What is rivastigmine? Rivastigmine is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease. Rivastigmine is not a cure for Alzheimer's or Parkinson's disease. Rivastigmine may also be used for purposes not listed in this medication guide. Warnings You should not take oral rivastigmine if you have ever had severe redness, itching, or skin irritation caused by wearing a rivastigmine transdermal skin patch. Before taking this medicine You should not take rivastigmine if you are allergic to rivastigmine or similar medicines, such as felbamate, meprobamate, or carisoprodol. You should not take oral rivastigmine if you have ever had severe redness, itching, or skin irritation caused by wearing a rivastigmine transdermal skin patch. Tell your doctor if you have ever had: an ulcer or stomach bleeding; a seizure; heart problems; liver or kidney disease; urination problems; or asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take rivastigmine? Do not wear a rivastigmine transdermal skin patch at the same time you are taking rivastigmine capsules or oral liquid. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take rivastigmine with food. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). You may swallow the liquid medicine directly from the syringe or mix the medicine with a small glass of water, fruit juice, or soda. Stir and drink this mixture within 4 hours after mixing. Add a little more water to the glass, swirl gently and drink right away. After using the syringe, wipe the outside of it with a clean tissue and put the syringe back into its protective case. Close the medicine bottle using the child-resistant closure. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking rivastigmine. Rivastigmine doses are based on weight. Your dose needs may change if you gain or lose weight. If you need surgery, tell your surgeon you currently use this medicine. If you stop taking rivastigmine for any reason, do not restart the medicine without talking to your doctor first. You may need to start with a lower dose. Store in an upright position at room temperature, away from moisture and heat. Do not allow the liquid medicine to freeze. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. If you miss several doses in a row, call your doctor before taking any more of rivastigmine. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe nausea, vomiting, salivation, sweating, slow heartbeats, weak or shallow breathing, fainting, or seizure (convulsions). What should I avoid while taking rivastigmine? Avoid driving or hazardous activity until you know how rivastigmine will affect you. Your reactions could be impaired. Rivastigmine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe or ongoing vomiting or diarrhea, loss of appetite, weight loss; bloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds; a light-headed feeling, like you might pass out; tremors (uncontrolled shaking), restless muscle movements in your eyes, tongue, jaw, or neck; seizure (convulsions); painful or difficult urination; severe skin redness, itching, or irritation; or dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin. Common side effects may include: upset stomach, nausea, vomiting; loss of appetite; or weakness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rivastigmine dosing information Usual Adult Dose for Alzheimer's Disease: MILD TO MODERATE ALZHEIMER'S DISEASE: ORAL: -Initial dose: 1.5 mg orally twice a day -Maintenance dose: After a minimum of 2 weeks of treatment, if the initial dosage is well tolerated, it can be increased to 3 mg twice a day; subsequent increases to 4.5 mg and 6 mg twice a day should be attempted only after a minimum of 2 weeks at the previous dosage TRANSDERMAL PATCH: -Initial Dose: 4.6 mg/24 hour patch applied to the skin once daily -Maintenance Dose: After a minimum of 4 weeks of treatment at the initial dose, and if well tolerated, the dose can be increased to 9.5 mg/24 hours for as long as this dose is beneficial; the dose can then be increased to 13.3 mg/24 hours -Maximum Dose: 13.3 mg/24 hour patch applied to skin daily; higher doses confer no appreciable additional benefit, and are associated with significant increase in the incidence of adverse events SEVERE ALZHEIMER'S DISEASE: TRANSDERMAL PATCH: -Recommended dose: 13.3 mg/24 hours transdermal patch applied to skin once daily; replace with a new patch every 24 hours Use: For the treatment of mild, moderate, or severe dementia of the Alzheimer's type (AD) Usual Adult Dose for Parkinson's Disease: MILD TO MODERATE PARKINSON'S DISEASE DEMENTIA: ORAL: Initial dose: 1.5 mg orally twice a day with morning and evening meals Maintenance dose: Subsequently, the dose can be increased to 3 mg orally twice a day and further to 4.5 mg twice a day and 6 mg twice a day (based on tolerability) with a minimum of 4 weeks at each dose TRANSDERMAL PATCH: Initial dose: 4.6 mg/24 hours applied to the skin once a day Maintenance dose: After a minimum of four weeks of treatment and if well tolerated, the dose of the patch can be increased to 9.5 mg/24 hours for as long as this dose is beneficial. The dose can then be increased to 13.3 mg/24 hours. Maximum dose: 13.3 mg/24 hours. Higher doses confer no appreciable additional benefit, and are associated with significant increase in the incidence of adverse events. Use: For the treatment of mild to moderate dementia associated with Parkinson's disease   What other drugs will affect rivastigmine? Tell your doctor about all your other medicines, especially: medicine to treat depression, anxiety, mood disorders, or mental illness; cold or allergy medicine (Benadryl and others); beta blocker heart or blood pressure medication; medicine to treat Parkinson's disease; medicine to treat nausea/vomiting, stomach problems, motion sickness, or irritable bowel syndrome; medicine to treat overactive bladder; bronchodilator asthma medication; or an NSAID (nonsteroidal anti-inflammatory drug such as aspirin, ibuprofen, naproxen, Advil, Motrin, Aleve, and others. This list is not complete and many other drugs may affect rivastigmine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rizatriptan? Rizatriptan is a headache medicine that narrows the blood vessels around the brain. Rizatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Rizatriptan is used to treat migraine headaches. Rizatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. Rizatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use rizatriptan only if your condition has been confirmed by a doctor as migraine headaches. Rizatriptan may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you have uncontrolled high blood pressure, heart problems, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body. Do not take rizatriptan within 24 hours before or after using another migraine headache medicine. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Before taking this medicine You should not use rizatriptan if you are allergic to it, or if you have: heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; uncontrolled high blood pressure; severe liver disease; or a headache that seems different from your usual migraine headaches. Do not use rizatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: liver or kidney disease; heart problems, chest pain; shortness of breath; or risk factors for coronary artery disease (such as high blood pressure, high cholesterol, diabetes, menopause, smoking, a family history of coronary artery disease, being overweight, or being older than 40 and a man). Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with rizatriptan and cause a serious condition called serotonin syndrome. Rizatriptan disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). Tell your doctor if you are pregnant or breastfeeding. Rizatriptan is not approved for use by anyone younger than 6 years old. How should I use rizatriptan? Take rizatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Take the regular tablet whole with a full glass of water. Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves. After taking a tablet (for adults): If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. If your symptoms have not improved, contact your doctor before taking any more tablets. After taking a tablet (for children ages 6 to 17): If your headache does not completely go away, or goes away and comes back, contact your doctor before taking any more tablets. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Call your doctor if your symptoms do not improve, or if you have more than 4 headaches in one month (30 days). Rizatriptan can raise blood pressure to dangerous levels. Your blood pressure may need to be checked often while you are using rizatriptan. If you use rizatriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Store at room temperature away from moisture and heat. What happens if I miss a dose? Since rizatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using rizatriptan? Do not take rizatriptan within 24 hours before or after using another migraine headache medicine, including: almotriptan, eletriptan, frovatriptan, naratriptan, sumatriptan, zolmitriptan; or ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine. Avoid driving or hazardous activity until you know how rizatriptan will affect you. Your reactions could be impaired. Rizatriptan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using rizatriptan and call your doctor at once if you have: sudden and severe stomach pain and bloody diarrhea; cold feeling or numbness in your feet and hands; severe headache, blurred vision, pounding in your neck or ears; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: dizziness, drowsiness, feeling tired; or pain or a feeling of pressure in your throat or chest. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rizatriptan dosing information Usual Adult Dose for Migraine: Use only after a clear diagnosis of migraine has been established Initial dose: 5 mg or 10 mg orally, once -Provided there has been a response to first dose, a second dose may be administered at least 2 hours later if migraine returns Maximum dose: 30 mg in a 24-hour period Comments: -The 10 mg dose may provide greater effect, however there may be a greater risk of adverse reactions. -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the effectiveness of a second dose or subsequent doses has not been established in placebo-controlled trials. Use: For the acute treatment of migraine with or without aura. Usual Pediatric Dose for Migraine: Use only after a clear diagnosis of migraine has been established 6 years or older and weight less than 40 kg: -Initial dose: 5 mg orally once 6 years or older and weight 40 kg or greater: -Initial dose: 10 mg orally once Maximum: 1 dose in any 24-hour period Comments: -This drug should not be used to treat basilar or hemiplegic migraines because these patients are at a greater risk of stroke. -The safety of treating an average of 4 or more migraine attacks in a 30-day period has not been established; the safety and effectiveness of more than 1 dose within 24 hours has not been established. Use: For the acute treatment of migraine with or without aura in patients 6 years or older.   What other drugs will affect rizatriptan? Tell your doctor about all your other medicines, especially: propranolol; an antidepressant; or medicine to treat a mood disorder. This list is not complete. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Tell your doctor about all your other medicines, especially any type of antidepressant. Other drugs may affect rizatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is ropinirole? Ropinirole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Ropinirole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Ropinirole is also used to treat restless legs syndrome (RLS). Only immediate-release ropinirole (Requip) is approved to treat either Parkinson symptoms or RLS. Extended-release ropinirole (Requip XL) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. Ropinirole may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use ropinirole if you are allergic to it. To make sure ropinirole is safe for you, tell your doctor if you have: high or low blood pressure; kidney disease (or if you are on dialysis); heart disease, heart rhythm problems; a sleep disorder such as narcolepsy, or other conditions that may cause daytime sleepiness; or if you smoke. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether ropinirole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether ropinirole passes into breast milk or if it could affect the nursing baby. Ropinirole may slow breast milk production. Tell your doctor if you are breast-feeding. Ropinirole is not approved for use by anyone younger than 18 years old. How should I take ropinirole? Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you are taking immediate-release ropinirole (Requip) you should not take extended-release ropinirole (Requip XL) at the same time. The dose and timing of ropinirole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of ropinirole you receive at the pharmacy. Ropinirole can be taken with or without food. Take the medicine at the same time each day. Do not crush, chew, or break an extended-release tablet (Requip XL). Swallow it whole. Call your doctor if you see part of the ropinirole tablet in your stool. This is a sign that your body may not have absorbed all of the medicine. If you are taking this medicine for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using ropinirole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking ropinirole? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Dizziness may impair your thinking or reactions. Avoid driving or operating machinery until you know how ropinirole will affect you. Drinking alcohol can increase certain side effects of ropinirole. Ropinirole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking ropinirole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Call your doctor at once if you have: extreme drowsiness, falling asleep suddenly (even after feeling alert); worsening or no improvement in your symptoms; a light-headed feeling, like you might pass out; unusual changes in mood or behavior; tremors, twitching uncontrollable muscle movements; or hallucinations (seeing or hearing things that are not real). Side effects such as confusion or hallucinations may be more likely in older adults. Common side effects may include: drowsiness, dizziness, weakness; headache, confusion, hallucinations; increased blood pressure (severe headache, pounding in your neck or ears, nosebleed, irregular heartbeats); nausea, vomiting, upset stomach, constipation; flu symptoms (fever, chills, body aches); sudden muscle movements; increased sweating; or swelling in your legs or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect ropinirole? Taking ropinirole with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with ropinirole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is ropinirole? Ropinirole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Ropinirole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Ropinirole is also used to treat restless legs syndrome (RLS). Only immediate-release ropinirole (Requip) is approved to treat either Parkinson symptoms or RLS. Extended-release ropinirole (Requip XL) is approved only to treat Parkinson symptoms. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. Ropinirole may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use ropinirole if you are allergic to it. To make sure ropinirole is safe for you, tell your doctor if you have: high or low blood pressure; kidney disease (or if you are on dialysis); heart disease, heart rhythm problems; a sleep disorder such as narcolepsy, or other conditions that may cause daytime sleepiness; or if you smoke. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether ropinirole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether ropinirole passes into breast milk or if it could affect the nursing baby. Ropinirole may slow breast milk production. Tell your doctor if you are breast-feeding. Ropinirole is not approved for use by anyone younger than 18 years old. How should I take ropinirole? Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. If you are taking immediate-release ropinirole (Requip) you should not take extended-release ropinirole (Requip XL) at the same time. The dose and timing of ropinirole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of ropinirole you receive at the pharmacy. Ropinirole can be taken with or without food. Take the medicine at the same time each day. Do not crush, chew, or break an extended-release tablet (Requip XL). Swallow it whole. Call your doctor if you see part of the ropinirole tablet in your stool. This is a sign that your body may not have absorbed all of the medicine. If you are taking this medicine for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Do not stop using ropinirole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking ropinirole? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Dizziness may impair your thinking or reactions. Avoid driving or operating machinery until you know how ropinirole will affect you. Drinking alcohol can increase certain side effects of ropinirole. Ropinirole side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Some people taking ropinirole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. Call your doctor at once if you have: extreme drowsiness, falling asleep suddenly (even after feeling alert); worsening or no improvement in your symptoms; a light-headed feeling, like you might pass out; unusual changes in mood or behavior; tremors, twitching uncontrollable muscle movements; or hallucinations (seeing or hearing things that are not real). Side effects such as confusion or hallucinations may be more likely in older adults. Common side effects may include: drowsiness, dizziness, weakness; headache, confusion, hallucinations; increased blood pressure (severe headache, pounding in your neck or ears, nosebleed, irregular heartbeats); nausea, vomiting, upset stomach, constipation; flu symptoms (fever, chills, body aches); sudden muscle movements; increased sweating; or swelling in your legs or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect ropinirole? Taking ropinirole with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with ropinirole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is rosuvastatin? Rosuvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Rosuvastatin is also used to treat hereditary types of high cholesterol (hypercholesterolemia): The heterozygous type (inherited from one parent) or the homozygous type (inherited from both parents). For the heterozygous type, rosuvastatin can be used in children who are at least 8 years old. For the homozygous type, rosuvastatin can be used in children as young as 7 years old. The Ezallor brand of rosuvastatin is for use only in adults. Crestor is also used in adults to slow the progression of atherosclerosis (a build-up of plaque in blood vessels that can block blood flow). Crestor is also used to lower the risk of stroke, heart attack, and other complications in men 50 years and older or women 60 years and older who have coronary heart disease or other risk factors. Rosuvastatin may also be used for purposes not listed in this medication guide. Warnings Do not use rosuvastatin if you are pregnant. It could harm the unborn baby. You should not take rosuvastatin if you have liver disease, or if you breastfeeding a baby. Before taking this medicine You should not take rosuvastatin if you are allergic to it, or if you have: liver disease; or if you are pregnant or breast-feeding. Do not take rosuvastatin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are taking rosuvastatin. Stop taking rosuvastatin and tell your doctor right away if you become pregnant. Do not breastfeed while you are taking rosuvastatin. Tell your doctor if you have ever had: liver problems; kidney disease; a thyroid disorder; a habit of drinking more than 2 alcoholic beverages per day; if you are of Asian descent; or if you are 65 or older. Rosuvastatin can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). People of Asian descent may absorb rosuvastatin at a higher rate than other people. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose. How should I take rosuvastatin? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Rosuvastatin is usually taken once a day, with or without food. Take the medicine at the same time each day. While using rosuvastatin, you may need frequent blood tests. Keep using rosuvastatin as directed, even if you feel well. High cholesterol usually has no symptoms. You may need to take rosuvastatin on a long-term basis. You may need to stop using rosuvastatin for a short time if you have: uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; dehydration; or surgery or a medical emergency. You should not stop using rosuvastatin unless your doctor tells you to. Rosuvastatin is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rosuvastatin? Avoid eating foods high in fat or cholesterol, or rosuvastatin will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Some antacids can make it harder for your body to absorb rosuvastatin. Avoid taking an antacid that contains aluminum or magnesium within 2 hours after taking rosuvastatin. Rosuvastatin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: unexplained muscle pain, tenderness, or weakness; muscle weakness in your hips, shoulders, neck, and back; trouble lifting your arms, trouble climbing or standing; confusion, memory problems; or liver problems--upper stomach pain, tiredness, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: headache; weakness; muscle aches; or nausea, stomach pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect rosuvastatin? When you start or stop taking rosuvastatin, your doctor may need to adjust the doses of any other medicines you take on a regular basis. Using certain medicines together with rosuvastatin can increase your risk of serious muscle problems. It is very important to tell your doctor about all medicines you use, and those you start or stop using during your treatment with rosuvastatin, especially: colchicine; cyclosporine; antifungal medicine--fluconazole, itraconazole, ketoconazole; antiviral medicine to treat HIV or hepatitis C--atazanavir, fosamprenavir, ledipasvir, lopinavir, ritonavir, simeprevir, sofosbuvir, tipranavir, Epclusa, Mavyret, Viekira, Vosevi, and others; a blood thinner--warfarin, Coumadin, Jantoven; cancer medicine--darolutamide, regorafenib; medicines that contain niacin or nicotinic acid--vitamin B3, Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others; or other cholesterol medications--fenofibrate, gemfibrozil. This list is not complete. Other drugs may affect rosuvastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is rufinamide? Rufinamide is a seizure medication, also called an anti-epileptic or anticonvulsant. Rufinamide is used together with other medicines to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems. Rufinamide is for use in adults and children who are at least 1 year old. Rufinamide may also be used for purposes not listed in this medication guide. Warnings You should not use rufinamide if you have a severe liver disease, or a genetic heart rhythm disorder called short QT syndrome. You should not stop taking rufinamide suddenly, unless your doctor tells you to stop the medicine because of a serious side effect. Some people have thoughts about suicide while taking seizure medication. Stay alert to changes in your mood or symptoms. Before taking this medicine You should not use rufinamide if you are allergic to it, or if you have: a genetic heart rhythm disorder called short QT syndrome; or severe liver disease. Tell your doctor if you have ever had: heart disease; liver disease; kidney disease (or if you are on dialysis); or depression, mental illness, or suicidal thoughts or actions. Some people have thoughts about suicide while taking rufinamide. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of rufinamide on the baby. Rufinamide can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using rufinamide, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Rufinamide should not be given to a child younger than 1 year old. How should I take rufinamide? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take rufinamide with food. The rufinamide tablet may be swallowed whole, crushed, or cut in half. Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid using the dosing syringe and bottle adapter provided with rufinamide. Insert the adapter into the bottle and snap it into place. Insert the syringe into the adapter and turn the bottle upside down. To measure your dose, pull the plunger to the correct number of milliliters marked on the side of the syringe. Rinse the syringe with water after each use. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Call your doctor if your seizures get worse or you have them more often while taking rufinamide. You should not stop using rufinamide suddenly, unless your doctor tells you to stop the medicine because of a serious side effect. Stopping suddenly may cause increased seizures. Follow your doctor's instructions very carefully. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Store the liquid medicine in an upright position. Do not try to remove the bottle adapter once it is in place. Throw away rufinamide liquid 90 days after you first opened the bottle, even if there is medicine left inside. In case of emergency, wear or carry medical identification to let others know you use rufinamide. