Donnatal Elixir Mint or Grape

Prescription Required for this Medicine
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Donnatal Elixir Mint or Grape

Detail Description

What is Donnatal?

Donnatal is made up of belladonna alkaloids (atropine, hyoscyamine, scopolamine) and phenobarbital.

Donnatal is a combination medicine used to treat irritable bowel syndrome and ulcers in the intestine.

Donnatal may also be used for purposes not listed in this medication guide.


This medicine may be habit-forming. Misuse can cause addiction, overdose, or death.

Before taking this medicine

You should not use Donnatal if you are allergic to atropine, hyoscyamine, phenobarbital, or scopolamine. You also should not use this medicine if you have:

  • a bladder obstruction, enlarged prostate, or other urination problems;
  • a stomach or bowel obstruction (including paralytic ileus);
  • chronic constipation or lack of bowel function (especially in older adults and those who are ill or debilitated);
  • severe ulcerative colitis or toxic megacolon;
  • glaucoma;
  • reflux disease with a hiatal hernia;
  • active bleeding with fast heartbeats, low blood pressure, shortness of breath, and cold hands or feet;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • an allergy to primidone; or
  • a muscle disorder called myasthenia gravis.

Tell your doctor if you have ever had:

  • ulcerative colitis or a stomach ulcer;
  • a colostomy or ileostomy;
  • a nerve-muscle disorder;
  • heart problems, high blood pressure;
  • gallbladder disease;
  • alcoholism or drug addiction;
  • breathing problems;
  • a thyroid disorder; or
  • liver or kidney disease.

Donnatal may harm an unborn baby, but the benefit of treating your condition with this medicine may outweigh any risk. Tell your doctor if you are pregnant or if you become pregnant.

This medicine can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. This medicine can slow breast milk production.

Do not give this medication to a child without the advice of a doctor.

How should I take Donnatal?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

This medicine contains phenobarbital, a barbiturate that may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if your symptoms do not improve, or if they get worse.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Donnatal.

Store at room temperature away from moisture, heat, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Detailed Donnatal dosage information

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, dizziness, nausea, vomiting, dry mouth, blurred vision, hot or dry skin, trouble swallowing, and feeling excited or agitated.

What should I avoid while taking Donnatal?

Donnatal may cause drowsiness or blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Drinking alcohol with this medicine can increase certain side effects.

Avoid becoming overheated or dehydrated during exercise and in hot weather. This medicine can decrease sweating and you may be more prone to heat stroke.

Donnatal side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop using this medicine and call your doctor at once if you have:

  • fast or pounding heartbeats;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • diarrhea (especially if you have a colostomy or ileostomy);
  • decreased sweating and hot or dry skin;
  • painful or difficult urination;
  • loss of coordination, slurred speech, fainting;
  • confusion, agitation, depression, suicidal thoughts;
  • fever, sore throat; or
  • pale skin, easy bruising, unusual tiredness, cold hands and feet;


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