Diabetes GLUCOSE  Does this test have other names? Blood sugar, Fasting blood glucose (FBG), self-monitoring of blood glucose (SMBG), glucose challenge test, random blood sugar, oral glucose tolerance test (OGTT), fasting plasma glucose (FPG) What is a blood glucose test? This test determines the level of glucose in your body. This test screens and diagnoses carbohydrate metabolic disorders like hyperglycemia, diabetes mellitus, hypoglycemia, etc. Glucose is a type of sugar that provides energy to the body, which moves from your bloodstream to cells by insulin, a hormone. A very high or low level of glucose may show severe medical conditions.   High glucose levels, also known as hyperglycemia, can indicate a sign of diabetes and lead to serious health problems. High blood sugar levels occur in many other conditions, including problems with your adrenal glands or pancreas, and affect glucose levels or insulin in your blood.  People with type 1 and type 2 diabetes and those who take specific diabetes medicines have a common disease of low glucose levels (hypoglycemia). Some conditions like liver disease may also lead to low glucose levels in people having no diabetes, which is not common in people. If you don’t take treatment, very low blood sugar can cause severe health problems, such as seizures and brain damage.  What is the use of this test? Your doctor recommends this test to analyze and monitor the diabetes of a person. A blood glucose test indicates the sugar levels in your blood. When do I need the blood sugar test? If you experience symptoms of a high or a low level of glucose, you may need to order this test. Some symptoms of low levels of glucose, such as   Fatigue Difficulty in speaking or seeing Headache Hunger Shaky feeling Headache A feeling of confusion or irritation Disturbance in the flow of the heartbeat or arrhythmia (problem with the rhythm of your heartbeat) Seizures or fainting A few symptoms of a high level of glucose include   Frequent urination  Feeling thirsty Weight loss when people are not trying any effort to lose weight Vision blurriness Healing of sores takes a long time Tingling or numbness in your feet or hands What are the other causes that develop diabetes? Your doctor may recommend the blood sugar test if you are at a high risk of type 2 diabetes.  Some of the reasons that lead to diabetes: Having a high blood pressure Having a history of heart disease or stroke Lack of exercise Overweight  Having a family history of diabetes Older people of age 45 or more Gestational diabetes (diabetes that occurs in pregnancy only) In pregnant women, your provider recommends a diabetes glucose test between the 24th and 28th week of your pregnancy to observe diabetes disease.  What happens during the test? Your healthcare provider collects your blood sample for the test. A small needle injects into a vein of your arm. Small quantity of blood collects in the test tube. A healthcare provider applies a bandage to your vein. You can return to your home for daily activities. The blood sugar test usually takes at least 5 minutes. You may need to drink a sugary liquid for some types of glucose blood tests, such as a glucose challenge test and an oral glucose tolerance test (OGTT). You also need to wait for an hour before the blood test.  How do I need to prepare for the test? You will keep fast for at least 7-8 hours if your healthcare provider recommends a fasting blood glucose test. For other glucose tests, you don’t need special preparation. You can ask your provider when you need to keep fast for your glucose test.  When should I get the results of a blood sugar test? You will get the report of your blood glucose test in between 1 to 2 days. The glucometer indicates the test results on the spot for a capillary glucose test.   What are the risks involved in the test? A blood test does not have a high risk. You may experience a little pain when the needle injects into your vein. Generally, symptoms do not stay for a long time. You can feel faint after an oral glucose tolerance test.  What do the test results mean? You may be at risk for developing diabetes if your test results indicate higher than normal glucose levels. High glucose levels can also result due to   Pancreas disorders Trauma, stress from surgery, and a specific illness Hyperthyroidism  Low blood sugar levels may occur due to    Intake of specific diabetes medicines Avoiding intake of enough food, specifically after the use of diabetes medicines Increase in physical activity than normal   When you don’t experience diabetes, signs of low blood glucose levels occur due to   Kidney disease Inactive pituitary, adrenal, or thyroid gland Alcohol use disorder   What are the recommended values of glucose in a blood test? The normal values for fasting blood glucose range from 70 to 99 mg/dL (3.9 to 5.5 mmol/L. Values between 50 to 70 mg/dL can be usual for those who do not have diabetes.  What are the high or low values of a blood glucose level? If the value of blood sugar is between 100 to 125 mg/dL, then it leads to prediabetes. While higher than 126 mg/dL shows that you already experience diabetes. A value of less than 70 mg/dL of blood sugar is low. It will result in type 1 and type 2 diabetes in people.  Your doctor will always depend on one or more tests to observe diabetes. The blood glucose test does not always show the medical disease. The test values may effect due to the use of certain medications or avoiding fasting.  You can place the order for the test by visiting UmbrellaMD. You can book the lab test and discuss your test results with the doctor from an online appointment. Umbrella Health Care Systems reduces the distance between you and a doctor. We are providing valuable and efficient services for you. Learn more from our website and register here.   

Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance Dog Fennel (w46) IgE - This allergen-specific IgE antibody test quantifies an individual’s IgE response to dogfennel. It is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated. Preferred Specimen(s) 0.3 mL serum Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days Methodology Immunoassay (IA) Assay Category This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes. Alternative Name(s) ImmunoCAP®

Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance Duck Feathers (e86) IgE - This allergen-specific IgE antibody test quantifies an individual’s IgE response to duck feathers. It is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated. Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

"Clinical Significance Egg Component Panel - For use in the identification and severity of which specific egg protein a patient is allergic. This knowledge enables the clinician and the patient to make the correct treatment and lifestyle choices to mitigate exposure and reaction risk. Preferred Specimen(s) 0.5 mL serum Minimum Volume 0.3 mL Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance Eggplant (f262) IgE - This test quantifies an individual’s IgE response to eggplant. It is an in vitro quantitative assay, which is intended to be used in conjunction with other clinical information to aid in the diagnosis of food allergy [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. Food-specific IgE tests are extremely sensitive. However, a positive test result only indicates that a patient is IgE sensitized to the food of concern. Many IgE-sensitized patients do not develop any symptoms when this food is ingested. A diagnosis of food allergy should only be made by a trained medical provider, after conducting a thorough clinical evaluation [2,3]. While food-specific IgE test results may contribute to that evaluation, they cannot replace it. In this regard, detection of food-specific IgE in serum provides evidence of IgE sensitization, but a history of clinical reactivity to the food of concern, is required to make a diagnosis of IgE-mediated food allergy. Moreover, several forms of food hypersensitivity are not associated with the presence of food-specific IgE in serum. Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum separator tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Electrolyte Panel Does this test have other names? Potassium (K), Chloride (Cl), Carbon dioxide (CO2), Sodium (Na), Lytes, Serum electrolyte test, Electrolyte blood test What is an electrolyte panel? An electrolyte panel called a serum electrolyte test is a blood test that determines the number of electrolytes in the blood. An electrolyte imbalance can show lung, heart, or kidney disease. Abnormal levels of electrolytes also occur due to dehydration in the body. What is an electrolyte? Electrolytes are minerals found in blood, tissue, urine, and other body fluids. They regulate the fluid flow and maintain the acid-base balance in your body. They are also responsible for muscle and nerve regular activity, heart movement, and other significant functions. You take electrolytes from foods, supplements, and drinks. What are the components of an electrolyte panel? An electrolyte panel helps to measure the following electrically charged minerals in your body. The components are   Sodium - It helps to regulate the amount of fluid in the body. It also provides support for the functions of muscles and nerves.   Chloride - It also helps to regulate the amount of fluid in the body. It aims to balance the blood volume and blood pressure within the normal range.   Potassium - It plays a role in the heart and for muscles to work under ideal conditions.   Bicarbonate - It is a significant mineral in the body that maintains the acid-base level. Bicarbonate moves carbon dioxide within your bloodstream. What is the purpose of the test? An electrolyte panel is a blood test often part of a comprehensive metabolic panel or a routine blood screening. The test may use to identify an abnormal acid-base balance and the levels of electrolytes in the body. The test may detect electrolyte imbalances due to cancer, burns, diabetes, dehydration, heart disease, kidney disease, and liver disease. In general, all electrolytes can test simultaneously. You can place an order for the electrolytes separately as well. Your provider recommends a separate test if they see some problem with that electrolyte. When do I need a serum electrolyte test? Your healthcare provider asks you to conduct an electrolyte panel if you experience symptoms of abnormal electrolyte levels in your body. Signs and symptoms include   Weakness   Disturbed heartbeat   Nausea or/and vomiting   Confusion What is the procedure for the test? You may need to provide a blood sample to your provider for a serum electrolyte test. A small needle inserts in a vein in your arm to collect a blood sample in a test tube. A bandage applies to your vein. The test does not take time greater than 5 minutes. How do I get ready for the test? You may need to stop taking certain medicines that can affect your test results. Your provider will inform you about any specific instructions for the test until you do not need to prepare for the test. If you may need to order additional blood tests, you have to keep fast for at least 7 to 8 hours before the test. What are the risks involved in the test? A serum electrolyte test is a blood test that does not have a high risk. You may experience a little pain at the point in your vein from where the blood collects. A chance of bleeding or bruising may also occur, but generally, these signs do not last long. What does the serum electrolyte test result mean? Your test results indicate the levels of each electrolyte in your blood. Abnormal levels of electrolytes may occur due to different reasons, such as   Kidney disease   Acidosis is a condition that indicates high levels of acid in your blood that may lead to nausea, vomiting, and fatigue.   Heart problems   Dehydration   Alkalosis is a condition that indicates high levels of a base in your blood that may lead to muscle shivering, tingling in the finger and toes, and feeling annoyed. Your specific test results depend on which electrolytes are disturbed and show high or low levels in your blood. If your test results are not in the recommended range, it does not always mean that you have a medical condition. There are many elements that may alter electrolyte levels, such as the intake of large quantities of fluid or the excretion of fluid due to vomiting or diarrhea. Specific medicines, including antacids and blood pressure medicines, may also affect the test results. You can discuss your test results with a doctor by making an online appointment. What is the recommended range for electrolytes? The test results depend on a person's age, gender, medical history, and other factors. The results of a serum electrolyte test may vary slightly from one lab to another. That's because each lab may use different measurement methods for the test. The ideal range for an electrolyte depends are as follows: Sodium - 136 to 144 mmol/L. Potassium - 3.7 to 5.1 mmol/L Chloride - 97 to 105 mmol/L. Bicarbonate - 22 to 30 mmol/L. What else do I need to know about an electrolyte panel? Your healthcare provider may ask for an additional test known as an anion gap besides an electrolyte panel. Electrolytes contain positive or negative electric charges. An anion gap measures the difference between the negative and positive charged electrolytes. You may experience severe medical problems if the anion gap indicates a high or low level. You can place an online order for the lab test at UmbrellaMD. It is an online healthcare provider that offers e-consultation, laboratory tests, medical imaging, and pharmacies. You do not need a prescription for the test. You can register here to get more information about our services.  

