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Detail Description

Clinical Significance

For differential diagnosis of primary, secondary, and tertiary hypothyroidism. Also useful in screening for hyperthyroidism. This assay allows adjustment of exogenous thyroxine dosage in hypothyroid patients and in patients on suppressive thyroxine therapy for thyroid neoplasia.

Preferred Specimen(s)
1 mL serum

Minimum Volume
0.7 mL

Transport Container
Serum Separator Tube (SST®)

Transport Temperature
Room temperature

Specimen Stability
Room temperature:
7 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria

Patient Preparation
Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks.
According to the assay manufacturer Siemens: "Samples containing fluorescein can produce falsely depressed values when tested with the Advia Centaur TSH3 Ultra assay."

Immunoassay (IA)

Reference Range(s)
Premature Infants (28-36 Weeks)     

  1st Week of Life    0.20-27.90 mIU/L
Term Infants (>37 Weeks)     
Serum or Cord Blood    1.00-39.00 mIU/L
  1-2 Days    3.20-34.60 mIU/L
  3-4 Days    0.70-15.40 mIU/L
  5 Days-4 Weeks    1.70-9.10 mIU/L
  1-11 Months    0.80-8.20 mIU/L
  1-19 Years    0.50-4.30 mIU/L
  ≥20 Years    0.40-4.50 mIU/L
First Trimester    0.26-2.66 mIU/L
  Second Trimester    0.55-2.73 mIU/L
  Third Trimester    0.43-2.91 mIU/LTSH levels decline rapidly during the first week of life in most children, but may remain transiently elevated in a few individuals despite normal free T4 levels. For proper interpretation of an abnormal TSH from a newborn thyroid screen, a Free T4 by Dialysis (test code 35167) or Total T4 (test code 867) should be considered.

Alternative Name(s)
Thyrotropin,Thyroid Stimulating Hormone

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