brittle bones (osteoporosis, osteomalacia). Topiramate can increase the level of acid in your blood (metabolic acidosis). This can weaken your bones, cause kidney stones, or cause growth problems in children or harm to an unborn baby. You may need blood tests to make sure you do not have metabolic acidosis, especially if you are pregnant. Some people have thoughts about suicide while taking an anticonvulsant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Taking topiramate during pregnancy may increase the risk of cleft lip and/or cleft palate, a birth defect that can develop early in pregnancy even before you know you are pregnant. However, having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant. If you take topiramate during pregnancy: The benefit of preventing seizures may outweigh any risks posed by topiramate. There may be other medications that are safer to use. Do not start or stop taking topiramate without your doctor's advice. If you are not pregnant or planning to become pregnant, use effective birth control to prevent pregnancy while taking topiramate. Topiramate can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks. How should I take topiramate? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Topiramate can be taken with or without food. Swallow the tablet whole and do not crush, chew, or break it. The Trokendi XR extended-release capsule must be swallowed whole. Do not break or open. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). If you cannot swallow a Qudexy XR or Topamax Sprinkle Capsule whole, open it and sprinkle the medicine into a spoonful of applesauce or other soft food. Swallow the mixture right away without chewing. Do not save it for later use. Carefully follow the swallowing instructions for your medicine. Topiramate doses are sometimes based on weight in children. Your child's dose needs may change if the child gains or loses weight. Drink plenty of liquids while you are taking topiramate, to prevent kidney stones or an electrolyte imbalance. You will need frequent medical tests. If you need surgery, tell the surgeon ahead of time that you are using topiramate. Any medical care provider who treats you should know that you take seizure medication. Do not stop using topiramate suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. Call your doctor if your seizures get worse or you have them more often while taking topiramate. Store at cool room temperature away from moisture, light, and high heat.   What happens if I miss a dose? Take the medicine as soon as you can. Do not take two doses at one time. Skip a missed Topamax dose if your next dose is due in less than 6 hours. Call your doctor if you have missed more than one dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of topiramate can be fatal. Overdose can cause drowsiness, agitation, depression, double vision, thinking problems, problems with speech or coordination, fainting, and seizure (convulsions). What should I avoid while taking topiramate? Do not drink alcohol. Dangerous side effects or increased seizures may occur. Avoid becoming overheated or dehydrated in hot weather. Topiramate can increase body temperature and decrease sweating, leading to life-threatening dehydration (especially in children). Avoid the use of a ketogenic or "ketosis" diet (high in fat, low in carbohydrates) while you are taking topiramate. Topiramate may cause blurred vision or impair your thinking or reactions. Avoid driving or operating machinery until you know how topiramate will affect you. Also avoid activities that could be dangerous if you have an unexpected seizure, such as swimming or climbing in high places. Topiramate side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening mood symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a skin rash, no matter how mild; vision problems, blurred vision, eye pain or redness, sudden vision loss (can be permanent if not treated quickly); confusion, problems with thinking or memory, trouble concentrating, problems with speech; dehydration symptoms--decreased sweating, high fever, hot and dry skin; signs of a kidney stone--severe pain in your side or lower back, painful or difficult urination; signs of too much acid in your blood--irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or signs of too much ammonia in your blood--vomiting, unexplained weakness, feeling like you might pass out. Common side effects may include: dizziness, drowsiness, tiredness, slow reactions; problems with speech or memory, abnormal vision; numbness or tingling in your arms and legs, decreased sensation (especially in the skin); changes in your sense of taste, feeling nervous; nausea, diarrhea, stomach pain, loss of appetite; fever, weight loss; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect topiramate? Using topiramate with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or depression. Tell your doctor about all your other medicines, especially: zonisamide; birth control pills; divalproex, valproic acid; or other glaucoma medications, including eye drops. This list is not complete. Other drugs may affect topiramate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is topiramate? Topiramate is a seizure medicine, also called an anticonvulsant. Topiramate is used to treat certain types of seizures in adults and children who are at least 2 years old. Trokendi XR is for use in adults and children who are at least 6 years old. Some brands of topiramate are also used to prevent migraine headaches in adults and teenagers who are at least 12 years old. These medicines will only prevent migraine headaches or reduce the number of attacks, but will not treat a headache that has already begun. Topiramate may also be used for purposes not listed in this medication guide. Warnings Topiramate may cause vision problems that can be permanent if not treated quickly. Call your doctor right away if you have a sudden decrease in vision. Topiramate can increase body temperature and decrease sweating, which may lead to life-threatening dehydration. Tell your doctor if you have decreased sweating, high fever, and hot dry skin. Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Before taking this medicine You should not use topiramate if you are allergic to it. Do not take Trokendi XR within 6 hours before or 6 hours after drinking alcohol. Tell your doctor if you are sick with diarrhea, or if you have ever had: glaucoma or other eye problems; metabolic acidosis (high levels of acid in your blood); kidney disease, kidney stones, or dialysis; lung disease, breathing problems; mood problems, depression, or suicidal thoughts or actions; liver disease; a growth disorder; or soft or brittle bones (osteoporosis, osteomalacia). Topiramate can increase the level of acid in your blood (metabolic acidosis). This can weaken your bones, cause kidney stones, or cause growth problems in children or harm to an unborn baby. You may need blood tests to make sure you do not have metabolic acidosis, especially if you are pregnant. Some people have thoughts about suicide while taking an anticonvulsant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Taking topiramate during pregnancy may increase the risk of cleft lip and/or cleft palate, a birth defect that can develop early in pregnancy even before you know you are pregnant. However, having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant. If you take topiramate during pregnancy: The benefit of preventing seizures may outweigh any risks posed by topiramate. There may be other medications that are safer to use. Do not start or stop taking topiramate without your doctor's advice. If you are not pregnant or planning to become pregnant, use effective birth control to prevent pregnancy while taking topiramate. Topiramate can make birth control pills less effective. Ask your doctor about other birth control options such as an injection, implant, skin patch, vaginal ring, condom, diaphragm, cervical cap, or contraceptive sponge. It may not be safe to breastfeed a baby while you are using this medicine. Ask your doctor about any risks. How should I take topiramate? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Topiramate can be taken with or without food. Swallow the tablet whole and do not crush, chew, or break it. The Trokendi XR extended-release capsule must be swallowed whole. Do not break or open. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). If you cannot swallow a Qudexy XR or Topamax Sprinkle Capsule whole, open it and sprinkle the medicine into a spoonful of applesauce or other soft food. Swallow the mixture right away without chewing. Do not save it for later use. Carefully follow the swallowing instructions for your medicine. Topiramate doses are sometimes based on weight in children. Your child's dose needs may change if the child gains or loses weight. Drink plenty of liquids while you are taking topiramate, to prevent kidney stones or an electrolyte imbalance. You will need frequent medical tests. If you need surgery, tell the surgeon ahead of time that you are using topiramate. Any medical care provider who treats you should know that you take seizure medication. Do not stop using topiramate suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. Call your doctor if your seizures get worse or you have them more often while taking topiramate. Store at cool room temperature away from moisture, light, and high heat.   What happens if I miss a dose? Take the medicine as soon as you can. Do not take two doses at one time. Skip a missed Topamax dose if your next dose is due in less than 6 hours. Call your doctor if you have missed more than one dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of topiramate can be fatal. Overdose can cause drowsiness, agitation, depression, double vision, thinking problems, problems with speech or coordination, fainting, and seizure (convulsions). What should I avoid while taking topiramate? Do not drink alcohol. Dangerous side effects or increased seizures may occur. Avoid becoming overheated or dehydrated in hot weather. Topiramate can increase body temperature and decrease sweating, leading to life-threatening dehydration (especially in children). Avoid the use of a ketogenic or "ketosis" diet (high in fat, low in carbohydrates) while you are taking topiramate. Topiramate may cause blurred vision or impair your thinking or reactions. Avoid driving or operating machinery until you know how topiramate will affect you. Also avoid activities that could be dangerous if you have an unexpected seizure, such as swimming or climbing in high places. Topiramate side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening mood symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a skin rash, no matter how mild; vision problems, blurred vision, eye pain or redness, sudden vision loss (can be permanent if not treated quickly); confusion, problems with thinking or memory, trouble concentrating, problems with speech; dehydration symptoms--decreased sweating, high fever, hot and dry skin; signs of a kidney stone--severe pain in your side or lower back, painful or difficult urination; signs of too much acid in your blood--irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or signs of too much ammonia in your blood--vomiting, unexplained weakness, feeling like you might pass out. Common side effects may include: dizziness, drowsiness, tiredness, slow reactions; problems with speech or memory, abnormal vision; numbness or tingling in your arms and legs, decreased sensation (especially in the skin); changes in your sense of taste, feeling nervous; nausea, diarrhea, stomach pain, loss of appetite; fever, weight loss; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect topiramate? Using topiramate with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or depression. Tell your doctor about all your other medicines, especially: zonisamide; birth control pills; divalproex, valproic acid; or other glaucoma medications, including eye drops. This list is not complete. Other drugs may affect topiramate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is tramadol? Tramadol is a pain medicine similar to an opioid and is classified as a synthetic opioid. It acts in the central nervous system (CNS) to relieve pain. Tramadol is used to treat moderate to severe pain in