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking rufinamide? Avoid driving or hazardous activity until you know how rufinamide will affect you. Your reactions could be impaired. Drinking alcohol can increase certain side effects of rufinamide. Rufinamide side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, agitated, hostile, aggressive, restless, irritable, hyperactive, talkative, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: loss of balance or coordination; trouble walking; or worsening or increased seizures. Common side effects may include: headache; dizziness, drowsiness; nausea; or feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Rufinamide dosing information Usual Adult Dose for Lennox-Gastaut Syndrome: Initial dose: 400 to 800 mg orally per day in 2 equally divided doses -Titrate in 400 to 800 mg increments every other day until a maximum daily dose of 3200 mg/day is reached Maintenance dose: 1600 mg orally twice a day Comments: -It is not known if doses lower than 3200 mg/day are effective. -For patients concomitantly receiving valproate, initial doses should be lower; see dose adjustments section. Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome. Usual Pediatric Dose for Lennox-Gastaut Syndrome: 1 year of age or older: Initial dose: 10 mg/kg/day orally in 2 equally divided doses -Titrate in 10 mg/kg increments every other day to a target dose of 45 mg/kg/day Maintenance dose: 45 mg/kg orally per day in 2 equally divided doses Maximum dose: 3200 mg/day Comments: -It is not known if doses lower than 45 mg/kg (not to exceed 3200 mg/day) are effective. -For patients concomitantly receiving valproate, initial doses should be lower; see dose adjustments section. Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older   What other drugs will affect rufinamide? Using rufinamide with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: valproic acid (Depakene, Stavzor). This list is not complete. Other drugs may affect rufinamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is Salagen? Salagen affects the nervous system and increases saliva secretion in the mouth. Salagen is used to treat dry mouth caused by Sjogren's syndrome, or by radiation to treat head and neck cancer. Salagen may also be used for purposes not listed in this medication guide. Warnings You should not use Salagen if you have narrow-angle glaucoma, or asthma that is untreated or uncontrolled. Before taking this medicine You should not use Salagen if you are allergic to it, or if you have: untreated or uncontrolled asthma; or narrow-angle glaucoma. To make sure Salagen is safe for you, tell your doctor if you have: asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), or other breathing disorder; glaucoma or vision problems; liver disease; kidney disease; heart disease; gallbladder problems; mental illness; if you take heart or blood pressure medicine; or if you use a bronchodilator to treat a breathing disorder. FDA pregnancy category C. It is not known whether Salagen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Salagen. It is not known whether pilocarpine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take Salagen? Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Salagen with or without food. Drink plenty of liquids while you are taking Salagen. This medicine can cause increased sweating and you may get dehydrated easily. Use Salagen regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Salagen can be fatal at very high doses. What should I avoid while taking pilocarpine? Salagen may cause blurred vision, especially at night or in low light. Be careful if you drive or do anything that requires you to be able to see clearly. Avoid becoming overheated during exercise and in hot weather. Salagen can increase sweating and you may be more prone to dehydration. Salagen side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Salagen and call your doctor at once if you have: shortness of breath; fast or slow heart rate; severe headache, pounding in your neck or ears; confusion, tremors; or a light-headed feeling, like you might pass out. Common side effects may include: increased sweating, urinating more than usual; chills, or flushing (warmth, redness, or tingly feeling); headache, dizziness, weakness; nausea, vomiting, diarrhea; blurred vision, watery eyes; or runny nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Salagen? Other drugs may interact with pilocarpine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using

What is sertraline? Sertraline is an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Sertraline is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). Sertraline is also used to treat premenstrual dysphoric disorder. Warnings You should not use sertraline if you also take pimozide, or if you are being treated with methylene blue injection. Do not use sertraline if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some children and young adults have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Before taking this medicine You should not use sertraline if you are allergic to it, or if you also take pimozide. Do not use the liquid form of this medicine if you take disulfiram (Antabuse). Do not use sertraline within 14 days before or 14 days after using an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others. Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with sertraline could cause a serious condition called serotonin syndrome. To make sure sertraline is safe for you, tell your doctor if you have ever had: bipolar disorder (manic depression); heart disease, high blood pressure, or a stroke; liver or kidney disease; seizures; glaucoma; bleeding problems, or if you take warfarin (Coumadin, Jantoven); long QT syndrome; or low levels of sodium in your blood. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Sertraline is approved for use in children at least 6 years old, only to treat obsessive-compulsive disorder but not depression. Taking sertraline during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop this medicine without asking your doctor. Ask a doctor if it is safe to breastfeed while using this medicine. How should I take sertraline? Take sertraline exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Take sertraline with or without food, at the same time each day. Sertraline liquid (oral concentrate) must be diluted with a liquid right before you take it. Read and carefully follow all mixing instructions provided with your medicine. Ask your doctor or pharmacist if you need help. Measure the mixed medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Sertraline may cause false results on a drug-screening urine test. Tell the laboratory staff that you use this medicine. Do not stop using sertraline suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine. Store tightly closed at room temperature, away from moisture and heat. Dosing information Usual Adult Dose for Depression: Initial dose: 50 mg orally once a day Maintenance Dose: 50 to 200 mg orally once a day. Usual Adult Dose for Obsessive Compulsive Disorder: Initial dose: 50 mg orally once a day Maintenance Dose: 50 to 200 mg orally once a day Usual Adult Dose for Panic Disorder: Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day. Usual Adult Dose for Post Traumatic Stress Disorder: Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day Usual Adult Dose for Social Anxiety Disorder: Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day Maintenance dose: 50 to 200 mg orally once a day. Usual Adult Dose for Premenstrual Dysphoric Disorder: Continuous regimen: -Initial dose: 50 mg orally once a day during the menstrual cycle -Maintenance dose: 50 to 150 mg orally once a day during the menstrual cycle Cyclic regimen: -Initial dose: 50 mg orally once a day starting 14 days prior to the anticipated start of menstruation through to the first full day of menses, and repeated with each new cycle -Maintenance dose: 50 to 100 mg orally once a day. Usual Pediatric Dose for Obsessive Compulsive Disorder: 6 to 12 years: -Initial dose: 25 mg orally once a day -Maintenance dose: 25 to 200 mg orally once a day 13 to 17 years: -Initial dose: 50 mg orally once a day -Maintenance dose: 50 to 200 mg orally once a day.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sertraline? Drinking alcohol with sertraline can cause side effects. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Sertraline side effects Get emergency medical help if you have signs of an allergic reaction to sertraline: skin rash or hives (with or without fever or joint pain); difficulty breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: a seizure; vision changes, eye pain, redness, or swelling; low blood sodium - headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or manic episodes - racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Sertraline can affect growth in children. Your child's height and weight may be checked often. Common sertraline side effects may include: indigestion, nausea, diarrhea, loss of appetite; sweating; tremors; or sexual problems. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sertraline? Sertraline can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with sertraline may cause you to bruise or bleed easily. Other drugs may interact with sertraline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is sevelamer? Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Sevelamer is used to control phosphorus levels in people with chronic kidney disease who are on dialysis. Sevelamer may also be used for purposes not listed in this medication guide. Warnings You should not take sevelamer if you have a bowel obstruction. Before taking this medicine You should not take sevelamer if you are allergic to it, or if you have a bowel obstruction. To make sure sevelamer is safe for you, tell your doctor if you have: trouble swallowing; severe constipation; a blockage in your intestines; slow digestion; a stomach or intestinal disorder; or if you have recently had stomach or intestinal surgery. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Your dose needs may be different during pregnancy. Taking sevelamer while you are pregnant can lower your blood levels of certain vitamins or folic acid. Follow your doctor's instructions about taking vitamins or mineral supplements during pregnancy. Because sevelamer is not absorbed into the bloodstream, it is not expected to be harmful to a nursing baby. Sevelamer is not approved for use by anyone younger than 6 years old. How should I take sevelamer? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use sevelamer in larger or smaller amounts or for longer than recommended. Take sevelamer with meals. Sevelamer powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water. Stir the powder in water until it is completely dissolved. Stir and drink this mixture right away. To get the entire dose, add a little more water to the same glass, swirl gently and drink right away. While using sevelamer, you may need frequent blood tests. Call your doctor if you have have trouble swallowing the tablet, or if it feels like it gets stuck in your esophagus after you swallow it. Sevelamer may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Be sure to take the missed dose with food. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sevelamer? You may be taking other medicines that should not be taken at the same time. Taking sevelamer can make it harder for your body to absorb certain drugs, making them less effective: ciprofloxacin (Cipro) should be taken at least 2 hours before or 6 hours after you take sevelamer; mycophenolate mofetil (CellCept) should be taken at least 2 hours before you take sevelamer. Sevelamer side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using sevelamer and call your doctor at once if you have: choking, or trouble swallowing; black, bloody, or tarry stools; severe constipation with stomach pain; or constipation that gets worse or does not clear up. Common side effects may include: nausea, vomiting, stomach pain, loss of appetite; upset stomach, gas, bloating; diarrhea, constipation; tired feeling; itching; or joint pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Sevelamer dosing information Usual Adult Dose for Hyperphosphatemia of Renal Failure: Initial Dosing for patients not on a phosphate binder: 800 mg to 1600 mg orally 3 times a day with meals Based on serum phosphorus level: -Phosphorus greater than 5.5 to less than 7.5 mg/dL: 800 mg 3 times a day with meals -Phosphorus greater than or equal to 7.5 mg/dL: 1600 mg 3 times a day with meals -Titrate in increments of 800 mg 3 times a day at 2-week intervals with the goal of controlling serum phosphorus within target range. Average prescribed dose: 7.2 g/day (2.4 g with each meal) Maximum studied dose: 14 g per day (carbonate); 13 g per day (hydrochloride) Switching from the hydrochloride salt to carbonate: Use the same dose, however further titration may be necessary to achieve desired phosphorus levels. Switching from calcium acetate: Substitute approximately mg for mg Comment: Treatment of hyperphosphatemia includes reduction in dietary intake of phosphate, inhibition of intestinal phosphate absorption with phosphate binders, and removal of phosphate with dialysis. Use: To control serum phosphorus levels in patients with chronic kidney disease on dialysis.   