"Preferred Specimen(s) 1 mL plasma collected in a lithium heparin (green-top) tube Minimum Volume 0.5 mL Collection Instructions Separate plasma from cells promptly Transport Container Transport tube Transport Temperature Room temperature Specimen Stability Room temperature: 72 hours Refrigerated: 72 hours Frozen: 28 days Reject Criteria See individual tests Includes Carbon Dioxide, Chloride, Potassium, Sodium Methodology See individual tests Reference Range(s) See individual tests

Clinical Significance Elm (t8) IgE - This test quantifies an individual’s IgE response to elm. It is an in vitro quantitative assay, which is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare professional after all clinical and laboratory findings have been evaluated. Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance Epicoccum purpurascens (m14) IgE - This allergen-specific IgE antibody test quantifies an individual’s IgE response to Epicoccum purpurascens. It is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated. Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum separator tube (SST) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

ESTRADIOL TEST What are the other names for this test? Estrone (E1), Estrogen test, Estriol (E3), Estrogenic hormone test What is an estradiol test? This test helps to determine the amount of estradiol in your blood. Estradiol is a type of estrogen. Estrogens include several hormones that have vital functions in the reproductive system for females. These functions include pregnancy, puberty, menstruation, and menopause. Estrogens are essential for the better health of the heart, bones, and brain in men and women. Estrogen levels may change throughout the life of females but often do not change in males. High or low estrogen levels may indicate health problems. What are the types of estrogen? The common types of estrogen are: Estrone - This is also known as E1. The unique estrogen that develops in females even after menopause. Menopause is a span in which the menstrual period finishes for a year. The adrenal glands (glands located above each kidney) are the place in the body where estrone develops in males and females. Ovaries that possess eggs produce estrone in females. The body fat also develops estrone. Estradiol - This is also known as E2. Estradiol is a significant estrogen in non-pregnant women. It often develops in the ovaries (female glands contain eggs). This estrogen is necessary for female fertility (the power to become pregnant). Estradiol helps in the function of the brain and the health of bones. Testicles (glands that develop sperm) also produce this estrogen in males. Estriol - This is also called E3. Its levels rise during pregnancy. The placenta develops estriol. The placenta is the organ that forms in the uterus to transfer nutrients and oxygen to a growing baby. The health of the pregnant lady and the unborn baby may monitor by checking the estriol levels. Low estriols are often present in non-pregnant women and men. What is the purpose of this test? This test checks the estradiol levels in men and women. An estradiol test may need to take in females because of the following conditions: This test help to   Diagnose problems that may lead to high or low estrogen levels. These include early or delayed puberty, menstrual disorder, and infertility (inability to get pregnant). Monitor how well the treatment is working for infertility. Observe hormone replacement therapy for menopause. Look for hormone treatment due to specific cancer like breast cancer. This test may use during pregnancy to identify defects in the birth. It also observes the high chance of pregnancy. The estradiol test may use in males to determine conditions that lead to high estrogen levels, including   Delayed puberty Infertility Breast growth Erectile dysfunction - problem in getting and keeping an erection. When do I need to take this test? Your healthcare provider may recommend the estradiol test if you have conditions that may lead to low or high estradiol levels. These conditions are:   Breast cancer Tumors in the ovary Menstrual problems Gynecomastia - A disease in which the growth of noncancerous glandular breast tissue happens in males). Symptoms of menopause Your provider may also recommend this test if you have ongoing treatment for assisted reproductive technology (ART) for infertility. This test may monitor your hormone levels during ART. In adults, this test may use to see early puberty. Give an online order for an estradiol test here to know your health conditions. What is the procedure for this test? An estradiol test is a blood test that requires a blood sample. The following are the steps for this test.   