adults. The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain. Warnings Seizures have been reported in patients taking tramadol. Your risk of seizures is higher if you are taking higher doses than recommended. Seizure risk is also higher in those with a seizure disorder or those taking certain antidepressants or opioid medications. Tramadol should not be used if you are suicidal or prone to addiction. You should not take tramadol if you have severe breathing problems, a blockage in your stomach or intestines, or if you have recently used alcohol, sedatives, tranquilizers, narcotic medication, or an MAO inhibitor (isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others). Tramadol can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Keep this medicine where others cannot get to it. Tramadol should not be given to a child younger than 12 years old, or anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids. Ultram ER should not be given to anyone younger than 18 years old. Taking tramadol during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Before taking this medicine You should not take tramadol if you are allergic to it, or if you have: severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine). Tramadol should not be given to a child younger than 12 years old. Ultram ER should not be given to anyone younger than 18 years old. Do not give this medicine to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids. Seizures have occurred in some people taking tramadol. Your seizure risk may be higher if you have ever had: a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder. To make sure tramadol is safe for you, tell your doctor if you have ever had: breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt. If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks. Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby. How should I take tramadol? Take tramadol exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use tramadol in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine. Never share tramadol with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law. Stop taking all opioid medications when you start taking tramadol. Tramadol can be taken with or without food, but take it the same way each time. Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Never crush or break a tramadol tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death. You may have withdrawal symptoms if you stop using tramadol suddenly. Ask your doctor before stopping the medicine. Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription. Do not keep leftover tramadol. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash. Dosing information Usual Adult Dose for Pain: Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day. Usual Adult Dose for Chronic Pain: Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Tramadol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from other Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day. Usual Geriatric Dose for Pain: Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day. Usual Geriatric Dose for Chronic Pain: Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day. Usual Pediatric Dose for Pain: Tramadol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.   What happens if I miss a dose? Since tramadol is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing. Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive. Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it. What should I avoid while taking tramadol? Do not drink alcohol. Dangerous side effects or death could occur. Avoid driving or hazardous activity until you know how tramadol will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Tramadol side effects Get emergency medical help if you have signs of an allergic reaction to tramadol (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Tramadol can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once if you have: noisy breathing, sighing, shallow breathing, breathing that stops during sleep; a slow heart rate or weak pulse; a light-headed feeling, like you might pass out; seizure (convulsions); or low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Serious breathing problems may be more likely in older adults and people who are debilitated or have wasting syndrome or chronic breathing disorders. Common tramadol side effects may include: constipation, nausea, vomiting, stomach pain; dizziness, drowsiness, tiredness; headache; or itching. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tramadol? You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Many other drugs can be dangerous when used with tramadol. Tell your doctor if you also use: medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder; other opioid medicines; a benzodiazepine sedative like Valium, Klonopin, or Xanax; sleep medicine, muscle relaxers, or other drugs that make you drowsy; or drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease. This list is not complete. Other drugs may interact with tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Many other drugs can be dangerous when used with tramadol. Tell your doctor if you also use: medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder; other opioid medicines; a benzodiazepine sedative like Valium, Klonopin, or Xanax; sleep medicine, muscle relaxers, or other drugs that make you drowsy; drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease. drugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting. This list is not complete. Many other drugs may affect tramadol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is tramadol? Tramadol is a pain medicine similar to an opioid and is classified as a synthetic opioid. It acts in the central nervous system (CNS) to relieve pain. Tramadol is used to treat moderate to severe pain in adults. The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain. Warnings Seizures have been reported in patients taking tramadol. Your risk of seizures is higher if you are taking higher doses than recommended. Seizure risk is also higher in those with a seizure disorder or those taking certain antidepressants or