What other drugs will affect sevelamer? Other drugs may interact with sevelamer, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is sildenafil? Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Viagra while also taking Revatio. Warnings Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Do not take sildenafil with riociguat. Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis. Stop using sildenafil and get emergency medical help if you have sudden vision loss. Before taking this medicine You should not use sildenafil if you are allergic to it, or: if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). Do not take this medicine if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. To make sure sildenafil is safe for you, tell your doctor if you have ever had: heart problems (chest pain, a heart rhythm disorder, heart attack); high or low blood pressure; blood circulation problems; retinitis pigmentosa (an inherited condition of the eye); blindness in one or both eyes; bleeding problems; a stomach ulcer; pulmonary veno-occlusive disease (PVOD); liver or kidney disease; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a physical deformity of the penis (such as Peyronie's disease); or if you have been told you should not have sexual intercourse for health reasons. Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether this medicine is the actual cause of vision loss. This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor. Do not give this medication to anyone under 18 years old without medical advice. How should I take sildenafil? Take sildenafil exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Revatio is usually taken three times each day, about 4 to 6 hours apart. Viagra is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Do not take Viagra more than once per day. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Viagra can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of sildenafil. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Since Viagra is used as needed, you are not likely to miss a dose. If you miss a dose of Revatio, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol with sildenafil can cause side effects. Grapefruit may interact with sildenafil and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. Sildenafil side effects Get emergency medical help if you have signs of an allergic reaction to sildenafil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking sildenafil and get emergency medical help if you have: heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; vision changes or sudden vision loss; erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis); ringing in your ears, or sudden hearing loss; irregular heartbeat; swelling in your hands, ankles, or feet; shortness of breath; seizure (convulsions); or a light-headed feeling, like you might pass out. Common sildenafil side effects may include: flushing (warmth, redness, or tingly feeling); headache, dizziness; heartburn, nausea, or upset stomach abnormal vision (blurred vision, changes in color vision) runny or stuffy nose, nosebleeds; sleep problems (insomnia); or muscle pain, back pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sildenafil? Do not take sildenafil with similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra). Tell your doctor about all other medications you use for erectile dysfunction. Do not take sildenafil if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. In addition, tell your doctor about all your other medicines, especially: drugs to treat high blood pressure or a prostate disorder; antifungal medicine - ketoconazole or itraconazole; or medicine to treat HIV/AIDS - ritonavir and others. This list is not complete. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is silodosin? Silodosin is an alpha-blocker that is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Silodosin may also be used for purposes not listed in this medication guide. Warnings Tell your doctor about all your other medicines. Some drugs should not be used with silodosin. Before taking this medicine You should not take silodosin if you are allergic to it, or if you have: severe liver disease; or severe kidney disease. Some drugs should not be used with silodosin. Your treatment plan may change if you also use: nefazodone; an antibiotic--clarithromycin, telithromycin; antifungal medicine--itraconazole, ketoconazole, posaconazole, voriconazole; or antiviral medicine for HIV or hepatitis C--boceprevir, cobicistat, dasabuvir, elvitegravir, indinavir, lopinavir/ritonavir, nelfinavir, ombitasvir, paritaprevir saquinavir, telaprevir, or tipranavir. Tell your doctor if you have ever had: low blood pressure; kidney disease (or if you are on dialysis); heart disease; prostate cancer; a condition for which you take a diuretic or "water pill"; or if you are on a low-salt diet. Silodosin can affect your pupils. If you need eye surgery, tell the surgeon about your use of silodosin, even if you no longer take it. Silodosin is not for use in women, and the effects of this medicine during pregnancy or in breastfeeding women are unknown. Not approved for use by anyone younger than 18 years old. How should I take silodosin? Your doctor may test your prostate specific antigen (PSA) to check for prostate cancer before you take silodosin. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take once daily with a meal. If you cannot swallow a capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing. Your blood pressure may get too low during prolonged illness. Call your doctor if you are sick with vomiting or diarrhea. Your blood pressure will need to be checked often. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking silodosin? Avoid driving or hazardous activity until you know how silodosin will affect you. Your reactions could be impaired. Silodosin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe dizziness, or if you feel like you might pass out. Silodosin may cause dizziness or fainting, especially when you first start taking it. You may feel very dizzy when you first wake up or get up too fast from a sitting or lying position. Common side effects may include: dizziness, feeling like you might pass out; headache; diarrhea; abnormal ejaculation; or stuffy nose, sinus pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Silodosin dosing information Usual Adult Dose for Benign Prostatic Hyperplasia: 8 mg orally once a day with a meal Comments: Patients who have difficulty swallowing may open the capsule and sprinkle the powder on a tablespoonful of applesauce. The applesauce should not be hot, and should be soft enough to be swallowed within 5 minutes without chewing and followed with 8 ounces of cool water.   What other drugs will affect silodosin? Tell your doctor about all your current medicines. Many drugs can increase your risk of very low blood pressure while taking silodosin, especially: medicines similar to silodosin (alfuzosin, doxazosin, prazosin, tamsulosin, or terazosin); heart or blood pressure medication; or sildenafil (Viagra) and other erectile dysfunction medicines. This list is not complete and many other drugs may affect silodosin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is simvastatin? Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors. Simvastatin is used in adults and children who are at least 10 years old. Warnings In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects. Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily. Simvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant or planning to become pregnant. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication. Some medicines can cause unwanted or dangerous effects when used with simvastatin. Your doctor may need to change your treatment plan if you use certain antibiotics or antifungal medicines, hepatitis C medication, heart medication, or medicines to treat HIV/AIDS. Stop taking this medication and tell your doctor right away if you become pregnant. Before taking this medicine You should not take this medicine if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease. The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. These drugs should not be used while you are taking this medicine: cyclosporine; danazol; gemfibrozil; nefazodone; an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir. Before you start taking simvastatin, tell your doctor if you are already using any of these other medicines: lomitapide; or heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil. To make sure simvastatin is safe for you, tell your doctor if you have: history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily. Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take simvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine. Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking this medicine.   How should I take simvastatin? Take simvastatin exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects. Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results. While using simvastatin, you may need frequent blood tests at your doctor's office. You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to. Simvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine. Avoid eating foods that are high in fat or cholesterol. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Simvastatin side effects Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor at once if you have: signs of a kidney problem - little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or muscle weakness in your hips, shoulders, neck, and back; trouble lifting your arms, trouble climbing or standing; or liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common simvastatin side effects may include: headache; constipation, nausea, stomach pain; or cold symptoms such as stuffy nose, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect simvastatin? Many drugs can interact with simvastatin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment, especially: delavirdine; fenofibrate; or fluconazole. This list is not complete and many other drugs can interact with simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

What is solifenacin? Solifenacin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage). Solifenacin oral suspension (liquid), Vesicare LS is used to treat overactive bladder caused by a neurologic disorder (such as multiple sclerosis or spinal cord injury) in children at least 2 years old when other medicines cannot be used or have not worked. Solifenacin may also be used for purposes not listed in this medication guide. Warnings You should not use solifenacin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate. Before taking this medicine You should not use solifenacin if you are allergic to it, or if you have: untreated or uncontrolled narrow-angle glaucoma; a stomach disorder causing delayed emptying; or if you are unable to urinate. Tell your doctor if you have ever had: glaucoma; liver disease; kidney disease; trouble emptying your bladder (or you have a weak stream of urine); slow digestion; a blockage in your stomach or intestines; or long QT syndrome. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using solifenacin. How should I take solifenacin? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Solifenacin is usually taken once per day with or without food. Follow your doctor's instructions. Do not crush, chew, or break the tablet. Swallow it whole. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Take the tablet with water. After taking solifenacin liquid drink a glass of water or milk. Avoid taking the liquid with food or other drinks or you may have a bitter aftertaste. Store solifenacin in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use. Throw away any unused liquid 28 days after you first opened the bottle. What happens if I miss a dose? Tablets: Skip the missed dose and use your next dose at the regular time. Do not take 2 doses on the same day. Oral suspension: Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking solifenacin? Avoid driving or hazardous activity until you know how solifenacin will affect you. Your reactions could be impaired. Avoid becoming overheated or dehydrated during exercise and in hot weather. Solifenacin can decrease perspiration and you may be more prone to heat stroke. Solifenacin side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Stop using solifenacin and call your doctor at once if you have: severe stomach pain, or constipation for 3 days or longer; pain or burning when you urinate; headache, confusion, drowsiness, hallucinations; vision changes, eye pain, or seeing halos around lights; little or no urination, pain or burning when you urinate; dehydration symptoms--dizziness, tiredness, feeling very thirsty or hot, decreased sweating, or hot and dry skin; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: blurred vision; dry mouth, dry eyes; painful urination; constipation; or heat stroke--decreased sweating, dry skin, dizziness, tiredness, nausea, feeling hot. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Solifenacin dosing information Usual Adult Dose for Urinary Incontinence: Initial dose: 5 mg orally once daily Maintenance dose: 5 to 10 mg orally once daily Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency Usual Adult Dose for Urinary Frequency: Initial dose: 5 mg orally once daily Maintenance dose: 5 to 10 mg orally once daily Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency   What other drugs will affect solifenacin? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can affect solifenacin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sotalol? Sotalol is a beta-blocker that affects the heart and circulation within the atrium and ventricles (the upper and lower chambers of the heart that allow blood to flow into and out of the heart). Sotalol is used to help keep the heart beating normally in people with certain heart rhythm disorders, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. Sotalol may also be used for purposes not listed in this medication guide. Warnings You should not use sotalol if you have asthma, low potassium, or a serious heart condition such as severe heart failure, long QT syndrome, slow heartbeats that have caused you to faint, "sick sinus syndrome" or "AV block" (unless you have a pacemaker). You will receive your first few doses of sotalol in a hospital setting where your heart can be monitored in case the medicine causes serious side effects. Before taking this medicine You should not use sotalol if you are allergic to it, or if you have: a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); long QT syndrome (in you or a family member); severe heart failure; slow heartbeats that have caused you to faint; asthma or other breathing disorder; very low levels of potassium in your blood; or (if you take sotalol for atrial fibrillation or atrial flutter) severe kidney disease; Do not give sotalol to a child without medical advice. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); congestive heart failure; coronary artery disease (hardened arteries); breathing problems such as bronchitis or emphysema; a thyroid disorder; diabetes (using sotalol can make it harder for you to tell when you have low blood sugar); a severe allergic reaction. Tell your doctor if you are pregnant. You should not breastfeed while using sotalol. How should I take sotalol? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Sotalol oral is taken by mouth. Sotalol injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. You will receive your first few doses of sotalol in a hospital setting where your heart can be monitored in case the medicine causes serious side effects. If you already take heart rhythm medication, you may need to stop taking it when you start using sotalol. Carefully follow your doctor's instructions. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Sotalol doses are based on age and body surface area (height and weight) in children. Your child's dose needs may change if the child gains or loses weight, or is still growing. Call your doctor if you are sick with vomiting or diarrhea, or if you have increased thirst, decreased appetite, or are sweating more than usual. You can easily become dehydrated while taking sotalol. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. You will need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). You may also need heart function tests for 1 to 2 weeks after your last dose. Keep using this medicine as directed, even if you feel well. You may need to take sotalol for the rest of your life. Do not skip doses or stop using sotalol without your doctor's advice. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose. If you need surgery, tell your surgeon you currently use this medicine. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze. Your pharmacist may prepare an oral suspension (liquid) form of sotalol. Keep the suspension at room temperature and throw away suspension any left over after 3 months of use.   What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. Try not to miss any doses. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of sotalol can be fatal. What should I avoid while taking sotalol? Avoid taking an antacid within 2 hours before or 2 hours after you take sotalol. Some antacids can make it harder for your body to absorb sotalol. Sotalol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; fast or pounding heartbeats, fluttering in your chest; sudden dizziness (like you might pass out); slow heartbeats (especially if you feel light-headed); swelling, rapid weight gain; or feeling short of breath. Common side effects may include: slow heartbeats; trouble breathing; dizziness; or feeling weak or tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sotalol? Tell your doctor about all your other medicines, especially: other heart medications; blood pressure medication; or insulin or oral diabetes medicine. This list is not complete. Other drugs may affect sotalol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is spironolactone? Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Spironolactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. Warnings You should use spironolactone with caution if you have kidney problems, high levels of potassium in your blood, Addison's disease, if you are unable to urinate, or if you are also taking eplerenone. Spironolactone has caused tumors in animals but it is not known whether this could occur in people. Do not use this medicine for any condition that has not been checked by your doctor. Before taking this medicine You should not use spironolactone if you are allergic to it, or if you have: Addison's disease (an adrenal gland disorder); high levels of potassium in your blood (hyperkalemia); if you are unable to urinate; or if you are also taking eplerenone. To make sure spironolactone is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of calcium, magnesium, or sodium in your blood); kidney disease; liver disease; or heart disease. Tell your doctor if you are pregnant or plan to become pregnant. Having congestive heart failure, cirrhosis, or uncontrolled high blood pressure during pregnancy may lead to medical problems in the mother or the baby. Your doctor should decide whether you take spironolactone if you are pregnant. It may not be safe to breastfeed while using spironolactone. Ask your doctor about any risk. How should I take spironolactone? Take spironolactone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Do not share this medicine with another person, even if they have the same symptoms you have. You may take spironolactone with or without food, but take it the same way each time. You will need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using spironolactone. If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from heat, light, and moisture. Dosing information Usual Adult Dose for Edema: 25 to 200 mg orally per day in single or divided doses Duration of therapy: When given as the sole diuretic, continue the initial dose for at least 5 days, after which the initial dose may be adjusted to an optimal maintenance dose.Comments:-A second diuretic that acts more proximally at the renal tubule may be added if adequate diuresis has not been achieved after 5 days. The dose of this drug should remain unchanged if a second diuretic is added.Uses:-Treatment of edematous conditions in patients with congestive heart failure who are only partially responsive to or intolerant of other therapeutic measures or who are taking digitalis when other therapies are considered inappropriate.-Treatment of edematous conditions in patients with liver cirrhosis accompanied by edema and/or ascites. -Treatment of edematous conditions in patients with nephrotic syndrome when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response. Usual Adult Dose for Hypertension: Initial dose: 50 to 100 mg orally per day in single or divided doses Duration of therapy: Treatment should be continued for at least 2 weeks to achieve a maximum response. Subsequently, the dose may be adjusted according to patient response. Usual Adult Dose for Congestive Heart Failure: Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL Maintenance dose:-Patients tolerant of initial dose: May increase to 50 mg orally once a day as clinically indicated-Patients intolerant of initial dose: May decrease to 25 mg orally every other dayUse: To increase survival and reduce the need for hospitalization of severe heart failure patients (New York Heart Association [NYHA] class III to IV) when used in addition to standard therapy. Usual Adult Dose for Primary Hyperaldosteronism: Diagnostic dose: -Long test: 400 mg orally per day for 3 to 4 weeks-Short test: 400 mg orally per day for 4 daysMaintenance dose: 100 to 400 mg orally per day until surgery; may be used long-term at the lowest effective dose in patients deemed unsuitable for surgery.Comments:-For the long test, correction of hypokalemia and hypertension provides presumptive evidence of primary hyperaldosteronism.-For the short test, increased serum potassium with this drug and a decrease upon discontinuation provide presumptive evidence of primary hyperaldosteronism.Uses:-Initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets.-Short-term preoperative treatment of patients with primary hyperaldosteronism.-Long-term maintenance therapy for patients deemed unsuitable for surgery or those with idiopathic hyperaldosteronism. Usual Adult Dose for Hypokalemia: 25 to 100 mg orally per day Uses:-Treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate.-Prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate. Detailed Spironolactone dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol can increase certain side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Avoid driving or hazardous activity until you know how spironolactone will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Spironolactone side effects Get emergency medical help if you have signs of an allergic reaction to spironolactone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; high potassium level - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; o signs of other electrolyte imbalances - increased thirst or urination, confusion, vomiting, muscle pain, slurred speech, severe weakness, numbness, loss of coordination, feeling unsteady. Common spironolactone side effects may include: breast swelling or tenderness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect spironolactone? Using spironolactone with other drugs that make you dizzy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Tell your doctor about all your other medicines, especially: colchicine; digoxin; lithium; loperamide; trimethoprim; heart or blood pressure medicine (especially another diuretic); medicine to prevent a blood clot; or NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may interact with spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and spironolactone? Hydrochlorothiazide is a thiazide diuretic (water pill). Spironolactone is a potassium-sparing diuretic. Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. hydrochlorothiazide and spironolactone also treats high blood pressure (hypertension), or low potassium levels (hypokalemia) caused by using a diuretic. Do not use this medicine for any condition that has not been checked by your doctor. Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you have kidney problems, Addison's disease, high blood levels of calcium or potassium, an allergy to sulfa drugs, or if you are unable to urinate. Before taking this medicine You should not use hydrochlorothiazide and spironolactone if you are allergic to hydrochlorothiazide or spironolactone, or if you have: kidney disease or urination problems; liver disease; high levels of calcium or potassium in your blood; an allergy to sulfa drugs; or Addison's disease (an adrenal gland disorder). Tell your doctor if you have ever had: cirrhosis or other liver disease; severe kidney disease; asthma or allergies; glaucoma; gout; diabetes; or lupus. In animal studies, spironolactone caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine. This medicine is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and spironolactone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Do not share this medicine with another person, even if they have the same symptoms you have. You may need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using hydrochlorothiazide and spironolactone. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and spironolactone. You may need to stop using the medicine for a short time. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion, skin rash, nausea, vomiting, diarrhea, dizziness, and drowsiness. What should I avoid while taking hydrochlorothiazide and spironolactone? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol with hydrochlorothiazide and spironolactone can cause side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Hydrochlorothiazide and spironolactone side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if you have: a light-headed feeling, like you might pass out; blurred vision, tunnel vision, eye pain, or seeing halos around lights; breast swelling and tenderness; low blood cell counts--easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: drowsiness, dizziness, lack of energy; leg cramps; weakness; feeling like you might pass out; severe pain in your upper stomach spreading to your back, nausea and vomiting; or electrolyte imbalance. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and spironolactone dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 50 to 100 mg-Spironolactone 50 to 100 mg orally daily in 1 to 2 divided doses Uses: -Treatment of essential hypertension when other measures are considered inadequate or inappropriate. -Treatment of diuretic-induced hypokalemia in hypertensive patients when other measures are considered inappropriate. -Treatment of hypertension. Usual Adult Dose for Edema: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Usual Adult Dose for Congestive Heart Failure: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Uses: -Management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. -Treatment of diuretic-induced hypokalemia in patients with congestive heart failure (CHF) when other measures are considered inappropriate. -Treatment of patients with CHF taking digitalis when other therapies are considered inadequate or inappropriate. Usual Adult Dose for Ascites: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Use: Maintenance therapy together with bed rest and fluid and sodium restriction for cirrhosis of the liver accompanied by edema and/or ascites. Usual Adult Dose for Nephrotic Syndrome: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Use: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response.   What other drugs will affect hydrochlorothiazide and spironolactone? Using hydrochlorothiazide and spironolactone with other drugs that make you drowsy or lower your blood pressure can worsen these effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cholestyramine; digoxin; lithium; heart or blood pressure medicine, especially another diuretic; insulin or oral diabetes medicine; medicine to prevent a blood clot; NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or steroid medicine--dexamethasone, prednisone, or others. This list is not complete. Other drugs may affect hydrochlorothiazide and spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is Sprintec? Sprintec is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Sprintec also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Sprintec is used as contraception to prevent pregnancy. There are many available brands of this medicine. Not all brands are listed on this leaflet. Sprintec may also be used for purposes not listed in this medication guide. Warnings Do not use birth control pills if you are pregnant or if you have recently had a baby. You should not use birth control pills if you have: uncontrolled high blood pressure, heart disease, coronary artery disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you also take certain hepatitis C medication, if you will have major surgery, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or birth control pills, or cancer of the breast, uterus/cervix, or vagina. Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take birth control pills if you smoke and are over 35 years old. Before taking this medicine Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight. Your risk of stroke or blood clot is highest during your first year of taking birth control pills. Your risk is also high when you restart birth control pills after not taking them for 4 weeks or longer. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. Your risk increases the older you are and the more you smoke. You should not take combination birth control pills if you smoke and are over 35 years old. Do not use if you are pregnant. Stop using Sprintec and tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills. You should not take birth control pills if you have: untreated or uncontrolled high blood pressure; heart disease (chest pain, coronary artery disease, history of heart attack, stroke, or blood clot); an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; circulation problems (especially if caused by diabetes); a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; unusual vaginal bleeding that has not been checked by a doctor; liver disease or liver cancer; severe migraine headaches (aura, numbness, vision changes), especially if you are older than 35; or if you take any hepatitis C medication containing ombitasvir/paritaprevir/ritonavir (Technivie). Tell your doctor if you have ever had: heart problems, high blood pressure, or if you are prone to having blood clots; high cholesterol or triglycerides, or if you are overweight; depression; a seizure or migraine headache; diabetes, gallbladder disease, underactive thyroid; liver or kidney disease; jaundice caused by pregnancy or birth control pills; irregular menstrual cycles; or fibrocystic breast disease, lumps, nodules, or an abnormal mammogram. This medicine can slow breast milk production. Tell your doctor if you are breast-feeding. How should I take birth control pills? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may need to use back-up birth control, such as condoms with spermicide, when you first start using this medicine. Follow your doctor's instructions. Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not take one pill daily. Some birth control packs contain "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills. You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy. Use a back-up birth control if you are sick with severe vomiting or diarrhea. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol and levonorgestrel. While taking birth control pills, you will need to visit your doctor regularly. Store this medicine at room temperature away from moisture and heat.   What happens if I miss a dose? Follow the instructions provided with your medicine. Missing a pill increases your risk of becoming pregnant. If you miss 1 active pill, take 2 pills on the day you remember. Then take 1 pill per day for the rest of the pack. If you miss 2 active pills in a row in Week 1 or 2, take 2 pills per day for 2 days in a row. Then take 1 pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills. If you miss 2 active pills in a row in Week 3, throw out the pack and start a new pack the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 3 active pills in a row in Week 1, 2, or 3, throw out the pack and start a new pack on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 2 or more pills, you may not have a period during the month. If you miss a period for 2 months in a row, call your doctor because you might be pregnant. If you miss a reminder pill, throw it away and keep taking one reminder pill per day until the pack is empty. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking birth control pills? Do not smoke while taking birth control pills, especially if you are older than 35 years of age. Birth control pills will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases. Birth control pills side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using birth control pills and call your doctor at once if you have: signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); severe headache, pounding in your neck or ears; swelling in your hands, ankles, or feet; changes in the pattern or severity of migraine headaches; a breast lump; or symptoms of depression--sleep problems, weakness, tired feeling, mood changes. Common side effects may include: stomach pain, gas, nausea, vomiting; breast tenderness; acne, darkening of facial skin; headache, nervousness, mood changes; problems with contact lenses; changes in weight; breakthrough bleeding; vaginal itching or discharge; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect birth control pills? Other drugs may affect birth control pills, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is Sprintec? Sprintec is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Sprintec also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Sprintec is used as contraception to prevent pregnancy. There are many available brands of this medicine. Not all brands are listed on this leaflet. Sprintec may also be used for purposes not listed in this medication guide. Warnings Do not use birth control pills if you are pregnant or if you have recently had a baby. You should not use birth control pills if you have: uncontrolled high blood pressure, heart disease, coronary artery disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you also take certain hepatitis C medication, if you will have major surgery, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or birth control pills, or cancer of the breast, uterus/cervix, or vagina. Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take birth control pills if you smoke and are over 35 years old. Before taking this medicine Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight. Your risk of stroke or blood clot is highest during your first year of taking birth control pills. Your risk is also high when you restart birth control pills after not taking them for 4 weeks or longer. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. Your risk increases the older you are and the more you smoke. You should not take combination birth control pills if you smoke and are over 35 years old. Do not use if you are pregnant. Stop using Sprintec and tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills. You should not take birth control pills if you have: untreated or uncontrolled high blood pressure; heart disease (chest pain, coronary artery disease, history of heart attack, stroke, or blood clot); an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; circulation problems (especially if caused by diabetes); a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; unusual vaginal bleeding that has not been checked by a doctor; liver disease or liver cancer; severe migraine headaches (aura, numbness, vision changes), especially if you are older than 35; or if you take any hepatitis C medication containing ombitasvir/paritaprevir/ritonavir (Technivie). Tell your doctor if you have ever had: heart problems, high blood pressure, or if you are prone to having blood clots; high cholesterol or triglycerides, or if you are overweight; depression; a seizure or migraine headache; diabetes, gallbladder disease, underactive thyroid; liver or kidney disease; jaundice caused by pregnancy or birth control pills; irregular menstrual cycles; or fibrocystic breast disease, lumps, nodules, or an abnormal mammogram. This medicine can slow breast milk production. Tell your doctor if you are breast-feeding. How should I take birth control pills? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may need to use back-up birth control, such as condoms with spermicide, when you first start using this medicine. Follow your doctor's instructions. Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not take one pill daily. Some birth control packs contain "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills. You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy. Use a back-up birth control if you are sick with severe vomiting or diarrhea. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol and levonorgestrel. While taking birth control pills, you will need to visit your doctor regularly. Store this medicine at room temperature away from moisture and heat. Detailed Sprintec dosage information What happens if I miss a dose? Follow the instructions provided with your medicine. Missing a pill increases your risk of becoming pregnant. If you miss 1 active pill, take 2 pills on the day you remember. Then take 1 pill per day for the rest of the pack. If you miss 2 active pills in a row in Week 1 or 2, take 2 pills per day for 2 days in a row. Then take 1 pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills. If you miss 2 active pills in a row in Week 3, throw out the pack and start a new pack the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 3 active pills in a row in Week 1, 2, or 3, throw out the pack and start a new pack on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 2 or more pills, you may not have a period during the month. If you miss a period for 2 months in a row, call your doctor because you might be pregnant. If you miss a reminder pill, throw it away and keep taking one reminder pill per day until the pack is empty. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking birth control pills? Do not smoke while taking birth control pills, especially if you are older than 35 years of age. Birth control pills will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases. Birth control pills side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using birth control pills and call your doctor at once if you have: signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); severe headache, pounding in your neck or ears; swelling in your hands, ankles, or feet; changes in the pattern or severity of migraine headaches; a breast lump; or symptoms of depression--sleep problems, weakness, tired feeling, mood changes. Common side effects may include: stomach pain, gas, nausea, vomiting; breast tenderness; acne, darkening of facial skin; headache, nervousness, mood changes; problems with contact lenses; changes in weight; breakthrough bleeding; vaginal itching or discharge; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Sprintec side effects (more detail) What other drugs will affect birth control pills? Other drugs may affect birth control pills, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sucralfate? Sucralfate is used short-term (up to 8 weeks) to treat an active duodenal ulcer. Sucralfate works mainly in the lining of the stomach and is not highly absorbed into the body. sucralfate adheres to ulcer sites and protects them from acids, enzymes, and bile salts. Sucralfate can heal an active ulcer, but it will not prevent future ulcers from occurring. Sucralfate may also be used for purposes not listed in this medication guide. Warnings The liquid form of sucralfate should never be injected through a needle into the body, or death may occur. Before taking this medicine You should not use sucralfate if you are allergic to it. Tell your doctor if you have ever had: diabetes; kidney disease (or if you are on dialysis); or trouble swallowing tablets. Older adults may be more sensitive to the effects of sucralfate. Tell your doctor if you are pregnant or breastfeeding. Do not give this medicine to a child without medical advice. How should I take sucralfate? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take sucralfate on an empty stomach. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). If you are diabetic, check your blood sugar regularly. Your doctor may adjust your dose based on your blood sugar levels. The liquid from of this medicine should never be injected through a needle into the body, or death may occur. Sucralfate oral suspension is to be taken only by mouth. It may take 2 to 8 weeks before you receive the full benefit of taking sucralfate. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Your doctor may want you to keep taking sucralfate at a lower dose once your active ulcer has healed. Follow your doctor's dosing instructions very carefully. Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sucralfate? Avoid taking any other medications within 2 hours before or after you take sucralfate. Sucralfate can make it harder for your body to absorb other medications you take by mouth. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for sucralfate to work in your stomach. Avoid taking an antacid within 30 minutes before or after taking sucralfate. Sucralfate side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Common side effects may include: constipation, diarrhea; nausea, vomiting, gas, indigestion; itching, rash; dizziness, drowsiness; sleep problems (insomnia); headache; or back pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Sucralfate dosing information Usual Adult Dose for Duodenal Ulcer: 1 g orally 4 times a day -Duration of therapy: 4 to 8 weeks Comments: -Each dose should be taken on an empty stomach. -For most patients, treatment should continue for 4 to 8 weeks; however, treatment may be stopped early if healing is demonstrated on x-ray/endoscopic tests. -Antacids may be given, but use should be separated by at least 30 minutes. Use: Short-term treatment of active duodenal ulcers Usual Adult Dose for Duodenal Ulcer Prophylaxis: Oral Tablets: 1 g orally 2 times a day -Duration of therapy: Up to 1 year Comments: -Each dose should be taken on an empty stomach. -Controlled studies did not extend beyond 12 months. Use: Maintenance therapy for patients after healing of acute duodenal ulcers   What other drugs will affect sucralfate? Other drugs may affect sucralfate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sulfamethoxazole and trimethoprim? Sulfamethoxazole and trimethoprim is a combination antibiotic used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia. Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use sulfamethoxazole and trimethoprim if you are allergic to sulfamethoxazole or trimethoprim, or if you have: severe liver disease; kidney disease that is not being treated or monitored; anemia (low red blood cells) caused by folic acid deficiency; a history of low blood platelets after taking trimethoprim or any sulfa drug; or if you take dofetilide. May cause birth defects. Do not use if you are pregnant. Tell your doctor if you become pregnant. Do not breastfeed. This medicine should not be given to a child younger than 2 months old. Tell your doctor if you have ever had: kidney or liver disease; a folate (folic acid) deficiency; asthma or severe allergies; HIV or AIDS; a thyroid disorder; malnourishment; alcoholism; an electrolyte imbalance (such as low blood sodium or high potassium); porphyria, or glucose-6-phosphate dehydrogenase (G6PD) deficiency; or if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests. How should I use sulfamethoxazole and trimethoprim? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Sulfamethoxazole and trimethoprim oral is taken by mouth. Shake the oral suspension (liquid). Measure a dose with the supplied measuring device (not a kitchen spoon). Sulfamethoxazole and trimethoprim injection is given in a vein. Be sure you understand how to properly mix this medicine with a liquid (diluent) and how to store the mixture. Ask your doctor or pharmacist if you don't understand how to use an injection. Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it. Mixed medicine must be used within 2 to 6 hours depending on the amount of diluent in the mixture. Follow your doctor's instructions. Do not refrigerate mixed medicine. Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets. Drink plenty of fluids to prevent kidney stones. Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody. Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Sulfamethoxazole and trimethoprim will not treat a viral infection (flu or a common cold). You may need blood and urine tests, and this medicine may be stopped based on the results. Store at room temperature away from moisture, heat, and light. Do not refrigerate.   What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include loss of appetite, vomiting, fever, blood in your urine, yellowing of your skin or eyes, confusion, or loss of consciousness. What should I avoid while using sulfamethoxazole and trimethoprim? If you use the injection form of sulfamethoxazole and trimethoprim, do not eat or drink anything that contains propylene glycol (an ingredient in many processed foods, soft drinks, and medicines). Dangerous effects could occur. Sulfamethoxazole and trimethoprim could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Sulfamethoxazole and trimethoprim side effects Get emergency medical help if you have signs of an allergic reaction (hives, cough, chest pain, shortness of breath, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, joint pain, muscle aches, severe weakness, pale skin, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); any skin rash, no matter how mild; yellowing of your skin or eyes; a seizure; new or unusual joint pain; increased or decreased urination; swelling, bruising, or irritation around the IV needle; increased thirst, dry mouth, fruity breath odor; new or worsening cough, fever, trouble breathing; high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; low blood sodium--headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or low blood cell counts--fever, chills, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. Common side effects may include: nausea, vomiting, loss of appetite; or skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is sulfasalazine? Sulfasalazine is used to treat ulcerative colitis (UC), and to decrease the frequency of UC attacks. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines that did not work or have stopped working. Sulfasalazine may also be used for purposes not listed in this medication guide. Warnings You should not use sulfasalazine if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfa drugs, aspirin, or similar medicines called salicylates. Before taking this medicine You should not use sulfasalazine if you are allergic to it, or if you have: a blockage in your bladder or intestines; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); an allergy to sulfa drugs; or an allergy to aspirin or other salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others). Tell your doctor if you have ever had: frequent infections; asthma; low blood cell counts; or liver or kidney disease. Tell your doctor if you are pregnant. Taking sulfasalazine can make it harder for your body to absorb folic acid, and folic acid helps prevent major birth defects of the baby's brain or spine. You may need to take folic acid supplements if you take sulfasalazine during pregnancy. Follow your doctor's instructions. Sulfasalazine can pass into breast milk and may cause diarrhea or bloody stools in a nursing baby. Tell your doctor if you are breast-feeding. Sulfasalazine is not approved for use by anyone younger than 2 years old. How should I take sulfasalazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take sulfasalazine after a meal. Swallow the tablet whole and do not crush, chew, or break it. You will need frequent medical tests. Drink plenty of liquids to keep your kidneys working properly while you are taking sulfasalazine. Sulfasalazine can affect the results of certain medical tests. Tell any doctor who treats you that you are using sulfasalazine. Sulfasalazine may cause your skin or urine to appear orange-yellow in color. Call your doctor if you also have yellowing of your eyes, brown urine, or stomach pain. These may be signs of liver problems. If you are treating arthritis, do not stop using any of your other arthritis medicines until your doctor tells you to. Sulfasalazine may not improve your symptoms right away, and you may still need your other medicines for awhile. Sulfasalazine is only part of a complete treatment for rheumatoid arthritis that may also include rest and physical therapy. Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure. What should I avoid while taking sulfasalazine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Sulfasalazine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, sore throat; mouth sores, red or swollen gums; pale skin, easy bruising, unusual bleeding; or chest discomfort, wheezing, dry cough or hack, rapid weight loss. Also call your doctor at once if you have: fever with headache, rash, and vomiting; a skin rash, no matter how mild; severe nausea or vomiting when you first start taking sulfasalazine; little or no urination, urine that looks foamy; puffy eyes, swelling in your ankles or feet, weight gain; or liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sulfasalazine? Other drugs may affect sulfasalazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sulfasalazine? Sulfasalazine is used to treat ulcerative colitis (UC), and to decrease the frequency of UC attacks. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines that did not work or have stopped working. Sulfasalazine may also be used for purposes not listed in this medication guide. Warnings You should not use sulfasalazine if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfa drugs, aspirin, or similar medicines called salicylates. Before taking this medicine You should not use sulfasalazine if you are allergic to it, or if you have: a blockage in your bladder or intestines; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); an allergy to sulfa drugs; or an allergy to aspirin or other salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others). Tell your doctor if you have ever had: frequent infections; asthma; low blood cell counts; or liver or kidney disease. Tell your doctor if you are pregnant. Taking sulfasalazine can make it harder for your body to absorb folic acid, and folic acid helps prevent major birth defects of the baby's brain or spine. You may need to take folic acid supplements if you take sulfasalazine during pregnancy. Follow your doctor's instructions. Sulfasalazine can pass into breast milk and may cause diarrhea or bloody stools in a nursing baby. Tell your doctor if you are breast-feeding. Sulfasalazine is not approved for use by anyone younger than 2 years old. How should I take sulfasalazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take sulfasalazine after a meal. Swallow the tablet whole and do not crush, chew, or break it. You will need frequent medical tests. Drink plenty of liquids to keep your kidneys working properly while you are taking sulfasalazine. Sulfasalazine can affect the results of certain medical tests. Tell any doctor who treats you that you are using sulfasalazine. Sulfasalazine may cause your skin or urine to appear orange-yellow in color. Call your doctor if you also have yellowing of your eyes, brown urine, or stomach pain. These may be signs of liver problems. If you are treating arthritis, do not stop using any of your other arthritis medicines until your doctor tells you to. Sulfasalazine may not improve your symptoms right away, and you may still need your other medicines for awhile. Sulfasalazine is only part of a complete treatment for rheumatoid arthritis that may also include rest and physical therapy. Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure. What should I avoid while taking sulfasalazine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Sulfasalazine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, sore throat; mouth sores, red or swollen gums; pale skin, easy bruising, unusual bleeding; or chest discomfort, wheezing, dry cough or hack, rapid weight loss. Also call your doctor at once if you have: fever with headache, rash, and vomiting; a skin rash, no matter how mild; severe nausea or vomiting when you first start taking sulfasalazine; little or no urination, urine that looks foamy; puffy eyes, swelling in your ankles or feet, weight gain; or liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sulfasalazine? Other drugs may affect sulfasalazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sumatriptan injection? Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Sumatriptan is used to treat migraines and cluster headaches in adults. Sumatriptan will only treat a headache. sumatriptan will not prevent headaches or reduce the number of attacks. Sumatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches. Sumatriptan may also be used for purposes not listed in this medication guide. Warnings You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not use sumatriptan within 24 hours before or after using another migraine headache medicine. Before taking this medicine You should not use sumatriptan if you are allergic to it, if you have a headache that seems different from your usual migraine headaches, or if you have ever had: heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome; uncontrolled high blood pressure; or severe liver disease. Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: liver or kidney disease; epilepsy or other seizure disorder; high blood pressure, a heart rhythm disorder; or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or being older than 40 and a man). It is not known whether sumatriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using sumatriptan. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Sumatriptan injection is not approved for use by anyone younger than 18 years old. How should I use sumatriptan injection? Use sumatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Sumatriptan is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself. This medicine comes in a vial (bottle), a needle-free injector device, or a prefilled cartridge for an auto-injector syringe. Each type is for one use only. Read and carefully follow any Instructions for Use provided with your medicine. Do not use sumatriptan if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions. Prepare your injection only when you are ready to give it. Do not use a vial if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine. After an injection: If your headache does not completely go away, call your doctor before using a second injection. If your headache goes away and then comes back, use a second injection if it has been at least 1 hour since your first injection. Do not use more than 2 injections in 24 hours. Call your doctor if your symptoms do not improve. Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed. Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.   What happens if I miss a dose? Since sumatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using sumatriptan. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions). What should I avoid while using sumatriptan injection? Do not use sumatriptan within 24 hours before or after using another migraine headache medicine, including: sumatriptan tablets or nasal spray, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan; or ergot medicine such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine. Avoid driving or hazardous activity until you know how sumatriptan will affect you. Your reactions could be impaired. Sumatriptan injection side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sumatriptan and call your doctor at once if you have: sudden and severe stomach pain and bloody diarrhea; severe chest pain, shortness of breath, irregular heartbeats; a seizure (convulsions); blood circulation problems in your legs or feet--cramps, tight or heavy feeling, numbness or tingling, muscle weakness, burning pain, cold feeling, color changes (pale or blue), hip pain; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: numbness, tingling, warmth, redness, or burning sensation; pressure or heavy feeling in any part of your body; dizziness, drowsiness, feeling weak or tired; neck pain or stiffness; or pain or redness where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sumatriptan injection? Using sumatriptan while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use: medicine to treat depression or a psychiatric disorder; medicine for Parkinson's disease; medicine for serious infections; herbal products; stimulant medicine; opioid medicine; or medicine to prevent nausea and vomiting. This list is not complete. Other drugs may affect sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is tacrolimus? Tacrolimus is used together with other medicines in people who have had a heart, kidney, liver, or lung transplant. Tacrolimus weakens your immune system to prevent your body from "rejecting" the transplanted organ. Tacrolimus may also be used for purposes not listed in this medication guide. Warnings Tacrolimus may increase your risk of developing a serious infection, skin cancer, or lymphoma. Talk with your doctor about the risks and benefits of using tacrolimus. Call your doctor right away if you have any signs of infection such as fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. Before taking this medicine You should not use this medicine if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours. Using tacrolimus may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Your risk may be higher if you are treated over long periods of time with drugs that weaken the immune system. Ask your doctor about this risk and about symptoms to watch for. Some people taking tacrolimus after a kidney transplant have developed diabetes. This effect has been seen most commonly in people who are Hispanic or African-American. Tell your doctor if you have ever had: problems with your liver, kidney, or heart that are not related to your transplant; long QT syndrome (in you or a family member); or if you are scheduled to receive a vaccine; Tell your doctor if you plan to get pregnant. Tacrolimus may harm an unborn baby, and can worsen conditions such as diabetes or high blood pressure in the mother. Use effective birth control before and during treatment with tacrolimus. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tacrolimus on the baby. If you are a man, use birth control before and during treatment with tacrolimus if your sex partner is able to get pregnant. Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby. Ask a doctor if it is safe to breastfeed while using this medicine. How should I take tacrolimus? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may receive an injection of tacrolimus shortly after your transplant. Tacrolimus injection is given until you are ready to take the pill form of tacrolimus. Take oral tacrolimus at the same time each day, with a full glass of water. Swallow the tablet or capsule whole and do not crush, chew, break, or open it. Mix tacrolimus oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water. Take Astragraf XL or Envarsus XR in the morning on an empty stomach, at least 1 hour before or 2 hours after a meal. You may take Prograf with or without food, but take it the same way each time. Your dose needs may change if you switch to a different brand, strength, or form of tacrolimus. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes. You will need frequent medical tests, and your blood pressure will need to be checked often. Store at room temperature away from moisture and heat.   What happens if I miss a dose? For Prograf: Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. For Astragraf XL: Take the medicine as soon as you can, but skip the missed dose if you are more than 14 hours late for the dose. For Envarsus XR: Take the medicine as soon as you can, but skip the missed dose if you are more than 15 hours late for the dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tacrolimus? Avoid receiving a "live" vaccine. The vaccine may not work as well while you are using tacrolimus. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles). Grapefruit may interact with tacrolimus and cause side effects. Avoid consuming grapefruit products. Tacrolimus side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. Also call your doctor at once if you have: general ill feeling, pain or swelling near your transplanted organ; headaches, vision changes, pounding in your neck or ears; confusion, behavior changes; tremors, a seizure; fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); chest pain, cough, trouble breathing (even while lying down); high blood sugar--increased thirst, increased urination, hunger, fruity breath odor, nausea, loss of appetite, drowsiness, confusion; high potassium level--nausea, weakness, chest pain, irregular heartbeats, loss of movement; kidney problems--swelling, urinating less, feeling tired or short of breath; low magnesium or phosphate--bone pain, jerky muscle movements, muscle weakness or limp feeling, slow reflexes; or low blood cell counts--fever, flu symptoms, tiredness, pale skin, cold hands and feet. Common side effects may include: low blood cell counts, infections; fever; nausea, diarrhea, constipation, stomach pain; weakness, pain; fluid around your heart; tremors; headache; cough, breathing problems; high blood sugar, high potassium levels, high cholesterol or triglycerides levels; low levels of magnesium or phosphate; numbness or tingling in your hands and feet; sleep problems (insomnia); or swelling in your hands, legs, ankles, or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tacrolimus? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tacrolimus can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Tell your doctor about all your current medicines. Many drugs can affect tacrolimus, especially: amiodarone; cisplatin; cyclosporine; sirolimus; antibiotic, antifungal, or antiviral medicines; or heart or blood pressure medication, such as a diuretic or "water pill." This list is not complete and many other drugs may affect tacrolimus. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.