Sit in front of your provider. Be relaxed and stay in a fixed position. It is difficult for your provider to collect a blood sample if you do the muscle movement. Remove the portion of your cloth from the arm. A small needle will inject into a vein in your arm. A small amount of blood will collect in a test tube. Blood samples will store in the laboratory for examination of an allergy. You can go home for regular activities. This test finishes within five minutes. How do I get ready for this test? You do not need special preparation for this test. You may inform your provider about medicines, vitamins, and supplements you use. Do not avoid any medication before consulting with a doctor. You may need to fast for several hours if your provider asks for additional blood tests. Are there any risks involved in this test? An estradiol test has low risk when you give a blood sample. Veins differ from person to person. Some people may have difficulty providing a blood sample compared to others. Risks that link when the needle injects into a vein in your arm are:   Extreme Bleeding Slight pain Bruising Infection Hematoma (Deposition of blood under the skin) What do the test results indicate? The recommended range for the estradiol test is: For premenopausal women, the value lies between 30 to 400 picograms per milliliter (pg/mL). The estradiol levels should be 0 to 30 pg/mL for postmenopausal women. For males, the value lies between 10 to 50 pg/mL. In men, generally, the estradiol levels remain constant throughout their life. The test results depend on many factors, such as age, gender, and medical history. The test results may also slightly differ among laboratories. It is because each lab may use different methods for examination. Low estradiol levels may indicate a condition of ovarian failure. It is also known as early menopause. High estradiol levels may mean a tumor of the ovary, testes, or adrenal glands. You can talk with a doctor about your test results with an online appointment. What factors may affect the estradiol test results? Birth control pills and hormone therapy may affect your test results. What additional tests do I need along with this test? Your healthcare provider may recommend the following tests along with an estradiol test:   Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) - This test uses for menstrual problems and their treatment. TSH test, prolactin, FSH, and LH for infertility problems in both males and females. FSH, TSH (thyroid-stimulating hormone), and prolactin (a hormone required for breast milk if your periods have ended).

Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Minimum Volume 0.15 mL/allergen Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days

Clinical Significance Alternative Names: Globin, Fecal,InSure®,Fecal Occult Blood Test (FOBT),OB,Guaiac,FOB,Fecal Immunochemical Test (FIT),FOBT,Occult Blood,FIT Fecal Globin by Immunochemistry (InSure®) - The fecal occult blood test is an immunochromatographic fecal occult blood test that qualitatively detects human hemoglobin from blood in fecal samples. This is a useful screening aid for detecting primarily lower gastrointestinal (G.I.) disorders that may be related to iron deficiency anemia, diverticulitis, ulcerative colitis, polyps, adenomas, colorectal cancers or other G.I. lesions that can bleed. It is recommended for use by health professionals as part of routine physical examinations and in screening for colorectal cancer or other sources of lower G.I. bleeding. Patient Preparation No special diet or avoidance of drugs or supplements is required for the InSure® test Methodology Immunochromatography Preferred Specimen(s) Fecal specimen collected from toilet water and brushed on the InSure® FOBT test card Collection Instructions See collection instructions included in InSure® test kit. One InSure® FOBT test card with specimen applied to both windows. Transport Container InSure® FOBT test card Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: Unacceptable Frozen: Unacceptable Reject Criteria Stool submitted in any container • InSure® FOBT cards with stool applied to the sample windows • Any test card with obvious blood present • Received refrigerated • Received frozen

Clinical Significance Ferret Epithelium (e217) IgE - This allergen-specific IgE antibody test quantifies an individual’s IgE response to ferret epithelium. It is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated. Preferred Specimen(s) 0.3 mL serum Transport Container Serum Separator Tube (SST®) Transport Temperature Room temperature Specimen Stability Room temperature: 14 days Refrigerated: 14 days Frozen: 30 days