opioid medications. Tramadol should not be used if you are suicidal or prone to addiction. You should not take tramadol if you have severe breathing problems, a blockage in your stomach or intestines, or if you have recently used alcohol, sedatives, tranquilizers, narcotic medication, or an MAO inhibitor (isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others). Tramadol can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Keep this medicine where others cannot get to it. Tramadol should not be given to a child younger than 12 years old, or anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids. Ultram ER should not be given to anyone younger than 18 years old. Taking tramadol during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Before taking this medicine You should not take tramadol if you are allergic to it, or if you have: severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine). Tramadol should not be given to a child younger than 12 years old. Ultram ER should not be given to anyone younger than 18 years old. Do not give this medicine to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids. Seizures have occurred in some people taking tramadol. Your seizure risk may be higher if you have ever had: a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder. To make sure tramadol is safe for you, tell your doctor if you have ever had: breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt. If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks. Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby. How should I take tramadol? Take tramadol exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use tramadol in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine. Never share tramadol with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law. Stop taking all opioid medications when you start taking tramadol. Tramadol can be taken with or without food, but take it the same way each time. Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Never crush or break a tramadol tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death. You may have withdrawal symptoms if you stop using tramadol suddenly. Ask your doctor before stopping the medicine. Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription. Do not keep leftover tramadol. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash. Dosing information Usual Adult Dose for Pain: Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day. Usual Adult Dose for Chronic Pain: Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Tramadol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from other Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day. Usual Geriatric Dose for Pain: Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day. Usual Geriatric Dose for Chronic Pain: Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day. Usual Pediatric Dose for Pain: Tramadol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.   What happens if I miss a dose? Since tramadol is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing. Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive. Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it. What should I avoid while taking tramadol? Do not drink alcohol. Dangerous side effects or death could occur. Avoid driving or hazardous activity until you know how tramadol will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Tramadol side effects Get emergency medical help if you have signs of an allergic reaction to tramadol (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Tramadol can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once if you have: noisy breathing, sighing, shallow breathing, breathing that stops during sleep; a slow heart rate or weak pulse; a light-headed feeling, like you might pass out; seizure (convulsions); or low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Serious breathing problems may be more likely in older adults and people who are debilitated or have wasting syndrome or chronic breathing disorders. Common tramadol side effects may include: constipation, nausea, vomiting, stomach pain; dizziness, drowsiness, tiredness; headache; or itching. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tramadol? You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Many other drugs can be dangerous when used with tramadol. Tell your doctor if you also use: medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder; other opioid medicines; a benzodiazepine sedative like Valium, Klonopin, or Xanax; sleep medicine, muscle relaxers, or other drugs that make you drowsy; or drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease. This list is not complete. Other drugs may interact with tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Many other drugs can be dangerous when used with tramadol. Tell your doctor if you also use: medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder; other opioid medicines; a benzodiazepine sedative like Valium, Klonopin, or Xanax; sleep medicine, muscle relaxers, or other drugs that make you drowsy; drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease. drugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting. This list is not complete. Many other drugs may affect tramadol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is acetaminophen and tramadol? Acetaminophen and tramadol is a combination medicine used to treat moderate to severe pain. Acetaminophen and tramadol contains an opioid-like medicine, and may be habit-forming. Acetaminophen and tramadol may also be used for purposes not listed in this medication guide. Warnings MISUSE OF acetaminophen and tramadol CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Do not give this medicine to anyone younger than 12 years old, or anyone under 18 who recently had surgery to remove the tonsils or adenoids. Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Before taking this medicine You should not use this medicine if you are allergic to acetaminophen (Tylenol) or tramadol (Ultram), or if you have: severe asthma or breathing problems; a blockage in your stomach or intestines; or if you have used an MAO inhibitor (such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine) in the past 14 days. Acetaminophen and tramadol is not approved for use by anyone younger than 12 years old. Do not give this medicine to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids. Seizures have occurred in some people taking tramadol. Your risk of a seizure may be higher if you have ever had: alcoholism or drug addiction; breathing problems, sleep apnea; a metabolic disorder; a head injury, brain tumor, or seizures; or if you have recently used sedatives, tranquilizers, or narcotic medications. Tell your doctor if you have ever had: liver disease, or if you drink alcohol; kidney disease, urination problems; problems with your pancreas, gallbladder, or thyroid; or depression, mental illness, or a suicide attempt. If you use this medicine during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks. Ask a doctor before using this medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby. How should I take acetaminophen and tramadol? Follow the directions on your prescription label and read all medication guides. Never use acetaminophen and tramadol in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine. Never share acetaminophen and tramadol with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law. The maximum amount of acetaminophen and tramadol is 2 tablets per dose, or 8 tablets per day. Do not take this medicine for longer than 5 days in a row. You may take this medicine with or without food, but take it the same way each time. You should not stop using this medicine suddenly after long-term use. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture and heat. Keep your medicine in a place where no one can use it improperly. Do not keep leftover medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash. What happens if I miss a dose? Since this medicine is used for pain, you are not likely to miss a dose. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or person using acetaminophen and tramadol without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing. Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive. Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it. What should I avoid while taking acetaminophen and tramadol? Do not drink alcohol. Dangerous side effects or death could occur. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen (sometimes abbreviated as APAP). Taking certain medications together can lead to a fatal overdose. Acetaminophen and tramadol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking acetaminophen and tramadol and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. This medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Stop using this medicine and call your doctor at once if you have: noisy breathing, sighing, shallow breathing, breathing that stops during sleep; a slow heart rate or weak pulse; a light-headed feeling, like you might pass out; seizure (convulsions); chest pain; liver problems--upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); low cortisol levels-- nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea. Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders. Common side effects may include: dizziness, drowsiness; stomach pain, nausea, loss of appetite, diarrhea, constipation; or sweating. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Acetaminophen / tramadol side effects (more detail) Acetaminophen and tramadol dosing information Usual Adult Dose for Pain: Usual dose: 2 tablets orally every 4 to 6 hours as needed for pain Maximum dose: 8 tablets per day Maximum duration: 5 days Comments: -Each tablet contains Tramadol 37.5 mg and Acetaminophen 325 mg. Maximum daily doses are Tramadol: 300 mg per day and Acetaminophen 2600 mg per day. -Use of more than 1 product at time containing acetaminophen is not recommended. -Due to the risks of addiction, abuse, and misuse, this drug is reserved for patients who have not been or are not expected to tolerate non-opioid pain medications or who have not obtained or are not expected to obtain analgesia with other pain management treatments. Use: For the short-term (use should be limited to 5 days or less) management of acute pain, severe enough to require an opioid analgesic and for whom alternative treatments are inadequate. Detailed Acetaminophen / tramadol dosage information What other drugs will affect acetaminophen and tramadol? You may have a fatal acetaminophen and tramadol overdose if you start or stop using certain other medicines. Tell your doctor about all your medications. Many other drugs can be dangerous when used with acetaminophen and tramadol. Tell your doctor if you also use: medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder; opioid medicines; a benzodiazepine sedative like Valium, Klonopin, or Xanax; sleep medicine, muscle relaxers, or other drugs that make you drowsy; or drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease. This list is not complete. Many drugs may affect acetaminophen and tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is trandolapril? Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Trandolapril is used to treat high blood pressure (hypertension), and to improve survival after a heart attack. Trandolapril may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant, and tell your doctor right away if you become pregnant. If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine). Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). Before taking this medicine You should not use trandolapril if you are allergic to it, or if you: have a history of angioedema; recently took a heart medicine called sacubitril; or are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, or ramipril. Do not take trandolapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). If you have diabetes, do not use trandolapril together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking trandolapril with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); liver disease; heart disease or congestive heart failure; diabetes; or if you are on a low-salt diet. Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Trandolapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using trandolapril. How should I take trandolapril? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Trandolapril can be taken with or without food. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking trandolapril. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. Your blood pressure will need to be checked often. Your kidney function and electrolytes may also need to be checked. If you need surgery, tell the surgeon ahead of time that you are using trandolapril. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. Detailed Trandolapril dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking trandolapril? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Trandolapril side effects Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American. Call your doctor at once if you have: a light-headed feeling, like you might pass out; upper stomach pain, and jaundice (yellowing of the skin or eyes); chest pain, pounding heartbeats or fluttering in your chest; high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; low white blood cell counts--fever, chills, feeling light-headed, mouth sores, skin sores, sore throat, cough, trouble breathing; or lung problems--anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus. Common side effects may include: cough; dizziness; or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Trandolapril side effects (more detail) What other drugs will affect trandolapril? Tell your doctor about all your current medicines and any you start or stop using, especially: a diuretic or "water pill"; gold injections to treat arthritis; insulin or oral diabetes medicine; lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect trandolapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here

What is trazodone? Trazodone is an antidepressant that belongs to a group of drugs called serotonin receptor antagonists and reuptake inhibitors (SARIs). While trazodone is not a true member of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, it does still share many properties of the SSRIs. Trazodone is used to treat major depressive disorder. It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression. Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain. Warnings You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection. Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, tranylcypromine and others. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or other caregivers should also be alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Trazodone is not approved for use in children. Before taking this medicine You should not use trazodone if you are allergic to it. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI. Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with trazodone could cause a serious condition called serotonin syndrome. To make sure this medicine is safe for you, tell your doctor if you have ever had: liver or kidney disease; heart disease, or a recent heart attack; a bleeding or blood clotting disorder; seizures or epilepsy; narrow-angle glaucoma; long QT syndrome; drug addiction or suicidal thoughts; or bipolar disorder (manic depression). Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Taking trazodone during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop this medicine without asking your doctor. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. Trazodone is not approved for use by anyone younger than 18 years old. How should I take trazodone? Take trazodone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Take trazodone after a meal or a snack. It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. You should not stop using this medicine suddenly, or you could have unpleasant symptoms (such as dizziness, vomiting, agitation, sweating, confusion, numbness, tingling, or electric shock feelings). Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose for Depression: Initial dose: 150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days Maximum dose: -Inpatients: 600 mg/day -Outpatients: 400 mg/day Comments: -Patients should be screened for a personal/family history of bipolar disorder, mania, or hypomania prior to initiating treatment. -Patients should be monitored for withdrawal symptoms when discontinuing therapy. -After an adequate response has been reached, dosage may be gradually reduced depending on therapeutic response. -If drowsiness develops, a major portion of the daily dose may be administered at bedtime or a reduction of dosage may be necessary. -This drug should be taken shortly after a meal or light snack. Use: Treatment of major depressive disorder (MDD)   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal when trazodone is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium). Overdose symptoms may include extreme drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops. What to avoid Do not drink alcohol. Dangerous side effects or death could occur. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with trazodone may cause you to bruise or bleed easily. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Trazodone side effects Get emergency medical help if you have signs of an allergic reaction to trazodone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); slow heartbeats; unusual thoughts or behavior; easy bruising, unusual bleeding; or low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Common trazodone side effects may include: drowsiness, dizziness, tiredness; swelling; weight loss; blurred vision; diarrhea, constipation; or stuffy nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect trazodone? Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your current medicines. Many drugs can interact with trazodone, especially: any other antidepressants; phenytoin; St. John's wort; tramadol; a diuretic or "water pill"; medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia; a blood thinner - warfarin, Coumadin, Jantoven; or migraine headache medicine - sumatriptan, Imitrex, Maxalt, Treximet, and others. This list is not complete and many other drugs may interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.